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| 1 | Hydrogen Sulfide Promotes Root Organogenesis in Ipomoea batatas, Salix matsudana and Glycine max显示文摘In this report, we demonstrate that sodium hydrosulfide (NaHS), a hydrogen sulfide (H2S) donor, promoted adventitious root formation mediated by auxin and nitric oxide (NO). Application of the H2S donor to seedling cuttings of sweet potato (Ipomoea batatas L.) promoted the number and length of adventitious roots in a dose-dependent manner. It was also verified that H2S or HS- rather than other sulfur-containing components derived from NaHS could be attributed to the stimulation of adventitious root formation. A rapid increase in endogenous H2S, indole acetic acid (IAA) and NO were sequentially observed in shoot tips of sweet potato seedlings treated with HaHS. Further investigation showed that H2S-mediated root formation was alleviated by N-1-naphthylphthalamic acid (NPA), an IAA transport inhibitor, and 2-(4-carboxyphenyl)- 4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), an NO scavenger. Similar phenomena in H2S donor-dependent root organogenesis were observed in both excised willow (Salix matsudana var. tortuosa Vilm) shoots and soybean (Glycine max L.) seedlings. These results indicated that the process of H2S-induced adventitious root formation was likely mediated by IAA and NO, and that H2S acts upstream of IAA and NO signal transduction pathways. | Hua Zhang Jun Tang Xiao-Ping Liu Yun Wang Wei Yu Wei-Yan Peng Fang Fang Dai-Fu Ma Zhao-Jun Wei Lan-Ying Hu | 2009 | Journal of Integrative Plant Biology2009，51，12： | 58 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 4 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 5 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 6 | Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma显示文摘AIM: To investigate the expression of Toll-like receptor (TLR) 3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma (ESCC). METHODS: Reverse transcription-polymerase chain reaction and immunohistochemistry were used to analyze the expression of TLR3, TLR4, TLR7 and TLR9 mRNA and protein in samples from 87 esophageal cancer patients consisting of both tumor and normal tissue. RESULTS: A significant increase in TLR3, TLR4, TLR7 and TLR9 mRNA levels was detected in ESCC samples. Tumors exhibited high TLR protein expression, (70.1%, 72.4%, 66.7% and 78.2% for TLR3, TLR4, TLR7 and TLR9, respectively, P < 0.05). Nevertheless, a significant percentage of tumors also exhibited TLR4 expression in mononuclear inflammatory cells (48.3%) and TLR9 expression in fibroblast-like cells (60.9%). Tumors with high TLR3 expression in tumor cells or high TLR4 expression in mononuclear inflammatory cells were significantly associated with a higher probability of lymph node metastasis and increased depth of invasion. However, tumors with high TLR9 expression in fibroblast-like cells were associated with low probabilities of invasion and metastasis. There was no significant variation between the expression of TLR3, TLR4, TLR7 and TLR9 among different ethnic groups. CONCLUSION: TLR3, TLR4, TLR7 and TLR9 expression appears important to the biological pathogenesis of ESCC. TLRs may represent therapeutic targets for ESCC. | Ilyar Sheyhidin Gulnaz Nabi Ayshamgul Hasim Rui-Ping Zhang Julaiti Ainiwaer Hong Ma Hua Wang | 2011 | World Journal of Gastroenterology2011，17，32： | 22 |
| 7 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 8 | Chronic ankle instability is associated with proprioception deficits:A systematic review and meta-analysis显示文摘Background:Acute ankle injury causes damage to joint mechanoreceptors and deafferentation and contributes to proprioception deficits in patients with chronic ankle instability(CAI).We aimed to explore whether deficits of proprioception,including kinesthesia and joint position sense(JPS),exist in patients with CAI when compared with the uninjured contralateral side and healthy people.We hypothesized that proprioception deficits did exist in patients with CAI and that the deficits varied by test methodologies.Methods:The study was a systematic review and meta-analysis.We identified studies that compared kinesthesia or JPS in patients with CAI with the uninjured contralateral side or with healthy controls.Meta-analyses were conducted for the studies with similar test procedures,and narrative syntheses were undertaken for the rest.Results:A total of 7731 studies were identified,of which 30 were included for review.A total of 21 studies were eligible for meta-analysis.Compared with the contralateral side,patients with CAI had ankle kinesthesia deficits in inversion and plantarflexion,with a standardized mean difference(SMD)of 0.41 and 0.92,respectively,and active and