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| 1 | Experimental Study on Effects of Fuel Injection on Scramjet Combustor Performance显示文摘In order to investigate the effects of fuel injection distribution on the scramjet combustor performance, there are conducted three sets of test on a hydrocarbon fueled direct-connect scramjet test facility. The results of Test A, whose fuel injection is carried out with injectors located on the top-wall and the bottom-wall, show that the fuel injection with an appropriate close-front and centralized distribution would be of much help to optimize combustor performances. The results of Test B, whose fuel injection is performed at the optimal injection locations found in Test A, with a given equivalence ratio and different injection proportions for each injector, show that this injection mode is of little benefit to improve combustor performances. The results of Test C with a circumferential fuel injection distribution displaies the possibility of ameliorating combustor performance. By analyzing the effects of injection location parameters on combustor performances on the base of the data of Test C, it is clear that the injector location has strong coupled influences on combus- tor performances. In addition, an inner-force synthesis specific impulse is used to reduce the errors caused by the disturbance of fuel supply and working state of air heater while assessing combustor performances. | Wu Xianyu Li Xiaoshan Ding Meng Liu Weidong Wang Zhenguo | 2007 | Chinese Journal of Aeronautics2007，20，6： | 7 |
| 2 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 3 | Frequency Control at the Power Sending Side for HVDC Asynchronous Interconnections Between Yunnan Power Grid and the Rest of CSG显示文摘For a large-scale high voltage direct current (HVDC)asynchronous interconnected power grid, the frequency issue atthe power sending side under DC faults is a crucial problem.To solve this problem, based on rotor motion equations, theeffect of unbalanced power on the system frequency under DCfaults is analyzed. The characteristics and dynamic developmentprocess of frequencies after the injection of disturbances areanalyzed. In addition, the actions and coordinated strategies ofvarious frequency control measures are also investigated. Basedon the testing projects of an asynchronous interconnection in theChina Southern Power Grid (CSG), the frequency features arestudied according to the measured PMU data. The outcome showsthat the frequency problem of the Yunnan Power Grid after anasynchronous interconnection can be solved and controlled. Italso shows that the frequency limit control (FLC) is importantfor the frequency regulation of large scale HVDC asynchronousinterconnected DC power grids. As demonstrated, DC FLC caneffectively suppress the deviation of the transient frequency.However, reasonable frequency regulation parameters shouldbe set and other area frequency control measures should becoordinated to maintain the frequency stability of the system. | Hong Rao Wei Wu Tian Mao Baorong Zhou Chao Hong Yongjun Liu Xiaoshan Wu | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 4 |
| 4 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
| 5 | rCOS: a formal model-driven engineering method for component-based software显示文摘模型驱动的建筑学(MDA ) 为软件集中的系统设计成为了一种主要的流技术。在它后面的主要工程原则是软件开发的固有的复杂性能仅仅由造被掌握,分析并且操作系统模型。MDA 也由提供基于部件的设计技术处理系统复杂性,允许基于部件的部件设计,实现和推广,然后系统集成和重构连接的独立人士。在任何阶段的一个系统的模型是不同观点的模型的集成。因此,一个模型驱动的方法有效地被使用,它必须为模型建设,确认,和转变提供技术和工具的一间综合套房的身体。这为不同担心的说明和系统的观点要求很多个当模特儿的符号。这些符号应该正式定义句法和语义的一个统一理论。方法的内在的理论被需要支撑,以及正式在关键应用程序关于系统的性质验证并且推理工具的开发和在软件开发的工具的正确使用。当模特儿的符号,技术,和工具必须被设计以便他们能在在软件设计过程支持发展活动和人工制品的文档无缝地被使用。这篇文章介绍如此的一个方法,叫了 rCOS,在软件开发进程在不同阶段集中于一个系统的模型,他们的语义集成,并且他们怎么被构造,分析,转变,验证,并且验证。 | Wei KE Xiaoshan LI Zhiming LIU Volker STOLZ | 2012 | Frontiers of Computer Science2012，6，1： | 4 |
