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| 1 | Diversity characterization and association analysis of agronomic traits in a Chinese peanut (Arachis hypogaea L.) mini-core collection显示文摘Association mapping is a powerful approach for exploring the molecular basis of phenotypic variations in plants.A peanut(Arachis hypogaea L.)mini-core collection in China comprising 298 accessions was genotyped using 109 simple sequence repeat(SSR)markers,which identified 554 SSR alleles and phenotyped for 15 agronomic traits in three different environments,exhibiting abundant genetic and phenotypic diversity within the panel.A model-based structure analysis assigned all accessions to three groups.Most of the accessions had the relative kinship of less than 0.05,indicating that there were no or weak relationships between accessions of the mini-core collection.For 15 agronomic traits in the peanut panel,generally the Q t K model exhibited the best performance to eliminate the false associated positives compared to the Q model and the general linear model-simple model.In total,89SSR alleles were identified to be associated with 15 agronomic traits of three environments by the Q t K model-based association analysis.Of these,eight alleles were repeatedly detected in two or three environments,and 15 alleles were commonly detected to be associated with multiple agronomic traits.Simple sequence repeat allelic effects confirmed significant differences between different genotypes of these repeatedly detected markers.Our results demonstrate the great potential of integrating the association analysis and marker-assisted breeding by utilizing the peanut mini-core collection. | Huifang Jiang Li Huang Xiaoping Ren Yuning Chen Xiaojing Zhou Youlin Xia Jiaquan Huang Yong Lei Liying Yan Liyun Wan Boshou Liao | 2014 | Journal of Integrative Plant Biology2014，56，2： | 14 |
| 2 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 3 | Space-confined growth of monolayer ReSe2 under a graphene layer on Au foils显示文摘Vertical heterostructures based on two-dimensional(2D)materials have attracted widespread interest for their numerous applications in electronic and optoelectronic devices.Herein,we report the direct construct!on of an abnormal graphene/ReSe2 stack on Au foils by a two-step chemical vapor deposition(CVD)strategy.During the second growth stage,mono layer ReSe2 is found to prefere ntially evolve at the irUerface between the first-grown graphene layer and the Au substrate.The unusual stacking behavior is unraveled by in-situ'cutting open'the upper graphene from the defects to expose the lower ReSe2 using scanning tunneling microscopy(STM).From combination of these results with density functional theory calculations,the domain boundaries and edge sites of graphene are proposed to be adsorption sites for Re and Se precursors,further facilitating the growth of ReSe2 at the van der Waals gap of graphene/Au.This work hereby offers an intriguing strategy for obtaining vertical 2D heterostructures featured with an ultra-clean interface and a designed stacking geometry. | Chunyu Xie Shaolong Jiang Xiaolong Zou Yuanwei Sun Liyun Zhao Min Hong Shulin Chen Yahuan Huan Jianping Shi Xiebo Zhou Zhepeng Zhang Pengfei Yang Yuping Shi Porun Liu Qing Zhang Peng Gao Yanfeng Zhang | 2019 | Nano Research2019，12，1： | 4 |
| 4 | Phenotypic identification of peanut germplasm for resistance to southern stem rot显示文摘Southern stem rot,caused by Sclerotium rolfsii Sacc.,is a destructive soil fungal disease of peanut in China and other countries.To evaluate resistant germplasm,a total of 256 peanut accessions were investigated on their resistance to southern stem rot in 3 environments by artificial inoculation.Variance analysis indicated that disease index was significantly influenced by environment,genotype and genotypeenvironment interactions.Peanut accessions of var.vulgaris type exhibited higher resistance to southern stem rot.Disease index was significantly negatively correlated with linoleic acid content,while positively correlated with oleic acid content.Six resistant accessions were identified,including Hua 28,Shandongzai,ICG 6326,Quanhua 7,Quanhua 9 and Guihua 836,with their disease indexes under 40 and mortality were less than 30%in the three environments.The identified resistant accessions showed the great potential to be applied in resistant peanut breeding,and would be good genetic resources for enhancing the resistance to southern stem rot. | Pengmin Fan Wanduo Song Yanping Kang Liyun Wan Yong Lei Dongxin Huai Yuning Chen Xin Wang Huifang Jiang Liying Yan Boshou Liao | 2020 | Oil Crop Science2020，5，4： | 3 |
