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| 1 | In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy显示文摘In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial.Its corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests.Pure magnesium was used as control.The results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance.The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell viability.Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro.Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications. | WANG YongPing HE YaoHua ZHU ZhaoJin JIANG Yao ZHANG Jian NIU JiaLin MAO Lin YUAN GuangYin | 2012 | Chinese Science Bulletin2012，57，17： | 8 |
| 2 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Biocompatibility of Mg-Nd-Zn-Zr alloy with rabbit blood显示文摘In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr (JDBM) alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy (P>0.05). Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility. | WANG YongPing OUYANG YuanMing HE YaoHua CHEN DaoYun JIANG Yao MAO Lin NIU JiaLin ZHANG Jian YUAN GuangYin | 2013 | Chinese Science Bulletin2013，58，23： | 2 |
| 4 | Effects of cyclic extrusion and compression parameters on microstructure and mechanical properties of Mg–1.50Zn–0.25Gd alloy显示文摘 | Hua Huang Zibo Tang Yuan Tian Gaozhi Jia Jialin Niu Hua Zhang Jia Pei Guangyin Yuan Wenjiang Ding | 2015 | Materials & Design2015，，： | 1 |
| 5 | Biocorrosion properties of as-extruded Mg–Nd–Zn–Zr alloy compared with commercial AZ31 and WE43 alloys显示文摘 | Xiaobo Zhang Guangyin Yuan Lin Mao Jialin Niu Wenjiang Ding | 2011 | Materials Letters2011，，1： | 1 |
| 6 | Geometrical design of variable ratio tooth profile based on Boolean subtraction operation and a novel modification method显示文摘Variable transmission ratio racks show great potential in rice transplanters as a key component of variable transmission ratio steering to balance steering portability and sensitivity.The objective of this study was to develop a novel geometrical design method to achieve quick,high-quality modeling of the free curvilinear tooth profile of a variable transmission ratio rack.First,a discrete envelope motion 3D model was established between the pinion-sector and the variable transmission ratio rack blank based on the mapping relationship between the rotation angle of the pinion-sector and the displacement of the rack,according to the variable transmission ratio function.Based on the loop Boolean subtraction operation,which removed the pinion-sector from the rack blank during all moments of the discrete motion process,the final complex changing tooth shape of the variable transmission ratio rack was enveloped.Then,since Boolean cutting residues made the variable ratio tooth surface fluctuant and eventually affected the precision of the model,this study proposed a modification method for establishing a smooth and continuous tooth profile.First,a novel fitting algorithm used approximate variable ratio tooth profile points extracted from the Boolean cutting marks and generated a series of variable ratio tooth profiles by utilizing B-spline with different orders.Next,based on a transmission stability simulation,the variable ratio tooth profile with optimal dynamic performance was selected as the final design.Finally,tests contrasting the transmission stability of the machining samples of the initial variable ratio tooth profile and the final variable ratio tooth profile were conducted.The results indicated that the final variable ratio tooth profile is more effective than the initial variable ratio tooth profile.Therefore,the proposed variable ratio tooth profile modeling and modification method for eliminating Boolean cutting residues and improving surface accuracy is proved to be feasible. | Ziru Niu Jianlei Li Shuai Xin Liangliang Zou Yuhua Li Jialin Hou Ming Tu Ting Sun | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 7 | Comparison of biodegradable behaviors of AZ31 and Mg–Nd–Zn–Zr alloys in Hank’s physiological solution显示文摘 | Yang Zong Guangyin Yuan Xiaobo Zhang Lin Mao Jialin Niu Wenjiang Ding | 2012 | Materials Science & Engineering B2012，，5： | 1 |
