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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Metal-organic framework-derived, Zn-doped porous carbon polyhedra with enhanced activity as bifunctional catalysts for rechargeable zinc-air batteries显示文摘锌空气电池最近与他们的锂离子对应物相比由于更大的存储能力和更低的费用吸引了可观的兴趣。为氧减小反应(ORR ) 和氧进化反应(OER ) 的电极催化剂在可充电的锌空气电池的操作起一个关键作用。此处,我们报导简单、可伸缩的策略作为先锋用做 Zn 的共同基于的 zeolitic imidazolate 框架(ZnCo-ZIFs ) 制作多孔的碳 polyhedra。惊人地,做的 Zn 导致更小的公司 nanoparticles 和更高的氮内容,它接着提高获得的多孔的碳 polyhedra 的 ORR 和 OER 活动。做 N 的碳和钴 nanoparticles 在的 synergistic 效果合成,源于碳的高 graphitization 的改进传导性,和多孔的多面的结构的大表面区域在碱的媒介与优秀 ORR 和 OER electrocatalytic 活动导致了多孔的碳 polyhedra。更重要地,空气阴极在新窗户中在主要、可充电的锌空气 batteries.Open 图象基于最佳的多孔的碳 polyhedra 推进展出优异性能到 Pt/C | Xuan Wu Ge Meng Wenxian Liu Tian Li Qiu Yang Xiaoming Sun Junfeng Liu | 2018 | Nano Research2018，11，1： | 10 |
| 3 | Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process显示文摘 | Fanbin Meng Huagao Wang Wei Zijian Chen Tian Li Chunyuan Li Yu Xuan Zuowan Zhou | 2018 | Nano Research2018，11，5： | 9 |
| 4 | Toxicity of Multi-Walled Carbon Nanotubes,Graphene Oxide,and Reduced Graphene Oxide to Zebrafish Embryos显示文摘Objective This study was aimed to investigate the toxic effects of 3 nanomaterials, i.e. multi-walled carbon nanotubes(MWCNTs), graphene oxide(GO), and reduced graphene oxide(RGO), on zebrafish embryos. Methods The 2-h post-fertilization(hpf) zebrafish embryos were exposed to MWCNTs, GO, and RGO at different concentrations(1, 5, 10, 50, 100 mg/L) for 96 h. Afterwards, the effects of the 3 nanomateria on spontaneous movement, heart rate, hatching rate, length of larvae, mortality, and malformations ls were evaluated. Results Statistical analysis indicated that RGO significantly inhibited the hatching of zebrafish embryos. Furthermore, RGO and MWCNTs decreased the length of the hatched larvae at 96 hpf. No obvious morphological malformation or mortality was observed in the zebrafish embryos after exposure to the three nanomaterials. Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed. | LIU Xiao Tong MU Xi Yan WU Xiao Li MENG Li Xuan GUAN Wen Bi MA Yong Qiang SUN Hua WANG Cheng Ju LI Xue Feng | 2014 | Biomedical and Environmental Sciences2014，27，9： | 6 |
| 5 | The Changes in the Awareness of Cervical Cancer Prevention and the Acceptability of HPV Vaccines among Women after Their Introduction in China显示文摘Cervical cancer is a form of malignant tumor that seriously threatens women’s health. In China,according to the cancer statistics, 98,900 new cervical cancer cases and 30,500 deaths due to cervical cancer were estimated to have occurred in2015, and the incidence and mortality rates still exhibited an upward trend[1]. | MA Quan Fu GUO Yu Lin YAN Bin FAN Chun Li XU Meng DAI Xuan WANG Ying ZOU Miao WANG Chao Nan WU Xu Feng | 2019 | Biomedical and Environmental Sciences2019，32，11： | 5 |
| 6 | Study on ReactiveAdsorption Desulfurization of Model Gasoline on Ni/ZnO-HY Adsorbent显示文摘The reactive adsorption desulfurization of model gasoline was carried out on Ni/ZnO-HY adsorbent.The Ni/ZnO-HY adsorbent was characterized by N2adsorption-desorption test(BET),X-ray diffractometry(XRD),and temperature-programmed reduction(TPR)analysis.The test results have demonstrated that HY-zeolite is a feasible support for Ni/ZnO components used in reactive adsorption desulfurization.The results of XRD and TPR analyses showed that most of nickel element was present as Ni2+species with only a small part existing as Ni3+species,and the Ni2+species had interactions with HY-zeolite.Under the conditions of this study,which specified a 50% ratio of HY-zeolite in the adsorbent,a Zn/Ni molar ratio of 10,and a reduction temperature of 400℃,the Ni/ZnO-HY adsorbent showed the best desulfurization performance.The sulfur capacity of Ni/ZnO-HY adsorbent could be recovered to 92.19% of the fresh one after being subjected to regeneration at 500℃,and could be maintained at 82.17% of the fresh one after 5 regeneration cycles. | Huang Huan Salissou M.Nour Yi Dezhi Meng Xuan Shi Li | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 4 |
