|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Evaluation of Chlorophyll Content and Fluorescence Parameters as Indicators of Drought Tolerance in Barley显示文摘Drought is a major abiotic stress that severely affects food production worldwide. Agronomic and physiological traits associated with drought tolerance are suitable indicators for selection of drought tolerance genotypes to reduce the impact of water deficit on crop yield in breeding program. The objective of this study was to identify indicators related to drought tolerance through analysis of photosynthetic traits in barley (Hordeum vulgare L.). These traits included chlorophyll content, initial fluorescence (Fo), maximum primary yield of photochemistry of photosystem Ⅱ (Fv / Fo) and maximum quantum yield of photosystem II (Fv / Fm). Four genotypes (Tadmor, Arta, Morocco9-75 and WI2291) variable in drought tolerance were used to investigate the correlation between these traits and drought tolerance. The results reflected that all of these traits were affected negatively in the four genotypes at different levels of post-anthesis drought stress, but the decrease in drought tolerant genotypes was much less than that of drought sensitive genotypes. The results further revealed that the components of the photosynthetic apparatus could be damaged significantly in drought sensitive genotypes, while drought tolerant genotypes were relatively less affected. On the other hand, the values of chlorophyll content, Fo, Fv / Fo and Fv / Fm in drought tolerance genotypes were significantly higher than those in drought sensitive genotypes under drought stress. It was concluded that chlorophyll content, Fo, Fv / Fo and Fv / Fm could be considered as reliable indicators in screening barley germplasm for drought tolerance. | LI Rong-hua GUO Pei-guo Michael Baum Stefania Grando Salvatore Ceccarelli | 2006 | Agricultural Sciences in China2006，5，10： | 51 |
| 3 | 肝内和肝外胆管癌肿瘤抑制基因启动子甲基化分析显示文摘目的 探讨胆管癌的表遗传学改变。方法 用甲基化特异PCR(MSP)法 ,检测了 12个候选肿瘤抑制基因 (APGE cad herin/CDH1,MGMT ,RASSF1A ,GSTP ,RAR β ,p14 ARF,p15 INK4b,p16INK4a,p73 ,hMLH1,DAPK)启动子在 72例胆管癌中的甲基化情况 ,其中肝内和肝外胆管癌各 3 6例 ,10例良性胆管上皮作为对照。结果 85 %的胆管癌至少有一个肿瘤抑制基因的甲基化 ,在胆管癌中 ,肿瘤抑制基因的甲基化顺序是 :RASSF1A(65 %) ,p15 INK4b(5 0 %) ,p16INK4a(5 0 %) ,APC(4 6%) ,E cadherin/CDH1(4 3 %) ,p14 ARF(3 8%) ,p73 (3 6%) ,MGMT(3 3 %) ,hMHL1(2 5 %) ,GSTP(14 %) ,RAR β(14 %)和DAPK(3 %)。虽然单个肿瘤抑制基因的甲基化可见于良性胆管上皮 ,但是多个肿瘤抑制基因的甲基化只见于胆管癌。约 70 %(5 0 /72 )的胆管癌有 3个或 3个以上的肿瘤抑制基因的甲基化 ,5 2 %(3 8/72 )有 4个或 4个以上肿瘤抑制基因的甲基化。多个肿瘤抑制基因的协同甲基化 ,和RASSF1A ,p15 INK4b,p16INK4a和 /或hMHL1密切相关。RASSF1A的甲基化在肝外胆管癌 (83 %)较肝内胆管癌更常见 (4 7%) (P =0 . 0 0 3 ) ,而GSTP更多见于肝内胆管癌(肝内 3 1%,肝外 6%,P =0 . 0 12 ) ,本研究提示肿瘤抑制基因启动子CpG岛的甲基化在胆管癌中是一? | YANG Bin Michael G.House GUO Mingzhou James G.Herman Douglas P.Clark | 2005 | 胃肠病学和肝病学杂志2005，14，1： | 46 |
| 4 | 中国个人投资者处置效应研究——一个非理性信念的视角显示文摘处置效应是指投资者过早卖出盈利股票而长期持有亏损股票的现象。大量文献表明金融市场投资者存在显著的处置效应,但其产生的原因和机理存在争议。本文在前景理论框架下,构建了包含投资者非理性预期的离散时间投资组合决策模型,发现处置效应随投资者情绪升高而减弱。本文使用我国某券商2007—2009年近177万个人投资者股票账户的交易数据进行了实证分析,得到与理论模型预测的一致结果,即投资者情绪与投资者处置效应之间呈现显著的负相关关系。而且,受情绪影响,投资者处置效应在估值难度较大的股票中更弱。本文结论对理解投资者处置效应、优化投资者卖出决策和加强资本市场基础制度建设具有一定理论和实践意义。 | 武佳薇 汪昌云 陈紫琳 Jie Michael Guo | 2020 | 金融研究2020，，2： | 17 |
| 5 | Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis显示文摘Acyl-CoA:cholesterol acyltransferase (ACAT ) 从胆固醇和长链的 fatty-acyl-coenzyme A 催化 cholesteryl 酉旨的形成。在单个房间的水平, ACAT 用作细胞内部的胆固醇动态平衡的一个管理者。另外, ACAT 在肝和小肠为脂蛋白汇编供应 cholesteryl 酉旨。在病理学的条件下面, ACAT 在巨噬细胞生产的 cholesteryl 酉旨的累积贡献泡沫房间形成,动脉粥样硬化的早阶段的一个特点。探讨 ACAT 和 ACAT 禁止者的各种各样的方面的几评论是可得到的。这评论简短在人的 ACAT 的生物化学的性质上构画出当前的知识,然后集中于对动脉粥样硬化为药品的干预作为一个药目标讨论 ACAT 的优点。 | Catherine CHANG Ruhong DONG Akira MIYAZAKI Naomi SAKASHITA Yi ZHANG Jay LIU Michael GUO Bo-Liang LI Ta-Yuan CHANG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，3： | 13 |
