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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | The Occurrence of Oleananes in the Beibuwan Basin and Its Application to the Study of Maturity and Oil-Source Rock Correlation显示文摘摘要: oleanane 参数,即,在 Beibuwan 盆的二沉积的列的 OP (oleananes/( oleananes+C30hopanes )),华南海,能被用来限定油产生窗户的顶,与在井 M1 的 0.53 的 Ro (/%)并且 0.55 在井 H1/Hd1/Hd2 ,分别地。与 vitrinite 反射(Ro/%) 作比较, OP 展示一个动态范围和罐头更精确显示油产生窗户。由使用 OP 和另外的 geochemical 索引,油来源关联也被进行。它建议在井 M1 和 M2 的油在 situ 从来源岩石被导出。在 Huachang 的 mudstone 高举不是为在这个区域的油的主要来源岩石。OP 也是在一些第三级的湖的盆的一个有用油来源关联参数。 | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 9 |
| 3 | Physical picture of the optical memory effect显示文摘The optical memory effect is an interesting phenomenon that has attracted considerable attention in recent decades. Here, we present a new physical picture of the optical memory effect, in which the memory effect and the conventional spatial shift invariance are united. Based on this picture we depict the role of thickness, scattering times, and anisotropy factor and derive equations to calculate the ranges of the angular memory effect(AME) of different scattering components(ballistic light, singly scattered, doubly scattered, etc.), and hence a more accurate equation for the real AME ranges of volumetric turbid media. A conventional random phase mask model is modified according to the new picture. The self-consistency of the simulation model and its agreement with the experiment demonstrate the rationality of the model and the physical picture, which provide powerful tools for more sophisticated studies of the memory-effect-related phenomena and wavefront-sensitive techniques, such as wavefront shaping, optical phase conjugation, and optical trapping in/through scattering media. | Honglin Liu Zhentao Liu Meijun Chen Shensheng Han Lihong V.Wang | 2019 | Photonics Research2019，7，11： | 9 |
| 4 | Review of systematic reviews and Meta-analyses investigating Traditional Chinese Medicine treatment for type 2 diabetes mellitus显示文摘OBJECTIVE: To conduct a review of the systematic reviews and meta-analyses on the Traditional Chinese Medicine(TCM) treatment of type 2 diabetes mellitus(T2DM).METHODS: We searched Pub Med, Cochrane, Web of Science, Chinese Biomedical Literature Database(CBM), China National Knowledge Infrastructure(CNKI), China Science and Technology Journal Database(VIP), Wanfang, and other databases from database inception to May 2014 for systematic reviews and meta-analyses on TCM treatment of T2 DM. Manuscripts were read by two investigators if they met the inclusion criteria, and data were extracted. A Measurement Tool to Assess Systematic Reviews(AMSTAR) was used to classify research quality, and the evidence quality was graded by the Grade of Recommendation, Assessment, Development, and Evaluation(GRADE) system.RESULTS: Eighteen systematic reviews and meta-analyses were considered. Fifteen analyzed the efficacy of Chinese herbal medicines, and three investigated the efficacy of acupuncture. AMSTAR evaluation ranged from 3-10, and re-evaluation of the main results implied that treatment of T2 DM with TCM has certain advantages when compared with conventional Western medicine. However, the evidence quality was generally low.CONCLUSION: This work shows favorable evidence for the clinical treatment of TCM on T2 DM. However, it is recommended that evidence-based decisions are made based on clinical trials because of the GRADE scores of the studies. To achieve higher quality of clinical research, clinical research on TCM requires specific and suitable research methods. Further trials may increase the quality of evidence to evaluate the clinical efficacy of TCM for T2 DM. | Liu Meijun Liu Zhicheng Xu Bin Zhang Wei Cai Jianwei | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 3 |