| 7 | Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China显示文摘Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many regions.Screening forβ-thalassemia carriers is crucial for controlling this condition.To investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019. | GU Heng WANG Yong Xia DU Meng Xuan XU Shan Shan ZHOU Bing Yi LI Ming Zhen | 2021 | Biomedical and Environmental Sciences2021，34，8： | 4 |
| 8 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 9 | Evidence-based intervention on postoperative fear,compliance,and self-efficacy in elderly patients with hip fracture显示文摘BACKGROUND Elderly patients tend to have poor self-efficacy and poor confidence in postoperative rehabilitation for hip fractures,and are prone to negative emotions,which affect treatment compliance.AIM To evaluate the effects of evidence-based intervention on postoperative fear,compliance,and self-efficacy in elderly patients with hip fractures.METHODS A total of 120 patients with hip fracture surgically treated from June 2018 to June 2020 at the orthopedic department of our hospital were selected and divided into intervention and routine groups(n=60 each)according to different nursing methods.The basic rehabilitation methods of the two groups were consistent,but patients in the intervention group received evidence-based nursing interventions at the same time.Differences between groups in the scores of motion phobia,pain fear,rehabilitation training compliance,self-efficacy,nursing satisfaction,and hip joint function were compared before and after the intervention.RESULTS Before the intervention,there were no statistically significant differences in motion phobia and pain fear scores between the groups(all P>0.05).However,motion phobia scores at 1 wk after intervention initiation(P<0.05),and pain fear scores at 1 wk and 2 wk after intervention initiation(all P<0.05),were significantly lower in the intervention group than in the routine group.On the first day of intervention,there was no significant difference in rehabilitation treatment compliance between the groups(P>0.05);however,at 2 wk after intervention initiation,rehabilitation compliance was significantly better in the intervention group than in the routine group(P<0.05).Before the intervention,there were no statistically significant differences in the scores for the two self-efficacy dimensions(overcoming difficulties and rehabilitation exercise self-efficacy)and the total self-efficacy score between the groups(all P>0.05).After 2 wk of intervention,the scores for these two dimensions of self-efficacy and the total self-efficacy score were significantly higher in the intervention group than in the routine group(all P<0.05).At 3 and 6 mo after surgery,hip function as evaluated by the Harris hip score,was significantly better in the intervention group than in the routine group(P<0.05).Additionally,overall nursing satisfaction was significantly higher in the intervention group than in the routine group(P<0.05).CONCLUSION Evidence-based nursing intervention can alleviate fear of postoperative rehabilitation in elderly patients who underwent hip fracture surgery,and improve rehabilitation treatment compliance and patient self-efficacy,which promote hip function recovery. | Ying Fu Li-Juan Zhu Da-Cheng Li Jing-Lei Yan Hai-Ting Zhang Yu-Hong Xuan Chun-Ling Meng Yan-Hong Sun | 2022 | World Journal of Clinical Cases2022，10，10： | 4 |
