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| 1 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 2 | Retrospect and prospect of Geographical Sciences in China: A comparison with the Strategic Directions for Geography in the USA显示文摘理解变化行星:为地理科学(UCP ) 的战略方向,出版了由国家研究委员会(美国) ,和它在职业地理学者的评价建议那大写和复数地理科学(GS ) 是为在为我们的很快变化的行星的更好的理解的下一十年的地理的战略方向。根据这些评价, UCP 过分地珍视技术和工具(任务) ,并且没对方法论(纪律) 给予许多注意。实际上,任务和纪律是地理翅膀,特别在大科学的时间。从 UCP 和它的注释的启发是应该在任务和学科之间被平衡的战略方向, GS 应该是一个纪律系统,方法论,和技术和工具的三维的构造,并且这个系统应该是基于科学精神的科学人性并且由人性指导。在最后 60 年期间,中国地理学者把自己奉献给 GS,包括实践和理论。显然,进步和眼界作为学科交差的 GS,地球表面科学(S 字) 和地理建设(GC ) 被建议。GS 的纪律系统是很复杂的,并且由象科学,技术,工程,和哲学的如此的人的知识领域构成。主要使命是研究户外,建筑群,和宏地球系统(不仅科学地,而且人性地) ,并且一重要方法论是质、量的工具(CIQQM ) 的全面集成。同时,在中国地理的另一个变化方向是人经济的地理(HEG ) 。 | SUN Jun PAN Yujun TANG Maolin WU Youde | 2013 | Journal of Geographical Sciences2013，23，6： | 4 |
| 3 | Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia显示文摘Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological features.Rare variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD development.It is still unknown whether TREM2 is related to cognitive impairment in T2DM.Here,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed mice.Male C57BL/6J mice were maintained on HFD for 50 weeks.TREM2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene delivery.The results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and memory.Compared with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD mice.The overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic transmission.Dendritic complexity and spine density in the CA1 region were rescued after TREM2 overexpression.Furthermore,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial activation.In sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory phenotype.Our study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline. | Min Wu Maolin Liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu Li Jibin Li Yuxiang Sun Chaodong Wu Qifu Li Xiaoqiu Xiao | 2022 | Genes & Diseases2022，9，2： | 4 |
| 4 | Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma显示文摘Objective:To establish a new classification of biliary tumor thrombus(BTT).Methods:Overall survival of patients with BTT was first used to determine whether it correlated with current hepatocellular carcinoma staging systems.Univariate and multivariate analyses were used to determine factors affecting the overall survival(OS)to form the basis of our new classification for BTT.Results:All 6 international staging systems showed overlapping survival curves.Univariate followed by multivariate analyses showed that total bilirubin and intrahepatic/extrahepatic BTT were significant risk factors of OS.Based on these data,a new BTT classification was defined as:TypeⅠ:intrahepatic BTT;and TypeⅡ:extrahepatic BTT involving a common bile duct or common hepatic duct.TypeⅠwas further subdivided into type Ia:BTT involving a second-order intrahepatic duct or above,and type Ib:BTT involving a first-order intrahepatic duct.TypeⅡwas further subdivided into typeⅡa and typeⅡb using a cut-off total bilirubin(TB)>300μmol/L.The numbers(percentages)of patients with typesⅠandⅡBTT were 69(34.2%)and 133(65.8%),respectively.The median OS of typeⅠpatients was significantly higher than that of typeⅡpatients(37.5 months vs.23.2 months;P=0.002).Using subgroup analyses,OS outcomes were significantly different between the subgroups of typeⅡb and type IIa,although there was no significant difference between the type Ia and type Ib subgroups(P=0.07).Conclusions:A new BTT classification was established to predict prognoses of HCC patients with BTT who underwent liver resection. | Juxian Sun Jiayi Wu Chang Liu Jie Shi Yonggang Wei Jianyin Zhou Zhibo Zhang Wan Yee Lau Maolin Yan Shuqun Cheng | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 5 | Designing for Long Campaign Life Blast Furnace (2)-The Simulation of Temperature Field of Lining and Cooling Apparatus显示文摘Through the numerical modeling of temperature field for Blast Furnace (BF) lining and stave coolers, it can tell designers how to design a cooler which the hot surface temperature is less than its critical temperature under very high heat flux. Applying low heat re- sistance lining and staves cooler to BF is good for a layer of slag skull frozen on the hot surface of cooling stave. As long as the slag skull can stand, the furnace wall is stable and the heat loss of furnace does not increase. This is the basic principle for designing long campa- ignship BF. | Qingguo Xue Weiguo Yang Susen Cheng Maolin Wu Tianjun Yang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China The Center of Engineering and Research for Iron and Steel, 100053, China | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 3 |
