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| 1 | Land surface temperature retrieval for arid regions based on Landsat-8 TIRS data:a case study in Shihezi,Northwest China显示文摘Scientific interest in geophysical information about land surface temperature(LST) is ever increasing, as such information provides a base for a large number of applications, including environmental and agricultural monitoring. Therefore, the research of LST retrieval has become a hot topic. Recent availability of Landsat-8 satellite imagery provides a new data source for LST retrieval. Hence, exploring an adaptive method with reliable accuracy seems to be essential. In this study, basing on features of Landsat-8 TIRS thermal infrared channels, we re-calculated parameters in the atmospheric transmittance empirical models of the existing split-window algorithm, and estimated the ground emissivity with the help of the land cover classification map of the study area. Furthermore, a split-window algorithm was rebuilt by virtual of the estimation model of the updated atmospheric transmittance and the ground emissivity, and then a remote sensing retrieval for the LST of Shihezi city in Xinjiang Uygur autonomous region of Northwest China was conducted on the basis of this modified algorithm. Finally, precision validation of the new model was implemented by using the MODIS LST products. The results showed that the LST retrieval from Landsat-8 TIRS data based on our algorithm has a higher credibility, and the retrieved LST is more consistent with the MODIS LST products. This indicated that the modified algorithm is suitable for retrieving LST with competitive accuracy. With higher resolutions, Landsat-8 TIRS data may provide more accurate observation for LST retrieval. | Lei YANG YunGang CAO XiaoHua ZHU ShengHe ZENG GuoJiang YANG JiangYong HE XiuChun YANG | 2014 | Journal of Arid Land2014，6，6： | 17 |
| 2 | Integration of Metabolomics and Subcellular Organelle Expression Microarray to Increase Understanding the Organic Acid Changes in Post-harvest Citrus Fruit显示文摘Citric acid plays an important role in fresh fruit favor and its adaptability to post-harvest storage conditions.In order to explore organic acid regulatory mechanisms in post-harvest citrus fruit,systematic biological analyses were conducted on stored Hirado Buntan Pummelo(HBP;Citrus grandis)fruits.High-performance capillary electrophoresis,subcellular organelle expression microarray,real-time quantitative reverse transcription polymerase chain reaction,gas chromatography mass spectrometry(GC-MS),and conventional physiological and biochemical analyses were undertaken.The results showed that the concentration of organic acids in HBP underwent a regular fuctuation.GC-MS-based metabolic profling indicated that succinic acid,g-aminobutyric acid(GABA),and glutamine contents increased,but 2-oxoglutaric acid content declined,which further confrmed that the GABA shunt may have some regulatory roles in organic acid catabolism processes.In addition,the concentration of organic acids was signifcantly correlated with senescence-related physiological processes,such as hydrogen peroxide content as well as superoxide dismutase and peroxidase activities,which showed that organic acids could be regarded as important parameters for measuring citrus fruit post-harvest senescence processes. | Xiaohua Sun Andan Zhu Shuzhen Liu Ling Sheng Qiaoli Ma Li Zhang Elsayed Mohamed Elsayed Nishawy Yunliu Zeng Juan Xu Zhaocheng Ma Yunjiang Cheng Xiuxin Deng | 2013 | Journal of Integrative Plant Biology2013，55，11： | 14 |
| 3 | Fine mapping of locus S-b for F_1 pollen sterility in rice (Oryza sativa L.)显示文摘Hybrid sterility is the main barrier in util-izing the heterosis of subspecies in rice. A knowledge of the underlying molecular mechanism of the hybrid sterility will be useful for overcoming the barrier. In this research, the F1 pollen sterility locus, S-b, was mapped between SSR markers PSM8 and PSM202. To fine map the locus, one F2 mapping population of 3910 plants was developed using the near-isogenic lines of the locus. Ninety-seven recombinants be-tween two markers were selected. Moreover, a series of markers, including two SSR markers, two InDel markers and four CAPS markers, were developed on the region. Linkage analysis showed that marker W4 was co-segregated with locus S-b, while makers A8 and A14 were located on the two sides of the locus with a distance of 0.026 and 0.038 cM, respectively. The markers were then integrated with the se-quences of the clones of the region. Results showed that all the polymorphic markers were anchored on the three end-to-end jointed clones AC093089, AC079021 and AC134931. According to the physical information of the markers, locus S-b was finally de-limited to a region of 27 kb between A8 and A14. Seven ORFs were identified on the region based on the annotation results of RiceGAAS system. These results laid the foundation for further cloning the gene. | LI Wentao ZENG Ruizhen ZHANG Zemin DING Xiaohua ZHANG Guiquan | 2006 | Chinese Science Bulletin2006，51，6： | 12 |