| 6 | Hepatitis B virus reactivation and hepatitis in diffuse large B-cell lymphoma patients with resolved hepatitis B receiving rituximab-containing chemotherapy:risk factors and survival显示文摘Introduction:Hepatitis B virus(HBV) reactivation has been reported in B-cell lymphoma patients with resolved hepatitis B(hepatitis B surface antigen[HBsAg]-negative and hepatitis B core antibody[HBcAb]-positive).This study aimed to assess HBV reaaivation and hepatitis occurrence in diffuse large B-cell lymphoma(DLBCL) patients with resolved hepatitis B receiving rituximab-containing chemotherapy compared with HBsAg-negative/HBcAb-negative patients to identify risk factors for HBV reaaivation and hepatitis occurrence and to analyze whether HBV reaaivation and hepatitis affect the survival of DLBCL patients with resolved hepatitis B.Methods:We reviewed the clinical data of 278 patients with DLBCL treated with rituximab-containing therapy between January 2004 and May 2008 at Sun Yat-sen University Cancer Center,China.Prediaive faaors for HBV reaaivation,hepatitis development,and survival were examined by univariate analysis using the chi-square or Fisher's exact test and by multivariate analysis using the Cox regression model.Results:Among the 278 patients,165 were HBsAg-negative.Among these 165 patients,6(10.9%) of 55 HBcAb-positive(resolved HBV infeaion) patients experienced HBV reactivation compared with none(0%) of 110 HBcAb-negative patients(P=0.001).Patients with resolved hepatitis B had a higher hepatitis occurrence rate than HBsAg-negative/HBcAb-negative patients(21.8%vs.8.2%,P = 0.013).HBcAb positivity and elevated baseline alanine aminotransferase(ALT) levels were independent risk factors for hepatitis.Among the 55 patients with resolved hepatitis B,patients with elevated baseline serum ALT or aspartate aminotransferase(AST) levels were more likely to develop hepatitis than those with normal serum ALT or AST levels(P = 0.037,P = 0.005,respeaively).An elevated baseline AST level was an independent risk factor for hepatitis in these patients.Six patients with HBV reactivation recovered after immediate antiviral therapy,and chemotherapy was continued.HBcAb positivity,HBV reactivation,or hepatitis did not negatively affect the survival of DLBCL patients.Conclusions:DLBCL patients with resolved hepatitis B may have a higher risk of developing HBV reaaivation and hepatitis than HBsAg-negative/HBcAb-negative patients.Close monitoring and prompt antiviral therapy are required in these patients. | Kai-Lin Chen Jie Chen Hui-Lan Rao Ying Guo Hui-Qiang Huang Liang Zhang Jian-Yong Shao Tong-Yu Lin Wen-Qi Jiang De-Hui Zou Li-Yang Hu Michael Lucas Wirian Qing-Qing Cai | 2015 | Chinese Journal of Cancer2015，34，5： | 11 |
| 7 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 8 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 9 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 10 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 11 | Factors affecting genomic selection revealed by empirical evidence in maize显示文摘Genomic selection(GS) as a promising molecular breeding strategy has been widely implemented and evaluated for plant breeding, because it has remarkable superiority in enhancing genetic gain, reducing breeding time and expenditure, and accelerating the breeding process. In this study the factors affecting prediction accuracy(rMG) in GS were evaluated systematically, using six agronomic traits(plant height, ear height, ear length, ear diameter,grain yield per plant and hundred-kernel weight) evaluated in one natural and two biparental populations. The factors examined included marker density, population size, heritability,statistical model, population relationships and the ratio of population size between the training