|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells显示文摘Oxaliplatin 是在 colorectal 癌,而是它的毒性的化疗的重要的药,特别剂量相关的 neurosensory 毒性,很好没被容忍。在这研究,我们调查了 honokiol 是否能在 vitro 在结肠癌 HT-29 房间扩充 oxaliplatin 的反肿瘤效果并且 honokiol 是否能与 oxaliplatin 被使用到减少 oxaliplatin 剂量。我们使用了正常冒号房间,人的结肠的上皮的房间(HCoEpiCs ) 作为控制房间。细胞增长, apoptosis,前列腺素 E2 (PGE2 ) 和脉管的 endothelial 生长因素(VEGF ) 层次也被调查。cyclo-oxygenase 的表示层次 2 (COX-2 ) , VEGF, AKT/p-AKT,细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 1/2/p-ERK1/2,原子因素 kappa B (NF-B ) P65/p-P65,和 caspase-3 被测量。Honokiol 或 oxaliplatin 以一种集中依赖者方式,而是 honokiol 的仅仅高的集中压制了 HT-29 房间的增长将压制 HCoEpiCs 的增长。HT-29 房间面对 honokiol 对 oxaliplatin 治疗更敏感。与 honokiol 相结合的 Oxaliplatin 改进了 HT-29 房间的 apoptosis 率并且减少了 PGE2 和 VEGF 分泌物层次。COX-2 和 VEGF 蛋白质和 AKT, ERK1/2,和 NF-B P65 的 phosphorylation 的表示层次也被禁止。Caspase-3 层次是在 honokiol 处理以后的 upregulated。因此, honokiol 能在结肠癌的化疗与 oxaliplatin 在联合被使用。这联合在 oxaliplatin 剂量允许减小,并且从而减少它的不利效果。它可以也为这疾病提高 oxaliplatin 的化学疗法的效果。 | Hanju Hua Wenbin Chen Ling Shen Qinsong Sheng Lisong Teng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 7 |
| 2 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 3 | Efficient benzaldehyde photosynthesis coupling photocatalytic hydrogen evolution显示文摘Photosynthesis of organic compounds in coupling with promoted hydrogen evolution under mild conditions of light irradiation is considered as one of the most efficient and promising approach to obtain high purity hydrogen and value-added chemicals concurrently by utilizing green solar energy.Here,we report the synthesis of Ni S nanoparticle-modified Cd S nanorod composites(Ni S/Cd S)as an efficient bifunctional catalyst for the highly selective photocatalytic synthesis of high-value-added product benzaldehyde(BAD)from aqueous solution of benzyl alcohol(BA)under oxygen-free conditions,in accompanying with the efficient hydrogen evolution.The synergetic catalytic effect between Ni S and Cd S is proposed to play an important role in elevating the photo-redox performance.The composition-optimized 30%Ni S/Cd S catalyst affords an extraordinarily high H;generation rate of 207.8μmol h^(-1)and a simultaneous BAD generation rate of 163.8μmol h^(-1)under visible light irradiation,which are respectively 139 and 950 times higher than those of Cd S without Ni S modification.To our knowledge,these are the highest photocatalytic production rates of both H_(2)and aldehyde ever reported on the concurrent photocatalytic of aldehyde synthesis and hydrogen evolution in green aqueous solution.This work provides a highly efficient photosynthesis strategy for the concurrent productions of high-value-added fine chemicals and hydrogen. | Juanjuan Luo Min Wang Lisong Chen Jianlin Shi | 2022 | Journal of Energy Chemistry2022，31，3： | 2 |
| 4 | Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells显示文摘 | Yong Chen Lisong Yang Chao Feng Long-Ping Wen | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 5 | Nano neodymium oxide induces massive vacuolization and autophagic cell death in non- small cell lung cancer NCI-H460 cells显示文摘 | Chen Yong Yang Lisong Feng Chao | 2005 | Biochemical and Biophy- sical Research Communications2005，337，1： | 1 |
| 6 | Nano neodymium oxide induces massive vacuolization and autophagic cell death in non - small cell lung cancer NCl - H460 cells显示文摘 | Chen Yong Yang Lisong Feng Chao | 2005 | Biochemical and Biophysical Research Communications2005，337，1： | 1 |
| 7 | Organic acid metabolism in Citrus grandis leaves and roots is differently affected by nitric oxide and aluminum interactions 显示文摘 | YANG Lintong CHEN Lisong PENG Haoyang | 2012 | Scientia Horticuhurae2012，133，： | 1 |
| 8 | Multi-relaxation time lattice Boltzmann simulations of deep lid driven cavity flows at different aspect ratios显示文摘 | Lin Lisong Chen Yicheng Lin Chaoan | 2011 | Computers and Fluids2011，45，1： | 1 |