| 6 | Recent progress in ICF target fabrication at RCLF显示文摘Target is one of the essential parts in inertial confinement fusion(ICF)experiments.To ensure the symmetry and hydrodynamic stability in the implosion,there are stringent specifications for the target.Driven by the need to fabricate the target required by ICF experiments,a series of target fabrication techniques,including capsule fabrication techniques and the techniques of target characterization and assembly,are developed by the Research Center of Laser Fusion(RCLF),China Academy of Engineering Physics(CAEP).The capsule fabrication techniques for preparing polymer shells,glow discharge polymer(GDP)shells and hollow glass micro-sphere(HGM)are studied,and the techniques of target characterization and assembly are also investigated in this paper.Fundamental research about the target fabrication is also done to improve the quality of the target.Based on the development of target fabrication techniques,some kinds of target have been prepared and applied in the ICF experiments. | Kai Du Meifang Liu Tao Wang Xiaoshan He Zongwei Wang Juan Zhang | 2018 | Matter and Radiation at Extremes2018，3，3： | 4 |
| 7 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 8 | Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish显示文摘 | Xiaoshan Liu Kyunghee Ji Kyungho Choi | 2012 | Aquatic Toxicology2012，，： | 2 |
| 9 | Numerical simulation and inversion of offshore area depth based on x-band microwave radar显示文摘A detection method of offshore area depth utilizing the x-band microwave radar is proposed. The method is based on the sea clutter imaging mechanism of microwave radar, and combined with dispersion equation of the liner wave theorem and least square method(LSM), consequently get the inversion results of water depth in the detected region. The wave monitoring system OSMAR-X exploited by the Ocean State Laboratory, Wuhan University, based on a microwave radar has proven to be a powerful tool to monitor ocean waves in time and space. Numerical simulation and inversion of offshore area depth are carried out here; since JONSWAP model can give description of stormy waves in different growth phase, it is suitable for simulation. Besides, some results from measured data detected by OSMAR-X x-band radar located at Longhai of Fujian Province, China, validates this method. The tendency of the average water depths inferred from the radar images is in good agreement with the tide level detected by Xiamen tide station. These promising results suggest the possibility of using OSMAR-X to monitor operationally morphodynamics in coastal zones. This method can be applied to both shore-based and shipborne x-band microwave radar. | WANG Li WU Xiongbin PI Xiaoshan MA Ketao LIU Jianfei TIAN Yun | 2015 | Acta Oceanologica Sinica2015，34，3： | 2 |
| 10 | Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm显示文摘Objective Asymptomatic carotid stenosis(ACS)is closely associated to the incidence of severe cerebrovascular diseases.Early identifying the individuals with ACS and its associated risk factors could be beneficial for primary prevention of stroke.This study aimed to investigate a machine-learning algorithm for the detection of ACS among high-risk population of stroke based on the associated risk factors.Methods A novel model of machine learning was utilized to screen the associated predictors of ACS based on 30 potential risk factors.The algorithm of this model adopted a random forest pattern based on the training data and then was verified using the testing data.All of the original data were retrieved from the China National Stroke Screening and Prevention Project(CNSSPP),including demographic,clinical and laboratory characteristics.The individuals with high risk of stroke were enrolled and randomly divided into a training group and a testing group at a ratio of 4:1.The identification of carotid stenosis by carotid artery duplex scans was set as the golden standard.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)was used to evaluate the efficacy of the model in detecting ACS.Results Of 2841 high risk individual of stroke enrolled,326(11.6%)were diagnosed as ACS by ultrasonography.The top five risk fectors contributing to ACS in this model were identified as family history of dyslipidemia,high level of lowdensity lipoprotein cholesterol(LDL-c),low level of high-density lipoprotein cholesterol(HDL-c),aging,and low body. | Junxiong Yin Cheng Yu Lixia Wei Chuanyong Yu Hongxing Liu Mingyang Du Feng Sun Chongjun Wang Xiaoshan Wang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 2 |