| 6 | Identification of ancient ceramics by digital shape characterization显示文摘Shapes are important clues for the identification of ancient ceramics.In this study,digital extraction methods of shape characterization were discussed,using samples of flared mouthed porcelain bowls produced in Jingdezhen Hutian Kiln from the Five Dynasties to the Song and Yuan period.By employing the techniques of image enhancement,edge detection and curve fitting of Matlab,the method using digital shape characterization has advanced accuracy and effectiveness of traditional identification which is based on visual and tactual inspections.Together with the increasingly applied compositional data analysis and thermoluminescence dating technique,the method will further improve and upgrade the scientific identification system for ancient ceramics. | WU Juan LIU YingChun XIONG Lu TANG Min ZHANG MaoLin WU JunMing LI QiJiang HUANG MengXuan LI JiaZhi | 2012 | Science China(Technological Sciences)2012，55，9： | 3 |
| 7 | Computational and Experimental Study of Cooling Process in Coke Dry Quenching Experimental Shaft显示文摘Owing to its merits in energy savings, environmental protection and coke quality improvement, the Coke Dry Quenching (CDQ) technology is favorite in coke making industry today. In order to validate the mathematical model developed for the cooling process of real CDQ shaft, the one-seventh scale experimental setup was established. With the air as the working fluid and the coke as the packed bed, the coke and gas temperatures and the pressure drop in the cooling shaft were measured. A mathematical model based on the non-Darcian and non-thermal equilibrium model for the cooling process of the CDQ experimental shaft was presented. The computational results were compared to the experimental data. It was found that most numerical predictions were supported by the measured values. | Huafei Liu Xinxin Zhang Maolin Wu Yanhui Feng Yingbo Wang Dinan Wang Lie Xu Wenghua Zheng | 2002 | Journal of Thermal Science2002，11，2： | 2 |
| 8 | Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection. | Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 9 | Study on the diversification of origins and primary development of Chinese porcelain glazes显示文摘With the support of the Origin Exploring of Chinese Civilization Projects (II) and National Natural Science Foundation of China,the close relationship among 'pottery coat','kiln sweat' and Chinese proto-porcelain glaze were studied,the characteristics and the key foundation of the origin of porcelain glaze were also discussed based on the relevant research results by Shanghai Institute of Ceramics,Chinese Academy of Sciences and Jingdezhen Ceramics Institute. | WU Juan ZHANG MaoLin WU JunMing LI QiJiang LI JiaZhi DENG ZeQun JIANG Xia | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 10 | Earliest domestication of common millet(Panicummiliaceum)in East Asia extended to 10 000 years ago显示文摘 | Houyuan Lu Jianping Zhang Kam-biu Liu Naiqin Wu Yumei Li Kunshu Zhou Maolin Ye Tianyu Zhang Hai-jiang Zhang Xiaoyan Yang Licheng Shen Deke Xu Quan Li | 2009 | PNAS2009，106，18： | 1 |
| 11 | Novel functionalized ternary copolymer fluorescent nanoparticles: synthesis, fluorescent characteristics and protein immobilization显示文摘 | Maolin Lu Daocheng Wu Na Guo | 2009 | Journal of Materials Science: Materials in Medicine2009，，2： | 1 |
| 12 | On the consistency of credibility premiums regarding Esscher principle显示文摘 | Maolin PAN Rongming WANG Xianyi WU | 2008 | Insurance: Mathematics and Economics2008，42，1： | 1 |
| 13 | Earliest domestication of common millet(Panicummiliaceum)in East Asia extended to 10 000 years ago 显示文摘 | Houyuan Lu Jianping Zhang Kam-biu Liu Naiqin Wu Yumei Li Kunshu Zhou Maolin Ye Tianyu Zhang Hai-jiang Zhang Xiaoyan Yang Licheng Shen Deke Xu Quan Li | 2009 | Proceedings of the National Academy of Sciences of the Unit-ed States of America2009，106，： | 1 |
| 14 | On the consis- tency of credibility premiums regarding Esscher principle 显示文摘 | Pan Maolin Wang Rongming Wu Xianyi | 2008 | Insurance:Mathematical and Economics2008，42，1： | 1 |
