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| 1 | TRPM2: a candidate therapeutic target for treating neurological diseases显示文摘短暂受体潜力 melastatin (TRPM2 ) 2 是钙(Ca 2+)-permeable 属于 TRP 离子隧道家庭的非选择的阳离子隧道。氧化导致压力的 TRPM2 激活在许多房间类型挑起异常细胞内部的 Ca 2+ 累积和房间死亡,包括神经原。异常 TRPM2 功能包括局部缺血 / 击, Alzheimers 疾病,神经病的疼痛, Parkinsons 疾病和双极的混乱在几神经病学的混乱被含有。除了在疾病为 TRPM2 识别一个角色的研究,进步在大脑在 TRPM2 的生理的功能的鉴定被取得了,包括 TRPM2 为 N-methyl-D-aspartate ( NMDA )受体依赖者的正式就职是必要的最近的证据长期的消沉,在 glutamate 触处的 synaptic 粘性的一种重要形式。这里,我们处于健康和疾病在中央神经系统(CNS ) 在 TRPM2 的角色上总结最近的证据并且讨论指向 TRPM2 的潜在的治疗学的含意。一起,这些研究建议 TRPM2 为神经病学的混乱代表一个未来的新奇治疗学的目标。 | Jillian Corinne BELROSE Michael Frederick JACKSON | 2018 | Acta Pharmacologica Sinica2018，39，5： | 12 |
| 2 | Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia显示文摘 | Ankur BODALIA Hongbin LI Michael F JACKSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 11 |
| 3 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 4 | Temporal persistence and stability of surface soil moisture in a semi-arid watershed显示文摘 | Michael H. Cosh Thomas J. Jackson Susan Moran Rajat Bindlish | 2007 | Remote Sensing of Environment2007，，2： | 2 |
| 5 | Assessing impacts of Landuse and Landcover changes on hydrology for the upper San Pedro watershed显示文摘 | Wenming Nie Yongping Yuan William Kepner Maliha S. Nash Michael Jackson Caroline Erickson | 2011 | Journal of Hydrology2011，，1： | 2 |
| 6 | The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome显示文摘 | Philip M. Brown Douglas A. Drossman Alastair J.J. Wood Gary A. Cline Kenny S. Frazier Jessica I. Jackson Johanna Bronner Joel Freiman Brian Zambrowicz Arthur Sands Michael D. Gershon | 2011 | Gastroenterology2011，，2： | 2 |
| 7 | 子宫平滑肌肉瘤的治疗预后-来自悉尼妇科肿瘤中心的报告显示文摘目的复习20年子宫平滑肌肉瘤诊治经验,研究影响患者生存期的因素,为科学诊治提供依据。方法复习1987—2007年澳大利亚悉尼皇家医院和飞利浦医院悉尼妇科肿瘤中心子宫平滑肌肉瘤病例资料,采用卡方和t检验对数据进行统计分析。结果20年间共诊治27例子宫平滑肌肉瘤,22例资料完整、用于本研究。手术治疗21例,其中3例卵巢切除;辅助治疗12例。患者年龄大小,是否绝经、辅助治疗和切除卵巢的无瘤生存期(Progression-free Survival,PFS)和总生存期(overall survival,os)无差异,早期临床期别患者的PFS较长且有统计学意义。结论患者年龄和是否绝经对子宫平滑肌肉瘤预后影响不大,辅助化学或放射治疗和切除卵巢未能改善患者生存期限,临床期别是影响子宫平滑肌肉瘤预后的重要因素。 | 蒋春萍 Selvan Pather Chris Dalrymple Ehab Al-Rayyan Marcelo Nascimento Philip Beale Michael Jackson Chris Milross Jonathan Carter | 2009 | 国际医药卫生导报2009，15，17： | 2 |
| 8 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 9 | SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent显示文摘 | Zahid Hassan Viswananthan Mohan Liaquat Ali Rebecca Allotey Khalid Barakat M. Omar Faruque Raj Deepa Michael F. McDermott Alan E. Jackson Paul Cassell David Curtis Susan V. Gelding Shanti Vijayaravaghan Niklaus Gyr David C. Whitcomb A.K. Azad Khan Graham | 2002 | The American Journal of Human Genetics2002，，4： | 1 |
| 10 | The salting-out effect and phase separation in aqueous solutions of electrolytes and poly(ethylene glycol)显示文摘 | Michael J. Hey Daniel P. Jackson Hong Yan | 2005 | Polymer2005，，8： | 1 |
| 11 | Ethanolysis of seed oil in flowing supercritical carbon dioxide 显示文摘 | Michael A Jackson Jerry W King | 1996 | J Am Oil Chem Soc1996，73，： | 1 |
| 12 | Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents 显示文摘 | Richard F W Jackson Leslie J Oales Michael H Block | 2000 | Chem Commun2000，2，： | 1 |
| 13 | Changes in interstitial fluid flow,mass transport and the bone cell response in microgravity and normogravity显示文摘In recent years,our scientific interest in spaceflight has grown exponentially and resulted in a thriving area of research,with hundreds of astronauts spending months of their time in space.A recent shift toward pursuing territories farther afield,aiming at near-Earth asteroids,the Moon,and Mars combined with the anticipated availability of commercial flights to space in the near future,warrants continued understanding of the human physiological processes and response mechanisms when in this extreme environment.Acute