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| 1 | Hierarchical method of task assignment for multiple cooperating UAV teams显示文摘The problem of task assignment for multiple cooperating unmanned aerial vehicle(UAV) teams is considered. Multiple UAVs forming several small teams are needed to perform attack tasks on a set of predetermined ground targets. A hierarchical task assignment method is presented to address the problem. It breaks the original problem down to three levels of sub-problems: target clustering, cluster allocation and target assignment. The first two sub-problems are centrally solved by using clustering algorithms and integer linear programming, respectively, and the third sub-problem is solved in a distributed and parallel manner, using a mixed integer linear programming model and an improved ant colony algorithm. The proposed hierarchical method can reduce the computational complexity of the task assignment problem considerably, especially when the number of tasks or the number of UAVs is large. Experimental results show that this method is feasible and more efficient than non-hierarchical methods. | Xiaoxuan Hu Huawei Ma Qingsong Ye He Luo | 2015 | Journal of Systems Science & Complexity2015，28，5： | 14 |
| 2 | A biomimetic bi-layered tissue engineering scaffolds for osteochondral defects repair显示文摘Osteochondral defects are most commonly characterized by damages to both cartilage and underlying subchondral bone tissues,thus developing bi-layered scaffold that can concurrently regenerate these two specific lineages becomes challenge.In this study,the highly biomimetic bi-layered scaffolds were successfully prepared using human-like-collagen(HLC),hyaluronan(HA)and nano hydroxyapatite(HAP)particles,combined with'liquid phase synthesis'technology,freeze-drying and chemical crosslinking techniques,which was simulated the composition of natural extracellular matrix to repair osteochondral defects.This novel bilayer osteochondral graft had a seamlessly integrated layer structure,suitable pore size,high levels of porosity,and excellent mechanical properties.In vitro cell experiments of the bilayer scaffold indicated that the scaffold could promote the proliferation and adhesion of human bone marrow mesenchymal stem cells.In vivo osteochondral defects and micro-CT experiment revealed that bilayer scaffolds showed complete closure of the defect.Histology confirmed collagen and glycosaminoglycans were deposited in the new matrix of hyaline cartilage and bone in the bilayer scaffold group.Therefore,the developed bionic bilayer scaffold enhanced the regeneration of hyaline cartilage through subchondral bone formation and lateral host-tissue integration.In conclusion,this bilayer scaffold based on HLC could be used as the desired strategy for osteochondral defects regeneration. | LIU KaiQiang LIU YanNan DUAN ZhiGuang MA XiaoXuan FAN DaiDi | 2021 | Science China(Technological Sciences)2021，64，4： | 4 |
| 3 | Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers显示文摘Ginsenosides are the main pharmacologically active constituents of ginseng which have been used in East Asian countries for centuries to modulate blood pressure,metabolism and immune function.Following the technological advances in isolation,purification and mass production,their mechanisms of action are gradually elucidated,providing solid basis for clinical applications.Ginseng extracts(total ginsenosides)and ginsenoside Rg3,CK,Rd have been marketed or entered clinical trials as drugs or dietary supplements.Despite the proven safety and efficacy of some ginsenosides,their applications are hindered by inferior pharmacokinetics such as low solubility,poor membrane permeability and metabolic instability.Nanoparticle formulation of drugs and implantable drug depots are effective strategies to improve the pharmacokinetics of therapeutic agents by enhancing solubility,providing protection,facilitating intracellular transport,and enabling sustained and controlled release.This mini-review summarizes the recent advances in systemic delivery of ginsenosides using liposomes,micelles,albumin-based nanoparticles,and inorganic nanoparticles,as well as local delivery of ginsenosides by electronspun fibrous membranes and hydrogels. | Jing Zhao Zhiguang Duan Xiaoxuan Ma Yannan Liu Daidi Fan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 3 |
