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| 1 | The Phenotypic Characterization of Naturally Occurring Regulatory CD4^+CD25^+T Cells显示文摘免疫系统的动态平衡取决于在对自我抗原的对入侵的病原体和有免疫力的忍耐的有免疫力的反应之间的平衡。中央、外部的忍耐是为 T 房间忍耐的正式就职和维护的重要机制。最近,许多注意对规章的 T 房间(Treg ) 被给予了,它在维持外部有免疫力的忍耐起一个重要作用。到目前为止,关于 Treg 房间的表面标记没有令人满意的进展,因为任何一个都不为 Treg 房间是唯一的。在这评论,我们总结在自然地发生的CD4+CD25+ Treg 房间( nTreg )表示的一些重要分子,包括 forkhead/winged-helix 家庭 transcriptional 抑压者 p3 ( Foxp3 ),肿瘤坏死因素受体( TNFR )家庭, CD28/CTLA4 分子, chemokine 受体,像使用费的受体( TLR ), membranebound TGF-和其它分子例如 neuropilin-1 ,淋巴细胞激活 gene-3 (落后) -3 和 granzyme.This 评论在 nTreg | Huanfa Yi Yu Zhen Lingling Jiang Jialin Zheng Yong Zhao | 2006 | Cellular & Molecular Immunology2006，3，3： | 31 |
| 2 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 3 | Innovative backfilling longwall panel layout for better subsidence control effect-separating adjacent subcritical panels with pillars显示文摘In recent years,field trials of non-pillar longwall mining using complete backfill have been implemented successively in the Chinese coal mining industry.The objective of this paper is to get a scientific understanding of surface subsidence control effect using such techniques.It begins with a brief overview on complete backfill methods primarily used in China,followed by an analysis of collected subsidence factors under mining with complete backfill.It is concluded that non-pillar longwall panel layout cannot protect surface structures against damages at a relatively large mining height,even though complete backfill is conducted.In such cases,separated longwall panel layout should be applied,i.e.,panel width should be subcritical and stable coal pillars should be left between the adjacent panels.The proposed method takes the principles of subcritical extraction and partial extraction;in conjunction with gob backfilling,surface subsidence can be effectively mitigated,thus protecting surface buildings against mining-induced damage.A general design principle and method of separated panel layout have also been proposed. | Jialin Xu Dayang Xuan Changchun He | 2014 | International Journal of Coal Science & Technology2014，1，3： | 21 |
| 4 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 5 | Late Mesoarchean crust growth event: evidence from the ca. 2.8 Ga granodioritic gneisses of the Xiaoqinling area, southern North China Craton显示文摘Recently, more attention has been paid to Precambrian magma events and crustal growth of the North China Craton(NCC), accompanying with controversy in activity stages and dynamic mechanism. In this study, we report the Archean(2802 ± 13 Ma) granodioritic gneisses in the Taihua Complex from the Xiaoqinling area, located in the southern margin of the NCC. The zircon Lu–Hf isotope analysis of the rocks showed ^(176)Hf/^(177)Hf ratios of0.280977–0.281228, corresponding to ε_(Hf)(t) values ranging from-3.5 to +6.6, and two–stage Hf model ages varying from 2836 to 3409 Ma. It was confirmed that late Mesoarchean(2.9–2.8 Ga) juvenile crust made contribution to the source material of these ca. 2.8 Ga granodioritic gneisses in the Xiaoqinling area. The whole rock geochemical data indicate that the granodioritic gneisses are high-K calc-alkaline series, probably generated at relatively high pressure and temperature, and formed under the continental arc setting. Statistically, we conclude that the magmatic activities during 2.9–2.7 Ga may represent the most intense crustal growth events in the NCC and these Archean rocks at different locations in southern NCC underwent a similar crustal evolution history. | Xiaoliang Jia Xiyan Zhu Mingguo Zhai Yan Zhao Hong Zhang Jialin Wu Tao Liu | 2016 | Science Bulletin2016，61，12： | 16 |
| 6 | Spatio-temporal patterns of satellite-derived grassland vegetation phenology from 1998 to 2012 in Inner Mongolia, China显示文摘Spatio-temporal variations of vegetation phenology, e.g. start of green-up season(SOS) and end of vegetation season(EOS), serve as important indicators of ecosystems. Routinely processed products from remotely sensed imagery, such as the normalized difference vegetation index(NDVI), can be used to map such variations. A remote sensing approach to tracing vegetation phenology was demonstrated here in application to the Inner Mongolia grassland, China. SOS and EOS mapping at regional and vegetation type(meadow steppe, typical steppe, desert steppe and steppe desert) levels using SPOT-VGT NDVI series allows new insights into the grassland ecosystem. The spatial and temporal variability