passive JPS deficits in inversion(SMD=0.92 and 0.72,respectively).Compared with healthy people,patients with CAI had ankle kinesthesia deficits in inversion and eversion(SMD=0.64 and 0.76,respectively),and active JPS deficits in inversion and eversion(SMD=1.00 and 4.82,respectively).Proprioception deficits in the knee and shoulder of patients with CAI were not statistically significant.Conclusion:Proprioception,including both kinesthesia and JPS,of the injured ankle of patients with CAI was impaired,compared with the uninjured contralateral limbs and healthy people.Proprioception varied depending on different movement directions and test methodologies.The use of more detailed measurements of proprioception and interventions for restoring the deficits are recommended in the clinical management of CAI. | Xiao’ao Xue Tengjia Ma Qianru Li Yujie Song Yinghui Hua | 2021 | Journal of Sport and Health Science2021，10，2： | 21 |
| 9 | Effects of Urea and Controlled Release Urea Fertilizers on Methane Emission from Paddy Fields: A Multi-Year Field Study显示文摘A four-year(2008–2011) field study was implemented in a major rice-growing region of China to better understand the effect of urea and controlled release fertilier(CRF, thermoplastic resin-coated urea in this study) on CH4 emission from paddy fields. Over the four years, the average CH4 emission during the rice growing seasons was 76.9, 65.8 and 64.9 kg CH4ha-1in treatments CK(zero N), U(urea) and C(CRF), respectively. Urea and CRF significantly reduced CH4 emission by 14.4% and 15.6%, and increased average rice grain yield by 25.8% and 19.7%(P < 0.05), respectively, compared with treatment CK. Flooding duration would affect CRF's effect on CH4 emission from paddy fields. Under normal aeration conditions, CH4 emission tended to be 3.9%–15.2% lower in treatment C than in treatment U from 2009 to 2011, while it tended to be 4.2% higher under delayed aeration conditions in 2008. The findings suggest that mid-season aeration(MSA) starting on D30(30 days after rice transplanting), just like the local practice, would optimize the CRF's effect on CH4 emission from rice fields in China. Over the four years, average rice yield did not differ between treatments U and C, and tended to be 5% lower in treatment C than in treatment U. | JI Yang LIU Gang MA Jing ZHANG Guang-Bin XU Hua | 2014 | Pedosphere2014，24，5： | 21 |
| 10 | miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells显示文摘MicroRNAs (miRNAs ) 作为小调整 RNA 的一个班正在出现,并且 miRNAs 的改变在人的癌症的开始和前进被含有。我们的学习在房间线能压制的 OVCAR3 卵巢的癌症显示出 miR-20a 的那抑制,而 miR-20a 的 overexpression 能提高房间长期的增长和侵略。我们也作为 miR-20a 的直接目标基因证实了淀粉的先锋蛋白质(应用软件) 。而且,应用软件表示的抑制能也支持卵巢的癌症房间增长和侵略,它与 miR-20a overexpression 的结果一致。因此,我们断定应用软件的规定是重要机制让 miR-20a 在卵巢的癌症房间支持增长和侵略。 | Xingxing Fan Yankun Liu Jiechun Jiang Zhuoya Ma Haidong Wu Tao Liu Min Liu Xin Li Hua Tang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 11 | Recanalization of extracranial internal carotid artery occlusion A 12-year retrospective study显示文摘This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec-tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac-ranial internal carotid artery occlusion. The study included 65 patients with extracranial internal ca-rotid artery occlusion who underwent carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, or hybrid surgery in the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China between January 2006 and December 2012. Prior to surgery, all patients underwent perfusion CT or xenon CT to evaluate the occlusion. The procedure for each patient was chosen according to digital subtraction angiography data. The carotid artery was successfully recanalized in 46 of 51 patients who underwent carotid endarterectomy, 9 of 10 patients who underwent carotid endarterectomy combined with Fogarty catheter embolectomy, and 3 of 4 patients who underwent hybrid surgery. In patients with symptomatic carotid artery occlusion, the carotid artery can be recanalized by choosing a treatment procedure based on imaging ex-amination findings. | Liqun Jiao Gang Song Yang Hua Yan Ma Yanfei Chen Yabing Wang Feng Ling | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 12 | Perspectives on the Application of Genome-Editing Technologies in Crop Breeding显示文摘Most conventional and modern crop-improvement methods exploit natural or artificially induced genetic variations and require laborious characterization of the progenies of multiple generations derived from time-consuming genetic crosses.Genome-editing systems,in contrast,provide the means to rapidly modify genomes in a precise and predictable way,making it possible to introduce improvements directly into elite varieties.Here,we describe the range of applications available to agricultural researchers using existing genome-editing tools.In addition to providing examples of genome-editing applications in crop breeding,we discuss the technical and social challenges faced by breeders using genome-editing tools for crop improvement. | Kai Hua Jinshan Zhang Jose Ramon Botella Changle Ma Fanjiang Kong Baohui Liu Jian-Kang Zhu | 2019 | Molecular Plant2019，12，8： | 19 |