| 11 | Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization显示文摘In recent years, rapid development of tissue engineering technology provides possibilities for the construction of artificial tissues or organs. In construction of engineered kidneys, researchers used native decellularized extracellular matrix(ECM) as the scaffolds to recellularization. However, thrombosis has been a great issue that hinders the progress of transplantation in vivo. In this study, heparin was immobilized to the collagen part of decellularized scaffold with collagen-binding peptide(CBP). Through the anticoagulant and endothelial cell reperfusion experiments, it can be demonstrated that the heparinized scaffolds absorbed less platelets and red blood cells which can effectively reduce the formation of thrombosis. Moreover, it is conducive to longterm adhesion of endothelial cells which is important for the formation of subsequent vascularization. Taken together, our results reveal that the whole kidney can be modified by CBP-heparin composite to reduce the thrombosis and provide the better conditions for neovascularization. | Miao Wang Lili Bao Xinyu Qiu Xiaoshan Yang Siying Liu Yuting Su Lulu Wang Bo Liu Qing He Shiyu Liu Yan Jin | 2018 | Science China(Life Sciences)2018，61，10： | 1 |
| 12 | Pt support of multidimensional active sites and radial channels formed by SnO 2 flower-like crystals for methanol and ethanol oxidation显示文摘 | Hulin Zhang Chenguo Hu Xiaoshan He Liu Hong Guojun Du Yan Zhang | 2011 | Journal of Power Sources2011，，10： | 1 |
| 13 | Differentiation and apoptosis in K562 crythroleukemia cells induced by Matrine 显示文摘 | Zhang Yan Jiang Jikai Liu xiaoshan | 1998 | Natural Medicine1998，52，4： | 1 |
| 14 | Automated transformations from UML behavior models to contracts显示文摘In model driven architecture(MDA),system requirements are first captured by UML(unified modeling language)use cases with sequence diagrams to describe their intended use and implemented by classes of objected-oriented languages in the subsequent design stages.It is important that the dynamic behavior specified by the sequence diagrams is in full compliance with the implementation classes.This paper proposes an automatic approach and tool support for generating class contracts,which define a precondition and a postcondition for each operation of the class.The former serves as a guard to ensure invocations of the operations respect the semantics introduced by the sequence diagrams,and the latter places the system in a legal state to facilitate the succeeding operation calls.The contracts can be easily mapped to code of an object-oriented language such as Java.Thus,the approach helps to bridge the gap between the requirements and design stages of system development process.We use our model transformation tool to first generate a UML protocol state machine from the sequence diagrams,and then derive the contracts for a controller class.The transformations take into account the concurrency and critical constructs of the respective UML diagrams. | LI Dan LI XiaoShan LIU ZhiMing Volker STOLZ | 2014 | Science China(Information Sciences)2014，57，12： | 1 |
| 15 | Pt support of multidimensional active sites and radial channels formed by SnO 2 flower-like crystals for methanol and ethanol oxidation显示文摘 | Hulin Zhang Chenguo Hu Xiaoshan He Liu Hong Guojun Du Yan Zhang | 2011 | Journal of Power Sources2011，，10： | 1 |
| 16 | Crystal structure of a single-chain trimer of human adiponectin globular domain显示文摘 | Xiaoshan Min Bryan Lemon Jie Tang Qiang Liu Richard Zhang Nigel Walker Yang Li Zhulun Wang | 2012 | FEBS Letters2012，，： | 1 |