| 10 | LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling显示文摘 | LI Xiao-jin GUO Qing-hua WANG Xuan XUE Bing SUN Lian-qing MENG Qu-tao LU Ju-ming MU Yi-ming | 2012 | Chinese Medical Journal2012，，10： | 3 |
| 11 | Barley St#pe Mosaic Virus yb Interacts with Glycolate Oxidase and Inhibits Peroxisomal ROS Production to Facilitate Virus Infection显示文摘 | Meng Yang Zhenggang Li Kun Zhang Xuan Zhang Yongliang Zhang Xianbing Wang Chenggui Han Jialin Yu Kai Xu Dawei Li | 2018 | Molecular Plant2018，11，2： | 3 |
| 12 | MAPKs and acetyl-CoA are associated with Curvularia lunata pathogenicity and toxin production in maize显示文摘Mitogen-activated protein kinase(MAPK) cascades play an important role in extracellular signal transduction and are involved in the pathogenicity of fungal pathogens to host plants.In Curvularia lunata,the roles of two MAPK genes,Clk1 and Clm1,have already been studied.Clk1 is involved in conidia formation and pathogenicity,and Clm1 is closely related to pathogen cell wall formation and pathogenicity to maize leaves.In this study,a third C.lunata MAPK gene,Clh1,which is homologous to hog1,was successfully cloned.We found that a Clh1 deletion mutant had lower intracellular glycerol accumulation than the wild-type stain and was unable to grow normally under osmotic stress conditions.Furthermore,the deletion mutants of three C.lunata MAPK genes(Clk1,Clm1 and Clh1) had lower levels of acetyl-Co A,which is an important intermediate product in the synthesis of melanin and furan toxin,and down-regulated expression of pathogenicity-associated genes.Furthermore,pathogenicity and the ability to produce toxin were restored after adding acetyl-Co A to the culture medium,suggesting that acetyl-Co A is closely involved in the pathogen MAPK signaling pathway. | NI Xuan GAO Jin-xin YU Chuan-jin WANG Meng SUN Jia-nan LI Ya-qian CHEN Jie | 2018 | Journal of Integrative Agriculture2018，17，1： | 3 |
| 13 | Partial discharge measurement and analysis under lightning impulse superimposed DC voltage in SF6 gas显示文摘The presence of lightning impulses(LIs)on the DC waveform can seriously influence the insulation performance of a GIL system.The waveshape can be a superposition of the DC and impulse waveform.In this study,the behaviour of partial discharge(PD)on an epoxy surface is investigated under DC and LI superimposed voltage in SF6.The lightning impulses with different polarities are superimposed on the epoxy surface under both positive and negative DC voltages,respectively.Positive lightning impulses are superimposed on a negative DC voltage with a 90%of the partial discharge inception voltage(PDIV)magnitude.The number and amplitude of the PDs are used to evaluate the insulation performance.The experimental results show that the LI with a different polarity applied to DC can excite the PDs on the epoxy surface.The excitation effect of positive LI superimposed on negative DC is more significant.According to the impulse amplitude and PD characteristics,the influence of superimposed LI on PD excitation can be divided into three stages.As the superimposed LI increases,the amplitude of the excited PD increases gradually,while the PD number first increases and then decreases.This study is expected to provide reference for manufacture and protection of power equipment. | Haotian Wang Cong He Ruochen Guo Xuan Meng Wenze Yuan Junhao Li | 2022 | High Voltage2022，7，4： | 3 |
