|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 2 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 3 | Ag-catalyzed GaSb nanowires for flexible near-infrared photodetectors显示文摘High-quality narrow bandgap semiconductors nanowires(NWs)challenge the flexible near-infrared(NIR)photodetectors in next-generation imaging,data communication,environmental monitoring,and bioimaging applications.In this work,complementary metal oxide semiconductor-compatible metal of Ag is deposited on glass as the growth catalyst for the surfactantassisted chemical vapor deposition of GaSb NWs.The uniform morphology,balance stoichiometry,high-quality crystallinity,and phase purity of as-prepared NWs are checked by scanning electron microscopy,energy dispersive X-ray spectroscopy,high-resolution transmission electron microscopy,and X-ray diffraction.The electrical properties of as-prepared NWs are studied by constructing back-gated field-effect-transistors,displaying a high I_(on)/I_(off) ratio of 10^(4) and high peak hole mobility of 400 cm^(2)/(V·s).Benefiting from the excellent electrical and mechanical flexibility properties,the as-fabricated NW flexible NIR photodetector exhibits high sensitivity and excellent photoresponse,with responsivity as high as 618 A/W and detectivity as high as 6.7×10^(10) Jones.Furthermore,there is no obvious decline in NIR photodetection behavior,even after parallel and perpendicular folding with 1200 cycles. | Zixu Sa Fengjing Liu Dong Liu Mingxu Wang Jie Zhang Yanxue Yin Zhiyong Pang Xinming Zhuang Peng Wang Zaixing Yang | 2022 | Journal of Semiconductors2022，43，11： | 1 |
| 4 | Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 HTTPS://DOI.ORG/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction. | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu Qifeng Wang Shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong Hua Zhaohui Huang | 2021 | Protein & Cell2021，12，8： | 1 |
| 5 | Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43显示文摘目的: Argirein (rhein 精氨酸) 是从展出抗氧化剂和反煽动性的活动的中国大黄(感冒 Officinale Baill ) 孤立的 rhein 的衍生物。在现在的学习,我们调查了 argirein 的效果在上导致压力(hypergonadotrophic ) 并且在男 rats.Methods 的糖尿病患者(hypogonadotrophic ) 性腺机能减退: 导致压力、糖尿病的性腺机能减退经由 isoproterenol (ISO ) 或 streptozotocin (STZ ) 的注射在雄的老鼠被导致。 注射ISO 的老鼠与 argirein 被对待( 30 mg· ; kg −1·d−1, po )或睾丸激素代替( 0.5 mg· ; kg −1·d−1, sc )为 5 天,并且 注射STZ 的老鼠与 argirein 被对待( 40-120 mg· ; kg −1·d−1, po )或 aminoguanidine ( 100 mg· ; kg −1·d−1, po )为 4 个星期。在老鼠是 euthanized 以后,血样品和睾丸是镇定的。浆液荷尔蒙层次被测量,并且 endothelin 受体 A 的表示(et ), connexin 43 (Cx43 ) 并且在睾丸的另外的蛋白质被检测。为在 vitro 实验,睾丸 homogenate 从正常雄的老鼠被准备,并且与 ISO 孵化了( 1 μ ; mol/L )或高葡萄糖( 27 mmol/L ) .Results : ISO 注射导致了低睾丸激素和高 FSH 和 LH 层次在浆液描绘的 hyper-gonadotrophic 性腺机能减退,而 STZ 注射导致了在浆液由低睾丸激素和低 FSH 和 LH 层次证实了的 hypogonadotrophic 性腺机能减退。在注射 ISO 、注射 STZ 的老鼠的睾丸, et , MMP-9, NADPH oxidase 和 pPKCε显著地被增加,并且 Cx43 的表示被减少。argirein 的管理在注射 ISO 、注射 STZ 的老鼠稀释了反常浆液荷尔蒙层次和睾丸变化,并且 aminoguanidine 在注射 STZ 的老鼠产生了类似的行动;睾丸激素代替颠倒了反常浆液荷尔蒙层次,但是没在注射 ISO 的老鼠影响睾丸变化。Argirein (0.3-3 μ mol/L ) 在在 vitro.Conclusion 与 ISO 或高葡萄糖孵化的睾丸 homogenate 的施加的类似的效果: 雄的老鼠的性腺机能减退的二种类型在睾丸展出希腊语字母的第七字的增加的表示和 Cx43 的沮丧的表示,尽管有浆液 FSH 和 LH 的不同模式。Argirein 经由使 et 在睾丸的 和 Cx43。 | MingXU Chen HU Hussein-hamed KHAN T Fang.hong SHI Xiao-dong CONG Qing LI Yin DAI De-zai DAI | 2016 | Acta Pharmacologica Sinica2016，37，2： | 1 |
| 6 | Effect of Zn2+ content on the microstructure and magnetic properties of nanocrystalline Ni1?x Zn x Fe2O4 ferrite by a spraying-coprecipitation method显示文摘 | Yin Liu Fanfei Min Tai Qiu Mingxu Zhang Chuyang Xu | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 7 | Method for generating non-circular gear with addendum modification and its application in transplanting mechanism显示文摘With a focus on the design of tooth profiles of non-circular gears with addendum modifications that conform to the given complex transmission ratio curves and based on a series of discrete point sets on the pitch curves,the criteria for tooth profile distortion and undercut in non-circular gears were proposed.With the constraint of no tooth profile distortion and undercut,the addendum modification coefficient was introduced into the calculation of the distorted and undercut