| 5 | Effect of Huatan Jieyu granules in treatment of Parkinson’s disease patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind显示文摘OBJECTIVE: To investigate the safety and efficacy of Huatan Jieyu granules in treatment of Parkinson’s disease(PD) patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind in terms of the theory of Traditional Chinese Medicine.METHODS: In total, 107 Parkinson’s disease patients with sleep disorders identified as symptom pattern of phlegma-heat-stirring wind were selected and randomly divided into the experimental group(55 cases) and the control group(52 cases).Both groups were given basic treatment with prednisone. The experimental group of patients was treated with Huatan Jieyu granules and the control group of patents was treated with only the basic treatment. Treatment lasted for 4 weeks. Sleep polygraph were recorded before the study as well as 3 months and 6 months after treatment.RESULTS: After treated with Huatan Jieyu granules,the total sleep time, and the percentage of non rapid eye movement 2(NREM 2), non rapid eye movement 3(NREM 3) and rapid eye movement(REM)sleep period increased significantly, while the percentage of NREM1 sleep period decreased significantly compared with before treatment(P < 0.05).CONCLUSION: The treatment of PD patients with sleep disorder by Huatan Jieyu granules can improve their sleep structure and their sleep quality. | Liu Meijun Hu Chongshan Zhang Yaodan Li Qizheng Zhang Qi Fang Yu Sun Honghui Hou Xiaolin Jin Shuoguo Tao Liangjing Yang Dongdong | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 6 | Characteristics of Oil and Gas Accumulation in Yong'an-Meitai Area of the Fushan Depression,Beibuwan Basin,South China Sea显示文摘The Yong'an-Meitai area is the focus of the present exploration in the Fushan Depression,Beibuwan Basin,South China Sea. All oils from this area are geochemically characterized by higher Pr/Ph ratio,higher proportion of heavy molecular weight hydrocarbons,and higher proportion of C29 regular steranes,which indicate that the organic matter of source rocks might have been deposited in an oxidizing palaeoenvironment and be dominated by higher plant organic matter input. The oil from E3w2 (the second member of Weizhou Fm. of the Oligocene) has a much higher density,relatively higher Pr/nC17 and Ph/nC18 ratios,and a 'UCM-unresolved complex mixture' on gas chromatograms,which indicate that it has been slightly biodegraded. CPI and other terpane and sterane isomer ratios suggest they are all mature oils. The timing of oil charging in E3w2 and E2l1 (the first member of the Liushagang Fm. of the Eocene) determined by the homogenization temperatures of fluid inclusions and thermal evolution history are from 9-3 Ma and 8-3 Ma,respectively. Thus,the interpretation of E3w2 as a secondary reservoir is unlikely. The timing of oil charging is later than that of hydrocarbon generating and expulsion of Liushagang Fm. source rocks and trap formation,which is favorable for oil accumulation in this area. All molecular parameters that are used for tracing oil filling direction decrease with shallower burial depth,which suggests vertical oil migration. The widely occurring faults that penetrate through the source rocks of the Liushagang Fm. may serve as a fine oil charging conduit. | Li Meijun Wang Tieguan Liu Ju Zhang Meizhu Lu Hong Ma Qinglin Gao Lihui | 2007 | Petroleum Science2007，4，4： | 2 |
| 7 | Alkyl Naphthalenes and Phenanthrenes:Molecular Markers for Tracing Filling Pathways of Light Oil and Condensate Reservoirs显示文摘冷凝物和轻油被高成熟, sterane 的低集中和 terpane biomarkers 和非烃部分的低内容通常描绘。作为结果,某使用得通常的 sterane, terpane 和 carbazole,在常规油水库的迁居参数可以在煤气的层析团 spectrometry (GCMS ) 为他们的差的信号噪音比率在冷凝物和轻油水库有某个限制。然而,萘,菲和他们的 methylated 取代者在在冷凝物和轻油的重要集中是在场的。拿 Fushan 消沉(在 Beibuwan 盆,北华南海) 作为一个例子,这份报纸第一次试图使用多不的芳香的烃(哼) 跟踪迁居方向的相关参数和为冷凝物和光的充满的小径给水库上油。结果显示出那 TMNr (即 1,3,7-TMN/(1,3,7-TMN + 1,2,5-TMN ) , TMN:trimethylnaphthalene )) , MPI-1 (即 1.5 自从热历史在古生代不能在更低的古生代的继任由于有效热指示物的缺乏客观地被重建。磷灰石和锆石(U-Th )/He thermochronometry 能被用作技术的一种新类型学习热历史并且构造沉积的盆高举。把年龄,磷灰石分裂磁道数据和等价 vitrinite 反射(% EVRo ) 基于测量磷灰石和锆石(U-Th )/He,在 Bachu 的 5 口井的 tectonothermal 历史高举被建模。当模特儿的结果证明有相对高的坡度一吗? | LI Meijun WANG Tieguan LIU Ju ZHANG Meizhu LU Hong MA Qinglin GAO Lihui | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 2 |