and testing sets, the last being revealed by resampling individuals in different proportions from a population. Prediction accuracy continuously increased as marker density and population size increased and was positively correlated with heritability; rMGshowed a slight gain when the training set increased to three times as large as the testing set. Low predictive performance between unrelated populations could be attributed to different allele frequencies, and predictive ability and prediction accuracy could be improved by including more related lines in the training population. Among the seven statistical models examined, including ridge regression best linear unbiased prediction(RR-BLUP), genomic BLUP(GBLUP), Bayes A, Bayes B, Bayes C, Bayesian least absolute shrinkage and selection operator(Bayesian LASSO), and reproducing kernel Hilbert space(RKHS), the RKHS and additive-dominance model(Add + Dom model) showed credible ability for capturing non-additive effects, particularly for complex traits with low heritability. Empirical evidence generated in this study for GS-relevant factors will help plant breeders to develop GS-assisted breeding strategies for more efficient development of varieties. | Xiaogang Liu Hongwu Wang Hui Wang Zifeng Guo Xiaojie Xu Jiacheng Liu Shanhong Wang Wen-Xue Li Cheng Zou Boddupalli M.Prasanna Michael S.Olsen Changling Huang Yunbi Xu | 2018 | The Crop Journal2018，6，4： | 8 |
| 12 | Stable carbon and nitrogen isotope evidence of human and pig diets at the Qinglongquan site,China显示文摘Previous studies on the Rice-Millet(foxtail millet and common millet) Blended Zone in Chinese Neolithic have not clearly addressed such questions as the importance of primitive rice-millet mixed agriculture to human lifestyle and livestock managements within this region,the relationship among the development of the agriculture,paleoenvironment,and cultural interactions,and so on.Here stable carbon and nitrogen isotope analysis of human and pig bones from the Qinglongquan site was conducted,covering two cultural phases,namely the Qujialing Culture(3000 BC to 2600 BC) and the Shijiahe Culture(2600 BC to 2200 BC) .Based on this analysis,we further discussed the diets of ancient humans and pigs in the site,investigated the importance of rice-millet mixed agriculture to human and pig diets,and explored the relationship among the primitive rice agriculture and millet agriculture,cultural interactions,and paleoenvironment.The δ13C values of human bone collagen(-16.7‰ to-12.4‰,averaging-14.6‰±1.3‰,n=24) revealed that both C3 and C4 foods were consumed,probably from the contribution of rice(C3 plant) and millets(C4 plants) due to the coexistence of these crops at this site.In addition,the human mean δ13C value suggested that millet agriculture was only minor in human diets.The human δ15N values(6.6‰to 10.8‰,averaging 9.0‰±1.2‰,n=24) showed that animal resources played a significant role in human diets,and varied greatly.The mean δ13C value of the pigs(-14.3‰±2.5‰,n=13) was quite similar to that of the humans,but the mean δ15N value of the pigs was slightly less(1.3‰) .The similar δ13C and δ15N values between humans and pigs suggested that the pigs consumed a lot of humans'food remains.No correlations of the δ13C and δ15N values between humans and pigs showed that both human and pig diets were based mainly on plant foods,which might be related to highly developed rice-millet mixed agriculture at that time. In comparison with the human and pig diets between the two periods,millet agriculture contributed more than 10%in the Shijiahe Culture,if a simple mixing model was used.This apparent dietary shift matched the climatic variation and agricultural development through the time.In warm and humid climate with the expansion of the Qujialing Culture northwards,rice was widely cultivated.However,when the climate was cold and arid,northern culture was expanding southwards.Thus,millet agriculture became more important. | GUO Yi HU YaoWu ZHU JunYing ZHOU Mi WANG ChangSui Michael P. RICHARDS | 2011 | Science China Earth Sciences2011，54，4： | 6 |
