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| 1 | Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia显示文摘AIM: To examine histology- and tumor-location specific risk factors of gastric cancer (GC). METHODS: This was a case-control study. The study subjects were 216 GC patients newly diagnosed during the period 2000-2002 and 431 controls selected from non-cancer patients matching in age, gender, and hospital. We obtained information on lifestyles, dietary habits, and others by a questionnaire. RESULTS: The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk (OR 1.3; 95% CI 0.8-2.0). Salting meals before tasting was related to an increased GC risk (OR 3.5; 95% CI 1.6- 7.3). Frequent consumptions of fruits (OR 0.3; 95% CI 0.1-1.0) and vegetables (OR 0.3; 95% CI 0.1-1.0) were related to decreased GC risks. On the other hand, frying foods (OR 1.9; 95% CI 1.0-3.6) and cooking with coal (OR 1.8; 95% CI 1.3-2.6) were related to increased GC risks. Neither Lauren’s histological classification (intestinal and diffuse types) nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 (95% CI 1.0-2.8) and 1.9 (95% CI 0.8-4.3), respectively. The corresponding OR in the upper third stomach was 0.3 (95% CI 0.1-0.9). The differences of those three ORs were statistically significant (P = 0.010). CONCLUSION: The present study shows that birth or- der, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analy- ses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia. | Francia Campos Gabriel Carrasquilla Chihaya Koriyama Mauricio Serra Edwin Carrascal Tetsuhiko Itoh Mitsuharu Nomoto Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，36： | 11 |
| 2 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 3 | Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry显示文摘AIM:To identify criteria for predicting successful drainage of unresectable malignant hilar biliary strictures(UMHBS) because no ideal strategy currently exists.METHODS:We examined 78 patients with UMHBS who underwent biliary drainage.Drainage was considered effective when the serum bilirubin level decreased by ≥ 50% from the value before stent placement within 2 wk after drainage, without additional intervention.Complications that occurred within 7 d after stent placement were considered as early complications.Before drainage, the liver volume of each section(lateral and medial sections of the left liver and anterior and posterior sections of the right liver) was measured using computed tomography(CT) volumetry.Drained liver volume was calculated based on the volume of each liver section and the type of bile duct stricture(according to the Bismuth classification).Tumor volume, which was calculated by using CT volumetry, was excluded from the volume of each section.Receiver operating characteristic(ROC) analysis was performed to identify the optimal cutoff values for drained liver volume.In addition, factors associated with the effectiveness of drainage and early complications were evaluated.RESULTS:Multivariate analysis showed that drained liver volume [odds ratio(OR) = 2.92, 95%CI:1.648-5.197; P < 0.001] and impaired liver function(with decompensated liver cirrhosis)(OR = 0.06, 95%CI:0.009-0.426; P = 0.005) were independent factors contributing to the effectiveness of drainage.ROC analysis for effective drainage showed cutoff values of 33% of liver volume for patients with preserved liver function(with normal liver or compensated livercirrhosis)and 50%for patients with impaired liver function(with decompensated liver cirrhosis).The sensitivity and specificity of these cutoff values were82%and 80%for preserved liver function,and 100%and 67%for impaired liver function,respectively.Among patients who met these criteria,the rate of effective drainage among those with preserved liver function and impaired liver function was 90%and 80%,respectively.The rates of effective drainage in both groups were significantly higher than in those who did not fulfill these criteria(P<0.001 and P=0.02,respectively).Drainage-associated cholangitis occurred in 9 patients(12%).A smaller drained liver volume was associated with drainage-associated cholangitis(P<0.01).CONCLUSION:Liver volume drainage≥33%in patients with preserved liver function and≥50%in patients with impaired liver function correlates with effective biliary drainage in UMHBS. | Ei