| 13 | Lightweight,Flexible Cellulose-Derived Carbon Aerogel@Reduced Graphene Oxide/PDMS Composites with Outstanding EMI Shielding Performances and Excellent Thermal Conductivities显示文摘In order to ensure the operational reliability and infor-mation security of sophisticated electronic components and to protect human health,efficient electromagnetic interference(EMI)shielding materials are required to attenuate electromagnetic wave energy.In this work,the cellulose solution is obtained by dissolving cotton through hydrogen bond driving self-assembly using sodium hydroxide(NaOH)/urea solution,and cellulose aerogels(CA)are prepared by gelation and freeze-drying.Then,the cellulose carbon aerogel@reduced graphene oxide aerogels(CCA@rGO)are prepared by vacuum impregnation,freeze-drying followed by thermal annealing,and finally,the CCA@rGO/polydimethylsiloxane(PDMS)EMI shielding composites are prepared by backfilling with PDMS.Owing to skin-core structure of CCA@rGO,the complete three-dimensional(3D)double-layer con-ductive network can be successfully constructed.When the loading of CCA@rGO is 3.05 wt%,CCA@rGO/PDMS EMI shielding composites have an excellent EMI shielding effectiveness(EMI SE)of 51 dB,which is 3.9 times higher than that of the co-blended CCA/rGO/PDMS EMI shielding composites(13 dB)with the same loading of fillers.At this time,the CCA@rGO/PDMS EMI shielding composites have excellent thermal stability(T_(HRI) of 178.3℃)and good thermal conductivity coefficient(λ of 0.65 W m^(-1) K^(-1)).Excellent comprehensive performance makes CCA@rGO/PDMS EMI shielding composites great prospect for applications in lightweight,flexible EMI shielding composites. | Ping Song Bei Liu Chaobo Liang Kunpeng Ruan Hua Qiu Zhonglei Ma Yongqiang Guo Junwei Gu | 2021 | Nano-Micro Letters2021，13，6： | 19 |
| 14 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 15 | Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells显示文摘OBJECTIVE:To investigate the apoptotic effects and underlying molecular mechanisms of Celastrus orbiculatus(C.orbiculatus) extract in human hepatocellular carcinoma cells.METHODS:Human hepatocellular carcinoma cells(HCCLM6) were treated with C.orbiculatus extract(COE) at different nontoxic concentrations(10,20,40,80,and 160 μg/mL).The effect of COE on HC-CLM6 viability was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assays.Cellular apoptosis following COE treatment was assessed by flow cytometry and western blot analysis.RESULTS:COE significantly inhibited cell viability and induced apoptosis of HCCLM6 cells in a dose-dependent manner.Apoptosis was accompanied by increased Bax expression and decreased Bcl-2 expression.In addition,COE treatment led to the release of cytochrome c,activation of caspase-3,and cleavage of poly(ADP-ribose) polymerase(PARP).Furthermore,activation of extracellular signal-regulated kinase(ERK),p38 kinase,and c-Jun N-terminal kinase(JNK) phosphorylation,and down-regulation of Akt phosphorylation was observed.CONCLUSION:COE induces mitochondrial-mediated,caspase-dependent apoptosis in HCCLM6 cells,which might be attributed to the activation of mitogen-activated protein kinase(MAPK) and inhibition of Akt signaling pathways.These data suggest that COE may be a potential treatment for human hepatocellular carcinoma. | Hua Zhang Yayun Qian Yanqing Liu Guoqing Li Pingfang Cui Yaodong Zhu Hui Ma Xue Ji Shiyu Guo Hisamits Tadashi | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 18 |
| 16 | Effects of Acupuncture on Alzheimer’s Disease: Evidence from Neuroimaging Studies显示文摘As the worldwide population ages, the prevalence of Alzheimer's disease (AD) increases. However, the results of promising medications have been unsatisfactory. Chinese acupuncture has a long history of treating dementia, but lack of evidence from well-designed randomized controlled trials that validate its efficacy and safety, as well as its lack of clear underlying mechanisms, contribute to its limited application in clinical practice. In recent years, brain imaging technologies, such as functional magnetic resonance imaging and positron emission tomography, have been used to assess brain responses to acupuncture in a dynamic, visual, and objective way. These techniques are frequently used to explore neurological mechanisms of responses to acupuncture in AD and provide neuroimaging evidence as well as starting points to