of SOS and EOS during 1998–2012 was highlighted and presented, as were SOS and EOS responses to the monthly climatic fluctuations. Results indicated that SOS and EOS did not exhibit consistent shifts at either regional or vegetation type level; the one exception was the steppe desert, the least productive vegetation cover, which exhibited a progressive earlier SOS and later EOS. Monthly average temperature and precipitation in preseason(February, March and April) imposed most remarkable and negative effects on SOS(except for the non-significant impact of precipitation on that of the meadow steppe), while the climate impact on EOS was found to vary considerably between the vegetation types. Results showed that the spatio-temporal variability of the vegetation phenology of the meadow steppe, typical steppe and desert steppe could be reflected by the monthly thermal and hydrological factors but the progressive earlier SOS and later EOS of the highly degraded steppe desert might be accounted for by non-climate factors only, suggesting that the vegetation growing period in the highly degraded areas of the grassland could be extended possibly by human interventions. | SHA Zongyao ZHONG Jialin BAI Yongfei TAN Xicheng Jonathan LI | 2016 | Journal of Arid Land2016，8，3： | 13 |
| 7 | The texture and its optimization in magnesium alloy显示文摘The crystallographic orientations are generally non-random in wrought Mg alloy,which will lead to their macroscopic physical properties to be anisotropic.Understanding the texture evolution in processing of Mg alloy billets and its effect on mechanical properties is therefore an important project for all scientists and engineers in material area.This paper is concerned with the description of texture,with the mechanisms of texture evolution and with the interrelationships between texture and mechanical properties in Mg alloy.It is a full review of understanding of the basic mechanism on texture evolution,of texture altering by alloying or processing,and of the mechanism of texture weakening.Moreover,it provides theories necessary and available techniques to develop high-performance Mg wrought with optimized texture in the field. | Jialin Wu Li Jin Jie Dong Fenghua Wang Shuai Dong | 2020 | Journal of Materials Science & Technology2020，42，7： | 13 |
| 8 | Simulation research on the influence of eroded primary key strata on dynamic strata pressure of shallow coal seams in gully terrain显示文摘In Huojitu Coal Mine of Shendong mining area, the dynamic strata pressure (DSP) accidents occurred when the working faces passed the gully terrain. Focusing on this problem, we used physical simulation experimental method to thoroughly study the influence of eroded overlying primary key strata (PKS) in the gully terrain on DSP of shallow coal seams in this paper. The result show that when mining activities took place in the uphill section of shallow coal seams in gully terrain and the PKS were eroded, the blocks could not form stable bond-beam structures since the horizontal force of PKS blocks in adjacent sloping surfaces were relatively small. The sliding instability of blocks caused rapid increase of the load on the sub-key strata (SKS) blocks, which resulted into coal slide and roof fall as well as sharp drop of active columns. This led to DSP phenomenon. When the PKS blocks were intact, there was no DSP phenomenon to enable blocks provide certain horizontal force to maintain stable bond-beam structure. The simulation results were verified by the mining practices of working face 21306 crossing the gully terrain in the Huojitu Coal Mine. | Zhang Zhiqiang Xu Jialin Zhu Weibing Shan Zhenjun | 2012 | International Journal of Mining Science and Technology2012，22，1： | 12 |
| 9 | Geochronological Framework and Geodynamic Implications of Mafic Magmatism in the Liaodong Peninsula and Adjacent Regions,North China Craton显示文摘Mafic rocks are widespread on the Liaodong Peninsula and adjacent regions of the North China Craton.The majority of this magmatism was originally thought to have occurred during the Pre-Sinian,although the precise geochronological framework of this magmatism was unclear.Here,we present the results of more than 60 U-Pb analyses of samples performed over the past decade,with the aim of determining the spatial and temporal distribution of mafic magmatism in this area.These data indicate that Paleoproterozoic-Mesoproterozoic mafic rocks are not as widely distributed as previously thought.The combined geochronological data