| 8 | Design and Optimization of Planting Process Parameters for 2ZYX-2 Type Green Onion Ditching and Transplanting Machine显示文摘Considering the current low level of mechanization for domestic green onion planting and the high labor intensity of artificial planting,a 2ZYX-2 green onion ditching and transplanting machine,which can complete ditching,ridging,transplanting,repression,soil covering and other operations,is designed in this study.The Central Composite test design method was carried out with the speed of the transplanting machine,the depth of the opener and the horizontal position of the opener as the experimental factors and with the qualification ratio of perpendicularity,the variation coefficient of the plant spacing and the qualification ratio of the planting depth as the test index.Through the analysis of the model interaction and response surface,the change laws that the influence the machine’s forward speed,the depth of the opener and the horizontal position of the opener were studied.The regression model was optimized by Design-Expert 8.0.6 software,and the accuracy of the predicted results was verified by experiments.The optimal working parameters showed that the forward speed of the machine was 0.06 m/s,the depth of the opener was 102 mm,and the horizontal position of the opener was 29 mm.Under conditions of optimal working parameters,the qualification rate of the verticality was 86.83%,the coefficient of variation for the plant spacing was 2.77,and the pass rate of planting depth was 88.26%.The research related to the thesis can provide a reference for the mechanized planting of green onion,which is of great significance to the cost-effectiveness of the green onion industry. | Jiqiang Zhang Ziru Niu Tianhua Li Yanqiang Wu Rui Xi Yuhua Li Guanghua Li Jialin Hou | 2020 | Phyton-International Journal of Experimental Botany2020，89，1： | 0 |
| 9 | A general synthesis of inorganic nanotubes as high-rate anode materials of sodium ion batteries显示文摘Ino rganic tubular materials have an exceptionally wide range of applications,yet developing a simple and universal method to controllably synthesize them remains challenging.In this work,we report a vaporphase-etching hard-template method that can directly fabricate tubes on various thermally stable oxide and sulfide materials.This synthesis method features the introduction of a vapor-phase-etching process to greatly simplify the steps involved in preparing tubular materials and avoids complicated postprocessing procedures.Furthermore,the in-situ heating transmission electron microscopy(TEM)technique is used to observe the dynamic formation process of TiO_(2-x) tubes,indicating that the removal process of the Sb2S3 templates first experienced the Rayleigh instability,then vapor-phase-etching process.When used as an anode for sodium ion batteries,the TiO_(2-x) tube exhibits excellent rate performance of134.6 mA h g^(-1) at the high current density of 10 A g^(-1) and long-term cycling over 7000 cycles.Moreover,the full cell demonstrates excellent cycling performance with capacity retention of 98%after 1000 cycles,indicating that it is a promising anode material for batteries.This method can be expanded to the design and synthesis of other thermally-stable tubular materials such as ZnS,MoS_(2),and SiO_(2). | Chunting Wang Ningyan Cheng Zhongchao Bai Qinfen Gu Feier Niu Xun Xu Jialin Zhang Nana Wang Binghui Ge Jian Yang Yitai Qian Shixue Dou | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 10 | Research and development strategy for biodegradable magnesium-based vascular stents:a review显示文摘Magnesium alloys are an ideal material for biodegradable vascular stents,which can be completely absorbed in the human body,and have good biosafety and mechanical properties.However,the rapid corrosion rate and excessive localized corrosion,as well as challenges in the preparation and processing of microtubes for stents,are restricting the clinical application of magnesium-based vascular stents.In the present work we will give an overview of the recent progresses on biodegradable magnesium based vascular stents including magnesium alloy design,high-precision microtubes processing,stent shape optimisation and functional coating preparation.In particular,the Triune Principle in biodegradable magnesium alloy design is proposed based on our research experience,which requires three key aspects to be considered when designing new biodegradable magnesium alloys for vascular stents application,i.e.biocompatibility and biosafety,mechanical properties,and biodegradation.This review hopes to inspire the future studies on the design and development of biodegradable magnesium alloy-based vascular stents. | Jialin Niu Hua Huang Jia Pei Zhaohui Jin Shaokang Guan Guangyin Yuan | 2021 | Biomaterials Translational2021，2，3： | 0 |
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