| 14 | The influence of the type of N dopping on the performance of bifunctional N-doped ordered mesoporous carbon electrocatalysts in oxygen reduction and evolution reaction显示文摘To develop more ideal bifunctional heteroatom-doped carbon electrocatalysts toward the oxygen reduction reaction(ORR) and oxygen evolution reaction(OER) for regenerative fuel cells and rechargeable metal–air batteries, herein, tobacco-derived N-containing ordered mesoporous carbon(N-OMC) electrocatalysts with different N species distributions are designed. Results indicate that the as-prepared N-OMC with more pyrrolic and pyridinic Ns exhibits much higher activities for the ORR and OER than N-OMC with more graphitic N in both acidic and alkaline media, suggesting that the increase of pyrrolic and pyridinic Ns favors the improvement of ORR and OER activities of the N-containing carbon catalysts, and showing a great potential for the designing of more effective, lower-cost ORR and OER bifunctional electrocatalysts for future regenerative fuel cells and rechargeable metal–air batteries. | Meng Li Ziwu Liu Fang Wang Jinjin Xuan | 2017 | Journal of Energy Chemistry2017，26，3： | 2 |
| 15 | Sod gene of Curvularia lunata is associated with the virulence in maize leaf显示文摘Curvularia leaf spot,caused mainly by Curvularia lunata,is a widespread plant disease in China. In the recent years,directional host selection by the pathogen,which likely results in the virulence differentiation in pathogens,is widely reported. Among the hallmarks potentially associated to pathogen variation in virulence,superoxide dismutase gene Sod has been found to be closely related to the enhancement of virulence. In the present study,the full-length of Sod was obtained via Blastn alignment against Gen Bank and the whole genome of C. lunata. In order to understand the role of Sod in the virulence variation in C. lunata,targeted gene disruption was performed to construct Sod mutants. The cell wall degrading enzyme(CWDE)activities and toxin production of ΔSod were not distinctly different from wild-type strain CX-3 and its complon. However,at an early stage of infection,ΔSod virulence appeared to be lower than CX-3 and the complon,while at a later stage,its virulence gradually returned to the level of CX-3 and the complon. Furthermore,the melanin production of ΔSod was significantly reduced compared to CX-3 and the complon,suggesting that Sod gene influences the virulence by regulating melanin production at an early stage of infection but is not essential for pathogenicity. However,the disruption of Sod did not significantly affect the transcriptional expression of the melanin biosynthesis-associated genes,brn1 and scd. Therefore,we infer that Sod in C. lunata are involved,to some extent,with the virulence in maize leaf,but still needs further studies to have a clear understanding of its mechanism. | GAO Shi-gang NI Xuan LI Ying-ying FU Ke-he YU Chuan-jin GAO Jin-xin WANG Meng LI Ya-qian CHEN Jie | 2017 | Journal of Integrative Agriculture2017，16，4： | 2 |
| 16 | Adsorption desulfurization and weak competitive behavior from 1-hexene over cesium-exchanged Y zeolites(CsY)显示文摘The systematic research about the adsorption desulfurization and competitive behavior from 1-hexene over cesium-exchanged Y zeolites has been investigated. The structural properties of the adsorbents were characterized by X-ray diffraction(XRD), N_2 sorption(BET) and thermal analysis(TGA). The effects of calcination temperature, calcination atmosphere, and adsorption temperature were studied by the dynamic and static tests. The competitive adsorption mechanisms between thiophene and 1-hexene were studied by in-situ Fourier transform infrared spectroscopy(in-situ FTIR) and temperature-programmed desorption(TPD). CsY adsorbents exhibited high selectivity for thiophene even when a large amount of olefins exist.In-situ FTIR spectra of thiophene and 1-hexene adsorption indicated that both thiophene and 1-hexene were mainly adsorbed on CsY via π-complexation. The higher desorption activated energy and higher adsorption heat of thiophene than 1-hexene obtained by thiophene-TPD and hexene-TPD has revealed that thiophene is adsorbed more strongly in CsY adsorbents than 1-hexene. | Xiaojuan Liu Dezhi Yi Yuanyuan Cui Li Shi Xuan Meng | 2018 | Journal of Energy Chemistry2018，27，1： | 2 |
