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| 1 | Experimental studies on removal of carbon dioxide by aqueous ammonia fine spray显示文摘Experimental studies on carbon dioxide capture in a spray scrubber were carried out.Fine spray of aqueous ammonia was used as CO2 absorbent.Effects of different operating and design parameters on CO2 removal efficiency including concentration of aqueous ammonia,liquid flow rate,total gas flow rate,initial temperature and concentration of carbon dioxide were investigated. | NIU ZhenQi,GUO YinCheng & LIN WenYi Department of Engineering Mechanics,School of Aerospace,Tsinghua University,Beijing 100084,China | 2010 | Science China(Technological Sciences)2010，53，1： | 6 |
| 2 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 3 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 4 | A GA-DE hybrid evolutionary algorithm for path synthesis of four-bar linkage显示文摘 | LIN Wenyi | 2010 | Mechanism and Machine Theory2010，45，8： | 1 |
| 5 | Systematic analysis of clinical relevance and molecular characterization of m^(6)A in COVID-19 patients显示文摘N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers. | Sanqi An Zhouhua Xie Yanyan Liao Junjun Jiang Wenyi Dong Fuqiang Yin Wen-Xing Li Li Ye Jianyan Lin Hao Liang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 6 | A novel multistage anoxic/aerobic process with sludge regeneration zone (R-MAO) for advanced nitrogen removal from domestic sewage显示文摘To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was developed.The reactor was used to treat actual domestic sewage and the nitrogen removal capacity of the sludge regeneration zone(R zone)was investigated during the long-term operation.The best performance was obtained at the R zone’s Oxidation-Reduction Potential(ORP)of-50±30 mV and hydraulic residence times(HRT)of 1.2 hr.The average effluent COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N of the R-MAO process were 18.0±2.3,7.5±0.6,1.0±0.5 and 4.6±0.4 mg/L,respectively,with the corresponding removal efficiency of COD,TN and NH_(4)^(+)-N were 92.9%±1.0%,84.1%±1.5% and 97.5%±1.1%.Compared to the sole MAO system,the TN removal efficiency of the R-MAO increased by 10.1%.Besides,under the optimal conditions,the contribution of the R zone in the R-MAO that removal COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N were 0.36,0.15,0.032 and 0.82 g/day.High-throughput sequencing results showed that uncultured_bacterium_f_Burkholderiaceae(5.20%),OLB8(1.04%)and Ottowia(1.03%)played an important role in denitrification in the R zone.This study provided effective guidance for the design and operation of the R-MAO process in domestic sewage treatment. | Lin Cao Rong Sun Wenyi Dong Hongjie Wang Zhongyi Dai Xue Wang Jin Xie Hua Li | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 7 | Aggregation-induced emission enhancement of yellow photoluminescent carbon dots for highly selective detection of environmental and intracellular copper(Ⅱ) ions显示文摘Carbon dots (CDs) are prepared through a simple one-step hydrothermal treatment of o-phenylendiamine (OPD) and show yellow photoluminescent (PL) emission under the ultraviolet excitation, which can be further enhanced by Cu2+ ions owing to Cu2+ ions induced aggregation of OPD-CDs through the coordination of Cu2+ with amino groups on the surface of OPD-CDs. The aggregation induced emission enhancement (AIEE) property enables it feasible to develop a simple, sensitive and selective method to detect environmental and intracellular copper (Ⅱ) ions. The limit of detection as lowas 0.28 μmol/L (3σ/k) and a dynamic range from 0.5 μmol/L to 40 μmol/L make it veryeasy to detect the copper content inwater samples, such as river closure reservoir. Furthermore, fluorescence imaging of intracellular Cu2+ suggests that the AIEE features of OPD-CDs specific to Cu2+ ions can be also applied in biological systems. | Wenyi Lv Min Lin Rongsheng Li Qianqian Zhang Hui Liu Jian Wang Chengzhi Huang | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
| 8 | The Effect of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on NF-κB and the Inflammatory Response During Myocardial Ischemia Reperfusion Injury in Rats显示文摘 | Xingmei Liang Jianchun Huang Xing Lin Feizhang Qin Qingwei Wen Chunxia Chen Yingxin Li Wenyi Ge Renbin Huang | 2014 | Journal of Cardiovascular Pharmacology2014，，1： | 1 |
| 9 | Prognostic value of mutational characteristics in gastrointestinal stromal tumors: a single-center experience in 275 cases显示文摘 | Ming Wang Jia Xu Wenyi Zhao Lin Tu Weiqing Qiu Chaojie Wang Yangyin Shen Qiang Liu Hui Cao | 2014 | Medical Oncology2014，，1： | 1 |
| 10 | Simulations of mixing processes after coalescence of binary momentum-less droplets显示文摘The fate of the internal fluids after coalescence of droplets is very important and has been investigated rarely. In this paper, we report simulations of mixing processes after coalescence of binary momentum-less droplets by using a front tracking method.Firstly, the validation of the method used here was testified, and then the effects of viscosity of droplets, size ratio and properties of ambient phase on mixing were investigated. The results qualitatively agree well with previous experimental observations. | LIU Dong GUO YinCheng LIN WenYi | 2013 | Science China(Technological Sciences)2013，56，7： | 1 |