skeletal loss,more severe than any bone loss seen on Earth,has significant implications for deep space exploration,and it remains elusive as to why there is such a magnitude of difference between bone loss on Earth and loss in microgravity.The removal of gravity eliminates a critical primary mechano-stimulus,and when combined with exposure to both galactic and solar cosmic radiation,healthy human tissue function can be negatively affected.An additional effect found in microgravity,and one with limited insight,involves changes in dynamic fluid flow.Fluids provide the most fundamental way to transport chemical and biochemical elements within our bodies and apply an essential mechano-stimulus to cells.Furthermore,the cell cytoplasm is not a simple liquid,and fluid transport phenomena together with viscoelastic deformation of the cytoskeleton play key roles in cell function.In microgravity,flow behavior changes drastically,and the impact on cells within the porous system of bone and the influence of an expanding level of adiposity are not well understood.This review explores the role of interstitial fluid motion and solute transport in porous bone under two different conditions:normogravity and microgravity. | Fei Wei Kendal Flowerdew Michael Kinzel Luigi EPerotti Jackson Asiatico Mahmoud Omer Candice Hovell Veerle Reumers Melanie J.Coathup | 2022 | Bone Research2022，10，4： | 1 |
| 14 | Terra infirma: Understanding salt tectonics显示文摘 | Michael R. Hudec Martin P.A. Jackson | 2007 | Earth Science Reviews2007，，1： | 1 |
| 15 | Vascular distribution of stroke and its relationship to perioperative mortality and neurologic outcome after thoracic endovascular aortic repair显示文摘 | Brant W. Ullery Michael McGarvey Albert T. Cheung Ronald M. Fairman Benjamin M. Jackson Edward Y. Woo Nimesh D. Desai Grace J. Wang | 2012 | Journal of Vascular Surgery2012，，6： | 1 |
| 16 | Role of ferulic acid in preparing edible films from soy protein isolate显示文摘 | Shiyi Ou Yong Wang Shuze Tang Caihuan Huang Michael G. Jackson | 2004 | Journal of Food Engineering2004，，2： | 1 |
| 17 | 体重调整固定剂量普通肝素与低分子肝素治疗急性静脉血栓栓塞的比较显示文摘背景:普通肝素用于治疗急性静脉血栓栓塞时,通常在监测血凝下静脉输注给药,患者需要住院治疗。然而,体重调整后皮下注射固定剂量普通肝素可能既适用于住院也适用于门诊静脉血栓栓塞患者的治疗。
目的:确定皮下注射体重调整固定剂量普通肝素治疗静脉血栓栓塞是否与低分子肝素同样安全有效。设计、地点及患者:随机、开标、裁定者盲法、非劣效试验。708例急性静脉血栓栓塞患者来自加拿大和新西兰6所大学附属临床中心,年龄≥18岁。试验于1998年9月至2004年2月进行。在随机分组的患者中,11例从疗效分析中排除,8例从安全性分析中排除。
干预:普通肝素皮下注射初始剂量为333U/kg,以后给予固定剂量250U/kg,每12小时1次(n=345)。低分子肝素(依诺肝素或达肝素)按100IU/kg剂量皮下注射,每12小时1次(n=352)。两种治疗均可院外进行,配合华法林治疗3个月。
主要观测指标:随机分组后3个月内复发性静脉血栓栓塞事件及10天内严重出血情况。结果:普通肝素组有13例患者(3.8%)发生静脉血栓栓塞复发,而低分子肝素组有12例患者复发(3.4%;绝对差值,0.4%;95%可信区间,-2.6%~3.3%)。开始治疗后10天内普通肝素组有4例患者(1.1%)发生严重出血,而低分子肝素组有5例(1.4%;绝对差值,-0.3%;95%可信区间,-2.3%~1.7%)。院外治疗患者在普通肝素组占72%,低分子肝素组占68%。
结论:对于急性静脉血栓栓塞患者而言,皮下注射固定剂量普通肝素与低分子肝素一样安全有效,适于门诊治疗。 | Clive Kearon Jeffrey S. Ginsberg Jim A. Julian James Douketis Susan Solymoss Paul Ockelford Sharon Jackson Alexander G. Turpie Betsy MacKinnon Jack Hirsh Michael Gent 王春玲(译) 孙艺红(译) 胡大一(校) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 1 |
| 18 | Temporal Onset of Hypoxia and Oxidative Stress After Pulmonary Irradiation显示文摘 | Katharina Fleckenstein Larisa Zgonjanin Liguang Chen Zahid Rabbani Isabel L. Jackson Bradley Thrasher John Kirkpatrick W. Michael Foster Zeljko Vujaskovic | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 1 |
| 19 | Evolution of the Cretaceous Astrid thrust belt in the ultradeep-water Low- er Congo Basin, Gabon显示文摘 | Martin P A Jackson Michael R Hudec | 2008 | AAPG Bulletin2008，92，4： | 1 |
| 20 | Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors显示文摘 | Timothy S McClintock Teresa M Landers Alexander A Gimelbrant Lynn Z Fuller Brian A Jackson Channa K Jayawickreme Michael R Lerner | 1997 | Molecular Brain Research1997，，2： | 1 |
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