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| 1 | Constraints of (U-Th)/He ages on early Paleozoic tectonothermal evolution of the Tarim Basin,China显示文摘The thermal evolution of source rocks in the Paleozoic stratigraphic sequences has been an outstanding problem for petroleum exploration in the Tarim Basin, as the thermal history of the Paleozoic could not be reconstructed objectively due to the lack of effective thermal indicators in the early Paleozoic carbonate successions. The (U-Th)/He thermochronometry of apatite and zircon has recently been used as an effective tool to study the structural uplift and thermal history of sedimentary basins. The Paleozoic tectonothermal histories of two typical wells in the Tarim Basin were modeled using the thermal indicators of (U-Th)/He, apatite fission track (AFT), and vitrinite reflectance (Ro) data in this paper. The Paleozoic strata in the two wells were shallow due to persistent uplift and significant erosion during the Hercynian tectonic events (from Devonian to Triassic). Therefore, the paleothermal indicators in the Paleozoic strata may retain the original thermal evolution and can be used to re- construct the Paleozoic thermal history of the Tarim Basin. The apatite and zircon helium ages from core and cuttings samples were analyzed and the Paleozoic thermal histories of wells KQ1 and T1 were modeled by combining helium ages, AFT, and equivalence vitrinite reflectance (VRo) data. The modeling results show that the geothermal gradient evolution is different in the Kongquehe Slop and Bachu Uplift of Tarim Basin during the Paleozoic. The thermal gradient in Well T1 on the Bachu Up- lift was only 28–30°C/km in Cambrian, and it increased to 30–33°C/km in Ordovician and 31–34°C/km during the Silurian and Devonian. The thermal gradient of Ordovician in Well KQ1 on the Kongquehe Slope was 35°C/km and decreased to 32–35°C/km during the Silurian and Devonian. Therefore, the combined use of (U-Th)/He ages and other thermal indicators appears to be useful in reconstructing the basin thermal history and provides new insight into the understanding of the early Paleozoic thermal history of the Tarim Basin. | QIU NanSheng WANG JiYang MEI QingHua JIANG Guang TAO Cheng | 2010 | Science China Earth Sciences2010，53，7： | 22 |
| 2 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor显示文摘Embryo implantation is a crucial step in mammalian reproduction.However,little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation.Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation.Both transient and prolonged transgenic expression of miR-181 led to impaired implantation,which can be rescued by exogenous administration of leukemia inhibitory factor(LIF).Mechanistically,miR-181 is able to directly target LIF and downregulate LIF expression,thereby inhibiting embryo implantation.We also show that miR-181 expression is regu-lated by the transcriptional factor Emx2,and the Emx2–miR-181 axis plays an importantrole in regulating embryo implantation.Taken together,these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF,and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. | Bo Chu Liangwen Zhong Shuang Dou Jun Wang Jianmin Li Mingwei Wang Qinghua Shi Yide Mei Mian Wu | 2015 | Journal of Molecular Cell Biology2015，7，1： | 5 |
| 3 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 4 | On the technologies of Hα imaging spectrograph for the CHASE mission显示文摘The Hα imaging spectrograph(HIS) is the scientific payload of the first solar space mission, the Chinese Hα solar explorer(CHASE), supported by the China National Space Administration(CNSA). The CHASE/HIS achieves, for the first time in space, Hα spectroscopic observations with high spectral and temporal resolutions. Separate channels for the raster scanning mode(RSM) and continuum imaging mode(CIM) are integrated into one, and a highly integrated design is achieved through multiple folding of the optical path and ultra-light miniaturized components. The design of HIS implements a number of key technologies such as high-precision scanning of the optical field of view(FOV), high-precision integrated manufacturing inspection, a large-tolerance pre-filter window, and full-link solar radiation calibration. The HIS instrument has a pixel spectral resolution of 0.024 ? and can complete a full-Sun scanning within 46 s. | Qiang Liu Hongjiang Tao Changzheng Chen Chengshan Han Zhe Chen Gui Mei Liang Yang Qinglong Hu Hongwei Xin Xiansheng Li Hongyu Guan Donglin Xue Mingchao Zhu Changhong Hu Qinghua Ha Yukun He Cheng Fang Chuan Li Zhen Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 2 |
