|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats显示文摘Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar | 2015 | Neural Regeneration Research2015，10，1： | 4 |
| 2 | Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis显示文摘AIM:To investigate the efficacy of the digitally reinforced hematoxylin-eosin polarization(DRHEP)technique for detection of amyloidosis in rectal biopsies.METHODS:One hundred hematoxylin-eosin(HE)stained rectal biopsies with Congo-red(CR)-positive amyloid depositions and 50 control cases with CRnegative amyloid-mimicking areas were scanned blinded to the CR results for amyloid depositions under both bright and polarized light,and digitally photographed using the DRHEP technique,to accentuate the faint birefringence observed in HE slides under polarization.The results of DRHEP and HE evaluation were statistically correlated with CR polarization results with respect to presence and localization of amyloid deposits as well as amyloid types.RESULTS:Amyloid deposits showed yellowish-green birefringence by DRHEP,which allowed identification of amyloidosis in 41 HE-unsuspected cases(P=0.016),31 of which only had vascular deposits.True positivity was higher,and false negativity and positivity were lower by DRHEP,compared to evaluation by HE(69%,31%,and 0.8%vs 33%,67%,and 33%,respectively;P<0.0001).The sensitivity,specificity,accuracy,and positive and negative predictive values for DRHEP were69%,98%,78.6%,98.5%,and 61.25%,respectively.Reasons for DRHEP false negativity were presence of extensive background birefringence in 12 cases,absence of CR birefringent vessel in 3 cases,and missing of the tiny deposits in 9 cases,which could be improved by experience,especially in the latter case.No correlation was found between age,gender,sites of deposits,or amyloid types.CONCLUSION:The DRHEP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining,especially for cases with limited tissues for further analysis. | Basak Doganavsargil Gulruh Emiroglu Buberal Huseyin Toz Banu Sarsik Burcin Pehlivanoglu Murat Sezak Sait Sen | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 3 | Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties显示文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and-9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis. | Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat | 2014 | Neural Regeneration Research2014，9，21： | 2 |
| 4 | Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients显示文摘 | Yusuf Tavil Nihat Sen Hü seyin Yazici Murat Turfan Fatma Hizal Atiye ? engel Adnan Abaci | 2010 | Platelets2010，，5： | 1 |
| 5 | Amphiphilic beta-cyclodextrins modified on the primary face:synthesis, characterization, and evaluation of their potential as novel excipients in the preparation of nanocapsules显示文摘 | Erem Memisoglu Amelie Bochot Murat Sen | 2002 | J Pharm Sci2002，91，5： | 1 |
| 6 | Amphiphilic beta-cyclodextrins modified on the primary face: synthesis, characterization, and evaluation of their potential as novel excipients in the preparation of nano-capsules显示文摘 | Erem Memisoglu Amelie Bochot Murat Sen | 2002 | J Pharm Sci2002，91，5： | 1 |
| 7 | A Novel Application for Repair of Skin Defects of the Penis:Anterior Scrotal Artery Flap显示文摘 | Tonguc Isken Murat Onyedi Cenk Sen Hakki Izmirli | 2009 | Plast Reconstr Surg2009，124，1： | 1 |
| 8 | A statistical approach to classification of keratoconus显示文摘INTRODUCTION The front portion of the eye consists of a transparent layer called the cornea.The cornea is an important optical component for vision and plays a role in the specific refraction of the eye.The cornea normally has convexity but the amount of protrusion progressively increases in patients with keratoconus.In other words,the cornea prolapses forward.Keratoconus is a bilateral,typically asymmetric and non-inflammatory degeneration of the cornea caused by corneal protrusion as a result of progressive thinning of the corneal stroma.Corneal thinning generally occurs in the inferior,inferotemporal or central regions of the cornea^([1]).However,corneal thinning in the upper quadrants of | Murat Ucar Hasan Basri Cakmak Baha Sen | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 1 |
| 9 | Bifocal Compression-Distraction in the Acute Treatment of Grade III Open Tibia Fractures With Bone and Soft-Tissue Loss: A Report of 24 Cases显示文摘 | Cengiz Sen Mehmet Kocaoglu Levent Eralp Mahir Gulsen Murat Cinar | 2004 | Journal of Orthopaedic Trauma2004，，3： | 1 |
| 10 | Free-radical Complymerizations of N-phenyl Maleimide显示文摘 | Murat Sen | 1999 | Polymer1999，40，： | 1 |
| 11 | Clinical and prognostic significance of coagulation assays in lung cancer显示文摘 | Faruk Tas Leyla Kilic Murat Serilmez Serkan Keskin Fatma Sen Derya Duranyildiz | 2012 | Respiratory Medicine2012，，： | 1 |
| 12 | A new application for increasing breast projection in free-nipple-graft reduction mammaplasty显示文摘 | Tonguc Isken Cenk Sen Murat Onyedi | 2008 | Aesth Plast Surg2008，32，： | 1 |
| 13 | Ultraviolet-radiation-curing of an organically modified silicate-based material system with ep-oxy functionality,and the role of titanium显示文摘 | Mehmet Qopuroglu Murat Sen | 2012 | Radiation Physics and Chemistry2012，81，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员