| 4 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 5 | Monitor and control of neuronal activities with femtosecond pulse laser显示文摘Combined with the fluorescence labeling technique, two-photon microscopy excited with femtosecond pulse laser has become an important tool for neuroscience research. In this research, the calcium signals from neurons in rat cortex slice were monitored by a custom-built two-photon microscopy, and the spontaneous calcium signals and the pharmacological responses as well as the responses to femtosecond pulse laser stimulation were recorded. The results showed that the amplitude of the cal-cium signals increased in direct proportion to the corresponding electrical activities. Glutamate induced a calcium transient, but continuous application resulted in smaller response. Simultaneous monitoring of neuronal populations distinguished the neurons of different microcircuits. The femtosecond pulse laser induced local or global calcium signals in the pyramidal neurons. The approach of interrogation and control of neural activities using femtosecond pulse laser is non-contact, nondestructive, repeatable, and without any additional substrates, which will contribute to the development of neuroscience. | ZHOU Wei LIU XiuLi LU XiaoHua LI JiaSong LUO QingMing ZENG ShaoQun | 2008 | Chinese Science Bulletin2008，53，5： | 5 |
| 6 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 7 | Synthesis of LiFePO_4 in situ vapor-grown carbon fiber (VGCF) composite cathode material via microwave pyrolysis chemical vapor deposition显示文摘One of the most important factors that limits the use of LiFePO 4 as cathode material for lithium ion batteries is its low electronic conductivity.In order to solve this problem,LiFePO 4 in situ vapor-grown carbon fiber (VGCF) composite cathode material has been prepared in a single step through microwave pyrolysis chemical vapor deposition.The phase,microstructure,and electrochemical performance of the composites were investigated.Compared with the cathodes without in situ VGCF,the initial discharge capacity of the composite electrode increases from 109 to 144 mA h g-1 at a 0.5-C rate,and the total electric resistance decreases from 538 to 66.The possible reasons for these effects are proposed. | DENG Fei ZENG XieRong ZOU JiZhao HUANG JianFeng SHENG HongChao XIONG XinBo QIAN HaiXia LI XiaoHua | 2011 | Chinese Science Bulletin2011，56，17： | 4 |
| 8 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 9 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 10 | Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages显示文摘Interleukin-5 (IL-5) is manifested as its involvement in the process of atherosclerosis, but the mechanism is still unknown. In this study, we explored the effect of IL-5 on lipid metabolism and its underlying mechanisms in THP-1-derived macrophages. The quantitative polymerase chain reaction (qPCR) and western blot analysis results showed that IL-5 significantly up-regulated ATP-binding cassette transporter A1 (ABCA1) expression in a dose-dependent and time-dependent manner. [3H]-labeled cholesterol was used to assess the levels of cholesterol efflux, and the results showed that IL-5 increased ABCA1-mediated cholesterol efflux. A high-performance liquid chromatography assay indicated that cellular cholesterol content was decreased by IL-5 treatment in THP-1-derived macrophages. The selective inhibitor and small interfering RNA were used to block the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway. The results of the qPCR and western blot analysis showed that IL-5 activated JAK2/STAT3 pathway to up-regulate ABCA1 expression. Meanwhile, IL-5 reduced the expression level of miR-211. Furthermore, we found that JAK2 is a target gene of miR-211 and miR-211 mimic inhibited the expression of JAK2 and reduced the levels of p-STAT3 and ABCA1 as revealed by luciferase reporter assay, qPCR and western blot analysis. In summary, these findings indicated that IL-5 promotes ABCA1 expression and cholesterol efflux through the miR-211/JAK2/STAT3 signaling pathway in THP-1-derived macrophages. | Kong Chen Zhenwang Zhao Gang Wang Jin Zou Xiaohua Yu Dawei Zhang Gaofeng Zeng Chaoke Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 11 | Detection of lymphocystis disease virus infection to flounder gill cells in vitro by monoclonal antibodies显示文摘 | 邢婧 Zhan Wenbin Zeng Xiaohua Cheng Shunfeng | 2006 | High Technology Letters2006，12，1： | 3 |
