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| 1 | Mission overview and key technologies of the first Mars probe of China显示文摘The first Chinese Mars exploration will fulfill the goals of'orbiting,analyzes landing and roving'in one mission.This paper briefly describes the process of international Mars and exploration engineering profile,and the development of Chinese and Mars exploration.It focuses on introducing design the scientific probe,significance difficulties of Mars exploration,provides the an overview descent of the system of as the including the flight the preliminary selection of the landing site,entry,and the landing EDL(also known and EDL)structure process.and Four types of key technologies,including telecommunications,the autonomous the control,process,its mechanism,are detailed in this paper.Finally,paper highlights expected scientific and engineering results of the mission. | YE PeiJian SUN ZeZhou RAO Wei MENG LinZhi | 2017 | Science China(Technological Sciences)2017，60，5： | 34 |
| 2 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 3 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 4 | Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men显示文摘在这试验性的未来的研究,我们试图在男繁殖机关上分析短暂阴囊的过高热的效果,从精子参数的观点,精液血浆生物化学的标记,和氧化应力,评估热暴露的不同频率是否引起精子发生的损坏的不同的度。二组志愿者(10 每组) 在 43 ° 的收到的阴囊的温暖; C 水洗澡 10 次,为 30 min 每次:组 1:10 连续的天;组 2:一次每 3 天。精子参数, epididymis 和附件性腺工作,精液血浆氧化压力和浆液性荷尔蒙在治疗以后在治疗前并且在 16 星期的恢复经期被测试。最后,我们在精子集中发现了明显的可逆减少( P = 0.005 为组 1 并且为组 2 的 P= 0.008 当最小与基线层次相比时,一样在下面),活动性( P = 0.009 和 0.021 ,分别地), hypoosmotic 胀大的测试分数( P = 0.007 和 0.008 ,分别地),全部的精子酵素活动( P = 0.018 和 0.009 ,分别地),并且精液的血浆 malondialdehyde 集中的增加( P = 0.005 和 0.017 ,分别地)。精子集中的减少为比为组 1 的组 2 是更大的(P = 0.031 ) 。我们严重结束了那短暂阴囊的过高热,但是 reversibly,否定地影响了精子发生,氧化应力可以涉及这个过程。另外,断断续续的热暴露更严重与连续的热暴露相比压制精子发生。这可能基于热应力为临床的不孕病原学分析和避孕方法的设计是指示的。 | Meng Rao Xiao-Ling Zhao Jing Yang Shi-Fu HU Hui Lei Wei Xia Chang-Hong Zhu | 2015 | Asian Journal of Andrology2015，17，4： | 16 |
| 5 | Common dental diseases in children and malocclusion显示文摘Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition. This article highlights these diseases and their impacts on malocclusion in sequence. Prevention, treatment, and management of these conditions are also illustrated in order to achieve successful oral health for children and adolescents, even for their adult stage. | Jing Zou Mingmei Meng Clarice S Law Yale Rao Xuedong Zhou | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 6 | effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy显示文摘Importance:Post-intubation subglottic stenosis(SGS)in children can be life threatening.Definitive treatment varies and lacks a universally accepted approach.Objective:We performed a prospective study to assess the safety and feasibility of holmium laser combined with cryotherapy delivered via flexible bronchoscopy for the treatment of post-intubation SGS in children.Methods:This study involved all patients with post-intubation SGS seen at the Interventional Pulmonology Department of Beijing Children's Hospital between July 2014 and December 2016.Holmium laser treatment and cryotherapy was then performed under flexible bronchoscopy,whose parents refused to accept the alternative standard treatment of tracheotomy and balloon dilation under direct laryngoscopy.results:Sixteen patients with post-intubation SGS were included in this study.Ages ranged from 2 months to 12.25 years old.According to the Cotton-Myer grading