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| 1 | Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization显示文摘AIM: To evaluate the downstaging rates in hepatitis C virus-patients with hepatocellular carcinoma(HCC), treated with degradable starch microspheres transcatheter arterial chemoembolization(DSM-TACE), to reach new-Milan-criteria(nM C) for transplantation. METHODS: This study was approved by the Ethics Committee of our institution. From September 2013 to March 2014 eight patients(5 men and 3 women) with liver cirrhosis and multinodular HCC, that did not meet n MC at baseline, were enrolled in this study. Patients who received any other type of treatment such as termal ablation or percutaneous ethanol injection were excluded. DSM-TACE was performed in all patients using Embo Cept? S and doxorubicin. Baseline and follow-up computed tomography or magnetic resonance imaging was assessed measuring the longest enhancing axial dimension of each tumor according to the modified Response Evaluation Criteria In Solid Tumors measure-ments, and medical records were reviewed.RESULTS: DSM-TACE was successfully performed in all patients without major complication. We treated 35 lesions(mean 4.3 per patient). Six of eight patients(75%) had their HCC downstaged to meet nM C. Every patient whose disease was downstaged eventually underwent transplantation. The six patients who received transplant were still living at the time of this writing, without recurrence of HCC. Baseline age(P = 0.25), Model for End-stage Liver Disease score(P = 0. 77), and α-fetoprotein level(P = 1.00) were similar between patients with and without downstaged HCC. CONCLUSION: DSM-TACE represents a safely and effective treatment option with similar safety and efficacy of conventional chemoembolization and could be successfully performed also for downstaging disease in patients without n MC, allowing them to reach liver transplantation. | Antonio Orlacchio Fabrizio Chegai Stefano Merolla Simona Francioso Costantino Del Giudice Mario Angelico Giuseppe Tisone Giovanni Simonetti | 2015 | World Journal of Hepatology2015，7，12： | 23 |
| 2 | Association between non-alcoholic fatty liver disease and obstructive sleep apnea显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is an emerging liver disease and currently the most common cause of incidental abnormal liver tests.The pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration,inflammation,oxidative stress and progressive fibrosis have been proposed.Obstructive sleep apnea(OSA)may be linked with the pathogenesis and the severity of NAFLD.AIM To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure(CPAP)treatment.METHODS A Pub Med search was conducted using the terms'non-alcoholic fatty liver disease AND(obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea)'.Research was limited to title/abstract of articles published in English in the last 5 years;animal and child studies,case reports,commentaries,letters,editorials and meeting abstracts were not considered.Data were extracted on a standardized data collection table which included:First author,publication year,country,study design,number of patients involved,diagnosis and severity of OSA,diagnosis of NAFLD,patient characteristics,results of the study.RESULTSIn total,132 articles were initially retrieved on Pub Med search and 77 in the last five years.After removal of irrelevant studies,13 articles were included in the qualitative analysis.There was a total of 2753 participants across all the studies with a mean age between 42 and 58 years.The proportion of males ranged from21%to 87.9%and the mean body mass index ranged from 24.0 to 49.9 kg/m2.The results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA,even in the absence of coexisting comorbidities such as obesity or metabolic syndrome.Furthermore,the severity of NAFLD is associated with the increase in OSA severity.Effective CPAP treatment,although not always decisive,may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular functions.CONCLUSION In NAFLD patients,although asymptomatic,it is recommended to systematically perform polysomnography in order to early and better treat them before the development of potentially life threatening systemic dysfunctions. | Ilaria Umbro Valerio Fabiani Mario Fabiani Francesco Angelico Maria Del Ben | 2020 | World Journal of Gastroenterology2020，26，20： | 10 |