| 8 | Hierarchical porous carbon derived from coal-based carbon foam for high-performance supercapacitors显示文摘Hierarchical porous carbon(HPC)from bituminous coal was designed and synthesized through pyrolysis foaming and KOH activation.The obtained HPC(NCF-KOH)were characterized by a high specific surface area(S_(BET))of 3472.41 m^(2)/g,appropriate mesopores with V_(mes)/V_(total)of 57%,and a proper amount of surface oxygen content(10.03%).This NCF-KOH exhibited a high specific capacitance of 487 F/g at 1.0 A/g and a rate capability of 400 F/g at 50 A/g based on the three-electrode configuration.As an electrode for a symmetric capacitor,a specific capacitance of 299 F/g at 0.5 A/g was exhibited,and the specific capacitance retained 96%of the initial capacity at 5 A/g after 10,000 cycles.Furthermore,under the power density of 249.6 W/kg in 6 mol/L KOH,a high energy density of 10.34 Wh/kg was obtained.The excellent charge storage capability benefited from its interconnected hierarchical pore structure with high accessible surface area and the suitable amount of oxygen-containing functional groups.Thus,an effective strategy to synthesize HPC for high-performance supercapacitors serves as a promising way of converting coal into advanced carbon materials. | Nuannuan Yang Lei Ji Haichao Fu Yanfeng Shen Meijun Wang Jinghai Liu Liping Chang Yongkang Lv | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 9 | Biomarker 17a (H) -diahopane:a geochemical tool to study the petroleum system of a Tertiary lacustrine basin,Northern South China Sea显示文摘 | Li Meijun Wang Tieguan Liu Ju etal | 2009 | Applied Geochemistry2009，24，1： | 1 |
| 10 | Negative pressure closes the drainage technology application in enormous fresh lower limbs surface of a wound显示文摘 | LIU HEZHENG YU GUORONG ZHOU MEIJUN | 2001 | Clinical surgery magazine2001，9，4： | 1 |
| 11 | Biomarker 17a( H) -diahopane : a geochemical tool to study the petroleum systemof a Tertiary lacustrine basin, Northern South China Sea 显示文摘 | LI Meijun WANG Tieguan LIU Ju | 2009 | Applied Geochemistry2009，24，1： | 1 |
| 12 | Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects显示文摘Stem cell-based tissue engineering has provided a promising platform for repairing of bone defects.However,the use of exogenous bone marrow mesenchymal stem cells(BMSCs)still faces many challenges such as limited sources and potential risks.It is important to develop new approach to effectively recruit endogenous BMSCs and capture them for in situ bone regeneration.Here,we designed an acoustically responsive scaffold(ARS)and embedded it into SDF-1/BMP-2 loaded hydrogel to obtain biomimetic hydrogel scaffold complexes(BSC).The SDF-1/BMP-2 cytokines can be released on demand from the BSC implanted into the defected bone via pulsed ultrasound(p-US)irradiation at optimized acoustic parameters,recruiting the endogenous BMSCs to the bone defected or BSC site.Accompanied by the daily p-US irradiation for 14 days,the alginate hydrogel was degraded,resulting in the exposure of ARS to these recruited host stem cells.Then another set of sinusoidal continuous wave ultrasound(s-US)irradiation was applied to excite the ARS intrinsic resonance,forming highly localized acoustic field around its surface and generating enhanced acoustic trapping force,by which these recruited endogenous stem cells would be captured on the scaffold,greatly promoting them to adhesively grow for in situ bone tissue regeneration.Our study provides a novel and effective strategy for in situ bone defect repairing through acoustically manipulating endogenous BMSCs. | Yanni He Fei Li Peng Jiang Feiyan Cai Qin Lin Meijun Zhou Hongmei Liu Fei Yan | 2023 | Bioactive Materials2023，，3： | 1 |
