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57篇 您的检索式:作者名="Michael GU"
    题名 作者 年代 出处 被引量
1Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light.lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu 2017Science Bulletin2017,62,21:6
2Two Poplar Glycosyltransferase Genes, PdGATL 1.1 and PdGATL1.2, Are Functional Orthologs to PARVUS/AtGATL 1 in Arabidopsis显示文摘包括 PARVUS/AtGATL1,在 Arabidopsis 的几基因在木聚糖合成被含有。然而,在这多糖是木头的一个主要部件的地方,在木质的植物的木聚糖的生合成糟糕被理解。这里,我们描绘二 Populus 基因, PdGATL1.1 和 PdGATL1.2,最靠近的 orthologs 到 Arabidopsis PARVUS/GATL1 基因关于他们在白杨的基因表示,他们在 Arabidopsis 补充 parvus 变化的亚 cellular 本地化,和他们的能力。包括词法变化,在缺点的救的大多数由 parvus 变化引起了的 parvus 异种的二白杨基因的 Overexpression 折叠木部,并且改变了房间墙 monosaccharide 作文。量的 RTPCR 证明 PdGATL1.1 在开发白杨的木部最强烈被表示。相反, PdGATL1.2 在叶,射击尖端,外皮,韧皮部,和木部更一致地被表示,并且 PdGATL1.2 的抄本水平是比在检验的所有纸巾的 PdGATL1.1 的低得多的。亚 cellular 本地化实验证明这二蛋白质对局部性嗯并且与到这些亚 cellular 分隔空间的标记蛋白质居民比较的 Golgi。我们的数据显示 PdGATL1.1 和 PdGATL1.2 是 PARVUS/GATL1 的功能的 orthologs 并且能在木聚糖合成起一个作用,但是可以也在另外的墙聚合物的合成有角色。Yingzhen Kong Gongke Zhou Utku Avci Xiaogang Gu Chelsea Jones Yanbin Yin Ying Xu Michael G. Hahn 2009Molecular Plant2009,2,5:6
3Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system显示文摘加入的 Nonhomologous 脱氧核糖核酸结束(NHEJ ) 是为在人的房间并且在多细胞的优核质的双海滨脱氧核糖核酸裂缝的修理的主要小径。双海滨裂缝的原因经常碎裂在损坏的地点的脱氧核糖核酸,导致在那里的信息的损失。NHEJ 不恢复失去的信息并且可以将切除另外的核苷酸在修理过程期间。修理大量 overhang 并且损坏配置的能力反映 NHEJ 的核酸酶,聚合酶,和连接酶的灵活性。单个部件的灵活性也解释 NHEJ 能在修理脱氧核糖核酸结束的任何给定的对的方法的大数字。局部地,在 NHEJ 的地点,修理可以贡献癌症和老化的信息的损失,而是由 NHEJ 的行动保证染色体的全部片断没被失去。Michael R Lieber Haihui Lu Jiafeng Gu Klaus Schwarz 2008Cell Research2008,18,1:5
4MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis显示文摘Jinzhen Guo Liya Gu Michael Leffak Guo-Min Li 2016Cell Research2016,26,7:4
5Defective T wave combined with incomplete right bundle branch block: a new electrocardiographic index for diagnosing atrial septal defect显示文摘WANG Mu-xuan WU Gui-fu GU Jing-li LI Li LU Kun YANG Da CHEN Long ZHANG Xi LUO Fu-tian Andrew D. Michaels MA Hong 2012Chinese Medical Journal2012,,6:4
6P2X7 receptor signaling during adult hippocampal neurogenesis显示文摘Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.Regulation of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature neurons.The expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion dysregulation.Lastly,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease states.Understanding how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative medicine.This review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells.Hannah C. Leeson Tailoi Chan-Ling Michael D. Lovelace Jeremy C. Brownlie Ben J. Gu Michael W. Weible II 2019Neural Regeneration Research2019,14,10:3
7Input associativity underlies fear memory renewal显示文摘Synaptic associativity,a feature of Hebbian plasticity wherein coactivation of two inputs onto the same neuron produces synergistic actions on postsynaptic activity,is a primary cellular correlate of associative learning.However,whether and how synaptic associativity are implemented into context-dependent relapse of extinguished memory(i.e.fear renewal)is unknown.Here,using an auditory fear conditioning paradigm in mice,we show that fear renewal is determined by the associativity between convergent inputs