| 5 | Effect of Traditional Chinese Medicine plus narrow-band medium-wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series显示文摘OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. | Li Tiantian Zhou Dongmei Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 6 | Genetic diversity of atoxigenic Aspergillus flavus isolates from peanut kernels in China显示文摘Aflatoxin contamination in peanuts is a major threat to public health, especially in tropical and subtropical regions of the world. Recently, the use of atoxigenic Aspergillus flavus strains as biological control agents prove to be effective in reducing aflatoxin contamination in crops. A total of 208 atoxigenic A. flavus isolates, collected from peanut kernels, were grouped into 7 deletion patterns by quadruplex PCR products of nor-1, ver-1, aflR and omtA genes. 49 SNPs, found in 1254 bp fragment of omtA gene, showed genetic variation of omtA among different A. flavus isolates. These isolates were assigned to either MAT1-1 type or MAT1-2 type with primers for each MAT locus. Thus, rich genetic diversity was found in the atoxigenic A. flavus isolates of peanut in China. The results indicated that quadruplex PCR would be an effective method for rapid screening of atoxigenic isolates with gene deletion in aflatoxin biosynthetic cluster. | Liying Yan Yanping Kang Yong Lei Liyun Wan Dongxin Huai Huifang Jiang Xiaoping Ren Boshou Liao | 2018 | Oil Crop Science2018，3，1： | 2 |
| 7 | Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy显示文摘Photodynamic therapy(PDT),which utilizes light excite photosensitizers(PSs)to generate reactive oxygen species(ROS)and consequently ablate cancer cells or diseased tissue,has attracted a great deal of attention in the last decades due to its unique advantages.However,the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment(TME).It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes.Herein,we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles(P-CHNPs)via a facile synthesis procedure for boosting photodynamic anticancer therapy.Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME,which could be further amplified under light irradiation.Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS(hydroxyl radicals and singlet oxygen)generation efficiency,hypoxia relief,and glutathione depletion.Moreover,the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research. | Liyun Lin Wen Pang Xinyan Jiang Shihui Ding Xunbin Wei Bobo Gu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 8 | Biocontrol potential of reducing aflatoxin contamination by an atoxigenic strain of Aspergillus flavus. isolated from peanut显示文摘 | Liying YAN Yanping KANG Yong LEI Liyun WAN Dongxin HUAI Huifang JIANG Xiaoping REN Boshou LIAO | 2016 | Oil Crop Science2016，1，1： | 2 |
| 9 | Phylogeny and species differentiation of Mollitrichosiphum spp. (Aphididae, Greenideinae) based on mitochondrial CO1 and Cyt b genes显示文摘 | Ruiling ZHANG Xiaolei HUANG Liyun JIANG Gexia QIAO | 2011 | Current Zoology2011，57，6： | 2 |
| 10 | Advances in green synthesis and applications of graphene显示文摘Green synthesis has grabbed appreciable attention to eliminate the negative effects associated with various chemical processes. Due to the unparalleled electrical, mechanical, thermal and excellent physical properties, graphene, as the thinnest two-dimensional material with high surface area, has the unfathomable potential in the domain of green chemistry in terms of both synthesis and application. In this regard, we present an overview of the research progresses on the greener synthesis of graphene, including micromechanical exfoliation, chemical reduction of graphene oxide (GO), chemical vapor synthesis and popping of GO. Meanwhile, various applications of graphene pertinent to sustainable developments, such as energy storage, catalysis, electrochemistry, fuel cell, supercapacitor and biomedicine have also been highlighted. | Qi Yu Jianchao Jiang Liyun Jiang Qingqing Yang Ning Yan | 2021 | Nano Research2021，14，11： | 2 |
| 11 | Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid‐induced apoptosis through down‐regulation of EZH 2 expression by miR ‐101显示文摘 | Yongjun Wang Wei Xiang Miao Wang Tao Huang Xingyuan Xiao Liang Wang Dan Tao Liyun Dong Fuqing Zeng Guosong Jiang | 2014 | Br J Pharmacol2014，，3： | 2 |
