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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 3 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 4 | Involvement of substance P and the NK-1 receptor in pancreatic cancer显示文摘Pancreatic cancer is the fourth leading cause of cancer related-death for both men and women and the 1-and5-year relative survival rates are 25%and 6%,respectively.Thus,it is urgent to investigate new antitumor drugs to improve the survival of pancreatic cancer patients.The peptide substance P(SP)has a widespread distribution throughout the body.After binding to the neurokinin-1(NK-1)receptor,SP regulates biological functions related to cancer,such as tumor cell proliferation,neoangiogenesis,the migration of tumor cells for invasion,infiltration and metastasis,and it exerts an antiapoptotic effects on tumor cells.It is known that the SP/NK-1 receptor system is involved in pancreatic cancer progression:(1)pancreatic cancer cells and samples express NK-1 receptors;(2)the NK-1 receptor is overexpressed in pancreatic cancer cells in comparison with non-tumor cells;(3)nanomolar concentrations of SP induce pancreatic cancer cell proliferation;(4)NK-1 receptor antagonists inhibit pancreatic cell proliferation in a concentration-dependent manner,at a certain concentration,these antagonists inhibit100%of tumor cells;(5)this antitumor action is medi-ated through the NK-1 receptor,and tumor cells die by apoptosis;and(6)NK-1 receptor antagonists inhibit angiogenesis in pancreatic cancer xenografts.All these data suggest that the SP/NK-1 receptor system could play an important role in the development of pancreatic cancer;that the NK-1 receptor could be a new promising therapeutic target in pancreatic cancer,and that NK-1 receptor antagonists could improve the treatment of pancreatic cancer. | Miguel Muoz Rafael Coveas | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 5 | Firm productivity and export markets: a non-parametric approach显示文摘 | Miguel A. Delgado Jose C. Fari?as Sonia Ruano | 2002 | Journal of International Economics2002，，2： | 1 |
| 6 | Alzheimer’s disease: aclinical practice-oriented review 显示文摘 | Alves L Correia AS Miguel R | 2012 | Front Neurol2012，3，： | 1 |
| 7 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 8 | Ethanol production from steam-explosion pretreated wheat straw显示文摘 | Ignacio Ballesteros Ma José Negro José Miguel Oliva Araceli Caba?as Paloma Manzanares Mercedes Ballesteros | 2006 | Applied Biochemistry and Biotechnology (-)2006，，1： | 1 |
| 9 | Lack of association between intussusception and oral polio vaccine in Cuban children显示文摘 | Miguel A. Galindo Sardi?as Andrés Zambrano Cárdenas Gisele Coutin Marie Manuel Santin Pe?a Miriam Ali?o Santiago Marlen Valcárcel Sanchez C.P. Farrington | 2001 | European Journal of Epidemiology2001，，8： | 1 |
| 10 | Safety and feasibility of catheter ablation for atrioventricular nodal re-entrant tachycardia without fluoroscopic guidance显示文摘 | Miguel álvarez Luís Tercedor Isabel Almansa Natalia Ros Ricardo S. Galdeano Francisco Burillo Pablo Santiago Rocío Pe?as | 2009 | Heart Rhythm2009，，12： | 1 |
| 11 | Photonic Crystal Fiber Temperature Sensor Based on Quantum Dot Nanocoatings显示文摘 | Beatriz Larrión Miguel Hernáez Francisco J. Arregui Javier Goicoechea Javier Bravo Ignacio R. Matías Valerio Pruneri | 2009 | Journal of Sensors2009，，： | 1 |
| 12 | NK-1 receptor antagonists as antitumor drugs: a survey of the literature from 2000 to 2011显示文摘 | Miguel Mu?oz Juan Martinez-Armesto Rafael Cove?as | 2012 | Expert Opinion on Therapeutic Patents2012，，7： | 1 |
| 13 | Vitrification of goat, sheep, and cattle skin samples from whole ear extirpated afterdeath and maintained at different storage times and temperatures 显示文摘 | Miguel AS Juan PS Eenesto AG | 2004 | Cryobiology2004，49，： | 1 |
| 14 | Diabetes Mellitus in Older People: Position Statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes显示文摘 | Alan Sinclair John E. Morley Leo Rodriguez-Ma?as Giuseppe Paolisso Tony Bayer Andrej Zeyfang Isabelle Bourdel-Marchasson Ulrich Vischer Jean Woo Ian Chapman Trisha Dunning Graydon Meneilly Joel Rodriguez-Saldana Luis Miguel Gutierrez Robledo Tali Cukierma | 2012 | Journal of the American Medical Directors Association2012，，6： | 1 |
| 15 | Endoscopic Management of Biliary Complications After Adult Living-Donor Versus Deceased-Donor Liver Transplantation显示文摘 | Carlos Macías Gómez Jean-Marc Dumonceau Mariano Marcolongo Eduardo de Santiba?es Miguel Ciardullo Juan Pekolj Martín Palavecino Adrian Gadano Jorge Dávolos | 2009 | Transplantation2009，，11： | 1 |
| 16 | The Formation of a Tourist Destination’s Image via Information Sources: the Moderating Effect of Culture显示文摘 | Dolores M. Frías Miguel A. Rodríguez J. Alberto Casta?eda Carmen M. Sabiote Dimitrios Buhalis | 2011 | Int J Tourism Res2011，，5： | 1 |
| 17 | Esophageal Eosinophilic Infiltration Responds to Proton Pump Inhibition in Most Adults显示文摘 | Javier Molina–Infante Lucia Ferrando–Lamana Cristina Ripoll Moises Hernandez–Alonso Jose M. Mateos Miguel Fernandez–Bermejo Carmen Due?as Nuria Fernandez–Gonzalez Eva M. Quintana Maria Angeles Gonzalez–Nu?ez | 2011 | Clinical Gastroenterology and Hepatology2011，，2： | 1 |
| 18 | Efficient anchorage of Pt clusters on N-doped carbon nanotubes and their catalytic activity显示文摘 | Xavier Lepró Eduardo Terrés Yadira Vega-Cantú Fernando J. Rodríguez-Macías Hiroyuki Muramatsu Yoon Ahm Kim Takuya Hayahsi Morinobu Endo Miguel Torres R. Mauricio Terrones | 2008 | Chemical Physics Letters2008，，： | 1 |
| 19 | The substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonists显示文摘 | Miguel Mu?oz Ana González-Ortega Marisa Rosso María José Robles-Frias Andres Carranza Manuel Vicente Salinas-Martín Rafael Cove?as | 2012 | Peptides2012，，2： | 1 |
| 20 | Alzheimer's disease:a clinical practice-oriented review显示文摘 | Alves L Correia AS Miguel R | 2012 | Front Neurol2012，，3： | 1 |
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