| 11 | A GA–DE hybrid evolutionary algorithm for path synthesis of four-bar linkage显示文摘 | WenYi Lin | 2010 | Mechanism and Machine Theory2010，45，： | 1 |
| 12 | Some scheduling problems with time-dependent learning effect and deteriorating jobs 显示文摘 | LOW Chinyao LIN Wenyi | 2013 | Appl Math Model2013，37，20： | 1 |
| 13 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://db.cbi.pku.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 14 | Amphiphilic peptide dendrimer-based nanovehicles for safe and effective siRNA delivery显示文摘Small interfering RNA(siRNA)-based RNA interference has emerged as a promising therapeutic strategy for the treatment of a wide range of incurable diseases.However,the safe and effective delivery of siRNA therapeutics into the interior of target cells remains challenging.Here,we disclosed novel amphiphilic peptide dendrimers(AmPDs)that composed of hydrophobic two lipid-like alkyl chains and hydrophilic poly(lysine)dendrons with different generations(2C18-KK2 and 2C18-KK2K4)as nanovehicles for siRNA delivery.These AmPDs are able to self-assemble into supramolecular nanoassemblies that are capable of entrapping siRNA molecules into nanoparticles to protect siRNA from enzymatic degradation and promote efficient intracellular uptake without evident toxicity.Interestingly,by virtue of the optimal balance of hydrophobic lipid-like entity and hydrophilic poly(lysine)dendron generations,AmPD 2C18-KK2K4 bearing bigger hydrophilic dendron can package siRNA to form stable,but more ready to disassemble complexes,thereby resulting in more efficient siRNA releasing and better gene silencing effect in comparison with AmPD 2C18-KK2 bearing smaller dendron.Additional studies confirmed that 2Ci8-KK2K4 can capitalize on the advantages of lipid and peptide dendrimer vectors for effective siRNA delivery.Collectively,our AmPD-based nanocarriers indeed represent a safe and effective siRNA delivery system.Our findings also provide a new perspective on the modulation of selfassembly amphiphilic peptide dendrimers for the functional and adaptive delivery of siRNA therapeutics. | Chi Ma Dandan Zhu Yu Chen Yiwen Dong Wenyi Lin Ning Li Wenjie Zhang Xiaoxuan Liu | 2020 | Biophysics Reports2020，6，6： | 1 |
| 15 | Experimental studies on removal of carbon dioxide by aqueous ammonia fine spray显示文摘 | ZhenQi Niu YinCheng Guo WenYi Lin | 2010 | Science in China Series E: Technological Sciences2010，，1： | 1 |
| 16 | A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis显示文摘Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to treatment.Fibroblast growth factor receptor(FGFR)1 is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and dif-ferentiation.FGFR1 was predominantly expressed in GBM tissues,and FGFR1 expression was negatively correlated with overall survival.We rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1 protein in GBM cell lines in vitro.CYY292 also exerted an effect on the conserved Ser777 residue of FGFR1.CYY292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1/AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene knockdown.In vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than AZD4547.CYY292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM models.This study further elucidates the function of FGFR1 in the GBM and reveals the effect of CYY292,which targets FGFR1,on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells. | Yanran Bi Ruiling Zheng Jiahao Hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin | 2024 | Genes & Diseases2024，11，1： | 0 |
| 17 | Highly crystalline core dominated the catalytic performance of carbon dot for cyclohexane to adipic acid reaction显示文摘Carbon dots(CDs)have uniquely structural,physicochemical and photochemical properties,suggesting a promising platform for catalysis applications.The in-depth understanding of the structure-activity relationship in the CDs-based catalyst system needs to know the effect of the crystalline core on their catalytic performance.The efficient catalytic oxidation of cyclohexane is an urgent challenge in current chemical industry,in which,adipic acid(AA)plays an important role in industry for synthesis of nylon6 and nylon-66.Here,we fabricated the pristine CDs by electrochemical etching graphite rod method and derived CDs with high crystalline core(CD-600,CD-800,and CD-1100)through a thermal treatment method in tube furnace.Furthermore,these CDs performed an outstanding catalytic performance for one-step synthesis of AA from cyclohexane.With the help of machine learning(ML),the deep correlations between features(structures of CDs,catalytic conditions)and catalytic performances were investigated by XGBoost(XGB)model.Then under the optimization and prediction of XGB,it was found that high crystalline core preceded the other features and CD-1100 could get the best conversion of 30.696%and selectivity to AA of 92.52%at reaction conditions of 130℃,1.5 MPa,and 10 h.This work pioneered the application of ML in industrial issues and demonstrated a comprehensive understanding on CDs as catalyst to realize one-step synthesis of AA. | Xiao Wang Wenyi Bian Tianyang Zhang Yajie Zhao Mingwang Shao Haiping Lin Yang Liu Hui Huang Zhenhui Kang | 2022 | Nano Research2022，15，8： | 0 |