| 9 | CH_4 oxidation to oxygenates with N_2O over iron-containing Y zeolites:Effect of preparation显示文摘Developing effective iron-incorporated zeolites and determining their active centers for the direct oxidation of CH_4 to oxygenates have remained challenging topics so far.In this paper,we successfully prepare the highly-dispersed iron supported Y zeolites by a facile solid-state ion-exchange method with ferrocene,which was conducted under water-free conditions followed by a series of calcination.Moreover,extra-framework dinuclear Fe^(2+)complexes are identified as so-called activeα-iron sites on zeolites.ICP-OES,N_2 adsorption–desorption test,X-ray diffraction,solid-state^(27)Al NMR,N_2O titration,TEM,EPR and^(57)Fe M?ssbauer spectra were carried out to characterize properties of sample structure,acid sites,as well as the supported iron species.Characterization results indicate that high-temperature treatments have no effect on the typical structure feature of zeolites.Compared with catalysts synthesized by conventional impregnation,the samples prepared by the facile approach possess abundant dinuclear Fe^(2+)complexes but no Fe_2O_3 bulks and show weak acidity.These lead to a higher oxygenate selectivity in CH_4 oxidation to oxygenates.Remarkably,the oxygenate(HCHO and CH_3OH)selectivity of 6.5% at 375°C can be eventually obtained. | Jing Zhu Lisong Fan Lina Song Fengqiu Chen Dangguo Cheng | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 10 | Crosslinking of Poly Using Dicumyl Peroxide as Initiator显示文摘 | Fei Bin Dong Lisong Chen Cheng | 2004 | Polymer Inter- national2004，53，： | 1 |
| 11 | Preparation and characterization of biodegradable poly(L-lactide)/chitosan blends显示文摘 | Cheng chen Lisong Dong Man Ken Cheung | 2005 | European Polymer Journal2005，41，5： | 1 |
| 12 | Changes in organic acid metabolism differ between roots and leaves of Citrus grandis in response to phosphorus and aluminum interactions 显示文摘 | Chen Lisong Tang Ning Jiang Huanxin | 2009 | Journal of Plant Physiology2009，166，18： | 1 |
| 13 | Photosynthetic enzymes and carbohydrate metabolism of apple leaves in response to nitro- gen limitation显示文摘 | Chen Lisong Cheng Lailiang | 2004 | Journal of Hortcultural Science and Bio- technology2004，79，6： | 1 |
| 14 | Aluminum-induced effects on photosystem II photochemistry in Citrus leaves assessed by the chlorophyll a fluorescence transient显示文摘 | Jiang Huanxin Chen Lisong Zhang Jingui Han Shuang Tang Ning Smith B R | 2008 | Tree Physiology2008，28，： | 1 |
| 15 | ,Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells显示文摘 | Chen Yong Lisong Yang Feng Chao | 2005 | Biochem Biophys Res Commun2005，337，1： | 1 |
| 16 | Corigendum to“Efficient benzaldehyde photosynthesis coupling photocatalytic hydrogen evolution”[J.Energy Chem.66(2022)52-60]显示文摘It is regretful that the wrong image of Fig.4 was used in the paperin the final proof stage by editor.The correct one should be as follow. | Juanjuan Luo Min Wang Lisong Chen Jianlin Shi | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 17 | Anion-tuned nickel chalcogenides electrocatalysts for efficient 2e−ORR towards H_(2)O_(2)production in acidic media显示文摘Electrocatalytic 2e−oxygen reduction reaction(2e−ORR)is a promising approach to producing H_(2)O_(2) at ambient temperature and pressure especially in acidic media,which,however,is hindered by the high cost of precious metal-based electrocatalysts.Hence,the development of efficient earth-abundant electrocatalysts and reaction mechanism exploration for H_(2)O_(2) production by 2e−ORR in acidic solution are critically important but remain challenging at present.In this work,NiSe_(2)has been developed as a novel and high-performance 2e−ORR electrocatalyst in acidic media,moreover,using nickel chalcogenides as the models,the influence of different anion species(Se_(2)^(2−),S22−,and O^(2−))on 2e−ORR electrocatalytic performance of the catalysts has been investigated.The synthesized NiSe_(2)exhibits outstanding 2e−ORR performance of high selectivity(90%)and long-term durability(12 h).The maximum H_(2)O_(2) concentration of NiSe_(2)reaches 988 ppm,which is the highest among all the reported transition metal chalcogenides.This work demonstrates a novel point of view in anion tuning for designing high-efficiency transition-metal-based electrocatalysts for 2e−ORR. | Qingjia Sun Guanxing Xu Bingyan Xiong Lisong Chen Jianlin Shi | 2023 | Nano Research2023，16，4： | 0 |