elucidate the possible mechanisms. This review summarizes the existing brain imaging evidence that explains the effects of acupuncture for AD and analyzes brain responses to acupuncture at cognitive-related acupoints [Baihui (GV 20), Shenmen (HT 7), Zusanli (ST 36), Neiguan (PC 6), and Taixi (KI 3)] from perspectives of acupoint specificity and acupoint combinations. Key issues and directions to consider in future studies are also put forward. This review should deepen our understanding of how brain imaging studies can be used to explore the underlying mechanisms of acupuncture in AD. | YU Chao-chao MA Chao-yang WANG Hua KONG Li-hong ZHAO Yan SHEN Feng WU Miao | 2019 | Chinese Journal of Integrative Medicine2019，25，8： | 18 |
| 17 | Reduced Macular Vascular Density in Myopic Eyes显示文摘 | Hua Fan Hao-Yu Chen Hong-Jie Ma Zheng Chang Hai-Quan Yin Danny Siu-Chun Ng Carol Y Cheung Shan Hu Xiang Xiang Shi-Bo Tang Shuang-Nong Li | 2017 | Chinese Medical Journal2017，，4： | 17 |
| 18 | An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. | Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang | 2020 | Journal of Molecular Cell Biology2020，12，4： | 17 |
| 19 | Bi-directional Selection in Upland Rice Leads to Its Adaptive Differentiation from Lowland Rice in Drought Resistance and Productivity显示文摘Drought resistance is required in rice breeding to address the challenge of frequent droughts . However, the evolutionary mechanism of rice drought resistance is not fully understood. We investigated the genetic differentiation between upland and lowland rice domesticated in agro-ecosystems with contrasting water-soil conditions using genome-wide SNPs. We estimated morphological differences among upland and lowland rice in drought resistance and productivity through common garden experiments. Upland rice had better drought resistance but poorer productivity. The negative correlations between traits of drought resistance and productivity are attributed to the underlying genetic trade-offs through tight linkages (e.g., DCA1 and OsCesA7) or pleiotropic effects (e.g., LAX1). The genetic trade-offs are comm on and greatly shape the evolutio n of drought resista nee in upland rice . In genomic regions associated with both productivity and drought resistance, signs of balancing selection were detected in upland rice, while signs of directional selection were detected in lowland rice, potentially contributing to their adaptive differentiation. Signs of balancing selection in upland rice resulted from bi-directional selection during its domestication in drought-prone upland agro-ecosystems.Using genome-wide association analysis, we ide ntified several valuable quantitative trait loci associated with drought resista nee, for which highly differentiated genes should be considered candidates. Bi-directional selection breaking tight linkages by accumulating recombination events would be applicable in breeding water-saving and droughtresistance rice. | Hui Xia Zhi Luo Jie Xiong Xiaosong Ma Qiaojun Lou Haibin Wei Jie Qiu Hua Yang Guolan Liu Longjiang Fan Liang Chen Lijun Luo | 2019 | Molecular Plant2019，12，2： | 16 |
| 20 | Genotypic variations in the accumulation of Cd exhibited by different vegetables显示文摘It is an important approach to use the Cd-contaminated soils properly by growing low accumulator or excluder plants for Cd to produce safe foods. To find the suitable vegetable species for growing in Cd-contaminated soils, in the present study the variations in the Cd accumulation for twenty eight vegetable species and several cultivars of five common vegetables (cowpea, kidney pea, bitter gourd, cucumber and squash) were investigated in two soil Cd levels (1 and 2 mg/kg Cd). Experimental results showed that highly significant differences in Cd concentration were evident among 28 vegetables. For example, spinach Cd concentrations were 110-fold and 175-fold higher than that of sweet pea under the 1 and 2 mg/kg Cd exposures, respectively. For Cd accumulation, the order of vegetable species was: leafy vegetables > solanaceous vegetables > kale vegetables > root vegetables > allimus > melon vegetables > legumes. Distinctive differences were also identified when comparing different cultivars of the five common vegetables with an average range of 0.003–0.094 mg/kg Cd. Our results indicated that a large genotypic variation existed among vegetable species or cultivars when subjected to Cd exposure. Therefore, it is important and feasible to elect/breed vegetable species/cultivars with low accumulation of Cd, especially in mildly Cd-contaminated soils. | Junxing Yang Haitao Guo Yibing Ma Liqun Wang Dongpu Wei Luo Hua | 2010 | Journal of Environmental Sciences2010，22，8： | 16 |
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