| 4 | Adaptive estimation and nonlinear variable gain compensation of the contouring error for precise parametric curve following显示文摘Contour following is one of the most important issues faced by many computer-numerical-control(CNC) machine tools to achieve high machining precision. This paper presents a new real-time error compensation method aiming at reducing the contouring error caused by facts such as servo lag and dynamics mismatch in parametric curved contour-following tasks. Due to the lack of high-precision contouring-error estimation method for free-form parametric curved toolpath, the error can hardly be compensated effectively. Therefore, an adaptive accurate contouring-error estimation algorithm is proposed first, where a tangential-error backstepping method based on Taylor's expansion is developed to rapidly find the closest point on the parametric curve to the actual motion position. On this foundation, the contouring error is compensated using a proposed nonlinear variable-gain compensation method, where the compensation gain is obtained according to not only the contouring-error magnitude but also its direction variation. The stability of the system after compensation is analyzed afterwards according to the Jury stability criterion.By design of the compensator in accordance with the presented contouring-error compensation method as well as the stability analyzation result, the balance between the response speed and the contour control stability can be effectively made. Experimental tests demonstrate the feasibility of the presented methods in both contouring-error estimation and contour-accuracy improvement.Contributions of this research are significant for enhancing the contour-following performance of the CNC machine tools. | JIA ZhenYuan SONG DeNing MA JianWei ZHAO XiaoXuan SU WeiWei | 2017 | Science China(Technological Sciences)2017，60，10： | 2 |
| 5 | Effect of Temperature on Self-Interaction of Human-Like Collagen显示文摘似人类的骨胶原(HLC ) 的自我相互作用上的温度的效果被恐水病的相互作用调查层析, calorimetric 测量,和钠 dodecyl sulphate-polyacrylamide 胶化电气泳动(SDS 页) 分析。结果证明相互作用角色的三种类型可以在 350 点在 HLC | Fan, Daidi Xing, Jianyu Xue, Wenjiao Zhu, Chenhui Ma, Xiaoxuan Ma, Rong | 2011 | Chinese Journal of Chemistry2011，29，9： | 2 |
| 6 | The influence of target material and thickness on proton energy and angular distribution显示文摘The paper has studied the influence of target material and thickness on energy and angular distributions of the protons generated by using an 800 nm,60 fs,0.24 J laser pulse to irradiate solid target foils.The results show that the initial density and thickness of the targets will affect the formation of the acceleration sheath fields in the target normal direction.For the same target thickness,using lower density target materials can obtain a higher proton maximum energy.However,lower density targets tend to be deformed due to the shock waves launched by the laser pulses,making the proton spatial distribution more divergent. | SU LuNing LIU BiCheng LIN XiaoXuan LIU Feng DU Fei LIU XiaoLong ZHENG Yi GE XuLei LI YuTong SHENG ZhengMing CHEN LiMing WANG WeiMin MA JingLong LU Xin WEI ZhiYi CHEN JiaEr ZHANG Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 1 |
| 7 | Oxygen transfer rate control in the production of human-like collagen by recombinant Escherichia coil 显示文摘 | Xiaoxuan Ma Daidi Fan Long-an Shang | 2010 | Biotechnol Biochem2010，55，4： | 1 |
| 8 | Hierarchical Bi2Cu04 microspheres: hydrothermal synthesis and catalytic perfomance in wet oxidation of methylene blue显示文摘 | CHEN Xiangying MA Chao LI Xiaoxuan | 2009 | Catal Commun2009，10，6： | 1 |
| 9 | High-performance self-powered ultraviolet to near-infrared photodetector based on WS_(2)/InSe van der Waals heterostructure显示文摘van der Waals heterostructures(vdWHs)based on two-dimensional(2D)materials without the crystal lattice matching constraint have great potential for high-performance optoelectronic devices.Herein,a WS_(2)/InSe vdWH photodiode is proposed and fabricated by precisely stacking InSe and WS_(2)flakes through an all-dry transfer method.The WS_(2)/InSe vdWH forms an n–n heterojunction with strong built-in electric field due to their intrinsic n-type semiconductor characteristics and energy-band alignments with a large Fermi level offset between WS_(2)and InSe.As a result,the device displays excellent photovoltaic behavior with a large open voltage of 0.47 V and a short-circuit current of 11.7 nA under 520 nm light illumination.Significantly,a fast rising/decay time of 63/76μs,a large light on/off ratio of 105,a responsivity of 61 mA/W,a high detectivity of 2.5×10^(11) Jones,and a broadband photoresponse ranging from ultraviolet to near-infrared(325–980 nm)are achieved at zero bias.This study provides a strategy for developing high-performance self-powered broadband photodetectors based on 2D materials. | Jinping Chen Zhen Zhang Yi Ma Jiying Feng Xiaoyu Xie Xiaoxuan Wang Aoqun Jian Yuanzheng Li Zhuxin Li Heng Guo Yizhi Zhu Qiannan Cui Zengliang Shi Chunxiang Xu | 2023 | Nano Research2023，16，5： | 1 |
