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| 1 | Role of beauty treatment in the spread of parenterally transmitted hepatitis vi- ruses in Italy显示文摘 | Andrea Mariano Alfonso Mele Maria Elena Tosti | 2004 | Journal of Medical Virology2004，74，： | 1 |
| 2 | Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection<!-- Doctopic: VH -->显示文摘 | Barbara Oliviero Dalila Mele Elisabetta Degasperi Alessio Aghemo Eleonora Cremonesi Maria Grazia Rumi Carmine Tinelli Stefania Varchetta Stefania Mantovani Massimo Colombo Mario U. Mondelli | 2013 | Journal of Hepatology2013，，1： | 1 |
| 3 | Transcriptome driven characterization of curly-and smooth-leafed endives reveals molecular differences in the sesquiterpenoid pathway显示文摘Endives(Cichorium endivia L.)are popular vegetables,diversified into curly/frisée-and smooth/broad-leafed(escaroles)cultivar types(cultigroups),and consumed as fresh and bagged salads.They are rich in sesquiterpene lactones(STL)that exert proven function on bitter taste and human health.The assembly of a reference transcriptome of 77,022 unigenes and RNA-sequencing experiments were carried out to characterize the differences between endives and escaroles at the gene structural and expression levels.A set of 3177 SNPs distinguished smooth from curly cultivars,and an SNP-supported phylogenetic tree separated the cultigroups into two distinct clades,consistently with the botanical varieties of origin(crispum and latifolium,respectively).A pool of 699 genes maintained differential expression pattern(core-DEGs)in pairwise comparisons between curly vs smooth cultivars grown in the same environment.Accurate annotation allowed the identification of 26 genes in the sesquiterpenoid biosynthesis pathway,which included several germacrene A synthase,germacrene A oxidase and costunolide synthase members(GAS/GAO/COS module),required for the synthesis of costunolide,a key precursor of lactucopicrin-and lactucin-like sesquiterpene lactones.The core-DEGs contained a GAS gene(contig83192)that was positively correlated with STL levels and recurrently more expressed in curly than smooth endives,suggesting a cultigroup-specific behavior.The significant positive correlation of GAS/GAO/COS transcription and STL abundance(2.4-fold higher in frisée endives)suggested that sesquiterpenoid pathway control occurs at the transcriptional level.Based on correlation analyses,five transcription factors(MYB,MYB-related and WRKY)were inferred to act on contig83192/GAS and specific STL,suggesting the occurrence of two distinct routes in STL biosynthesis. | Giulio Testone Giovanni Mele Elisabetta di Giacomo Gian Carlo Tenore Maria Gonnella Chiara Nicolodi Giovanna Frugis Maria Adelaide Iannelli Giuseppe Arnesi Alessandro Schiappa Tiziano Biancari Donato Giannino | 2019 | Horticulture Research2019，6，1： | 1 |
| 4 | Nuclear factor κB is activated in small intestinal mucosa of celiac patients显示文摘 | Maria Chiara Maiuri Daniela De Stefano Guido Mele Simona Fecarotta Luigi Greco Riccardo Troncone Rosa Carnuccio | 2003 | Journal of Molecular Medicine2003，，6： | 1 |
| 5 | User Experience Evaluation of WhatsOnWeb: A Sonificated Visual Web Search Clustering Engine显示文摘 | Maria Laura Mele Stefano Federici Simone Borsci Giuseppe Liotta | 2012 | International Journal of Computer Information Systems and Industrial Management Applications2012，，4： | 1 |
| 6 | The evolving path of TQM: towards business excellence and stakeholder value 显示文摘 | Cristina Mele and Maria Colurcio | 2006 | International Journal of Quality & Reliability Management2006，23，5： | 1 |
