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| 1 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 2 | Regulatory effect of gut microbes on blood pressure显示文摘Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases.Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans.In this review,we outline the interaction between gut microbiota and hypertension,including gut microbial changes in hypertension,the effect of microbial dysbiosis on blood pressure(BP),indicators of gut microbial dysbiosis in hypertension,and the microbial genera that affect BP at the taxonomic level.For example,increases in Lactobacillus,Roseburia,Coprococcus,Akkermansia,and Bifidobacterium are associated with reduced BP,while increases in Streptococcus,Blautia,and Prevotella are associated with elevated BP.Furthermore,we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension.Finally,we summarize the commonly used treatments of hypertension that are based on gut microbes,including fecal microbiota transfer,probiotics and prebiotics,antibiotics,and dietary supplements.This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension. | Dong Yan Ye Sun Xiaoyue Zhou Wenhao Si Jieyu Liu Min Li Minna Wu | 2022 | Animal Models and Experimental Medicine2022，5，6： | 1 |
| 3 | Long-term field fertilization alters the diversity of autotrophic bacteria based on the ribulose-1,5-biphosphate carboxylase/oxygenase (RubisCO) large-subunit genes in paddy soil显示文摘 | Hongzhao Yuan Tida Ge Xiaohong Wu Shoulong Liu Chengli Tong Hongling Qin Minna Wu Wenxue Wei Jinshui Wu | 2012 | Applied Microbiology and Biotechnology2012，，4： | 1 |
| 4 | The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity显示文摘Plant diversity can be affected by both herbivore grazing and soil resources. However, it is unclear if the joint effects of herbivores and soil resources might vary with components of plant diversity. Here, we evaluated the relative and combined effects of herbivore assemblage and soil nitrogen(N) quantity and heterogeneity on the α and β components of plant diversity in a grassland that was subjected to four years of grazing under differing herbivore assemblages(no grazing, cattle grazing, sheep grazing, and mixed grazing). We found that herbivore assemblage combined with soil N quantity explained 41% of the variation in plant α-diversity, while herbivore assemblage combined with soil N heterogeneity explained 15% of the variation in plant β-diversity. The independent effects of herbivore assemblage explained more than those of soil N for both α-and β-diversity(α-diversity: 12% vs. 4%;β-diversity: 18% vs. 16%). We concluded that the effects of herbivores are stronger than those of soil N,and that grazing-induced changes in soil resources are important drivers of plant diversity change, especially α-diversity.Therefore, we suggest that managing herbivore species by accounting for the effects that their grazing can have on soil resources may be significant for plant diversity maintenance. | Minna Zhang Bai Liu Guangyin Li Yingying Kuang Xiuquan Yue Shicheng Jiang Jushan Liu Ling Wang | 2022 | Science China(Life Sciences)2022，65，4： | 1 |
| 5 | Differentiated Response of Denitrifying Communities to Fertilization Regime in Paddy Soil显示文摘 | Zhe Chen Jinbo Liu Minna Wu Xiaoli Xie Jinshui Wu Wenxue Wei | 2012 | Microbial Ecology2012，，2： | 1 |
| 6 | Electrochemical modification of active carbon fiber electrode and its application to double-layer capacitor显示文摘 | MINNA T LIU X OSAKA T | 1996 | J Power Sources1996，60，： | 1 |
| 7 | Facile ultrafine copper seed-mediated approach for fabricating quasi-two-dimensional palladium-copper bimetallic trigonal hierarchical nanoframes显示文摘有高度分叉的形态学的各向异性的 Pd nanoparticles 着急地由于他们的新奇结构和唯一的物理化学的性质为 nanoscale 设备,催化剂,和察觉到的材料作为积木被需要。然而,为这些材料认识到尺寸控制和分支操作是很挑战性的。在这研究,我们在水的阶段开发一条灵巧的极其细小的 Cu 调停种子的途径生产新奇 Pd-Cu 三角的层次 nanoframes (THNF ) 。大多数获得的 nanocrystals 的主要分支是像三脚架的,与沿着象有自我类似的框架单位的手臂的先进分支。在这个方法, Pd-Cu THNF 的尺寸能被操作包含 sub-3 nm Cu 种子的成核灵活地控制。这些 Pd-Cu THNF 关于他们的乙醇氧化表演超过 Pd 黑色,举办 9.7 和 6.6 分别地更高预定的一项特定的活动和集体活动。这研究为生产控制尺寸的各向异性的二金属的 nanoframes 提供一条万用的极其细小的调停种子的途径。 | Min Shen Yuanbiao Huang Dongshuang Wu Jian Lv Minna Cao Meimei Liu Yinglong Yang Hongfang Li Binbin Guo Rong Cao | 2017 | Nano Research2017，10，8： | 0 |
| 8 | Economic Evaluation of the Comprehensive AIDS Prevention and Control Program—Tianjin Municipality,China,2011-2022显示文摘What is already known about this topic?Acquired immunodeficiency syndrome(AIDS)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on society.What is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in Tianjin.Between 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese Yuan.What are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking. | Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun Bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng Jinyu Hou Zhuang Cui | 2023 | China CDC weekly2023，5，48： | 0 |
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