enabled the subdivision of the mafic magmatism into six episodes that occurred during the middle Paleoproterozoic,the late Paleoproterozoic,the Mesoproterozoic,the Late Triassic,the Middle Jurassic,and the Early Cretaceous.The middle Paleoproterozoic(2.1-2.2 Ga)mafic rocks formed in a subduction-related setting and were subsequently metamorphosed during a ca.1.9 Ga arc-continent collision event.The late Paleoproterozoic(ca.1.87-1.82 Ga)bimodal igneous rocks mark the end of a Paleoproterozoic tectonothermal event,whereas Mesoproterozoic mafic dike swarms record global-scale Mesoproterozoic rifting associated with the final breakup of the Columbia supercontinent.The Late Triassic mafic magmatism is part of a Late Triassic magmatic belt that was generated by post-collisional extension.The Middle Jurassic mafic dikes formed in a compressive tectonic setting,and the Early Cretaceous bimodal igneous rocks formed in an extensional setting similar to a back-arc basin.These latter two periods of magmatism were possibly related to subduction of the Paleo-Pacific plate. | LI Zhuang CHEN Bin WANG Jialin | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 12 |
| 10 | Late Mesozoic Ore-forming Events in the Ningwu Ore District, Middle-Lower Yangtze River Polymetallic Ore Belt, East China: Evidence from Zircon U-Pb Geochronology and Hf Isotopic Compositions of the Granodioritic Stocks显示文摘Late Mesozoic volcanic-subvolcanic rocks and related iron deposits, known as porphyry iron deposits in China, are widespread in the Ningwu ore district (Cretaceous basin) of the middle-lower Yangtze River polymetallic ore belt, East China. Two types of Late Mesozoic magmatic rocks are exposed: one is dioritic rocks closely related to iron mineralization as the hosted rock, and the other one is granodioritic (-granitic) rocks that cut the ore bodies. To understand the age of the iron mineralization and the ore-forming event, detailed zircon U-Pb dating and Hf isotope measurement were performed on granodioritic stocks in the Washan, Gaocun-Nanshan, Dongshan and Heshangqiao iron deposits in the basin. Four emplacement and crystallization (typically for zircons) ages of granodioritic rocks were measured as 126.1±0.5 Ma, 126.8±0.5 Ma, 127.3±0.5 Ma and 126.3±0.4 Ma, respectively in these four deposits, with the LA-MC-ICP-MS zircon U-Pb method. Based on the above results combined with previous dating, it is inferred that the iron deposits in the Ningwu Cretaceous basin occurred in a very short period of 131-127 Ma. In situ zircon Hf compositions of εHf(t) of the granodiorite are mainly from -3 to -8 and their corresponding 176Hf/177Hf ratio are from 0.28245 to 0.28265, indicating similar characteristics of dioritic rocks in the basin. We infer that granodioritic rocks occurring in the Ningwu ore district have an original relationship with dioritic rocks. These new results provide significant evidence for further study of this ore district so as to understand the ore-forming event in the study area. | DUAN Chao LI Yanhe HOU Kejun YUAN Shunda LIU Jialin ZHANG Cheng | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 11 |
| 11 | Gust response analysis and wind tunnel test for a high-aspect ratio wing显示文摘A theoretical nonlinear aeroelastic response analysis for a flexible high-aspect ratio wing excited by harmonic gust load is presented along with a companion wind tunnel test. A multidisciplinary coupled numerical calculation is developed to simulate the flexible model wing undergoing gust load in the time domain via discrete nonlinear finite element structural dynamic analysis and nonplanar unsteady vortex lattice aerodynamic computation. A dynamic perturbation analysis about a nonlinear static equilibrium is also used to determine the small perturbation flutter boundary. A novel noncontact 3-D camera measurement analysis system is firstly used in the wind tunnel test to obtain the spatial large deformation and responses. The responses of the flexible wing under different static equilibrium states and frequency gust loads are discussed. The fair to good quantitative agreements between the theoretical and experimental results demonstrate that the presented analysis method is an acceptable way to predict the geometrically nonlinear gust response for flexible wings. | Liu Yi Xie Changchuan Yang Chao Cheng Jialin | 2016 | Chinese Journal of Aeronautics2016，29，1： | 10 |