| 10 | Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the third leading cause of cancer death worldwide.Ginsenoside Rk3,an important and rare saponin in heat-treated ginseng,is generated from Rg1 and has a smaller molecular weight.However,the anti-HCC efficacy and mechanisms of ginsenoside Rk3 have not yet been characterized.Here,we investigated the mechanism by which ginsenoside Rk3,a tetracyclic triterpenoid rare ginsenoside,inhibits the growth of HCC.We first explored the possible potential targets of Rk3 through network pharmacology.Both in vitro(HepG2 and HCC-LM3 cells)and in vivo(primary liver cancer mice and HCC-LM3 subcutaneous tumor-bearing mice)studies revealed that Rk3 significantly inhibits the proliferation of HCC.Meanwhile,Rk3 blocked the cell cycle in HCC at the G1 phase and induced autophagy and apoptosis in HCC.Further proteomics and siRNA experiments showed that Rk3 regulates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway to inhibit HCC growth,which was validated by molecular docking and surface plasmon resonance.In conclusion,we report the discovery that ginsenoside Rk3 binds to PI3K/AKT and promotes autophagy and apoptosis in HCC.Our data strongly support the translation of ginsenoside Rk3 into novel PI3K/AKT-targeting therapeutics for HCC treatment with low toxic side effects. | Linlin Qu Yannan Liu Jianjun Deng Xiaoxuan Ma Daidi Fan | 2023 | Journal of Pharmaceutical Analysis2023，13，5： | 1 |
| 11 | Thermal Decomposition Dew Point Method for Determining the Trace Moisture in Ultra-purity Ammonia, 7 Ammonia 显示文摘 | MA Xiaoxuan LI Zenghe CAI Tijie LIU Yazhen | 2013 | Ad- vanced Materials Research2013，，718720： | 1 |
| 12 | Amphiphilic peptide dendrimer-based nanovehicles for safe and effective siRNA delivery显示文摘Small interfering RNA(siRNA)-based RNA interference has emerged as a promising therapeutic strategy for the treatment of a wide range of incurable diseases.However,the safe and effective delivery of siRNA therapeutics into the interior of target cells remains challenging.Here,we disclosed novel amphiphilic peptide dendrimers(AmPDs)that composed of hydrophobic two lipid-like alkyl chains and hydrophilic poly(lysine)dendrons with different generations(2C18-KK2 and 2C18-KK2K4)as nanovehicles for siRNA delivery.These AmPDs are able to self-assemble into supramolecular nanoassemblies that are capable of entrapping siRNA molecules into nanoparticles to protect siRNA from enzymatic degradation and promote efficient intracellular uptake without evident toxicity.Interestingly,by virtue of the optimal balance of hydrophobic lipid-like entity and hydrophilic poly(lysine)dendron generations,AmPD 2C18-KK2K4 bearing bigger hydrophilic dendron can package siRNA to form stable,but more ready to disassemble complexes,thereby resulting in more efficient siRNA releasing and better gene silencing effect in comparison with AmPD 2C18-KK2 bearing smaller dendron.Additional studies confirmed that 2Ci8-KK2K4 can capitalize on the advantages of lipid and peptide dendrimer vectors for effective siRNA delivery.Collectively,our AmPD-based nanocarriers indeed represent a safe and effective siRNA delivery system.Our findings also provide a new perspective on the modulation of selfassembly amphiphilic peptide dendrimers for the functional and adaptive delivery of siRNA therapeutics. | Chi Ma Dandan Zhu Yu Chen Yiwen Dong Wenyi Lin Ning Li Wenjie Zhang Xiaoxuan Liu | 2020 | Biophysics Reports2020，6，6： | 1 |
| 13 | The advantages of penehyclidine hydrochloride over atropine in acute organophosphorus pesticide poisoning:A meta-analysis显示文摘Background:Penehyclidine hydrochloride(PHC)has been used for many years as an anticholinergic drug for the treatment of acute organophosphorus pesticide poisoning(AOPP).The purpose of this meta-analysis was to explore whether PHC has advantages over atropine in the use of anticholinergic drugs in AOPP.Methods:We searched Scopus,Embase,Cochrane,PubMed,ProQuest,Ovid,Web of Science,China Science and Technology Journal Database(VIP),Duxiu,Chinese Biomedical literature(CBM),WanFang,and Chinese National Knowledge Infrastructure(CNKI),from inception to March 2022.After all qualified randomized controlled trials(RCTs)were included,we conducted quality evaluation,data extraction,and statistical analysis.Statistics using risk ratios(RR),weighted mean difference(WMD),and standard mean difference(SMD).Results:Our meta-analysis included 20,797 subjects from 240 studies across 242 different hospitals in China.Compared with the atropine group,the PHC group showed decreased mortality rate(RR=0.20,95%confidence