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| 1 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 2 | Electro-catalyze oxida- tion treatment of acid anthraquinone green GL dyestuff wastewater 显示文摘 | LI Qingxin YU Xunmin HU Lisong | 2007 | Journal of Yangtze University ( Nat Sci Edit) Sci & Eng V2007，4，2： | 1 |
| 3 | Double-Crystal x-Ray Diffraction Study on Ta/Al Multilayers显示文摘Double-crystal x-ray diffraction has been used to measure the rocking curve of Ta/Al multilayers.The diffraction profiles of the multilayers are different.Besides the normal profile,two kinds of distorted profiles have been found.The simulations show that the deformed profiles of the peaks are caused by the imperfect periodicity(e.g.systematic period deviation and coexistence of two slightly different periods)in the multilayers. | XIU Lisong YUAN Xiangyang WU Ziqin JIANG Shusheng HU An ZHAO Jiyong JIANG Jianhua | 1992 | Chinese Physics Letters1992，9，11： | 0 |
| 4 | Comparative transcriptome analysis revealed the influence of sucrose on flavor and taste quality of Coffea arabica and C.canephora varieties显示文摘Coffea arabica(Arabica)and C.canephora(Robusta)are the most popular coffee species in the world,accounting for 99%of overall consumption of coffee beans.Arabica generally possesses better coffee quality than Robusta partly due its higher sucrose content.The flavor and taste(FT)of coffee,as important aspects of coffee quality,are mainly affected by the content of caffeine,phenolic acid and terpenoid compounds,which use sucrose as an important precursor.However,how sucrose affects the coffee FT remains unclear.In this study,coffee beans at different developmental stages from Arabica#161(A161,high-sucrose variety)and Robusta#6(R6,low-sucrose variety)were sampled to perform transcriptomic analysis.Most differentially expressed genes(DEGs)between them were enriched in sucrose-related metabolisms and the FTrelated metabolism processes:caffeine biosynthesis,phenylpropanoid and flavonoid pathway,terpenoid metabolism.Thirty-four candidate DEGs probably contributed to the higher content of sucrose,anthocyanin and linalool in A161,and higher content of caffeine and carotenoid in R6.Generally,sucrose-related metabolisms were strongly associated with FT-related substance accumulation.The content of sucrose and its influence on the downstream secondary metabolism probably play important roles in the FT quality of coffee beans.Our results provide efficient targets for investigation regarding the influence of sucrose on FT quality of coffee beans. | Lifang Huang Lisong Hu Yu Fan Xiaoyang Wang Yunping Dong Fupeng Li Yuzhou Long Lin Yan Jie Meng | 2021 | Beverage Plant Research2021，1，1： | 0 |
| 5 | A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen显示文摘Dear Editor,Catharanthus roseus,an important medicinal plant native to Madagascar,is the sole source of the two important anticancer drugs vinblastine and vincristine,which are synthesized by the monoterpene-derived indole alkaloid(MIA)pathway(Das et al.,2020).It is also an important model plant for the study of Huanglongbing(HLB),a devastating citrus disease that causes severe economic losses worldwide(Ma et al.,2022).Vincristine is an FDA-approved drug that has been used for acute lymphocytic leukemia,lymphoid blast crisis of chronic myeloid leukemia,and Hodgkin’s/non-Hodgkin’s lymphoma(Below and M Das,2021). | Zhongping Xu Guanying Wang Qiongqiong Wang Xiaoting Li Guangyu Zhang Ali Qurban Can Zhang Yi Zhou Huan Si Lisong Hu Fuqiu Wang Ying Wang Zhitao Tian Wei Chen Shuangxia Jin Fang Ding | 2023 | Plant Communications2023，4，6： | 0 |
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