| 12 | Roof pre-blasting to prevent support crushing and water inrush accidents显示文摘Support crushing and water inrush when mining under an unconsolidated confined aquifer in the Qidong Coal Mine was prevented by roof pre-blasting. The mechanism and applicable conditions for this method have been studied. The results show that when an overburden structure that may cause support crushing and a water inrush accident exists the weakening of the primary key stratum, which thereby reduces its weighting step, roof pre-blasting is both feasible and effective. If the position of the primary key stratum can be moved upward to exceed 10 times the mining height the possibility of support crushing and water inrush disaster caused by key stratum compound breakage will be lowered. The overburden structure of the number 7121 working face was considered during the design of a technical proposal involving roof pre-blasting. After comprehensively analyzing the applicability of roof pre-blasting the resulting design prevented support crushing and water inrush disasters from happening at the number 7121 working face and laid a solid foundation for mining safely. | Wang Xiaozhen | 2012 | International Journal of Mining Science and Technology2012，22，3： | 10 |
| 13 | Optically pumped terahertz sources显示文摘High-power terahertz(THz) generation in the frequency range of 0.1-10 THz has been a fast-developing research area ever since the beginning of the THz boom two decades ago, enabling new technological breakthroughs in spectroscopy, communication, imaging,etc. By using optical(laser) pumping methods with near-or mid-infrared(IR) lasers, flexible and practical THz sources covering the whole THz range can be realized to overcome the shortage of electronic THz sources and now they are playing important roles in THz science and technology. This paper overviews various optically pumped THz sources, including femtosecond laser based ultrafast broadband THz generation, monochromatic widely tunable THz generation, single-mode on-chip THz source from photomixing, and the traditional powerful THz gas lasers. Full descriptions from basic principles to the latest progress are presented and their advantages and disadvantages are discussed as well. It is expected that this review gives a comprehensive reference to researchers in this area and additionally helps newcomers to quickly gain understanding of optically pumped THz sources. | ZHONG Kai SHI Wei XU DeGang LIU PengXiang WANG YuYe MEI JiaLin YAN Chao FU ShiJie YAO JianQuan | 2017 | Science China(Technological Sciences)2017，60，12： | 9 |
| 14 | Performance Evaluation of Two-Vector-Based Model Predictive Current Control of PMSM Drives显示文摘Conventional model predictive current control(MPCC)applies only one vector during one control period,which produces large torque and flux ripples and high current harmonics in permanent magnet synchronous motor(PMSM)drives.Recently MPCC with duty cycle control has been proposed to improve the steady state performance by applying one non-zero vector and one null vector during one control period.However,the prior method requires lots of calculations and predictions to find the optimal voltage vectors and calculate their respective duration.Different from prior enumeration-based MPCC,this paper proposes an efficient two-vector MPCC by applying two arbitrary voltage vectors during one control period.The reference voltage vector is firstly calculated based on the principle of deadbeat current control.Two optimal vectors and their duration are then obtained in a very efficient way,which does not require the calculation of current slopes in prior MPCC methods.The proposed method is compared to the state-of-the-art predictive control methods,including conventional MPCC,MPCC with duty cycle control,deadbeat control with space vector modulation(SVM)and modulated model predictive control(M2PC).Both simulation and experimental results prove that the proposed method achieves better steady state performance than conventional MPCC with or without duty cycle and the dynamic response is not degraded.Under the condition of insufficient dc bus voltage,the proposed method outperforms deadbeat control and M2PC by presenting even higher speed range and less torque ripples. | Yongchang Zhang Lanlan Huang Donglin Xu Jiali Liu Jialin Jin | 2018 | Chinese Journal of Electrical Engineering2018，4，2： | 9 |