system,three cases were Grade II,12 cases were Grade III,and one case was Grade IV.According to the McCaffrey system,eight cases were Stage 1,two cases were Stage 2,and six cases were Stage 3.The average number of procedures was 4.88.Fifteen of the 16 patients achieved clinical cure.One patient achieved clinical improvement.The average treatment course duration was 55.31 days.No severe complications were seen.Post-treatment clinical symptoms,endoscopic findings and quality of life showed marked improvement.Interpretation:Our study supports the conclusion that holmium laser treatment combined with cryotherapy via flexible bronchoscopy appears to be a safe and feasible treatment for post-intubation SGS in children. | Anxia Jiao Fang Liu Andrew D.Lerner Xiaochun Rao Yan Guo Chenfang Meng Yuena Pan Gan Li Zheng Li Fang Wang Jing Zhao Yuyan Ma Xicheng Liu Xin Ni Kunling Shen | 2019 | Pediatric Investigation2019，3，1： | 10 |
| 7 | Extracellular matrix from human umbilical cordderived mesenchymal stem cells as a scaffold for peripheral nerve regeneration显示文摘The extracellular matrix,which includes collagens,laminin,or fibronectin,plays an important role in peripheral nerve regeneration.Recently,a Schwann cell-derived extracellular matrix with classical biomaterial was used to mimic the neural niche.However,extensive clinical use of Schwann cells remains limited because of the limited origin,loss of an autologous nerve,and extended in vitro culture times.In the present study,human umbilical cord-derived mesenchymal stem cells(h UCMSCs),which are easily accessible and more proliferative than Schwann cells,were used to prepare an extracellular matrix.We identified the morphology and function of h UCMSCs and investigated their effect on peripheral nerve regeneration.Compared with a non-coated dish tissue culture,the h UCMSC-derived extracellular matrix enhanced Schwann cell proliferation,upregulated gene and protein expression levels of brain-derived neurotrophic factor,glial cell-derived neurotrophic factor,and vascular endothelial growth factor in Schwann cells,and enhanced neurite outgrowth from dorsal root ganglion neurons.These findings suggest that the h UCMSC-derived extracellular matrix promotes peripheral nerve repair and can be used as a basis for the rational design of engineered neural niches. | Bo Xiao Feng Rao Zhi-yuan Guo Xun Sun Yi-guo Wang Shu-yun Liu Ai-yuan Wang Quan-yi Guo Hao-ye Meng Qing Zhao Jiang Peng Yu Wang Shi-bi Lu | 2016 | Neural Regeneration Research2016，11，7： | 8 |
| 8 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 9 | 来自中国中部城市武汉的1808名大学生精液质量评估显示文摘武汉是全球大学生人数最多的城市,本研究对武汉在校大学生的精液质量进行了评估。研究对象为湖北省人类精子库2010—2013年招募的大学生捐精志愿者,对1808名大学生的3616份精液参数进行了回顾性分析。运用每个志愿者两次精液检测的平均值和WHO标准(第五版)进行比较,利用广义线性模型对影响精液质量的关键因素进行分析。结果发现精液体积的均值和中位数分别为3.0ml和2.8ml;精子浓度分别为50.2×10ml。和50.0×10ml-1;精子总数分别是148.1×10和142.1×10;精子活力分别为58.6%和60.O%。85.O%的志愿者所有精液参数均正常。分析发现季节和禁欲天数是影响精液参数的关键因素,精子浓度在这四年的观察中明显降低,这虽然不是精液质量降低的有力证据,但是武汉大学生不容乐观的精液质量应该引起高度重视,并且应该进一步对这种严峻的现状进行深入研究。 | Meng Rao Tian-Qing Meng Si-Heng Hu Huang-Tao Guan Qin-Yu Wei Wei Xia Chang-Hong Zhu Cheng-Liang Xiong | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 10 | The Portevin-Le Chatelier effect of gradient nanostructured 5182 aluminum alloy by surface mechanical attrition treatment显示文摘Nanocrystalline surface layers and gradient nanostructure in 5182 aluminum alloy have been produced through surface mechanical attrition treatment(SMAT). The results indicate that the gradient nanostructure can not only improve the mechanical properties of 5182 Al alloy, but also has a certain effect on the Portevin-Le Chatelier(PLC) effect. The yield and ultimate tensile strength of 5182 Al alloy with SMAT are significantly improved combining with the decrease of fracture elongation compared with the as-received one. The PLC effect of 5182 Al alloy could be effectively postponed by the formation of gradient nanostructure after SMAT. It leads to the increase of critical strain of the PLC effect, more concentrated distribution of serrated strain, and increase of average stress amplitude in special strain range. The influence of grain size and gradient nanostructure on the PLC effect of 5182 Al alloy was also discussed in detail. Grain refinement could sharply increase the density of dislocations and hinder the movement of dislocations, which results in the decrease of moving speed of dislocations and the more concentrated distribution of solute atoms. The solute atoms would aggregate to form nano precipitates and further impede movement of dislocation. The stronger interaction between the dislocations and the nano precipitates is the main mechanism of postponed PLC effect. | Xiangchen Meng Bei Liu Lan Luo Yan Ding Xi-Xin Rao Bin Hu Yong Liu Jian Lu | 2018 | Journal of Materials Science & Technology2018，34，12： | 4 |
| 11 | Morphological Evolution of Fe-Rich Phases in the AlSi_9Cu_3Mg_(0.19)(Fe)Alloy with the Addition of Minor Mn and Cr显示文摘The morphological evolution of Fe-rich phases in the Alalloy has been investigated with various contents of Fe,Mn,and Cr.The results show that coarse Chinese script Fe-rich phases appear in the alloy with 0.6 wt%Fe combined with trace Mn,while the blocky Fe-rich phases appear combined with trace Cr.Under the coexistence of trace Mn and Cr,a large number of fine Chinese script Fe-rich phases could be visible in the low iron-bearing AlSi_9Cu_3-alloy(0.60 wt%).At high Fe level(1.30 wt%),numerous Fe-rich phases with hexagonal morphologies are observed with the trace Cr,while fish-bone and pentagonal morphologies of Fe-rich phases could be simultaneously observed with the addition of both Mn and Cr.The results reveal that the trace Mn and Cr promote the morphological evolution of Fe-rich phases.The morphology evolution mechanism of Fe-rich phases has been discussed by using the atom radius and electronegativity differences of Fe,Mn,and Cr. | Zhi-Qiang Qiu Xiang-Chen Meng Qiu-Hong Yuan Xiao-Shu Zeng Xi-Xin Rao Yan Ding Lan Luo Yong Liu | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，6： | 3 |
| 12 | Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants显示文摘尽管引起 Kallmann 症候群(KS ) 的一些基因被传统的连接分析和候选人基因技术识别了,症候群是在遗体糟糕理解的病人的多数的分子的病原学。在这份报纸,我们在场对与三个 KS 后代一起的一个同宗的汉中国家庭的临床的评价。从一个染色体宽的观点理解 KS 的分子的病原学,我们用 Affymetrix 染色体宽的人的 SNP 数组在这个家庭调查了结构的变化的染色体宽的侧面 6.0 站台。结果表明三个影响个人在染色体 1p21.1, 2q32.2, 8q21.13, 14q21.2 和 Xp22.31 上有普通拷贝数字变体(microdeletions ) 。而且, Xp22.31 上的拷贝数字变体位于 KAL1 的 intron,它引起 X 连接 KS。二 PCR 试金在这些区域上被执行验证用薄片获得的结果。另外,在这个区域的 genomic microdeletions 在 29 个汉中国分散的 KS 案例之一和四个另外的家庭案例之一中,然而并非用 26 汉汉语被验证分散的 normosmic 自发的 hypogonadotropic 性腺机能减退案例和 100 无关的汉汉语正常控制。我们的结果提供新奇卓见进对 KS 的分子的病原学的某些拷贝数字变体的相对贡献并且为进一步的研究产生有趣的候选人区域的一张表。 | Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 13 | Effect of cold snare polypectomy for small colorectal polyps显示文摘BACKGROUND Colorectal cancer remains a considerable challenge in healthcare nowadays.Approximately 60%-80%of colorectal cancer is caused by intestinal polyps,and resection of intestinal polyps has been proved to reduce the incidence of colorectal cancer.The vast majority of intestinal polyps can be found during colonoscopy and removed endoscopically.Therefore,more attention has been paid to the development of endoscopic resection of intestinal polyps.In this study,we compared the efficacy and safety of cold snare polypectomy(CSP)and hot snare polypectomy(HSP).AIM To investigate the efficacy and safety of CSP and HSP for colorectal polyps.METHODS Between January and December 2020,301 patients with colorectal polyps 4-9 mm in diameter were treated with endoscopic therapy in our hospital,and were divided into the CSP group(n=154)and HSP group(n=147).The operating time,incidence of bleeding and perforation,use of titanium clips,and complete resection rate were compared between the two groups.RESULTS We included 249 patients(301 polyps).No differences in gender,age,and polyp size,location,shape and type were observed between the CSP and HSP groups,and the resection rates in these two groups were 93.4%and 94.5%,respectively,with no significant difference.The use of titanium clips was 15.6%and 95.9%,the operating time was 3.2±0.5 min and 5.6±0.8 min,the delayed bleeding rate was 0%and 2.0%,and delayed perforation was 0%and 0.7%,in the CSP and HSP groups,respectively.CONCLUSIONFor sessile colorectal polyps < 10 mm, CSP had the same resection rate of impaired tissue integrityas traditional HSP had. The rate of complications was lower in the CSP group. CSP is a safe andeffective method for polypectomy. | Qing-Qing Meng Min Rao Pu-Jun Gao | 2022 | World Journal of Clinical Cases2022，10，19： | 2 |
| 14 | Optimized Reimbursement Scheme of China's New Cooperative Medical System Using Monte Carlo Simulation显示文摘China’s Rural Cooperative Medical System collapsed alongside communal farming at the end of the Maoist period in 1976,leaving most farmers vulnerable[1].In rural areas,where 80%of people have been without health insurance of any kind,illness has emerged as a leading cause of poverty[2-4].To address the poor state of health care among the rural population,in 2003 the Chinese government launched the New Rural Cooperative Medical System (NCMS),an indemnity health insurance | MENG Xue Hui HUANG Yi Xiang RAO Dong Ping LIU Qing | 2013 | Biomedical and Environmental Sciences2013，26，11： | 2 |
| 15 | The coloring mechanism of a novel golden variety in Populus deltoides based on the RGB color mode显示文摘Compared to flower color and red leaf mutants,the mechanism of yellow leaf formation in woody plants is more complicated and less understood.Poplars are common and widely distributed perennial trees.Here,we obtained a golden leaf mutant poplar variety(JHY)and compared it with its original green leaf poplar(Populus sp.Linn.‘2025’)in terms of phenotype,pigment content,the transcriptomes and metabolomes.Through transcriptome sequencing,we found that the chlorophyll degradation genes,and the genes in anthocyanin metabolism in JHY were up-regulated compared to L2025 and the carotenoid synthesis genes were down-regulated.Further based on HPLC-ESI-MS/MS technology,16 differentially expressed anthocyanins were identified,14 reddish anthocyanins of which were significantly up-regulated.According to these results,we proposed a coloring mechanism of JHY based on the RGB color mode.The yellow color of carotenoids and the red color of anthocyanins overlay each other,combined with a reduction in chlorophyll,turning the leaves golden.This study systematic analyzes the causes of golden leaf formation through the omics integration approach,which will provide reference for the breeding of golden leaf trees. | Yuru Tian Shupei Rao Qianqian Li Meng Xu Aike Wang Hechen Zhang Jinhuan Chen | 2021 | Forestry Research2021，1，1： | 2 |