intervals[CI]:0.16–0.25,P<0.001),hospitalization time(WMD=-3.89,95%CI:-4.37 to-3.41,P<0.001),overall incidence rate of complications(RR=0.35,95%CI:0.28–0.43,P<0.001),overall incidence of adverse reactions(RR=0.19,95%CI:0.17–0.22,P<0.001),total symptom disappearance time(SMD=-2.13,95%CI:-2.35 to-1.90,P<0.001),time for cholinesterase activity to return to normal value 50–60%(SMD=-1.87,95%CI:-2.03 to-1.70,P<0.001),coma time(WMD=-5.57,95%CI:-7.20 to-3.95,P<0.001),and mechanical ventilation time(WMD=-2.16,95%CI:-2.79 to-1.53,P<0.001).Conclusion:PHC has several advantages over atropine as an anticholinergic drug in AOPP. | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Xinxin Guo Yi Li Yi Gou Yao Zhang Shengming Li Shaotong Zhang Xiaoxuan Wu Meihong Li Jing Lei Bingqian Li Chengfei Bi Like Ma Qingpeng Luo | 2023 | Journal of Intensive Medicine2023，3，2： | 0 |
| 14 | Low RBC counts predict high on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention and treated with clopidogrel显示文摘Dear Editor,Cardiovascular disease is the leading cause of deaths worldwide,with coronary artery disease(CAD)accounting for approximately 50%of its mortality.Dual antiplatelet therapy,including aspirin and a P2Y12 inhibitor,is the most important treatment for CAD patients undergoing percutaneous coronary intervention(PCI)to prevent recurrent ischemic events and cardiac death.Clopidogrel is one of the commonly used P2Y12 inhibitors.However,up to 30%of patients treated with a standard dose of clopidogrel present with high on-treatment platelet reactivity(HOPR),which is associated with the increased ischemic risks[1].The causes of HOPR are multifactorial and complex. | Qian Gu Qin Wang Rui Hua Wenhao Zhang Jianzhen Teng Jiazheng Ma Zhou Dong Xiaoxuan Gong Chunjian Li | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 15 | Assessing the contribution of global wildfire biomass burning to BaP contamination in the Arctic显示文摘Polycyclic aromatic hydrocarbons(PAHs)have become cause for growing concern in the Arctic ecosystems,partly due to their stable levels despite global emission reduction.Wildfire is considered one of the primary sources that influence PAH levels and trends in the Arctic,but quantitative investigations of this influence are still lacking.This study estimates the global emissions of benzo[a]pyrene(BaP),a congener of PAHs with high carcinogenicity,from forest and grassland fires from 2001 to 2020 and simulates the contributions of wildfire-induced BaP emissions from different source regions to BaP contamination in the Arctic.We find that global wildfires contributed 29.3%to annual averaging BaP concentrations in the Arctic from 2001 to 2020.Additionally,we show that wildfires contributed significantly to BaP concentrations in the Arctic after 2011,enhancing it from 10.1%in 2011 to 83.9%in 2020.Our results reveal that wildfires accounted for 94.2%and 50.8%of BaP levels in the Asian Arctic during boreal summer and autumn,respectively,and 74.2%and 14.5%in the North American Arctic for the same seasons.The source-tagging approach identified that local wildfire biomass emissions were the largest source of BaP in the Arctic,accounting for 65.7%of its concentration,followed by those of Northern Asia(17.8%)and Northern North America(13.7%).Our findings anticipate wildfires to play a larger role in Arctic PAH contaminations alongside continually decreasing anthropogenic emissions and climate warming in the future. | Shijie Song Boqi Chen Tao Huang Shuxin Ma Luqian Liu Jinmu Luo Huizhong Shen Jiaxin Wang Liang Guo Min Wu Xiaoxuan Mao Yuan Zhao Hong Gao Jianmin Ma | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 16 | Developing the QSPR model for predicting the storage lipid/water distribution coefficient of organic compounds显示文摘The distribution of organic compounds in stored lipids affects their migration,transformation,bioaccumulation,and toxicity in organisms.The storage lipid/water distribution coefficient(log K_(lip/w))of organic chemicals,which quantitatively determines such distribution,has become a key parameter to assist their ecological security and health risk.Due to the impossibility to measure K_(lip/w)values for a huge amount of chemicals,it is necessary to develop predictive approaches.In this work,a quantitative structure-property relationship(QSPR)model for estimating log K_(lip/w)values of small organic compounds was constructed based on 305 experimental log K_(lip/w)values.Quantum chemical descriptors and n-octanol/water partitioning coefficient were employed to characterize the intermolecular interactions that dominate log K_(lip/w)values.The hydrophobic and electrostatic interactions