| 13 | Application of Variable Strategies in the Low-cost and Energy-saving Rural Residences in Transitional Areas显示文摘Changeful and complex rural family structure and climatic features of transitional areas in China make the application of variable strategy in energy-saving rural residence designs possible.Aiming at the low cost,several effective and reasonable variable strategies were proposed for the design of interior spaces,main bedroom,sunshine room,staircase,west wall,door and window design to satisfy changing structure of a family during different periods and their different thermo-technical requirements in winter and summer.In this way,thermal comfort of rural indoor spaces will be improved,more energy saved,useful experience and thoughts provided for the energy-saving residence design in cold regions and regions hot in summer and cold in winter. | LU Meijun LIU Jingxia WANG Guixiu | 2012 | Journal of Landscape Research2012，4，9： | 1 |
| 14 | Biomarker 17α(H)-diahopane: A geochemical tool to study the petroleum system of a Tertiary lacustrine basin, Norther South China Sea显示文摘 | Li Meijun Wang Tieguan Liu Ju | 2009 | Applied Geochemistry2009，24，1： | 1 |
| 15 | Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency显示文摘Forkhead box(Fox)transcription factors play important roles in mammalian development and disease.However,their function in mouse somatic cell reprogramming remains unclear.Here,we report that FoxD subfamily and FoxG1 accelerate induced pluripotent stem cells(iPSCs)generation from mouse fibroblasts as early as day4 while FoxA and FoxO subfamily impede this process obviously.More importantly,FoxD3,FoxD4 and FoxG1 can replace Oct4 respectively and generate iPSCs with germline transmission together with Sox2 and Klf4.On the contrary,FoxO6 almost totally blocks reprogramming through inhibiting cell proliferation,suppressing the expression of pluripotent genes and hindering the process of mesenchymal to epithelial transition(MET).Thus,our study uncovers unexpected roles of Fox transcription factors in reprogramming and offers new insights into cell fate transition. | Meijun Fu Huan Chen Zepo Cai Yihang Yang Ziyu Feng Mengying Zeng Lijun Chen Yue Qin Baomei Cai Pinghui Zhu Chunhua Zhou Shengyong Yu Jing Guo Jing Liu Shangtao Cao Duanqing Pei | 2021 | Cell Regeneration2021，10，1： | 0 |
| 16 | 1,3-Dipolar cycloaddition for selective synthesis of functionalized spiro[indoline-3,3’-pyrrolizines]显示文摘The 1,3-dipolar cycloaddition reaction of dimethyl hex-2-en-4-ynedioate with azomethine ylides derived from reaction of L-proline with various isatins in methanol selectively resulted in the formation of functionalized spiro[indoline-3,3’-pyrrolizine]acrylates as main products and spiro[indoline-3,3’-pyrrolizine]propiolates as minor products.This result indicated that the electron-deficient alkyne has higher reactivity than that of electron-deficient alkene in 1,3-dipolar cycloaddition reaction. | Meijun Zhu Ying Han Changzhou Liu Weiqing Ma Chao-Guo Yan | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 17 | Energy-dispersive X-ray Spectroscopy for the Quantitative Analysis of Pyrite Thin Specimens显示文摘To explore ways to improve the accuracy of quantitative analysis of samples in the micrometer to nanometer range of magnitudes,we adopted analytical transmission electron microscopy(AEM/EDS)for qualitative and quantitative analysis of pyrite materials.Additionally,the k factor of pyrite is calculated experimentally.To develop an appropriate non-standard quantitative analysis model for pyrite materials,the experimentally calculated k factor is compared with that estimated from the non-standard quantitative analytical model of the instrument software.The experimental findings demonstrate that the EDS attached to a TEM can be employed for precise quantitative analysis of micro-and nanoscale regions of pyrite materials.Furthermore,it serves as a reference for improving the results of the EDS quantitative analysis of other sulfides. | LUO Tingting GUO Yi DENG Zhao LIU Xiaoqing SUN Zhenya QI Yanyuan YANG Meijun | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，6： | 0 |
