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| 1 | Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair显示文摘AIM: To determine the influence of intra-abdominal pressure(IAP) on respiratory function after surgical repair of ventral hernia and to compare two different methods of IAP measurement during the perioperative period. METHODS: Thirty adult patients after elective repair of ventral hernia were enrolled into this prospective study.IAP monitoring was performed via both a balloontipped nasogastric probe [intragastric pressure(IGP), Ci MON, Pulsion Medical Systems, Munich, Germany] and a urinary catheter [intrabladder pressure(IBP), Uno Meter Abdo-Pressure Kit, Uno Medical, Denmark] on five consecutive stages:(1) after tracheal intubation(AI);(2) after ventral hernia repair;(3) at the end of surgery;(4) during spontaneous breathing trial through the endotracheal tube; and(5) at 1 h after tracheal extubation. The patients were in the complete supine position during all study stages.RESULTS: The IAP(measured via both techniques) increased on average by 12% during surgery compared to AI(P < 0.02) and by 43% during spontaneous breathing through the endotracheal tube(P < 0.01). In parallel, the gradient between РаСО2 and Et CO2 [Р(а-et)CO2] rose significantly, reaching a maximum during the spontaneous breathing trial. The PаO2/Fi O2 decreased by 30% one hour after tracheal extubation(P = 0.02). The dynamic compliance of respiratory system reduced intraoperatively by 15%-20%(P < 0.025). At all stages, we observed a significant correlation between IGP and IBP(r = 0.65-0.81, P < 0.01) with a mean bias varying from-0.19 mm Hg(2SD 7.25 mm Hg) to-1.06 mm Hg(2SD 8.04 mm Hg) depending on the study stage. Taking all paired measurements together(n = 133), the median IGP was 8.0(5.5-11.0) mm Hg and the median IBP was 8.8(5.8-13.1) mm Hg. The overall r2 value( n = 30) was 0.76(P < 0.0001). Bland and Altman analysis showed an overall bias for the mean values per patient of 0.6 mm Hg(2SD 4.2 mm Hg) with percentage error of 45.6%. Looking at changes in IAP between the different study stages, we found an excellent concordance coefficient of 94.9% comparing IBP and IGP( n = 117).CONCLUSION: During ventral hernia repair, the IAP rise is accompanied by changes in Р(а-et)CO2 and PаO2/Fi O2-ratio. Estimation of IAP via IGP or IBP demonstrated excellent concordance. | Konstantin M Gaidukov Elena N Raibuzhis Ayyaz Hussain Alexey Y Teterin Alexey A Smetkin Vsevolod V Kuzkov Manu LNG Malbrain Mikhail Y Kirov | 2013 | World Journal of Critical Care Medicine2013，2，2： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Intensive insulin therapy in the intensive care unit assessment by eontinuons glucose monitoring 显示文摘 | De BC Manuely Y Keenoy B | 2006 | Diabetes Care2006，29，8： | 1 |
| 4 | Supply networks and complex adaptive systems: control versus emergence 显示文摘 | Thomas Y Choi Kevin J Dooley Manus Rungtusanatham | 2001 | Journal of Operations Management2001，19，： | 1 |
| 5 | Supply networks and complex adaptive systems:Control versus emergence显示文摘 | Chois T Y Dooley K J Manus R | 2001 | Journal of Operational Management2001，19，3： | 1 |
| 6 | Supply Networks and Complex Adaptive Systems: Control Versus Emergence 显示文摘 | Thomas Y Choi Kevin J Dooley Manus Rungtusanatham | 2001 | Journal of Operations Management2001，，19： | 1 |
| 7 | Supply networks and complex adaptive systems: control versus emergence显示文摘 | Choi T Y Dooley K J Manus R | 2001 | Journal of Operational Management2001，19，3： | 1 |
| 8 | Supply networks and complex adaptive systems: Control versus emergence显示文摘 | Thomas Y Choi Kevin J Dooley Manus R | 2011 | J of Operations Management2011，19，3： | 1 |
| 9 | Supply networks and complex adaptive systems: control versus emergence显示文摘 | Thomas Y Choi Kevin J Dooley Manus Rungtusanatham | 2001 | Journal of Operations Management2001，，3： | 1 |
| 10 | A Sensorless Optimal Control System for an Automotive Electric Power Assist Steering System显示文摘 | MANU Parmar JOHN Y Hung | 2004 | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS2004，51，2： | 1 |
| 11 | Antioxidant and anti- inflammatory effi- cacy of NAC in the treatment of COPD: dis- cordant in vitro and in vivo dose - effects : a re- view显示文摘 | Sadowska AM Manue Y Keenoy B De Backer WA | | PuIm Pharm0，，： | 1 |
| 12 | Modeling and Sensorless Optimal Control Design for an Electric Power Assist Steering System显示文摘 | Manu P John Y H | 2002 | IEEE Transactions on Industrial Electronics2002，49，5： | 1 |
| 13 | A Sensorless Optimal Control System for an Automotive Electric Power Assist Steering System显示文摘 | Manu P John Y H | 2004 | IEEE Transactions on Industrial Electronics2004，51，2： | 1 |
| 14 | Role of inflammatory markers in brain ischemia显示文摘 | Rodriguer Y Manue I Cast-Interleubinlo J | 2008 | Current Opinion in Neunology2008，21，3： | 1 |
| 15 | Concept convergence process: a framework for improving product concepts 显示文摘 | MANU A OM P Y RAKESH J | 2010 | Computers% Industrial Engineering2010，59，3： | 1 |
| 16 | Stress Rupture Predic- tions of Pressure Vessels Exposed to Fully Engulfing and Local Impingement Accidental Fire Heat Loads 显示文摘 | Manu C C Birk A M Kim I Y | 2009 | Engineering Failure Analysis2009，16，4： | 1 |
| 17 | Stress rupture predic- tions of pressure vessels exposed to fully engulfing and local impingement accidental fire heat loads 显示文摘 | Manu C C Birk A M Kim I Y | 2009 | En- gineering Failure Analysis2009，16，4： | 1 |
| 18 | Supply networks and complex adaptive systems:control versus emergence显示文摘 | Thomas Y Choi Kevin J Dooley Manus Rungtusanatham | 2001 | Journal of Operations Management2001，19，1： | 1 |
| 19 | A Sensorless Optimal Control System for an Automotive Electric Power Assist Steering System显示文摘 | Manu Parmar Hung John Y | | 0，，02： | 1 |
| 20 | Znten Sive in sulin therapy in the intensive care unit: assessment by continuons glucose monitoring 显示文摘 | De Block C Manuely Y Keenoy B Van Gaal LF | 2006 | Diabetes Care2006，29，8： | 1 |
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