and molecular size have been found to play important roles in governing the distribution of chemicals between lipids and aqueous phases.The regression(R2=0.959)and validation(Q2=0.960)results indicate good fitting performance and robustness of the developed model.A comparison with the predictive performance of other commercial software further proves the higher accuracy and stronger predictive ability of the developed K_(lip/w)predictive model.Thus,it can be used to predict the K_(lip/w)values of cycloalkanes,long-chain alkanes,halides(with fluorine,chlorine,and bromine as substituents),esters(without phosphate groups),alcohols(without methoxy groups),and aromatic compounds. | Miao Li Jian Li Yuchen Lu Cenyang Han Xiaoxuan Wei Guangcai Ma Haiying Yu | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 0 |
| 17 | A secreted catalase contributes to Puccinia striiformis resistance to host-derived oxidative stress显示文摘Plants can produce reactive oxygen species(ROS)to counteract pathogen invasion,and pathogens have also evolved corresponding ROS scavenging strategies to promote infection and pathogenicity.Catalases(CATs)have been found to play pivotal roles in detoxifying H_(2)O_(2)formed by superoxide anion catalyzed by superoxide dismutases(SODs).However,few studies have addressed H_(2)O_(2)removing during rust fungi infection of wheat.In this study,we cloned a CAT gene PsCAT1 from Puccinia striiformis f.sp.tritici(Pst),which encodes a monofunctional heme-containing catalase.PsCAT1 exhibited a high degree of tolerance to pH and temperature,and forms high homopolymers.Heterologous complementation assays in Saccharomyces cerevisiae reveal that the signal peptide of PsCAT1 is functional.Overexpression of PsCAT1 enhanced S.cerevisiae resistance to H_(2)O_(2).Transient expression of PsCAT1 in Nicotiana benthamiana suppressed Bax-induced cell death.Knockdown of PsCAT1 using a host-induced gene silencing(HIGS)system led to the reduced virulence of Pst,which was correlated to H_(2)O_(2)accumulation in HIGS plants.These results indicate that PsCAT1 acts as an important pathogenicity factor that facilitates Pst infection by scavenging host-derived H_(2)O_(2). | Pu Yuan Wenhao Qian Lihua Jiang Conghui Jia Xiaoxuan Ma Zhensheng Kang Jie Liu | 2021 | Stress Biology2021，1，1： | 0 |
| 18 | Efficacy of an adjusted treatment strategy on the management and in-hospital outcome of patients with STEMI during the COVID-19 pandemic显示文摘Dear Editor,The coronavirus disease 2019(COVID-19) broke out in early December 2019 in Wuhan, China~([1]), which put tremendous pressure on the medical system. A nationwide lockdown and strict quarantine measures proved effective in reducing the spread of the pandemic. However, it might have affected the management of time-dependent diseases such as STelevation myocardial infarction(STEMI)~([2]). | Jing Wang Inam Ullah Zhou Dong Zekang Ye Qian Gu Chuchu Tan Jiazheng Ma Jianzhen Teng Lu Shi Xiaoxuan Gong Yong Li Liang Yuan Zhihui Xu Chunjian Li | 2022 | The Journal of Biomedical Research2022，36，1： | 0 |
| 19 | Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice显示文摘Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM. | Ting Liu Si Chen Yunhe Qu Lujuan Zheng Xiaoxuan Yang Shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou Yuying Fan | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 20 | Emergent topological states via digital(001)oxide superlattices显示文摘Oxide heterostructures exhibit many intriguing properties.Here we provide design principles for inducing multiple topological states in(001)(AMO_(3))_(1)/(AM′O_(3))_(1)oxide superlattices.Aided by first-principles calculations and model analysis,we show that a(SrMO_(3))_(1)/(SrM′O_(3))_(1)superlattice(M=Nb,Ta and M′=Rh,Ir)is a strong topological insulator with Z_(2)index(1;001).More remarkably,a(SrMoO_(3))1/(SrIrO_(3))_(1)superlattice exhibits multiple coexisting topological insulator(TI)and topological Dirac semi-metal(TDS)states.The TDS state has a pair of type-II Dirac points near the Fermi level and symmetry-protected Dirac node lines.The surface TDS Dirac cone is sandwiched by two surface TI Dirac cones in the energy-momentum space.The non-trivial topological properties arise from the band inversion between d orbitals of two dissimilar transition metal atoms and a particular parity property of(001)superlattice geometry.Our work demonstrates how to induce non-trivial topological states in(001)perovskite oxide heterostructures by rational design. | Zhiwei Liu Hongquan Liu Jiaji Ma Xiaoxuan Wang Gang Li Hanghui Chen | 2022 | npj Computational Materials2022，，1： | 0 |
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