| 18 | Heterogenous glucose-stimulated insulin secretion at single islet level显示文摘Insulin secretion by pancreatic islets plays a vital role in regulating blood glucose levels.Nevertheless,the mech-anism responsible for this dynamic insulin secretion has not been completely understood,particularly at the single islet level.In this study,we have successfully developed an easy microfluidic platform that allows for the exploration of dynamic glucose-stimulated insulin secretion(GSIS)at the single islet level.With the utilization of this platform,we evaluated dynamic GSIS from single islets isolated from both normal and diabetic rats.Our results demonstrate that islets can be categorized into three types based on their dynamic GSIS:Type Ⅰ exhibits a biphasic GSIS profile with a fast first phase and flat second phase;Type Ⅱ also has a biphasic GSIS profile with a fast first phase but a slow increased second phase;Type Ⅲ displays only a slowly increased second phase and lacks a fast first phase.RNA sequencing analysis demonstrated that the cell type and exocytosis-specific genes are consistent with the proportion of cells and insulin release kinetics among the three types of islets,respectively.Moreover,our findings suggest that high expression of Atp5pb is anti-correlated with the first phase of insulin secretion.Furthermore,we revealed that diabetic islets exhibit only the type Ⅰ GSIS response,indicating a deliberate impairment of the second phase of insulin secretion.Together,this device serves as a crucial tool in the research field of islets and diabetes,allowing researchers to investigate islet functional heterogeneity and identity at the single islet level. | Jiaxiang Yin Hao Meng Haopeng Lin Meijun Mo Jingfang Lin Jingyi Chen Lihua Chen Xiaojun Xu Zonghong Li Wei Ji Tao Xu Huisheng Liu | 2023 | Engineered Regeneration2023，4，4： | 0 |
| 19 | Graphene/SiC-coated textiles with excellent electromagnetic interference shielding,Joule heating,high-temperature resistance,and pressure-sensing performances显示文摘Multifunctional,wearable,and durable textiles integrated with smart electronics have attracted tremendous attention.However,it remains a great challenge to balance new functionalities with high-temperature stability.Herein,textile-based pressure sensors with excellent electromagnetic interference(EMI)shielding,Joule heating,and high-temperature resistance were fabricated by constructing graphene/SiC(G/SiC)heterostructures on carbon cloth via laser chemical vapor deposition(LCVD).The resultant textiles exhibited excellent EMI efficiency of 74.2 dB with a thickness of 0.45 mm,Joule heating performance within a low working voltage(V)range of 1-3 V,and fast response time within 20 s.These properties arose from multiple reflections,interfacial polarization,and high conductivity due to the numerous amounts of nanoscale G/SiC heterostructures.More importantly,G/SiC/carbon fibers(CFs)demonstrated well high-temperature resistance with a heat resistance index(THri)of 380.2 C owing to the protection of a coating layer on the CFs upon oxidation.Meanwhile,the G/SiC/CFs presented good pressure-sensing performance with high sensitivity(S)of 52.93 kPal,fast response time of 85 ms,and a wide pressure range of up to 186 kPa.These features imply the potential of the G/SiC/CFs as efficient EMI shielding,electrical heater,and piezoresistive sensor textiles. | Chongjie Wang Qingfang Xu Jinrong Hu Pengjan Lu Han Wu Bingian Guo Rong Tu Kai Liu Meijun Yang Song Zhang Bao-Wen Li Chuanbin Wang Lianmeng Zhang | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
| 20 | USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID显示文摘Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants. | Yuewen Luo Xiantao Zhang Ran Chen Rong Li Yang Liu Junsong Zhang Qin liu Meijun Si Jun Liu Bolin Wu Xuemei Wang Shijian Wu Yiwen Zhang Xu Zhang Deyin Guo Xin He Ting Pan Hui Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
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