| 13 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 14 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 15 | Development of high-resolution multiple-SNP arrays for genetic analyses and molecular breeding through genotyping by target sequencing and liquid chip显示文摘Genotyping platforms,as critical supports for genomics,genetics,and molecular breeding,have been well implemented at national institutions/universities in developed countries and multinational seed companies that possess high-throughput,automatic,large-scale,and shared facilities.In this study,we integrated an improved genotyping by target sequencing(GBTS)system with capture-in-solution(liquid chip)technology to develop a multiple single-nucleotide polymorphism(mSNP)approach in which mSNPs can be captured from a single amplicon.From one 40K maize mSNP panel,we developed three types of markers(40K mSNPs,251K SNPs,and 690K haplotypes),and generated multiple panels with various marker densities(1K–40K mSNPs)by sequencing at different depths.Comparative genetic diversity analysis was performed with genic versus intergenic markers and di-allelic SNPs versus non-typical SNPs.Compared with the one-amplicon-one-SNP system,mSNPs and within-mSNP haplotypes are more powerful for genetic diversity detection,linkage disequilibrium decay analysis,and genome-wide association studies.The technologies,protocols,and application scenarios developed for maize in this study will serve as a model for the development of mSNP arrays and highly efficient GBTS systems in animals,plants,and microorganisms. | Zifeng Guo Quannv Yang Feifei Huang Hongjian Zheng Zhiqin Sang Yanfen Xu Cong Zhang Kunsheng Wu Jiajun Tao Boddupalli MPrasanna Michael SOlsen Yunbo Wang Jianan Zhang Yunbi Xu | 2021 | Plant Communications2021，2，6： | 5 |
| 16 | Light-absorbing impurities on Keqikaer Glacier in western Tien Shan: concentrations and potential impact on albedo reduction显示文摘Light-absorbing impurities on glaciers are important factors that influence glacial surface albedo and accelerate glacier melt. In this study, the quantity of light-absorbing impurities on Keqikaer Glacier in western Tien Shan, Central Asia, was measured. We found that the average concentrations of black carbon was 2,180 ng/g, with a range from 250 ng/g to more than 10,000 ng/g. The average concentrations of organic carbon and mineral dust were 1,738 ng/g and 194 μg/g, respectively. Based on simulations performed with the Snow Ice Aerosol Radiative model simulations, black carbon and dust are responsible for approximately 64% and 9%, respectively, of the albedo reduction, and are associated with instantaneous radiative forcing of 323.18 W/m2(ranging from 142.16 to 619.25 W/m2) and 24.05 W/m2(ranging from 0.15 to69.77 W/m2), respectively. For different scenarios, the albedo and radiative forcing effect of black carbon is considerably greater than that of dust. The estimated radiative forcing at Keqikaer Glacier is higher than most similar values estimated by previous studies on the Tibetan Plateau, perhaps as a result of black carbon enrichment by melt scavenging. Light-absorbing impurities deposited on Keqikaer Glacier appear to mainly originate from central Asia, Siberia, western China(including the Taklimakan Desert) and parts of South Asia in summer, and from the Middle East and Central Asia in winter.A footprint analysis indicates that a large fraction(>60%) of the black carbon contributions on Keqikaer Glacier comes from anthropogenic sources. These results provide a scientific basis for regional mitigation efforts to reduce black carbon. | YuLan Zhang ShiChang Kang Min Xu Michael Sprenger TanGuang Gao ZhiYuan Cong ChaoLiu Li JunMing Guo ZhiQiang Xu Yang Li Gang Li XiaoFei Li YaJun Liu HaiDong Han | 2017 | Research in Cold and Arid Regions2017，9，2： | 4 |