| 15 | A Review on Binderless Tungsten Carbide: Development and Application显示文摘WC-Co alloys have enjoyed great practical significance owing to their excellent properties during the past decades.Despite the advantages,however,recently there have been concerns about the challenges associated with the use of Co,i.e.price instability,toxicity and properties degeneration,which necessitates the fabrication of binderless tungsten carbide(BTC).On the other hand,BTC or BTC composites,none of them,to date has been commercialized and produced on an industrial scale,but only used to a limited extent for specialized applications,such as mechanical seals undergoing high burthen as well as high temperature electrical contacts.There are two challenges in developing BTC:fully densifying the sintered body together with achieving a high toughness.Thus,this review applies towards comprehensively summarize the current knowledge of sintering behavior,microstructure,and mechanical properties of BTC,highlighting the densification improving strategies as well as toughening methods,so as to provide reference for those who would like to enhance the performance of BTC with better reliability advancing them to further wide applications and prepare the material in a way that is environment friendly,harmless to human health and low in production cost.This paper shows that the fabrication of highly dense and high-performance BTC is economically and technically feasible.The properties of BTC can be tailored by judiciously selecting the chemical composition coupled with taking into careful account the effects of processing techniques and parameters. | Jialin Sun Jun Zhao Zhifu Huang Ke Yan Xuehui Shen Jiandong Xing Yimin Gao Yongxin Jian Hejie Yang Bo Li | 2020 | Nano-Micro Letters2020，12，1： | 8 |
| 16 | Effects of size variation and spatial structure on plastic response of plant height to light competition显示文摘Plants only interact with neighbors over restricted distances,so local conditions are of great significance for plants.In this study,a spatially-explicit,individual-based model was constructed to explore the effects of size variation and spatial structure on adaptive plasticity of plant height in response to light competition.In the model a plant maintains its height at an optimal value in order to maximize its growth rate,and this optimal height increases with the increase of the intensity of light competition experienced by the individual plant.When the spatial pattern of the population is non-uniform or there is size variation among individual plants,the height growth curves of individuals different from each other vary due to the differences in the local light environment,and there is also variation in the allocation of photosynthate to height growth among the individual plants.There is no ESS height or height growth strategy on which all plants will converge.Our results indicate that the plasticity of plants' height growth reactions to the light competition should be considered at the individual level and they argue strongly for the importance of the spatial pattern and neighborhood effects in generating the diversity of heights and height growth strategies in plant population. | CHEN ShuYan ZHANG JiaLin JIA Peng XU Jin WANG Gang XIAO Sa | 2010 | Chinese Science Bulletin2010，55，12： | 8 |
| 17 | Impending HRT wave precursors to the Wenchuan M_s8.0 earthquake and methods of earthquake impending prediction by using HRT wave显示文摘We deployed four geo-electric monitoring stations in Sichuan and Yunnan provinces from 2004, using the new generation of equipment (PS-100) and technologies to capture the HRT wave earthquake precursor. Before the Wenchuan Ms8.0 earthquake, we recorded the HRT wave precursor at the only operating station in Hongge (HG, Δ=465 km) and found that significant impending signal had been recorded at the station in the early morning ( 0―5 am) of 12th of May, 2008. The precursor for this earthquake is consistent with precursors recorded for other strong earthquakes. The measured physical properties (geo-resistivity and telluric-current) show tidal wave period oscillations from several days to several months before the earthquakes and the amplitude of such HT oscillation increases significantly towards the occurrence of an earthquake. These HT and RT waves from the epicenter have a causal relationship with the earthquakes that happened several days later. The arrival time of two RT waves is proportional to the distance from the station to the epicenter. The estimated natural decay of the amplitude is correlated with the natural period (T0) of the earthquake fault, which is proportional to the fault length. From this relationship, we can predict the earthquake magnitude. For