segments of the tooth profile of a non-circular gear,and the addendum modification coefficient of each contact point of the non-circular gear was obtained.Based on the generating principle for gear shaping with gear cutters,a theoretical model for calculating the tooth profile of non-circular gears with addendum modification was derived.The cutting and radial feeding motions of the pinion cutter were ignored,and only the meshing motion was considered.The involute tooth profiles of the pinion cutter enveloped the tooth profile of the non-circular gear.3D automatic non-circular gear model generation software was developed,which was a secondary development product of the software UG.A non-circular gear in a rice potted seedling transplanting mechanism was designed,and the transplanter was developed and tested.The test results showed that the designed tooth profile of non-circular gear achieved the variable transmission ratios required by the transplanting mechanism.When the transplanting efficiencies were 140 plants/min,160 plants/min and 180 plants/min,the transplanter completed the rice potted seedling transplanting operation with high quality. | Maile Zhou Yuchao Yang Mingxu Wei Daqing Yin | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 0 |
| 8 | Engineering Yarrowia lipolytica to produce nutritional fatty acids:Current status and future perspectives显示文摘Due to their vital physiological functions,nutritional fatty acids have great potential as nutraceutical food supplements for preventing an array of diseases such as inflammation,depression,arthritis,osteoporosis,diabetes and cancer.Microbial biosynthesis of fatty acids follows the trend of sustainable development,as it enables green,environmentally friendly and efficient production.As a natural oleaginous yeast,Yarrowia lipolytica is especially well-suited for the production of fatty acids.Moreover,it has a variety of genetic engineering tools and novel metabolic engineering strategies that make it a robust workhorse for the production of an array of value-added products.In this review,we summarize recent advances in metabolic engineering strategies for accumulating nutritional fatty acids in Y.lipolytica,including conjugated fatty acids and polyunsaturated fatty acids.In addition,the future prospects of nutritional fatty acid production using the Y.lipolytica platform are discussed in light of the current progress,challenges,and trends in this field.Finally,guidelines for future studies are also emphasized. | Lizhen Cao Mingxue Yin Tian-Qiong Shi Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 9 | A highly efficient La-modified ZnAl-LDO catalyst and its performance in the synthesis of dimethyl carbonate from methyl carbamate and methanol显示文摘In this paper,the highly efficient ZnAlLa layered double oxide(ZnAlLa-LDO)catalyst was evaluated and used in methyl carbamate(MC)alcoholysis synthesis of dimethyl carbonate.Under optimal conditions,the MC conversion was 33.5% and the dimethyl carbonate(DMC)selectivity was up to 92,4% at 443 K and in 9 h.The prepared catalysts were well characterized to investigate the effect on the catalytic performance and reaction catalysis mechanism.The experimental results show that the addition of La adjusted the structure and chemical properties of ZnAl composite oxide and that the synergistic effect among Zn,Al and La play a key role in adjusting the acid-base properties and stability of the catalyst,which definitely improved the DMC selectivity and catalytic stability.Based on the proposed reaction mechanism,two kinetic models of the catalytic reaction were established and modified:LangmuirHinshelwood and power-rate law kinetic model.The good agreement between kinetic models and experimental data showed that the power-rate law kinetic model based on the elementary reactions is a suitable model for providing a theoretical basis.The pre-exponential factor and activation energy of the main reaction are 5.77×10^(7)and 77.60 kJ·mol^(-1),respectively. | Mingxue Yin Bo Jia Kuiyi You Bo Jin Yangqiang Huang Xiao Luo Zhiwu Liang | 2023 | Chinese Journal of Chemical Engineering2023，61，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员