| 17 | Molecular Characterization of Atlas 66-Derived Wheat Near-lsogenic Lines Contrasting in Aluminum(Al)Tolerance显示文摘Aluminum (Al) toxicity is the major limiting factor for wheat growth in acidic soils. Genetic improvement of Al tolerance is one of the most cost-effective solutions to improve wheat productivity. The objective of this study was to characterize near isogenic lines (NILs) contrasting in Al tolerance derived from Atlas 66 in the backgrounds of Al-sensitive cultivars Chisholm and Century using amplified fragment length polymorphism (AFLP) and simple sequence repeat (SSR). A total of 200 AFLP and 88 SSR primer pairs were screened and 12 markers (11 AFLPs and one SSR) were associated with Al tolerance in NILs of at least one recurrent parental background. Among them, nine were linked to Al tolerance in the Chisholm-derived NILs, seven were associated with Al-tolerance in the Century-derived NILs, and three AFLPs derived from the primer combinations of pAG/mGCAG, pCAG/mAGC and pGTG/mGCG, and one SSR, Xwmc331 on chromosome 4D, associated with Al tolerance in NILs of both recurrent parental backgrounds. Those common markers across two backgrounds may be the major marker loci associated with Al-tolerance in Atlas 66 and could be useful for marker-assisted breeding to improve Al tolerance in wheat. In addition, evaluation of Al tolerance among different genotypes using hematoxylin stain and relative root growth revealed that Atlas 66 was more tolerant to Al stress than the NILs, therefore suggested that the Al-tolerant NILs might not carry all Al-tolerance loci from Atlas 66 and inheritance of Al tolerance in Atlas 66 is more likely multigenic. | GUO Pei-guo BAI Gui-hua LI Rong-hua Brett Carver Michael Baum | 2007 | Agricultural Sciences in China2007，6，5： | 4 |
| 18 | MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis显示文摘 | Jinzhen Guo Liya Gu Michael Leffak Guo-Min Li | 2016 | Cell Research2016，26，7： | 4 |
| 19 | Boosting Lean Electrolyte Lithium-Sulfur Battery Performance with Transition Metals: A Comprehensive Review显示文摘Lithium–sulfur(Li–S) batteries have received widespread attention, and lean electrolyte Li–S batteries have attracted additional interest because of their higher energy densities. This review systematically analyzes the effect of the electrolyte-to-sulfur(E/S) ratios on battery energy density and the challenges for sulfur reduction reactions(SRR) under lean electrolyte conditions. Accordingly, we review the use of various polar transition metal sulfur hosts as corresponding solutions to facilitate SRR kinetics at low E/S ratios(< 10 μL mg~(-1)), and the strengths and limitations of different transition metal compounds are presented and discussed from a fundamental perspective. Subsequently, three promising strategies for sulfur hosts that act as anchors and catalysts are proposed to boost lean electrolyte Li–S battery performance. Finally, an outlook is provided to guide future research on high energy density Li–S batteries. | Hui Pan Zhibin Cheng Zhenyu Zhou Sijie Xie Wei Zhang Ning Han Wei Guo Jan Fransaer Jiangshui Luo Andreu Cabot Michael Wübbenhorst | 2023 | Nano-Micro Letters2023，15，10： | 2 |
| 20 | Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia显示文摘 | Tieqiang Zhao Jun Guo Hui Li Wei Huang Xunde Xian Colin J.D. Ross Michael R. Hayden Zongyao Wen George Liu | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员