| 15 | Component and simulation of the 4,000-year-old noodles excavated from the archaeological site of Lajia in Qinghai,China显示文摘Noodles are a global food,but the periods when and places where they were made and originated,as well as their ingredients and the cooking methods used to manufacture them,have remained contentious.In the 2005 edition of the journal Nature,we wrote a summary of the millet noodle specimens found in the Late Neolithic Qijia cultural stratum of the Lajia archaeological site in Qinghai Province,China.However,how the ancient people made millet noodles remains controversial.This paper provides a systematic analysis of the remains of noodles found withinan earthenware bowl at the Lajia ‘‘noodle house'' in terms of their plant composition including phytoliths,starch and biomarkers.It provides evidence of how people used millet4,000 years ago and,most specifically,of the principal methods used for producing millet-based noodles.Further,we show how we used traditional hele tools to make hele millet noodles,with especial reference to the gelatinized hydrogel-forming method,to simulate morphology consistent with the composition and form of the unearthed millet noodles.The results of this study provide new evidence and new insights into the cultural characteristics of the prehistoric human diet. | Houyuan L Yumei Li Jianping Zhang Xiaoyan Yang Maolin Ye Quan Li Can Wang Naiqin Wu | 2014 | Chinese Science Bulletin2014，59，35： | 1 |
| 16 | The relationship of microstructure and property on annealing FeSiB alloy 显示文摘 | Chen Guojun Gao Maolin Wu Qiuju | 1992 | Research in Metallic Material1992，18，34： | 1 |
| 17 | 茶多酚对人膀胱癌BIU-87细胞间隙连接蛋白43表达和细胞间隙连接通讯功能的影响(英文)显示文摘Objective:The aim of our study was to investigate the effects of(-)-epigallocatechin-3-gallate(EGCG,the major phytochemistry component in green tea)on the expression of connexin43(Cx43)gene and detect the intercellular communication of the human bladder cancer cell lines BIU-87,and explore its possible mechanisms of prevention and cure for the bladder tumor.Methods:The methyl thiazolyl tetrazolium and Annexin-V/PI double-labeled flow cytometry methods were used to observe the growth inhibitory rate(IR)and apoptosis rate(AR)of BIU-87 cells treated by EGCG at different concentrations(0, 5,10 and 20 mg/L),respectively.The reverse transcription-polymerase chain reaction(RT-PCR)and Western Blotting analy- sis were employed to detect the relative expression levels of the Cx43 mRNA and its protein.The scrape-loading fluorescence dye transfer method was used to assess the gap junction intercellular communication(GJIC)under fluorescence microscope. Results:EGCG at concentrations(10 and 20 mg/L)both could significantly inhibit the proliferation and induce the apoptosis of BIU-87 cells.The IR and AR were(15.67±1.15)%,(18.33±1.53)%and(42.00±4.34)%,(27.33±3.21)%,respectively. And compared with the control groups of 0 mg/L and 5 mg/L(P﹤0.05),EGCG could significantly up-regulate the expression of Cx43 mRNA and its protein and enhance the function of BIU-87 cells.The effects had the significant correlation with the dose-dependent of EGCG.Conclusion:EGCG(10,20 mg/L)could effectively up-regulate Cx43 expression and enhance the GJIC of BIU-87 cells.The results may indicate the effects of EGCG inducing bladder tumor cells apoptosis and inhibiting its growth which provides the experimental evidence for further demonstrating the mechanism of chemical prevention and cure for the bladder tumor by EGCG. | Zhengguo Cao Chao Tian Maolin Jiang Kui Wu Xiaojian Zhong Jianxin Li Yuefu Han | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，12： | 0 |
| 18 | Beneficial effects of high-pressure homogenization on the dispersion stability of aqueous hydrolysate from Mytilus edulis显示文摘Owing to the formation of aggregation and gelation during storage,certain proteins and peptides exhibit limited applications in aqueous protein food products.The purpose of this study was to investigate the influence of homogenization and xanthan gum addition on the dispersion stability of Mytilus edulis hydrolysate(PHM).High-pressure homogenization(HPH)at 360 and 40 bar in the first and second values,respectively,and adding xanthan gum at a concentration of 1 mg/mL showed significantly improvement on the stability of the PHM solution.PHM-xanthan gum solutions(PHMX)showed the highest