| 16 | Taxonomic status and phylogenetic position of Phaeostigma in the subtribe Artemisiinae (Asteraceae)显示文摘Phaeostigma 在 subtribe Artemisiinae 是为它的分类地位和种系发生的位置的争论 taxon, Asteraceae。到地址,那些问题, Phaeostigma 的种系发生的评估和它 subtribe Artemisiinae 的相关的类基于分子以及词法的字符数据被执行。DNA 原子 ribosomal DNA 定序内部抄录分隔符,单个拷贝原子 CDS 基因,和五叶绿体 DNA loci (psbA-trnH, rpl16, trnC-ycf6, trnL-F,和 ycf6-psbM ) 被用来构造 20 个词法人物的基因树,和变化模式被分析。另外,花粉形态学在为 Phaeostigma 和 Ajania,前者被更早的分类学者与分开的代表性的种类扫描电子显微镜学下面被检验。所有上述分析出现了:(i) Ajania tibetica (Hook.f。与 Thomson ) Tzvelev,一。purpurea C。Shih,和 A。ramosa (Chang ) C。Shih 应该被合成 Phaeostigma 以便它是有六种的一个 monophyletic 类, P。ramosum (一。ramosa ) , P。purpureum (一。purpurea ) , P。tibeticum (一。tibetica ) , P。quercifolium (W.W Sm ) Muldashev, P。salicifolium (Mattf ) Muldashev,和 P。variifolium (C.C Chang ) Muldashev;(ii ) 所有六 Phaeostigma 种与丝的羽毛有花粉, reflexed 叶边缘,和 flowering 树枝的 Artemisia 类型(microechinate ) ;(iii ) Ajania 的二争论的种,一。pallasiana 和 A。shiwogiku,与 Ajania s.str 有更靠近的关系。比与 Phaeostigma,并且应该被放在 Ajania。就从现在和以前的研究的所有证据而言,我们断定地理、生态的因素以及第二等的接触在类 Phaeostigma 的分叉和种形成起重要作用。 | Yuan Huang Yi-Ming An Shi-Yong Meng Yan-Ping Guo Guang-Yuan Rao | 2017 | Journal of Systematics and Evolution2017，55，5： | 2 |
| 17 | Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96 - bound peptides显示文摘 | Meng S D Song J Rao Z | 2002 | J Immunol Methods2002，264，12： | 1 |
| 18 | Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96 -bound peptides显示文摘 | Meng SD Song Rao Z | 2002 | J Immunol Methods2002，264，12： | 1 |
| 19 | A non-wetting and conductive polyethylene dioxothiophene hole transport layer for scalable and flexible perovskite solar cells显示文摘The regulated crystallization of perovskite and highly repeatable preparation are decisive challenges for large-scale flexible perovskite solar cells(PSCs).Herein,we synthesize an oil-soluble poly(3,4-ethylenedioxythiophene)(Oil-PEDOT)as a hole transport layer(HTL).The non-wetting Oil-PEDOT HTL can promote the quality of large-area flexible perovskite films because of its optimized crystallinity and printability.The Oil-PEDOT layer also delivers desirable conductivity and charge transport without a complex doping.Consequently,the flexible PSCs with Oil-PEDOT HTL achieve an efficiency of 19.51%and 16.70%based on 1.05 and 22.50 cm^(2),respectively.Moreover,these large-scale flexible PSCs demonstrate remarkable mechanical robustness,and the efficiency exhibits 93%retention after 7,000 bending cycles.These results show that the Oil-PEDOT is a potentially efficient HTL for fabricating efficient large-scale flexible PSCs. | Chenxiang Gong Lin Zhang Xiangchuan Meng Zhi Xing Li Rao Hongyu Wang Zengqi Huang Licheng Tan Ting Hu Xiaotian Hu Yiwang Chen | 2021 | Science China Chemistry2021，64，5： | 1 |
| 20 | Remarkably high activities of testicular cytochrome C in destroying reactive oxygen species and in triggering apoptosis显示文摘 | LiuZ Lin H Ye S Liu Q Y Meng Z Zhang C M Xia Y Margoliash E Rao Z Liu X J | 2006 | Proc Natl Acad Sci Usa2006，103，： | 1 |
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