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| 1 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 2 | Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome显示文摘消费一本高度果糖的食谱导致象特征一样的新陈代谢的症候群(MS ) ,包括 endothelial 机能障碍。可勃起的机能障碍是 endothelial 机能障碍和全身的脉管的疾病的早表明。因为矿物质缺乏加强有害效果果糖消费和矿物质摄取对 MS 是保护的,我们试图在10%果糖喂 Sprague-Dawley 老鼠( FRUCT )在阴茎海绵体( CC )上在脉管的生长因素和受体的结构的组织和表示上描绘 8 星期自然的充满矿物质的水消费的效果。差别也没在脉管的 endothelial 生长因素(VEGF ) 或 angiopoietins/Tie2 系统的部件的表达式上在 CC 的组织被观察。然而,反对表示模式为 VEGF 受体被观察(为 VEGFR1 和 VEGFR2 的增加和减少,分别地) 在 FRUCT 动物,与这些,模式被充满矿物质的水摄取正在加强。充满矿物质的水摄取(FRUCTMIN ) 与 FRUCT 老鼠相比增加了光滑的肌肉房间的比例并且导致了 1 表情与控制和 FRUCT 相比组织的 sirtuin 的一个 upregulatory 趋势。西方的污点结果与双 immunofluorescence 评估一致。血浆氧化了低密度的脂蛋白和血浆睾丸激素层次在试验性的组之中是类似的,尽管为前者的增加的一个趋势在 FRUCTMIN 组被观察。类似于那些的介绍变化在与 MS 保护的充满多酚的饮料对待或使限制遭到了到精力的老鼠观察了的充满矿物质的对待水的老鼠,它带了我们到假设充满矿物质的水消费的效果可以直接是比那些广阔的更多,这在这观察了学习。 | Cidalia D Pereira Milton Severo Luisa Rafael Maria Joao Martins Delminda Neves | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 3 | Migraine, Celiac Disease, and Cerebral Calcifications: A New Case显示文摘 | Domenico D’Amico Andrea Rigamonti Luisa Spina Stefania Bianchi‐Marzoli Maurizio Vecchi Gennaro Bussone | 2005 | Headache: The Journal of Head and Face Pain2005，，9： | 1 |
| 4 | Antioxidant activities of sicilian prickly pear(opuntia ficus indica)fruit extracts and re ducing properties of its betalains: betanin and indicaxanthin显示文摘 | Daniela B Luisa T Francesca D G | 2002 | Agricultural and Food Chemistry2002，50，23： | 1 |
| 5 | Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population显示文摘 | Alessandro Cucchetti Franco Trevisani Matteo Cescon Giorgio Ercolani Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramonte Antonio D | 2012 | Journal of Hepatology2012，，5： | 1 |
| 6 | Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype显示文摘 | Mariantonietta Cicoira Luisa Zanolla Andrea Rossi Giorgio Golia Lorenzo Franceschini Giulio Cabrini Alberto Bonizzato Maristella Graziani Stefan D Anker Andrew J.S Coats Piero Zardini | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 7 | In vivo anti - inflammatory effect of statins is mediated by nonsteroi mevalonate products 显示文摘 | Luisa Diomede L Albani D Sottocorno M | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 8 | Novel pH -sensi- tive non - ionic surfaetant vesicles : Comparison between Tween 21 and Tween 20 显示文摘 | LUISA D M CARLOTTA M MARIADEA P | 2011 | Colloids and Surfaces B : Biointerfaccs2011，82，1： | 1 |
| 9 | Flowering phenology and female reproductive success in Silene acutifolia Link ex Rohrb显示文摘 | María Luisa Buide José Antonio Díaz-Peromingo Javier Guitián | 2002 | Plant Ecology2002，，1： | 1 |
| 10 | SNP genotyping in melons: genetic variation, population structure, and linkage disequilibrium显示文摘 | Cristina Esteras Gelsomina Formisano Cristina Roig Aurora Díaz José Blanca Jordi Garcia-Mas María Luisa Gómez-Guillamón Ana Isabel López-Sesé Almudena Lázaro Antonio J. Monforte Belén Picó | 2013 | Theoretical and Applied Genetics2013，，5： | 1 |
| 11 | Available techniques for ohiective assessment of upper airway narrowing in snoring and sleep apnea显示文摘 | CHRISTIAN E FABER M D LUISA M D | 2003 | Sleep Breath2003，7，： | 1 |
| 12 | Comparative analysis of 8 - oxoG: C, 8 - oxoG: A, A: C and C: C DNA repair in ex- tracts from wild type or 8 -oxoG DNA glycosylase deficient mammalian and bacterial ceils 显示文摘 | Francoise D Magnar B Luisa L | 2003 | DNA Repair2003，2，6： | 1 |
| 13 | An overview on silica aerogels synthesis and different mechanical reinforcing strategies显示文摘 | Hajar M Luisa D Antonio P | 2014 | Journal of Non-Crystalline Solids2014，385，2： | 1 |
| 14 | In vivo anti-inflammatory effect of statins is mediated by nonsterolmevalonate products显示文摘 | Luisa Diomede L Albani D Sottocomo M | 2001 | Arterioseler Thromb Vase BioL2001，21，8： | 1 |
| 15 | Efficacy of species-specific recA PCR tests in the identification of Burkholderia cepacia complex environmental isolates显示文摘 | Claudia D Luisa P Silvia T | 2005 | Microbiology2005，246，： | 1 |
| 16 | In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products显示文摘 | Luisa D Diego A Marcello S | 2001 | Arterioscler Thromb Vasc Biol2001，21，8： | 1 |
| 17 | In vivo anti-inflammatory effect of statins is mediated by nonsteroi mevalonate products显示文摘 | Luisa DL Albani D Sottocorno M | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 18 | Condensation of su- perheated vapour of R410A and R407C inside plate heat ex- changers : Experimental results and simulation proeedure显示文摘 | Simone M Davide D C Luisa R | 2012 | In- ternational Journal of Refrigeration2012，35，7： | 1 |
| 19 | Extent ofsonochemical degradation and change of toxicity of a phar-maceutical precursor(triphenylphosphine oxide)in wateras a unction of treatment conditions显示文摘 | Emery R J Papadaki M Luisa M F D S | 2005 | Environment In-ternational2005，31，： | 1 |
| 20 | Breakthrough bacteremia due to clostridium tertium in a patient with neutropenic fever,and identification by MALDI-TOF mass spectrometry显示文摘 | Francisco S Lorena P Luisa D | 2013 | International Journal of Infectious Diseases2013，17，： | 1 |
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