| 12 | Salt-assisted growth and ultrafast photocarrier dynamics of large-sized monolayer ReSe2显示文摘Owing to its anisotropic optical and electrical properties,rhenium diselenide(ReSe2)has garnered considerable attention recently as a candidate material for polarization-sensitive photodetectors.However,the direct and controllable synthesis of large-sized ReSe2 with a uniform thickness is still a great challenge.Herein,we have refined the synthesis method to obtain uniform monolayer ReSe2 flakes with a size of up to^106μm on sapphire via an ambient-pressure chemical vapor deposition technique using Na promoter from sodium chloride.Interestingly,optical pump-probe spectroscopy revealed a fast switching from saturable absorption(SA)to absorption enhancement(AE)in subpicosecond time scale,followed by a slower decay induced by exciton recombination.Furthermore,both AE and SA signals exhibited clear angular dependence with a periodicity of 180°,which reflected the dichroism in nonlinear absorption dynamics.In addition,the photocarrier dynamics including free-carrier transport and subpicosecond relaxation due to exciton formation or surface trapping was probed using time resolved terahertz spectroscopy.We believe that our study serves as a reference for atomically controlled synthesis of large-sized ReSe2 and provides useful insights on its optoelectronic properties for novel device applications. | Shaolong Jiang Jin Yang Yuping Shi Jing Zhao Chunyu Xie Liyun Zhao Jiatian Fu Pengfei Yang Yahuan Huan Qin Xie Huachao Jiang Qing Zhang Xianlong Wang Fuhai Su Yanfeng Zhang | 2020 | Nano Research2020，13，3： | 2 |
| 13 | Identification of major QTL for seed number per pod on chromosome A05 of tetraploid peanut(Arachis hypogaea L.)显示文摘The inheritance of pod-and seed-number traits(PSNT) in peanut(Arachis hypogaea L.) is poorly understood. In the present study, a recombinant inbred line(RIL) population of 188 lines was used to map quantitative trait loci(QTL) for number of seeds per pod(NSP),number of pods per plant(NPP), and numbers of one-, two-, and three-seeded pods per plant(N1 PP, N2 PP, and N3 PP) in four environments. A total of 28 consensus QTL and 14 single QTL were identified, including 11 major and stable QTL. Four major and stable QTL including qN3 PPA5.2, q N3 PPA5.4, qN3 PPA5.5, and qN3 PPA5.7 each explained 12.3%–33.0% of phenotype variation. By use of another integrated linkage map for the A5 group(hereafter referred to as INT A5 group), QTL for PSNT were located in seven intervals of 0.73–9.68 Mb in length on chromosome A05, and candidate genes underlying N3 PP were suggested. These findings shed light on the genetic basis of PSNT. Major QTL for N3 PP could be used as candidates for further positional cloning. | Yuning Chen Zhihui Wang Xiaoping Ren Li Huang Jianbin Guo Jiaojiao Zhao Xiaojing Zhou Liying Yan Huaiyong Luo Nian Liu Weigang Chen Liyun Wan Yong Lei Boshou Liao Dongxin Huai Huifang Jiang | 2019 | The Crop Journal2019，7，2： | 1 |
| 14 | Adsorption of Cr(VI) on STAC-modified rectorite显示文摘 | Hanlie Hong Wei-Teh Jiang Xiaoling Zhang Liyun Tie Zhaohui Li | 2008 | Applied Clay Science2008，，1： | 1 |
| 15 | Evolution of drug regulations and regulatory innovation for anticancer drugs in China显示文摘Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide. | Yang Liu Ning Zhang Cuicui Xie Yale Jiang Yunhe Qin Liyun Zhou Yi Fan Lianjie Ren Chen Yin Huan Yang Wei Xie Qing Zhai Guanqiao Li Hongzhuan Chen Xiaoyuan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
| 16 | Progress on genetic and genomic research for enhanced oil content and quality in peanut显示文摘 | Boshou LIAO Yong LEI Li HUANG Silong CHEN Xiaoping REN Liying YAN Yurong LI Dongxin HUAI Xiaojing ZHOU Liyun WAN Yuning CHEN Wei HUA Huifang JIANG | 2016 | Oil Crop Science2016，1，1： | 1 |
| 17 | Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid‐induced apoptosis through down‐regulation of EZH 2 expression by miR ‐101显示文摘 | Yongjun Wang Wei Xiang Miao Wang Tao Huang Xingyuan Xiao Liang Wang Dan Tao Liyun Dong Fuqing Zeng Guosong Jiang | | Br J Pharmacol0，，3： | 1 |
| 18 | Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma显示文摘Background:Adjuvant temozolomide(TMZ)chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma(HGG).However,the influence of long-term TMZ chemotherapy on serum ions concentration is unclear.Methods:One hundred and thirty-eight patients with HGG were included.Their blood samples were collected for blood biochemistry and routine test.The alteration in serum ions concentration,total protein,albumin,globin,and blood cells counts were used to identify the impact of long-term TMZ chemotherapy.Results:Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles,we identified that serum potassium concentration had a downward trend after TMZ administration(1st vs.6th,p<0.001;1st vs.12th,p<0.001).Additionally,the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles(r=−0.649,p=0.023).The hematological adverse events mainly centered on grade 1 to 2.Conclusion:Long-term administration of TMZ may lead to serum ions disturbance.Besides the myelosuppression,we should pay attention to the alteration in serum ions concentration,and give patients proper symptomatic treatment when necessary. | Liyun Zhong Pei Yang Chuanbao Zhang Zheng Wang Tao Jiang Baoshi Chen Xia Shan Xiaoguang Qiu | 2022 | Chinese Neurosurgical Journal2022，8，2： | 1 |