| 17 | Fatigue Characteristics and Microcosmic Mechanism of 6063 Aluminum Alloy under Multiracial Proportional Load- ing显示文摘 | He Guoqiu Liu Xiaoshan Cui Yongpeng | 2008 | Jounal Tongji University2008，36，10： | 1 |
| 18 | Facile synthesis of ultrafine Cu 2 ZnSnS 4 nanocrystals by hydrothermal method for use in solar cells显示文摘 | Wenchao Liu Binglei Guo Cheeleung Mak Aidong Li Xiaoshan Wu Fengming Zhang | 2012 | Thin Solid Films2012，，： | 1 |
| 19 | Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p显示文摘Endochondral bone formation is an important route for bone repair.Although emerging evidence has revealed the functions of long non-coding RNAs(lncRNAs)in bone and cartilage development,the effect of lncRNAs in endochondral bone repair is still largely unknown.Here,we identified a lncRNA,named Hypertrophic Chondrocyte Angiogenesis-related lncRNA(HCAR),and proved it to promote the endochondral bone repair by upregulating the expression of matrix metallopeptidase 13(Mmp13)and vascular endothelial growth factorα(Vegfa)in hypertrophic chondrocytes.Lnc-HCAR knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the CD31hiEmcnhi vessels number in a bone repair model.Mechanistically,we proved that lnc-HCAR was mainly enriched in the cytoplasm using fluorescence in situ hybridization(FISH)assay,and it acted as a molecular sponge for miR-15b-5p.Further,in hypertrophic chondrocytes,lnc-HCAR competitively bound to miR-15b-5p to increase Vegfa and Mmp13 expression.Our results proved that lncRNA is deeply involved in endochondral bone repair,which will provide a new theoretical basis for future strategies for promoting fracture healing. | Yun Bai Xiaoshan Gong Rui Dong Zhen Cao Ce Dou Chuan Liu Jianmei Li Fei Kang Jingjin Dai Chunrong Zhao Zhansone Tian Jiulin Tan Qijie Dai Shiwu Dong | 2022 | Genes & Diseases2022，9，2： | 1 |
| 20 | Effects of long-term exposure to TDCPP in zebrafish( Danio rerio )–Alternations of hormone balance and gene transcriptions along hypothalamus-pituitary axes显示文摘Background : TDCPP is one of the major chemical of organophosphate flame retardants(OPFRs) that has been detected ubiquitously in both the environment and biota. Previously we observed that it influenced the concentrations of sex and thyroid hormones in a sex-dependent pattern, leading to reproductive impairments after short-term exposure in zebrafish. Here we investigate the consequences of longerterm exposure to TDCPP on the hypothalamic-pituitary-gonad(HPG), hypothalamicpituitary-i nterrenal(HPI), and hypothalamic-pituitary-thyroid(HPT) axes of zebrafish( Danio rerio).Methods : A 120-day exposure test to 0.005, 0.05 and 0.5 mg/L TDCPP was initiated with fertilized eggs. Sex steroid hormones in the treated fishes were measured and transcriptional changes were analyzed.Results : In female fish, exposure to TDCPP resulted in increases in plasma cortisol,follicle stimulating hormone(FSH), luteinizing hormone(LH), 17β-estradiol(E2), cortisol, thyroxine(T4), and triiodothyronine(T3). Transcription of most target genes along HPG, HPI and HPT axes were increased by the exposure. While in male fish the exposure led to decreases in cortisol, FSH, LH, T4, T3, testosterone(T), and 11-ketotestosterone(11-KT). Transcription of genes along HPG, HPI and HPT axes,especially steroidogenic genes, were inhibited in male zebrafish. While, E2/T or E2/11-KT ratio was increased in both female and females. The sex-dependent changes in hormones might be due to differential responses to TDCPP induced stresses. An increase in cortisol level coincided with increases in E2 and THs in female fish, while in males decreases in cortisol as well as T, 11-KT and THs were observed. Long-term exposure to TDCPP at very low(μg/L) concentrations could disrupt hormone balances in a sex dependent way.Conclusion : This study revealed that TDCPP could affect endocrine axes – HPG, HPI and HPT – in zebrafish, and impair zebrafish development. | Xiaoshan Liu Xiaoxun Lu Jiabin Hong Jing Zhang Juntong Lin Mengzhu Jiang Qian Liu Kyungho Choi Jingjing Zhang | 2022 | Animal Models and Experimental Medicine2022，5，3： | 1 |
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