| 12 | Construction of mesoporous ceria-supported gold catalysts with rich oxygen vacancies for efficient CO oxidation显示文摘Bearing unique redox nature and high oxygen storage capacity,ceria(CeO_(2))has always been a promising CO oxidation catalyst support for gold(Au)catalysts and the like.Herein,a series of Au-CeO_(2)-P(P stands for pH value)samples was prepared by a co-precipitation method with the assistance of an alkaline environment and amino groups functionalized ordered mesoporous polymer(OMP-NH_(2)).Afterward,all samples described above were characterized that the Au-CeO_(2)-P catalysts are made of Au-Ce-O solid solution and Au nanoparticles(NPs)supported on CeO_(2).It turns out that OMP-NH_(2) is not just a simple sacrificial template for mesoporous structure,but also plays an important role as an amino source,explaining the presence of rich oxygen vacancies.Due to the concentration of oxygen vacancies in Au-Ce-O solid solution is the key factor for the oxygen mobility of CO oxidation,the catalytic results also demonstrate that the catalytic activity of Au-CeO_(2)-P catalysts is related to the concentration of their oxygen vacancies.Moreover,Au-CeO_(2)-9.6 with a highest concentration of oxygen vacancies(as high as 13.98%)in Au-CeO_(2)-P catalysts exhibits the best catalytic activity(complete conversion at 10℃). | Xin Shen Wang Li Shunmin Ding Xiaohua Ma Shaohua Wu Weiming Xiao Rong Zeng Sanguo Hong Chao Chen | 2022 | Journal of Rare Earths2022，40，3： | 2 |
| 13 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 14 | Microstructure and giant baro-caloric effect induced by low pressure in Heusler Co_(51)Fe_(1)V_(33)Ga_(15) alloy undergoing martensitic transformation显示文摘Solid-state refrigeration based on the magneto-or mechano-caloric effect,including elasto-and barocaloric in ferroic phase transition materials is promising to replace the current vapor compression refrigeration in consideration of environmental-friendliness and energy-saving.However,both high driven field and small thermal changes in all of these caloric materials hinder the development of solid-state refrigeration.Here we report a giant baro-caloric effect near room temperature induced by a low hydrostatic pressure in Co-based Co_(51)Fe_(1) V_(33)Ga_(15) Heusler alloy.The maximum adiabatic temperature change under the applied pressure change ofΔp=0.1-100 MPa can be as high asΔ_(Tad)^(Max)=7.7 K(Δ_(Tad)^(Max)/Δpreaches up to~7.7 K kbar-1),surpassing theΔ_(Tad)^(Max)/Δpvalue reported hitherto in baro-caloric alloys.In addition,the microstructure is also studied by using the electron microscopes.Along with the austenite and martensite,the submicron V-rich particles are precipitated in this alloy,which are believed to account for enhancing mechanical properties. | Kai Liu Hai Zeng Ji Qi Xiaohua Luo Xuanwei Zhao Xianming Zheng Yuan Yuan Changcai Chen Shengcan Ma Ren Xie Bing Li Zhenchen Zhong | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
| 15 | Vibration Analysis of a Drillstring in Horizontal Well显示文摘The complicated geological conditions will bring great challenges to the drillstring of horizontal wells for the reason that the increase of the well depth in Sichuan-Chongqing region.Since drillstring failure and friction during drilling are generally caused by drillstring vibration,great importance must be attached to computer simulation methods for the prediction of drillstring vibration.A finite element model considering axial,lateral and torsional vibration is established.In order to verify the established numerical model,an indoor experimental device based on the similarity principle was established.The vibration characteristics of three shale gas horizontal wells drillstrings are described.The reasons for the large difference