from the auditory cortex(ACx)and ventral hippocampus(v HPC)onto the lateral amygdala(LA)that reactivate ensembles engaged during learning.Fear renewal enhances synaptic strengths of both ACx to LA and the previously unknown v HPC to LA monosynaptic inputs.While inactivating either of the afferents abolishes fear renewal,optogenetic activation of their input associativity in the LA recapitulates fear renewal.Thus,input associativity underlies fear memory renewal.Wei-Guang Li Yan-Jiao Wu Xue Gu Hui-Ran Fan Qi Wang Jia-Jie Zhu Xin Yi Qin Wang Qin Jiang Ying Li- Ti-Fei Yuan Han Xu Jiangteng Lu Nan-Jie Xu Michael Xi Zhu Tian-Le Xu 2021National Science Review2021,8,9:2
8Compute and storage clouds using wide area high performance networks显示文摘Robert L. Grossman Yunhong Gu Michael Sabala Wanzhi Zhang 2008Future Generation Computer Systems2008,,2:1
9Characteristics of YouTube network traffic at a campus network – Measurements, models, and implications显示文摘Michael Zink Kyoungwon Suh Yu Gu Jim Kurose 2008Computer Networks2008,,4:1
10Patriotic stock repurchases: the two weeks following the 9-11 attack显示文摘Anthony Yanxiang Gu Michael Schinski 2003Review of Quantitative Finance and Accounting2003,20,3:1
11Computer and storage clouds using wide area high performance networks 显示文摘ROBERT L GU Yun- hong MICHAEL S 2009Future Generagtion Computer Systems2009,25,2:1
12The negative role of cyclin G in ATM-dependent P53 activation 显示文摘Takao Ohtsuka Michael R Jensen Hyung Gu Kim 2004Oncogene2004,23,:1
13Peroxisome proliferator-activated receptor-γ-mediated effects in the vasculature显示文摘Sheng ZD Michael GU Richard MM 2008Circ Res2008,102,3:1
14Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala 2008Bioorganic & Medicinal Chemistry Letters2008,,6:1
15Compute and storage clouds using wide area high performance networks显示文摘Robert L G Gu Yunhong Michael Sabala Zhang Wanzhi 2009Future Generation Computer Systems2009,25,2:1
16Compute and storage clouds using wide area high performance networks 显示文摘Robert L G Gu Yunhong Michael Sabala Zhang Wanzhi 2009Future Generation Computer Systems2009,25,2:1
17C-Reactive protein and coronary artery disease: Additional evidence of the implication of an inflammatory process in acute coronary syndromes显示文摘Idrissia Abdelmouttaleb Nicolas Danchin Claudio Ilardo Isabelle Aimone-Gastin Michael Angio? Alain Lozniewski Julien Loubinoux Alain Le Faou Jean-Louis Guéant 1999American Heart Journal1999,,2:1
18Physics-of-failure-based prognostics for electronic products显示文摘MICHAEL PECHT JIE GU 0,,3:1
19Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection)显示文摘Meeghan A. O’Connor Petra Koza-Taylor Sarah N. Campion Lauren M. Aleksunes Xinsheng Gu Ahmed E. Enayetallah Michael P. Lawton José E. Manautou 2014Toxicology and Applied Pharmacology2014,,1:1
20MERRA: NASA’s Modern-Era Retrospective Analysis for Research and Applications显示文摘Rienecker Michele M Suarez Max J Gelaro Ronald Todling Ricardo Bacmeister Julio Liu Emily Bosilovich Michael G Schubert Siegfried D Takacs Lawrence Kim Gi-Kong Bloom Stephen Chen Junye Collins Douglas Conaty Austin Da Silva Arlindo Gu Wei 2011Journal of Climate2011,,14:1
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