| 7 | Role of beauty treatment in the spread of parenterally transmitted hepatitis viruses in Italy 显示文摘 | Andrea Mariano Alfonso Mele Maria Elena Tosti | 2004 | Journal of Medical Virology2004，74，： | 1 |
| 8 | Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells显示文摘 | Paola Palozza Cristiana Torelli Alma Boninsegna Rossella Simone Assunta Catalano Maria Cristina Mele Nevio Picci | 2009 | Cancer Letters2009，，1： | 1 |
| 9 | Increased CDs + T cell expression and type 2 cytokine pattern during the muscluar phase of Trichinellia infection in humans 显示文摘 | Morales Maria Angeles Gomez Mele Raffaela Sanchez Massimo | 2002 | Infect Immun2002，70，1： | 1 |
| 10 | 一例罕见的位于网膜的胃肠道外间质瘤:PDGFRA基因14外显子双突变显示文摘Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they differently originate from adipose tissue adjacent to the GI tract(omentum and mesentery)or from the pancreas[2].So far,both GISTs and EGISTs have been managed indistinctively by combining surgery,histopathological distinctive features,imaging,and molecular analysis.Moreover. | Gianluca Caruso Luca Pacini Angelo Iossa Claudio Di Cristofano Daniela Bastianelli Gianfranco Silecchia Maria Mele Vincenzo Petrozza Antonella Calogero Elena De Falco | 2021 | Gastroenterology Report2021，9，4： | 0 |
| 11 | Neoadjuvant treatment:A window of opportunity for nutritional prehabilitation in patients with pancreatic ductal adenocarcinoma显示文摘Patients affected by pancreatic ductal adenocarcinoma(PDAC)frequently present with advanced disease at the time of diagnosis,limiting an upfront surgical approach.Neoadjuvant treatment(NAT)has become the standard of care to downstage non-metastatic locally advanced PDAC.However,this treatment increases the risk of a nutritional status decline,which in turn,may impact therapeutic tolerance,postoperative outcomes,or even prevent the possibility of surgery.Literature on prehabilitation programs on surgical PDAC patients show a reduction of postoperative complications,length of hospital stay,and readmission rate,while data on prehabilitation in NAT patients are scarce and randomized controlled trials are still missing.Particularly,appropriate nutritional management represents an important therapeutic strategy to promote tissue healing and to enhance patient recovery after surgical trauma.In this regard,NAT may represent a new interesting window of opportunity to implement a nutritional prehabilitation program,aiming to increase the PDAC patient’s capacity to complete the planned therapy and potentially improve clinical and survival outcomes.Given these perspectives,this review attempts to provide an in-depth view of the nutritional derangements during NAT and nutritional prehabilitation program as well as their impact on PDAC patient outcomes. | Ilaria Trestini Marco Cintoni Emanuele Rinninella Futura Grassi Salvatore Paiella Roberto Salvia Emilio Bria Carmelo Pozzo Sergio Alfieri Antonio Gasbarrini Giampaolo Tortora Michele Milella Maria Cristina Mele | 2021 | World Journal of Gastrointestinal Surgery2021，13，9： | 0 |
| 12 | Leaf nutrient content and transcriptomic analyses of endive (Cichorium endivia) stressed by downpour-induced waterlog reveal a gene network regulating kestose and inulin contents显示文摘Endive(Cichorium endivia L.),a vegetable consumed as fresh or packaged salads,is mostly cultivated outdoors and known to be sensitive to waterlogging in terms of yield and quality.Phenotypic,metabolic and transcriptomic analyses were used to study variations in curly-(‘Domari’,‘Myrna’)and smooth-leafed(‘Flester’,‘Confiance’)cultivars grown in short-term waterlog due to rainfall excess before harvest.After recording loss of head weights in all cultivars(6-35%),which was minimal in‘Flester’,NMR untargeted profiling revealed variations as