magnitude 6―9 earthquakes, the natural period is about 1―6 hours. Such oscillation comes from the epicenter area and they can propagate several thousand kilometers in the Earth's crust. Before a strong earthquake in the shallow crust, the conductive pore fluid will experience major changes before the fault rapture. Such fluid change will emit an oscillation in the pore fluid pressure. This is the mechanism for the HRT wave generation. Since the China Earthquake Administration funded the HRT wave short-term earth-quake prediction project in 2003, the first record of HRT precursor wave has been recorded from the 2004-12-26 Sumatra Mw9.0 earthquake with the largest epicentre distance Δ=2900 km. Thereafter, we have captured HRT waves from more than twenty strong earthquakes, which are well-matched and show repeatability, consistency and regularity. All our observation with the HRT waves demonstrate that HRT wave precursors to earthquakes indeed exist. Strong earthquakes can be predicted and short-term and impending earthquake prediction is achievable in the very near future. From all the observations, including the ones at HG station from Wenchuan Ms8.0 earthquake, we conclude that using HRT wave to predict earthquakes is feasible. | QIAN FuYe ZHAO BiRu QIAN Wei ZHAO Jian HE ShiGen ZHANG HongKui LI ShiYu LI ShaoKun YAN GuLiang WANG ChengMin SUN ZhenKai ZHANG DongNing LU Jun ZHANG Ping YANG GuoJun SUN JiaLin GUO ChunSheng TANG YuXiong XU JianMing XIA KunTao JU Hang YIN BangHong LI Ming YANG DongSheng QI WeiLuo HE TaiMing GUAN HuaPing ZHAO YuLin | 2009 | Science China Earth Sciences2009，52，10： | 8 |
| 18 | Longwall surface subsidence control by technology of isolated overburden grout injection显示文摘Surface subsidence is a typical ground movement due to longwall mining, which causes a series of environmental problems and hazards. In China, intensive coal extractions are commonly operated under dense-populated coalfields, which exacerbates the negative subsequences resulted from surface settlement. Therefore, effective approaches to control the ground subsidence are in urgent need for the Chinese coal mining industry. This paper presents a newly developed subsidence control technology: isolated overburden grout injection, including the theory, technique and applications. Relevant procedures such as injection system design, grouting material selection, borehole layout, grout take estimation and injection process design are proposed. The applicability of this technology has been demonstrated through physical modelling, field measurements, and case studies. Since 2009, the technology has been successfully applied to 14 longwall areas in 9 Chinese coal mines. The ultimate surface subsidence factors vary from 0.10 to 0.15. This method has a great potential to be popularized and performed where longwall mining are implemented under villages and ground infrastructures. | Xuan Dayang Xu Jialin | 2017 | International Journal of Mining Science and Technology2017，27，5： | 8 |
| 19 | In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy显示文摘In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial.Its corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests.Pure magnesium was used as control.The results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance.The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell viability.Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro.Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications. | WANG YongPing HE YaoHua ZHU ZhaoJin JIANG Yao ZHANG Jian NIU JiaLin MAO Lin YUAN GuangYin | 2012 | Chinese Science Bulletin2012，57，17： | 8 |
| 20 | FOXO3a Inhibits TNF-α-and IL-1β-Induced Astrocyte Proliferation:Implication for Reactive Astrogliosis显示文摘反应性星形胶质细胞增生是神经退行性疾病的特征性病理性改变之一。炎性细胞因子,如TNF-α和IL-1β,已被证实在神经退行性疾病中介导反应性星形胶质细胞增生,尽管其分子机制仍不清楚。本研究探讨严重反应性星形胶质细胞增生的一个主要方面——转录因子FOXO3a在星形胶质细胞增生中的作用。本研究通过Ki67和BrdU免疫染色证实TNF-α和IL-1β促进星形胶质细胞增生。本研究进一步发现细胞因子介导的星形胶质细胞增生伴有FOXO3a磷酸化的增加和核表达的下降。颅内注射TNF-α和IL-1β导致星形胶质细胞增生和肥大,这与星形胶质细胞中的Foxo3a核表达下降有关。为了确定Foxo3a在星形胶质细胞增生中的作用,在腺病毒中过表达野生型Foxo3a,引起p27Kip1及Gadd45α上调,且显著抑制细胞因子介导的星形胶质细胞增生。与之相反,负显性型FOXO3a的过表达使p27Kip1降低,下调Cyclin D1,促进星形胶质细胞增生。同样,Foxo3a敲除小鼠中分离的星形胶质细胞表现出更高的增生趋势。颅内注射细胞因子后,Foxo3a敲除小鼠在体内表现出严重的星形胶质细胞增生。综上所述,FOXO3a在促炎因子刺激时对于遏制星形胶质细胞增生发挥重要作用,FOXO3a功能的缺失可能是严重反应性星形胶质细胞增生中星形胶质细胞增生的原因。了解FOXO3a在反应性星形胶质细胞增生中的关键调节作用可能为神经炎症提供一个新的治疗靶点。 | MIN CUI YUNLONG HUANG CHANGHAI TIAN YONG ZHAO AND JIALIN ZHENG | 2011 | 神经损伤与功能重建2011，6，3： | 8 |
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