polypeptide precipitation rate and turbidity retention rate compared with those of PHM.Moreover,the centrifugal precipitation rate of PHMX without HPH was higher than that of homogeneous PHMX.After HPH treatment at 400 bar,the percentage of smaller particles in PHM and PHMX was increased,the aqueous system became more uniform,and the fluorescence intensity reached its maximum.HPH pretreatment improved the polypeptide dispersion stability and turbidity retention rate of PHM and PHMX and reduced the fluorescence intensity.The interactions of xanthan gum and polypeptide render the network microstructure more uniform under the conditions of homogenization,thus improving the dispersion stability of PHMX solutions.Therefore,under the premise of adding xanthan gum,HPH can better enhance the dispersion stability of the polypeptide in PHM. | Fengjiao Mao Maolin Tu Fengjiao Fan Chao Wu Cuiping Yu Ming Du | 2020 | Food Science and Human Wellness2020，9，4： | 0 |
| 19 | A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage显示文摘Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric acid.In this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified with the function of alleviating hyperuricemia.The relevant effects of L.brevis PDD-5 in lowering uric acid were analyzed by in vitro and in vivo experiments.The results showed that the L.brevis PDD-5 has(68.86±15.46)%of inosine uptake capacity and(95.75±3.30)%of guanosine uptake capacity in vitro.Oral administration of L.brevis PDD-5 to hyperuricemia rats reduced uric acid,creatinine,and urea nitrogen in serum,as well as decreased inosine and guanosine levels in the intestinal contents of rats.Analysis of relevant markers in the kidney by ELISA kits revealed that L.brevis PDD-5 alleviated oxidative stress and inflammation.Moreover,the gene expression of uric acid transporter 1(URAT1)and glucose transporter 9(GLUT9)was down-regulated,and the gene expression of organic anion transporter 1(OAT1)was up-regulated after treatment with L.brevis PDD-5.Western blot analysis showed that L.brevis PDD-5 alleviated hyperuricemia-induced kidney injury through the NLRP3 pathway.The se findings suggest that L.brevis PDD-5 can lower uric acid,repair kidney damage,and also has the potential to prevent uric acid nephropathy. | Jue Xu Maolin Tu Xiankang Fan Yuxing Guo Tao Zhang Xiaoqun Zeng Zhendong Cai Zhen Wu Daodong Pan | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 20 | Mesopause temperatures and relative densities at midlatitudes observed by the Mengcheng meteor radar显示文摘The atmospheric temperatures and densities in the mesosphere and lower thermosphere(MLT)region are essential for studying the dynamics and climate of the middle and upper atmosphere.In this study,we present more than 9 years of mesopause temperatures and relative densities estimated by using ambipolar diffusion coefficient measurements observed by the Mengcheng meteor radar(33.4°N,116.5°E).The intercomparison between the meteor radar and Thermosphere Ionosphere Mesosphere Energetics and Dynamics/Sounding of the Atmosphere by Broadband Emission Radiometry(TIMED/SABER)and Earth Observing System(EOS)Aura/Microwave Limb Sounder(MLS)observations indicates that the meteor radar temperatures and densities agree well with the simultaneous satellite measurements.Annual variations dominate the mesopause temperatures,with the maximum during winter and the minimum during summer.The mesopause relative densities also show annual variations,with strong maxima near the spring equinox and weak maxima before the winter solstice,and with a minimum during summer.In addition,the mesopause density exhibits a structure similar to that of the zonal wind:as the zonal wind flows eastward(westward),the mesopause density decreases(increases).At the same time,the meridional wind shows a structure similar to that of the mesopause temperature:as the meridional wind shows northward(southward)enhancements,the mesopause temperature increases(decreases).Simultaneous horizontal wind,temperature,and density observations provide multiple mesospheric parameters for investigating mesospheric dynamics and thermodynamic processes and have the potential to improve widely used empirical atmospheric models. | Wen Yi XiangHui Xue MaoLin Lu Jie Zeng HaiLun Ye JianFei Wu Chong Wang TingDi Chen | 2023 | Earth and Planetary Physics2023，7，6： | 0 |
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