influenced by genotype,environment and interactions,and included drop of total carbohydrates(6–50%)and polyols(3–37%),gain of organic acids(2–30%)and phenylpropanoids(98–560%),and cultivar-specific fluctuations of amino acids(−37 to+15%).The analysis of differentially expressed genes showed GO term enrichment consistent with waterlog stress and included the carbohydrate metabolic process.The loss of sucrose,kestose and inulin recurred in all cultivars and the sucrose-inulin route was investigated by covering over 50 genes of sucrose branch and key inulin synthesis(fructosyltransferases)and catabolism(fructan exohydrolases)genes.The lowered expression of a sucrose gene subset together with that of SUCROSE:SUCROSE-1-FRUCTOSYLTRANSFERASE(1-SST)may have accounted for sucrose and kestose contents drop in the leaves of waterlogged plants.Two anti-correlated modules harbouring candidate hub-genes,including 1-SST,were identified by weighted gene correlation network analysis,and proposed to control positively and negatively kestose levels.In silico analysis further pointed at transcription factors of GATA,DOF,WRKY types as putative regulators of 1-SST. | Giulio Testone Anatoly Petrovich Sobolev Giovanni Mele Chiara Nicolodi Maria Gonnella Giuseppe Arnesi Tiziano Biancari Donato Giannino | 2021 | Horticulture Research2021，8，1： | 0 |
| 13 | 肝局灶性病变非侵入性影像评估意大利指南:发展和结论(全译)显示文摘简介
成像技术的进步极大改善了肝局灶性病变(FLLs)的非侵入性检测和成像。由于良性FLLs的发病率极高,因此病变成像极其重要。相对而言,包括原发性肝癌和转移癌在内的肝癌是最常见的肿瘤疾病。 | Carlo Filice Fabrizio Calliada Salvatore De Masi Letizia Sampaolo Cristina Morciano Alfonso Mele Maria Franc Meloni Chiara Sileo Mara Scabini Paolo Ricci Vito Cantisani Giovanna Ferraioli | 2014 | 中华超声影像学杂志2014，23，2： | 0 |
| 14 | 基于中空单元的夹层平板结构设计方法研究(英文)显示文摘目的:大型的桁架结构或空间刚架结构可以认为是用中空单元组合而成的宏观结构,在结构初步设计时,如何设计排布中空基本单元以满足结构的性能要求是设计的关键。本文旨在探讨夹层平板结构,在给定竖向变形控制指标后,如何使用简化的方法快速设计各层中空基本单元的尺寸和空隙程度。创新点:1.对于水立方这种复杂的空间多面体网格结构,本文将其理想化为连续的中空介质,利用微观力学中的均质化分析方法,将结构分解为多个基本单元(RVE)进行分析,从而推导出结构性能指标与单元参数之间的关系。2.对于大跨度平板结构,本文提出一种基于RVE重复叠加组合的设计方法,并利用有限元法对该方法进行检验。方法:1.对夹层平板结构的弯曲特性进行理论分析,根据Kirchhoff-Love理论,得到板弯曲刚度与各层的截面惯性矩之间的关系;2.通过理论推导出结构弯曲刚度(图3)、材料使用量(图4)随层厚度和层密度的变化关系;3.从基本单元出发,利用均质化分析方法分别对中空立方体(图5)和空间桁架结构(图6)进行分析,得到结构抗弯刚度随单元中空程度和距截面中性轴距离的函数关系(图7和8),进而推导出结构参数化设计的拟合公式;4.利用该设计公式,针对一个90 m×90 m×2.5 m的平板结构,以跨中挠度为跨度的1/500为设计指标,分别设计由两种基本单元组成的夹层平板结构,并将结构挠度的有限元计算结果与设计指标进行比较(图12)。结论:1.本文提出的利用中空单元组成的夹层平板结构的设计方法,通过优化设计中空单元的各项参数,可以在保证性能指标的同时最大化降低结构质量,得到最优刚度质量比。2.本设计方法和有限元法得到的结果之间差异非常小,说明该设计方法准确可靠。 | Gianpaolo PERRELLA Giovanni Maria MONTUORI Massimiliano FRALDI Elena MELE | 2016 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2016，17，6： | 0 |
| 15 | 西57号街公寓显示文摘西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开阔,让较低的夕阳也能照进街区深处,并优雅地为一旁的Helena Tower保留河景。建筑的形式随着观察者的位置而不断变换。从西侧的高速公路上看. | David Brown Aleksander Tokarz Alessandro Ronfini Alessio Valmori Alvaro Mendive Benjamin Schulte Birk Daugaard Celine Jeanne Christoffer Gotfredsen Daniel Sundlin Dominyka Mineikyte Eivor Davidsen Felicia Guldberg Florian Oberschneider Soren Grunert Gabrielle Nadeau Gül Ertekin Ho Kyung Lee Hongyi Jin Julian Liang Julianne Gola Laura Youf Lucian Racovitan Marcella Martinez Maria Nikolova Maya Shopova Mitesh Dixit Nicklas A.Rasch Ola Hariri Riccardo Mariano Steffan Heath Stanley Lung Tara Hagan Thilani Rajarathna Tyler Polich Valentina Mele Valerie Lechene Xu Li Yi Li Aaron Hales Alessandro Ronfini Brian Foster Christoffer Gotfredsen Francesca Portesine Ho Kyung Lee Hongyi Jin Ivy Hume Jenny Chang Lauren Turner Mina Rafiee Rakel Karlsdottir Tara Hagan Thomas Fagan Tiago Barros Valentina Mele Iwan Baan 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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