| 5 | Tectono-thermal Evolution in the Bachu Uplift,Tarim Basin,China显示文摘来源岩石在的热进化古生代长是到在 Bachu 的石油探索的一个问题高举, Tarim 盆,自从热历史在古生代不能在更低的古生代的继任由于有效热指示物的缺乏客观地被重建。磷灰石和锆石(U-Th )/He thermochronometry 能被用作技术的一种新类型学习热历史并且构造沉积的盆高举。把年龄,磷灰石分裂磁道数据和等价 vitrinite 反射(% EVRo ) 基于测量磷灰石和锆石(U-Th )/He,在 Bachu 的 5 口井的 tectonothermal 历史高举被建模。当模特儿的结果证明在有相对高的坡度在 Bachu 早古生代高举并且它逐渐地减少了在期间全部古生代:3335 浯琠敨映牯敭汲 ? 捡畣畭慬整 ? 楯?湩琠敨洠摩汤?祳瑳浥戠?慬整慲?業牧瑡潩?污湯?桴?慳摮潢楤獥?桷牥慥?数牴汯略?捡畣畭慬楴湯椠?桴?敤灥牥猠獹整?慷?慭湩祬搠牥癩摥映潲?桴?祳瑳浥椠獴汥?祢氠瑡牥污洠杩慲楴湯愠潬杮琠敨猠湡'N摯敩?湡?慲敲祬洠杩慲整?畯?景琠敨猠獹整? | QIU Nansheng JIANG Guang MEI Qinghua WANG Shengjun | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 2 |
| 6 | Polymorphisms in DNA repair genes of XRCC1 , XPA , XPC , XPD and associations with lung cancer risk in C hinese people显示文摘 | Chaorong Mei Mei Hou Shanxian Guo Feng Hua Dejie Zheng Feng Xu Yong Jiang Lu Li Youlin Qiao Yaguang Fan Qinghua Zhou | 2014 | Thoracic Cancer2014，，3： | 1 |
| 7 | 胚胎干细胞体外减数分裂获得功能配子显示文摘随着不孕不育症的全球性高发,通过体外培养的方式获得功能配子被认为是解决不孕不育症生殖细胞缺乏问题最为有效的途径,但过往的研究表明真实的再现减数分裂过程是体外获得功能配子难以逾越的障碍。 | Quan Zhou Mei Wang Yan Yuan Xuepeng Wang Rui Fu Haifeng Wan Mingming Xie Mingxi Liu Xuejiang Guo Ying Zheng Guihai Feng Qinghua Shi 赵小阳 沙家豪 周琪 | 2017 | 科学新闻2017，19，4： | 0 |
| 8 | Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples显示文摘Flame retardants(FRs)are ubiquitous in environment and biota and may pose harm to human health.In recent years,concern regarding legacy and alternative FRs has been intensified due to their widespread production and increasing contamination in environmental and human matrices.In this study,we developed and validated a novel analytical method for simultaneous determination of legacy and alternative FRs,including polychlorinated naphthalenes(PCNs),short-and middle-chain chlorinated paraffins(SCCPs and MCCPs),novel brominated flame retardants(NBFRs),and organophosphate esters(OPEs)in human serum.Serum samples were prepared by liquid-liquid extraction using ethyl acetate,and purified with Oasis®HLB cartridge and Florisil–silica gel columns.Instrumental analyses were carried out using gas chromatography-triple quadrupole mass spectrometry,highresolution gas chromatography coupled with high-resolution mass spectrometry,and gas chromatography coupled with quadrupole time-of-flight mass spectrometry,respectively.The proposed method was validated for linearity,sensitivity,precision,accuracy,and matrix effects.Method detection limits for NBFRs,OPEs,PCNs,SCCPs,and MCCPs were 4.6×10^(–4)–8.6×10^(–2),4.3×10^(–3)–1.3,1.1×10^(–5)–1.0×10^(–4),1.5,and 9.0×10–1 ng/mL,respectively.Matrix spike recoveries ranged from 73%–122%,71%–124%,75%–129%,92%–126%,and 94%–126%for NBFRs,OPEs,PCNs,SCCPs,and MCCPs,respectively.The analytical method was applied for detection of real human serum.CPs were the dominant FRs in serum,indicating CPs were widely presented in human serum and should be pay more attention for their health risk. | Xiaolin Guan Gaoxin Zhang Lingling Meng Mei Liu Liyuan Zhang Chuxuan Zhao Yingming Li Qinghua Zhang Guibin Jiang | 2023 | Journal of Environmental Sciences2023，，9： | 0 |
| 9 | Occurrence and Health Risk of Perfluoroalkyl Acids in Popular Shellfish from a Typical Coastal Area of the East China显示文摘As crucial homologous members of per-and polyfluoroalkyl substances(PFASs),perfluoroalkyl acids(PFAAs)have aroused wide public concern because of their unique properties(persistence,bioaccumulation,long-distance migration and toxicity).Studies have shown their potential hazard to wildlife and humans,with food consumption as one of the primary routes of PFAA exposure for general population,especially seafood intake.In this study,17 PFAAs were quantified in 9 shellfish species from Yuhuan City,a typical coastal area of the East China.The total mean concentrations of PFAAs were in the range of 5.03–381 ng/g dry weight(dw),with the highest concentration found in Neverita didyma and the lowest in Babylonia lutosa.Concentrations and composition profiles of PFAAs varied significantly among different species,indicating differences in the bioaccumulation potential of PFAAs among species.Perfluorooctanoic acid(PFOA)was presented as the most abundant PFAA in this study,followed by perfluorobutanoic acid(PFBA).Significant positive correlations were observed among some individual PFAAs(p<0.05),indicating that they may share similar pollution sources or undergo similar compound behaviors.Health risk assessment indicated a relatively high threat for local residents exposed to PFAAs through shellfish consumption. | LIU Ruolin LIU Mei ZHAO Chuxuan FU Jianjie ZHOU Wei ZHANG Qinghua Martin HANSEN DONG Yin | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
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