| 3 | Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: potent antiviral activity but no clinical benefit if treatment is given late显示文摘 | Adriano M. Pellicelli Marzia Montalbano Raffaella Lionetti Christine Durand Peter Ferenci Gianpiero D’Offizi Viola Knop Andrea Telese Ilaria Lenci Arnaldo Andreoli Stefan Zeuzem Mario Angelico | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 4 | The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: The updated follow up at 78 months显示文摘 | Giuseppe Orlando Tommaso Manzia Leonardo Baiocchi Alberto Sanchez-Fueyo Mario Angelico Giuseppe Tisone | 2008 | Transplant Immunology2008，，1： | 2 |
| 5 | Obstructive sleep apnoea syndrome and the metabolic syndrome in an internal medicine setting显示文摘 | Francesco Angelico Maria del Ben Teresa Augelletti Rosanna de Vita Rocco Roma Francesco Violi Mario Fabiani | 2010 | European Journal of Internal Medicine2010，，3： | 1 |
| 6 | Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation显示文摘 | Maurizio Pompili Claudio Maurizio Pacella Giampiero Francica Mario Angelico Giuseppe Tisone Paolo Craboledda Erica Nicolardi Gian Ludovico Rapaccini Giovanni Gasbarrini | 2009 | European Journal of Radiology2009，，3： | 1 |
| 7 | Safety of complete and sustained prophylaxis withdrawal in patients liver-transplanted for HBV-related cirrhosis at low risk of HBV recurrence显示文摘 | Ilaria Lenci Giuseppe Tisone Daniele Di Paolo Fabio Marcuccilli Laura Tariciotti Marco Ciotti Valentina Svicher Carlo Federico Perno Mario Angelico | 2011 | Journal of Hepatology2011，，3： | 1 |
| 8 | Safety of complete and sustained prophylaxis withdrawal in patients liver-transplanted for HBV-related cirrhosis at low risk of HBV recurrence显示文摘 | Ilaria Lenci Giuseppe Tisone Daniele Di Paolo Fabio Marcuccilli Laura Tariciotti Marco Ciotti Valentina Svicher Carlo Federico Perno Mario Angelico | 2011 | Journal of Hepatology2011，，3： | 1 |
| 9 | Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV-related cirrhosis显示文摘 | Mario Angelico Daniele Di Paolo Massimo O. Trinito Alessandra Petrolati Antonio Araco Settimio Zazza Raffaella Lionetti Carlo U. Casciani Giuseppe Tisone | 2002 | Hepatology2002，，1： | 1 |
| 10 | Liver transplantation for the treatment of nodular regenerative hyperplasia显示文摘 | Tommaso Maria Manzia Gianpiero Gravante Daniele Di Paolo Giuseppe Orlando Luca Toti Maria Irene Bellini Paolo Ciano Mario Angelico Giuseppe Tisone | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 11 | Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence显示文摘 | Giuseppe Tisone Giuseppe Orlando Andrea Cardillo Giampiero Palmieri Tommaso Maria Manzia Leonardo Baiocchi Raffaella Lionetti Alessandro Anselmo Luca Toti Mario Angelico | 2006 | Journal of Hepatology2006，，4： | 1 |
| 12 | Operational tolerance in clinical liver transplantation: Emerging developments显示文摘 | Giuseppe Tisone Giuseppe Orlando Mario Angelico | 2006 | Transplant Immunology2006，，2： | 1 |
| 13 | Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: Effects on myocardial salvage显示文摘 | Raffaele Marfella Maria Rosaria Rizzo Mario Siniscalchi Pasquale Paolisso Michelangela Barbieri Celestino Sardu Antonella Savinelli Nicola Angelico Salvatore Del Gaudio Nicolino Esposito Pier Francesco Rambaldi Nunzia D’Onofrio Luigi Mansi Ciro Mauro Gius | 2013 | International Journal of Cardiology2013，，： | 1 |
| 14 | Liver Elasticity in NASH Patients Evaluated with Real-Time Elastography (RTE)显示文摘 | Antonio Orlacchio Francesca Bolacchi Marco Antonicoli Irene Coco Elisa Costanzo Daniela Tosti Simona Francioso Mario Angelico Giovanni Simonetti | 2012 | Ultrasound in Medicine & Biology2012，，4： | 1 |
| 15 | Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: Evidence from the liver match cohort study显示文摘 | Mario Angelico Alessandra Nardi Tania Marianelli Lucio Caccamo Renato Romagnoli Giuseppe Tisone Antonio D. Pinna Alfonso W. Avolio Stefano Fagiuoli Patrizia Burra Mario Strazzabosco Alessandro Nanni Costa | 2012 | Journal of Hepatology2012，，： | 1 |
| 16 | Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching显示文摘 | Mario Angelico Umberto Cillo Stefano Fagiuoli Antonio Gasbarrini Caius Gavrila Tania Marianelli Alessandro Nanni Costa Alessandra Nardi Mario Strazzabosco Patrizia Burra Salvatore Agnes Umberto Baccarani Fulvio Calise Michele Colledan Oreste Cuomo Luciano | 2010 | Digestive and Liver Disease2010，，2： | 1 |
| 17 | Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results显示文摘 | Antonio Orlacchio Francesca Bolacchi Maria Chiara Petrella Daniela Pastorelli Gabriele Bazzocchi Mario Angelico Giovanni Simonetti | 2011 | Ultrasound in Medicine & Biology2011，，1： | 1 |
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