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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Thalidomide induces mucosal healing in Crohn's disease: Case report显示文摘Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract that is defi ned by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn's disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn's disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximabafter three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response. | Márcio Rios Leite Sandra Sousa Santos André Castro Lyra Jaciane Mota Genoile Oliveira Santana | 2011 | World Journal of Gastroenterology2011，17，45： | 9 |
| 3 | Application of the photo-Fenton process to the treatment of wastewaters contaminated with diesel显示文摘 | Galvao Sara Amelia O Mota Andre L N Silva Douglas N | 2006 | Science of the Total Environment2006，367，： | 1 |
| 4 | Evaluation of normality and reproducibility parameters of scintigraphy with 99m Tc-MAA in the diagnosis of intrapulmonary vascular dilatations显示文摘 | Andréa Simone Siqueira Queirós Simone Cristina Soares Brand?o Liana Gon?alves Macedo Maira Souto Ourem Vitor Gomes Mota Luiz Arthur Calheiros Leite Edmundo Pessoa Almeida Lopes Ana Lúcia Coutinho Domingues | 2015 | Annals of Nuclear Medicine2015，，1： | 1 |
| 5 | Application of the photo-Fenton process to the treatment ofwastewaters contaminated with diesel显示文摘 | GALVO SARA AMLIA O MOTA ANDRL N SILVA DOUGLAS N | 2006 | Science of the Total Environ-ment2006，367，： | 1 |
| 6 | Reliability analysis of low-cost, full-scale domestic wastewater treatment plants for reuse in aquaculture and agriculture显示文摘 | Michael P. Alderson André B. dos Santos Cesar R. Mota Filho | 2015 | Ecological Engineering2015，，： | 1 |
| 7 | Gastric adenocarcinoma and Helicobacter pylori:Correlation with p53 mutation and p27 immunoexpression显示文摘 | André AR Ferreira MV Mota RM | 2010 | Cancer Epidemiol2010，34，5： | 1 |
| 8 | A Comparison between LAN and GPIB Instrument Interfaces in aAutomated Test System 显示文摘 | Leite Bruno Mota Andre | 2007 | ICEMI2007，，1： | 1 |
| 9 | Visualization of Power System Restoration Plans Using CPM/PERT Graphs 显示文摘 | Aiexandre Assis Mota Lia Toledo Moretra Mota Andre Morelato | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 10 | Gastric adenocarci- noma and Helicobacterpylori:correlation with p53 mutation and p27 immunoexpression显示文摘 | Andre AR Ferreira MV Mota RM et a/ | 2010 | Cancer Epidemiol2010，34，5： | 1 |
| 11 | Dengue in renal transplant recipients: Clinical course and impact on renal function显示文摘AIM To present clinical characteristics from renal transplant recipients with dengue fever and its impact on graft function.METHODS We retrospectively evaluated 11 renal transplant recipients(RTR) with dengue infection confirmed by laboratory test, between January 2007 and July 2012, transplanted in the Renal Transplant Center of Walter Cantídio University Hospital from Federal University of Ceará. RESULTS Positive dengue serology(IgM) was found in all patients. The mean time between transplant and dengue infection was 43 mo. Fever was presented in all patients. Nine patients presented with classical dengue and two(18%) with dengue hemorrhagic fever. All cases had satisfactory evolution with complete recovery of the symptoms. The time for symptom resolution varied from 2 to 20 d, with an average of 9 d. An increase of creatinine after the infection was observed in three(27.2%) patients with no clinically impact on the kidney graft function. CONCLUSION RTR with dengue infection seems to have a clinical presentation and evolution similar to those seen in the general population, with no long-term damage to patient and to the graft. | Paula Frassinetti Castelo Branco Camur?a Fernandes Reed AndréSiqueira Evelyne Santana Gir?o Rainne AndréSiqueira Márcia Uchoa Mota Leyla Castelo Branco Fernandes Marques Silvana Cristina Albuquerque Andrade Wilson Mendes Barroso S?nia Leite Silva Bruno Gomes Rodrigues dos Santos Claúdia Maria Costa de Oliveira | 2017 | World Journal of Transplantation2017，7，1： | 0 |
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