| 19 | Daily snow water equivalent product with SMMR,SSM/I and SSMIS from 1980 to 2020 over China显示文摘The reliable knowledge of seasonal snow volume and its trend is very important to understand Earth’s climate system.Thus,a long-time snow water equivalent(SWE)dataset is necessary.This work presents a daily SWE product of 1980-2020 with a linear unmixing method through passive microwave data including SMMR,SSM/I and SSMIS over China after cross-calibration and bias-correction.The unbiased root-mean-square error of snow depth is about 5-7 cm,corresponding to 10-15 mm for SWE,when compared with stations measurements and field snow course data.The spatial patterns and trends of SWE over China present significant regional differences.The overall slope trend presented an insignificant decreasing pattern during 1980-2020 over China;however,there is an obvious fluctuation,i.e.a significant decrease trend during the period 1980-1990,an upward trend from 2005 to 2009,a significant downward trend from 2009 to 2018.The increase of SWE occurred in the Northeast Plain,with an increase trend of 0.2 mm per year.Whereas in the Hengduan Mountains,it presented a downward trend of SWE,up to−0.3 mm per year.In the North Xinjiang,SWE has an increasing trend in the Junggar Basin,while it shows a decreasing trend in the Tianshan and Altai Mountains. | Lingmei Jiang Jianwei Yang Cheng Zhang Shengli Wu Zhen Li Liyun Dai Xiaofeng Li Yubao Qiu | 2022 | Big Earth Data2022，6，4： | 0 |
| 20 | Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients显示文摘Background COVID-19 pandemic continues,clarifying signatures in clinical characters and antibody responses between severe and non-severe COVID-19 cases would benefit the prognosis and treatment.Methods In this study,119 serum samples from 37 severe or non-severe COVID-19 patients from the First People's Hospital of Yueyang were collected between January 25 and February 182020.The clinical features,antibody responses targeting SARS-CoV-2 spike protein(S)and its different domains,SARS-CoV-2-specific Ig isotypes,IgG subclasses,ACE2 competitive antibodies,binding titers with FcγIIa and FcγIIb receptors,and 14 cytokines were comprehensively investigated.The differences between severe and non-severe groups were analyzed using Mann–Whitney U test or Fisher’s exact test.Results Severe group including 9 patients represented lower lymphocyte count,higher neutrophil count,higher level of LDH,total bile acid(TBA)(P<1×10–4),r-glutaminase(P=0.011),adenosine deaminase(P<1×10–4),procalcitonin(P=0.004),C-reactive protein(P<1×10–4)and D-dimer(P=0.049)compared to non-severe group(28 patients).Significantly,higher-level Igs targeting S,different S domains(RBD,RBM,NTD,and CTD),FcγRIIa and FcγRIIb binding capability were observed in a severe group than that of a non-severe group,of which IgG1 and IgG3 were the main IgG subclasses.RBD-IgG were strongly correlated with S-IgG both in severe and non-severe group.Additionally,CTD-IgG was strongly correlated with S-IgG in a non-severe group.Positive RBD-ACE2 binding inhibition was strongly associated with high titers of antibody(S-IgG1,S-IgG3,NTD-IgG,RBD-IgA,NTD-IgA,and CTD-IgA)especially RBD-IgG and CTD-IgG in the severe group,while in the non-severe group,S-IgG3,RBD-IgG,NTD-IgG,and NTD-IgM were correlated with ACE2 blocking rate.S-IgG1,NTD-IgM and S-IgM were negatively associated with illness day in a severe group,while S-IgG3,RBD-IgA,CTD-IgA in the severe group(r=0.363,P=0.011)and S-IgG1,NTD-IgA,CTD-IgA in the non-severe group were positively associated with illness day.Moreover,GRO-α,IL-6,IL-8,IP-10,MCP-1,MCP-3,MIG,and BAFF were also significantly elevated in the severe group.Conclusion Antibody detection provides important clinical information in the COVID-19 process.The different signatures in Ig isotypes,IgG subclasses,antibody specificity between the COVID-19 severe and non-severe group will contribute to future therapeutic and preventive measures development. | Hongye Wang Dongshan Yan Ya Li Yanfei Gong Yulin Mai Bingxiang Li Xiaoyong Zhu Xinrui Wan Liyun Xie HuaKe Jiang Min Zhang Ming Sun Yufeng Yao Yongzhang Zhu | 2022 | Infectious Diseases of Poverty2022，11，1： | 0 |
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