Takahashi Mitsuharu Fukasawa Tadashi Sato Shinichi Takano Makoto Kadokura Hiroko Shindo Yudai Yokota Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 4 | Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected complications.AIM To identify ERCP-related risk factors for perforation in patients with surgically altered anatomy.METHODS The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or retrocolic.RESULTS All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).CONCLUSION Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billroth-Ⅱ reconstruction and looping of the scope during BillrothⅡ procedure. | Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato Nobuyuki Enomoto | 2019 | World Journal of Clinical Cases2019，7，1： | 6 |
| 5 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 3 |
| 6 | Propagation of Weak Pressure Waves against Two Parallel Subsonic Streams显示文摘在这份报纸,在经常区域的直管对二条平行亚声的溪流宣传的一个压力波浪的特征被一个维的分析,二维的数字模拟,和实验调查。计算被二维的 Euler 方程用 Chakravarthy-Osher-type TVD 计划执行了。由象墙压力大小一样的 schlieren 方法的光观察被执行了澄清结构和压力波浪的繁殖速度。对溪流宣传的压力波浪变成一个区分的压力波浪和分叉的结果表演发生在低速度溪流。分析和计算获得的压力波浪的繁殖速度与现在的试验性的数据同意很好,这也被发现。关键词可压缩的流动 - 流动可视化 - 内部流动 - 化合物飘动 - 复合窒息的 CLC 数字 O354. | Makiko YONAMINE Takanori USHIJIMA Yoshiaki MIYAZATO Mitsuharu MASUDA Hiroshi KATANODA Kazuyasu MATSUO | 2006 | Journal of Thermal Science2006，15，2： | 2 |
| 7 | 1-((S)-γ-Substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors显示文摘 | Hiroshi Sakashita Hirsoshi Kitajima Mitsuharu Nakamura | 2005 | Bioorganic & Medicinal Chemistry Letters2005，15，： | 1 |
| 8 | Facile synthesis of p-tert-butylthia-calixarene by the reaction of p-tert-butylphenol with elemental sulfur in the presence of a base显示文摘 | Mitsuharu Hasegawa Setsuko Miyanari | 1997 | Tetrahedron Lett1997，38，22： | 1 |
| 9 | Hydrodynamics of a spouted bed with a porous draft tube containing a small amount of finer particles 显示文摘 | Toshifumi Ishikura Hiroshi Nagashima Mitsuharu Ide | 2003 | Powder Technology2003，131，1： | 1 |
| 10 | Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma显示文摘 | Takanao Sueyoshi Hirofumi Jono Satoru Shinriki Kazutoshi Ota Tomoko Ota Masayoshi Tasaki Eri Atsuyama Toshitake Yakushiji Mitsuharu Ueda Konen Obayashi Hiroshi Mizuta Yukio Ando | 2011 | Cancer Letters2011，，1： | 1 |
| 11 | Material design concept for Fe-substituted Li 2 MnO 3 -based positive electrodes显示文摘 | Mitsuharu Tabuchi Yoko Nabeshima Kazuaki Ado Masahiro Shikano Hiroyuki Kageyama Kuniaki Tatsumi | 2007 | Journal of Power Sources2007，，2： | 1 |
| 12 | The interferon system and interferon regulatory factor transcription factors – studies from gene knockout mice显示文摘 | Mitsuharu Sato Tadatsugu Taniguchi Nobuyuki Tanaka | 2001 | Cytokine and Growth Factor Reviews2001，，： | 1 |
| 13 | Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis显示文摘 | Mitsuharu Hanada Akemi Baba Yasuyuki Tsutsumishita Toshihiro Noguchi Takashi Yamaoka Nobuyoshi Chiba Fumio Nishikaku | 2009 | Cancer Chemotherapy and Pharmacology2009，，3： | 1 |
| 14 | Transmural dispersion of repolarization and ventricular tachyarrhythmias显示文摘 | Norikazu Watanabe Youichi Kobayashi Kaoru Tanno Fumito Miyoshi Taku Asano Mitsuharu Kawamura Yoshino Mikami Tarou Adachi Syunsyou Ryu Akira Miyata Takashi Katagiri | 2004 | Journal of Electrocardiology2004，，3： | 1 |
| 15 | Significancer of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung显示文摘 | Hiroshi H Yuichi O Mitsuharu S | | 0，，： | 1 |
| 16 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 1 |
| 17 | Transient Receptor Potential Channel A1 Involved in Sensory Transduction of Rat Urinary Bladder Through C-Fiber Pathway 显示文摘 | Shuqi Du Isao Araki Mitsuharu Yoshiyama | 2007 | Urology2007，70，4： | 1 |
| 18 | Successful treatment of a hepatic abscess that formed secondary to fish bone penetration by percutaneous transhepatic removal of the foreign body: Report of a case显示文摘 | Katsuhiko Horii Osamu Yamazaki Mitsuharu Matsuyama Ikko Higaki Shuichi Kawai Yoshihiro Sakaue | 1999 | Surgery Today1999，，9： | 1 |
| 19 | Global bifurcation result for the p-biharmonic operator 显示文摘 | Pavel Drcibek Mitsuharu tani | 2001 | Electronic Journal of Differential Equations2001，48，： | 1 |
| 20 | CFD simulation of mixing in anaerobic digesters显示文摘 | Mitsuharu Terashima Rajeev Goel Kazuya Komatsu | 2009 | Bioresource Technology2009，100，7： | 1 |
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