in vibration characteristics between the three wells were discussed by changing the well structure,BHA(bottom hole assembly)and drilling parameters.The simulation results show that the depth of ultra-deep well 3 is only 1.27 times of that of medium-deep well 2,but the fluctuation of WOB(weight on bit)is 2.8 times.The primary factor for the great difference of WOB fluctuation is the change of vertical section depth,the secondary factor is the change of the horizontal section length.Additionally,the reasonable range of speeds has been proposed and applied in the field.The advantage of this numerical analysis method is that it can judge the vibration and friction torque of drillstring in horizontal wells with arbitrary structure,drilling parameters and BHA.This method has certain guiding significance to the field practice. | Xiaohua Zhu Li Zeng Bo Li | 2019 | Computer Modeling in Engineering & Sciences2019，，11： | 2 |
| 16 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 17 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 18 | Multi-mode energy management strategy for hydraulic hub-motor auxiliary system based on improved global optimization algorithm显示文摘Heavy commercial vehicles equipped with a hydraulic hub-motor auxiliary system(HHMAS)often operate under complex road conditions.Selecting appropriate operating mode and realizing reasonable energy management to match unpredictable road conditions are the keys to the driving performance and fuel economy of HHMAS.Therefore,a multi-mode energy management strategy(MM-EMS)based on improved global optimization algorithm is proposed in this study for HHMAS.First,an improved dynamic programming(DP)algorithm for HHMAS is developed.This improved DP algorithm considers the effect of SOC and vehicle speed,thereby preventing the calculation results from falling into local optimization.This algorithm also reduces the dimension of the control variable data grid,and the calculation time is reduced by 35%without affecting the accuracy.Second,a MM-EMS with hierarchical control is proposed.This strategy extracts the optimal control rules from the results of the improved DP algorithm.Then it divides the system’s operating region into two types,namely,single-mode working region and mixedmode working region.In the single-mode working region,mode switching is realized through fixed thresholds.In the mixedmode working region,a linear quadratic regulator(LQR)is adopted to determine a target mode and realize SOC tracking control.Finally,the designed MM-EMS is verified separately in offline simulation and hardware-in-the-loop(HIL)under actual vehicle test cycles.Simulation results show that the results between HIL and offline simulation are largely coincidence.Besides,in comparison with the engine optimal control strategy,the designed MM-EMS can achieve an approximate optimal control,with oil savings of 3.96%. | ZENG XiaoHua WU ZiQiao WANG Yue SONG DaFeng LI GuangHan | 2020 | Science China(Technological Sciences)2020，63，10： | 1 |
| 19 | Syn-thesis,characterization and SOD-like activity of a ternary copper(II) complex with 1,10-phenanthroline and L-argi-nine显示文摘 | MA Huifang ZENG Xirui ZHOU Xiaohua | | 0，，23： | 1 |
| 20 | Self-perceived Burden among Advanced Cancer Patients: A Cross-Sectional Survey显示文摘Objective:The aims of this study are to explore the prevalence and the influencing factors of SPB(self-perceived burden)among advanced cancer patients.Methods:One hundred fifty-six patients were recruited from the Oncology Comprehensive wards of a comprehensive hospital in Zhuhai city from January to December 2019.Data consisted of a series of questionnaires a week after the patients’hospitalization.Relevant statistical analyses were conducted using SPSS 25.0.Results:58.34%patients reported moderate to severe SPB(VAS≥50 mm).Patients’SPB was associated with place of residence(β=0.160,p=0.049),and time since cancer diagnosis with 7~12 months(β=-0.266,p=0.009)and moderate medical burden(β=-0.209,p=0.037)scores.The proportion of explained variance was 36.0%.Conclusion:Health care professionals should be aware that about over half of advanced cancer patients experience moderate to severe SPB.They should adapt their support of patients who report such a feeling. | Xie Minyi Zeng Xiaoe Li Qiaomin Guan Xiaofang Li Siqing Gong Xiaohua | 2020 | Journal of US-China Medical Science2020，17，4： | 1 |
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