| 17 | Differentiation of Induced Pluripotent Stem Cells into Male Germ Cells In Vitro through Embryoid Body Formation and Retinoic Acid or Testosterone Induction显示文摘 | Peng Li Hongliang Hu Shi Yang Ruhui Tian Zhenzhen Zhang Wei Zhang Meng Ma Yong Zhu Xizhi Guo Yiran Huang Zuping He Zheng Li Xuan Jin | 2012 | BioMed Research International2012，，： | 2 |
| 18 | Overexpression of phosphatidylserine synthase IbPSS1 affords cellular Na+homeostasis and salt tolerance by activating plasma membrane Na^(+)/H^(+)antiport activity in sweet potato roots显示文摘Phosphatidylserine synthase(PSS)-mediated phosphatidylserine(PS)synthesis is crucial for plant development.However,little is known about the contribution of PSS to Na^(+)homeostasis regulation and salt tolerance in plants.Here,we cloned the IbPSS1 gene,which encodes an ortholog of Arabidopsis AtPSS1,from sweet potato(Ipomoea batatas(L.)Lam.).The transient expression of IbPSS1 in Nicotiana benthamiana leaves increased PS abundance.We then established an efficient Agrobacterium rhizogenes-mediated in vivo root transgenic system for sweet potato.Overexpression of IbPSS1 through this system markedly decreased cellular Na^(+)accumulation in salinized transgenic roots(TRs)compared with adventitious roots.The overexpression of IbPSS1 enhanced salt-induced Na^(+)/H^(+)antiport activity and increased plasma membrane(PM)Ca^(2+)-permeable channel sensitivity to NaCl and H2O2 in the TRs.We confirmed the important role of IbPSS1 in improving salt tolerance in transgenic sweet potato lines obtained from an Agrobacterium tumefaciens-mediated transformation system.Similarly,compared with the wild-type(WT)plants,the transgenic lines presented decreased Na^(+)accumulation,enhanced Na^(+)exclusion,and increased PM Ca^(2+)-permeable channel sensitivity to NaCl and H2O2 in the roots.Exogenous application of lysophosphatidylserine triggered similar shifts in Na^(+)accumulation and Na^(+)and Ca^(2+)fluxes in the salinized roots of WT.Overall,this study provides an efficient and reliable transgenic method for functional genomic studies of sweet potato.Our results revealed that IbPSS1 contributes to the salt tolerance of sweet potato by enabling Na^(+)homeostasis and Na^(+)exclusion in the roots,and the latter process is possibly controlled by PS reinforcing Ca^(2+)signaling in the roots. | Yicheng Yu Ying Xuan Xiaofeng Bian Lei Zhang Zhiyuan Pan Meng Kou Qinghe Cao Zhonghou Tang Qiang Li Daifu Ma Zongyun Li Jian Sun | 2020 | Horticulture Research2020，7，1： | 2 |
| 19 | Reactive Adsorption of Thiophene on ZnNi/Diatomite-Pseudo-Boehmite Adsorbents显示文摘The thiophene removal ability of the synthesized ZnNi/diatomite-pseudo-boehmite adsorbent was tested in a labscale fixed-bed reaction system.X-ray diffractograms(XRD) were used to characterize the adsorbent samples.The effects of Zn/Ni molar ratio,various model fuels and regeneration patterns on the RADS tests were studied.The adsorption mechanism was investigated by XRD and MS analyses.The results indicted that thiophene in the model fuel was first decomposed on the surface Ni of the adsorbent to form Ni3S2 while the hydrocarbon portion of the molecule was released back into the process stream,followed by reduction of Ni3S2 to form H2S in the presence of H2,and then H2S is stored in the adsorbent accompanied by the conversion of ZnO into ZnS. | Meng Xuan Weng Huixin Shi Li | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，3： | 2 |
| 20 | Desulfurization of model gasoline on modified bentonite显示文摘 | Tang Xiaolin Meng Xuan Shi Li | 2011 | Industrial & Engineering Chemistry Research2011，50，12： | 1 |
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