| 18 | Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)-associated systems(Cas)are efficient tools for targeting specific genes for laboratory research,agricultural engineering,biotechnology,and human disease treatment.Cas9,by far the most extensively used gene-editing nuclease,has shown great promise for the treatment of hereditary diseases,viral infection,cancers,and so on.Recent reports have revealed that some other types of CRISPR-Cas systems may also have surprising potential to join the fray as gene-editing tools for various applications.Despite the rapid progress in basic research and clinical tests,some underlying problems present continuous,significant challenges,such as editing efficiency,relative difficulty in delivery,off-target effects,immunogenicity,etc.This article summarizes the applications of CRISPR-Cas from bench to bedside and highlights the current obstacles that may limit the usage of CRISPR-Cas systems as gene-editing toolkits in precision medicine and offer some viewpoints that may help to tackle these challenges and facilitate technical development.CRISPR-Cas systems,as a powerful gene-editing approach,will offer great hopes in clinical treatments for many individuals with currently incurable diseases. | Wenyi Liu Luoxi Li Jianxin Jiang Min Wu Ping Lin | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 19 | Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine显示文摘Objective:Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor.However,at present,there is no immune vaccine targeting these cells.Octamer-binding transcription factor 4(OCT4),a marker of embryonic stem cells and germ cells,often highly expresses in the early stages of tumorigenesis and is therefore a good candidate for cancer vaccine development.Methods:To identify the optimal carrier and adjuvant combination,we chemically synthesized and linked three different OCT4 epitope antigens to a carrier protein,keyhole limpet hemocyanin(KLH),combined with Toll-like receptor 9 agonist(TLR9).Results:Immunization with OCT4-3+TLR9 produced the strongest immune response in mice.In prevention assays,significant tumor growth inhibition was achieved in BABL/c mice treated with OCT4-3+TLR9(P<0.01).Importantly,the results showed that cytotoxic T lymphocyte activity and the inhibition of tumor growth were enhanced in mice immunized with OCT4-3 combined with TLR9.Meanwhile,multiple cytokines[such as interferon(IFN)-γ(P<0.05),interleukin(IL)-12(P<0.05),IL-2(P<0.01),and IL-6(P<0.05)]promoting cellular immune responses were shown to be greatly enhanced in mice immunized with OCT4-3+TLR9.Moreover,we considered safety considerations in terms of the composition of the vaccines to help facilitate the development of effective next-generation vaccines.Conclusions:Collectively,these experiments demonstrated that combination therapy with TLR9 agonist induced a tumor-specific adaptive immune response,leading to the suppression of primary tumor growth in testis embryonic carcinoma. | Tingting Chen Kan Liu Jiangyao Xu Tianying Zhan Maixian Liu Li Li Zhiwen Yang Shuping Yuan Wenyi Zou Guimiao Lin Dennis ACarson Christina CNWu Xiaomei Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 20 | Study on the Practical Experience of Ecological Wisdom of Four Artificial Lakes in Guangzhou显示文摘The four artificial lakes in Guangzhou(Liwan Lake,Liuhua Lake,Lu Lake,Dongshan Lake)have maintained a benign relationship with the city for the symbiosis of human,nature and society since the end of the 1950s.Taking the four artificial lakes in Guangzhou as the research object,reviewing the construction process of the four artificial lakes in Guangzhou,and combing the ecological practice experience of the four artificial lakes.It is concluded that siting selection suitable for urban geographic conditions,considering the construction of artificial lakes in urban water systems,designing incorporating cultural,constructing and renovating the park combined with urban development and establishing lake-park symbiosis are the internal cause for the benign interoperability and coordinated development of the four artificial lakes and cities.In order to provide reference for the construction of urban artificial lakes in Guangzhou and the urban ecological environment construction of Guangdong,Hong Kong and Macao Dawan District. | Shangjiangfeng Lin Wenyi Zhang Wenying Zhang | 2019 | Journal of Architectural Research and Development2019，3，6： | 0 |
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