| 18 | Influence of extra-framework Al in Fe-MOR catalysts for the direct conversion of methane to oxygenates by nitrous oxide显示文摘Iron-containing zeolites play an important role in the selective oxidation of methane to oxygenates by nitrous oxide.A solid-state ion exchange method is adopted to prepare Fe-MOR zeolite catalysts with different amounts of extra-framework Al.EPR spectra and UV-vis spectra show that the percentage of iron ions in tetrahedral or octahedral coordination increases while those of clustered Fe species decrease by the addition of extra-framework Al species.Nitrous oxide titration reveals that more active Fe centers are formed,which promote the nitrous oxide consumption.The number of active centers in the catalyst with the introduction of extra-framework Al is about four times that of the catalyst without the addition of extra-framework Al.Due to this,there is an increase in the methane conversion,total selectivity and yield of oxygenates. | Shenglai Li Lisong Fan Lina Song Dangguo Cheng Fengqiu Chen | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 0 |
| 19 | Interactive Development-oriented Poverty Reduction Model for Bijie Experimental Region under the Guidance of Scientific Outlook on Development显示文摘Bijie Experimental Region takes the ecological construction as the guarantee and takes population control as the key,to promote development-oriented poverty reduction and explore benign interaction between development-oriented poverty reduction and ecological construction and population control.Development-oriented poverty reduction model includes combination of raising crops and livestock,coordinated development of multiple wealth sources,transferring labor,and partner assistance;ecological construction model includes'Five sons passed imperial examinations',desertification control,agricultural circular economy,and project promotion;population control models includes human-land linkage,combination of favorable policies and propaganda and education,and combination of ambition arousing and education promotion. | Faliang YU Lisong CHEN | 2013 | Asian Agricultural Research2013，5，9： | 0 |
| 20 | Microwave-Absorbing Properties of La_(1-x)Sr_xMn_ (1-y)Fe_yO_3显示文摘The experiment samples of La 1-xSrxMn 1-yFeyO3(x=0.15, 0.20, 0.23; y=0.10, 0.12, 0.14, 0.16) were prepared by sol-gel process, and the loss tangent and absorption coefficient in the range of 2~18 GHz were measured by HP8722 net analyzing apparatus. It is found that changing the content of Sr or Fe would effect the microwave absorbing. When the thickness of La 1-xSrxMn 1-yFeyO3 is 2 mm and x=0.20, y=0.14, the capability of microwave absorbing is the best one. There are two absorption peaks; the maximum is 34 dB and effective band width with 10 dB and more reaches 6.2 GHz. When the frequency between 2~12.5 GHz dielectric loss is considered as the major loss from the loss angle picture. When the frequency gets to near 12.5 GHz the loss angle tangent increases or decreases suddenly. When the frequency between 12.5~18 GHz magnetic loss is be considered as the major loss. The resistivity of La 0.8Sr 0.2Mn 0.86Fe 0.14O3 at room temperature presents its semiconductor character, which is more beneficial to absorbing microwave. | Wang Da Zhou Kesheng Yin Lisong Chen Mintao Deng Jianjie | 2006 | Journal of Rare Earths2006，24，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员