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| 1 | Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction显示文摘Objective To investigate whether recuperating lung decoction(RLD) can modulate the composition of gut microbiota in rats during asthma treatment.Methods Fifteen Sprague-Dawley rats were divided randomly and equally into control group,model group,dexamethasone(DEX) group,RLD medium-dose group,and RLD high-dose group.The asthma model was established in all groups,except for the control group.The rats in the DEX and RLD groups were treated orally with DEX and RLD,respectively.The rats in the control and model groups were treated orally with 0.9% saline.The intestinal bacterial communities were compared among groups using 16 S r RNA gene amplification and 454 pyrosequencing.Results The microbial flora differed between the control and model groups,but the flora in the RLD groups was similar to that in the control group.No significant differences were observed between the RLD high-dose and medium-dose groups.RLD treatment resulted in an increase in the level beneficial bacteria in the gut,such as Lactobacillus and Bifidobacterium spp.Conclusion Oral administration of RLD increased the number of intestinal lactic acid-producing bacteria,such as Lactobacillus and Bifidobacterium,in asthma model rats. | KONG Yan Hua SHI Qi HAN Na ZHANG Ling ZHANG Yuan Yuan GAO Tong Xin CHEN Chen LI You Lin | 2016 | Biomedical and Environmental Sciences2016，29，8： | 9 |
| 2 | Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma显示文摘AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative intent at our hospital.We evaluated preoperative prognostic factors associated with histologic grade of tumor,recurrence and survival,especially the findings of pre-operative imaging studies such as positron emission tomography-computed tomography(PETCT)and magnetic resonance imaging(MRI).And then,we established a scoring system to predict recurrence and survival after surgery dividing the patients into two groups based on a tumor size of 5 cm.RESULTS:Of the 298 patients,129(43.3%)developed recurrence during the follow-up period.The 5 year disease free survival and overall survival were 47.0%and58.7%respectively.In multivariate analysis,a serum alpha-fetoprotein(AFP)level of>100 ng/m L and a standardized uptake value(SUV)of PET-CT of>3.5 were predictive factors for histologic grade of tumor,recurrence,and survival.Tumor size of>5 cm and a relative enhancement ratio(RER)calculated from preoperative MRI were also significantly associated with prognosis in univariate analysis.We established a scoring system to predict prognosis using AFP,SUV,and RER.In those with tumors of>5 cm,it showed predicted both recurrence(P=0.005)and survival(P=0.001).CONCLUSION:The AFP,tumor size,SUV and RER are useful for prognosis preoperatively.An accurate prediction of prognosis is possible using our scoring system in large size tumors. | Jae Hyun Han Dong Goo Kim Gun Hyung Na Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You | 2014 | World Journal of Gastroenterology2014，20，45： | 8 |
| 3 | Range ambiguity resolving of HPRF radar based on hybrid filter显示文摘In this paper,a novel method of range ambiguity resolving based on hybrid filter is proposed for high-pulse repetition frequency (HPRF) radars.By considering the discrete-valued pulse interval number (PIN) which is described as the radial range of the target divided by the maximum unambiguous range for a certain HPRF and its incremental variable as target states,the problem of range ambiguity resolving is converted to the hybrid state estimation problem.In the initial time steps,since the range measurement is ambiguous,the hybrid state initialization is achieved by utilizing multiple HPRFs based on Euclidean distance.Then,to avoid the choice of the thresholds,the hybrid model based on six-dimension state vector is made equivalent to several hybrid models based on five-dimension state vector according to the values that PIN incremental variable may take.The hybrid estimation is achieved by comparing 2-norm of the innovations obtained from several hybrid filters.Simulation results demonstrate that the proposed method can converge more rapidly than the existing multiple hypothesis method when only one HPRF has target measurement and overcome the mistake that multiple hypothesis method makes when PIN varies. | WANG Na WANG GuoHong ZENG JiaYou HE You | 2011 | Science China(Information Sciences)2011，54，7： | 8 |
| 4 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 5 | Forecasting promising technology using analysis of patent information:Focused on next generation mobile communications显示文摘In order to forecast promising technologies in the field of next generation mobile communication, various patent indicators were analyzed such as citation per patent, patent family information, patent share, increase rate, and patent activity. These indicators were quantified into several indexes and then integrated into an evaluation score to provide promising technologies. As a result of the suggested patent analysis, four technologies out of twenty two in details classification were selected, which showed outstanding technology competitiveness, high patent share and increasing rates as well as high recent-patent-ratios and triad-patent-family-ratios. Each of the selected technologies scored more than 10 points in total, and the following four technologies were suggested as promising ones in the field of next generation mobile communication: 1) 3GPP based mobile communication, 2) beyond 4G mobile communication, 3) IEEE 802.16 based mobile communication, which are in medium classification of broadband mobile communication system, and 4) testing/certification system of mobile communication, which is in medium classification of mobile communication testing/certification system. | CHOI Seung-Wook YOU Yen-Yoo NA Kwan-Sik | 2014 | Journal of Central South University2014，21，11： | 8 |
| 6 | Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation显示文摘AIM:To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma(HCC)patients in living-donor liver transplantation(LDLT).METHODS:From October 2000 to November 2011,224 patients who underwent living donor liver transplantation for HCC at our institution were enrolled in this study.We analyzed disease-free survival(DFS)and overall survival(OS)after LT in patients with HCC and designed a new score model using pretransplant neutrophil-lymphocyte ratio(NLR)and C-reactive protein(CRP).RESULTS:The DFS and OS in patients with an NLR level≥6.0 or CRP level≥1.0 were significantly worse than those of patients with an NLR level<6.0 or CRP level<1.0(P=0.049,P=0.003 for NLR and P=0.010,P<0.001 for CRP,respectively).Using a new score model using the pretransplant NLR and CRP,we can differentiate HCC patients beyond the Milan criteria with agood prognosis from those with a poor prognosis.CONCLUSION:Combined with the Milan criteria,new score model using NLR and CRP represent new selection criteria for LDLT candidates with HCC,especially beyond the Milan criteria. | Gun Hyung Na Dong Goo Kim Jae hyun Han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You | 2014 | World Journal of Gastroenterology2014，20，21： | 6 |
| 7 | Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation显示文摘AIM: To evaluated patterns and outcomes of hepatocellular carcinoma(HCC) recurrence after living donor liver transplantation(LDLT).METHODS: From 2001 to 2014, 293 patients underwent LDLT for HCC at our transplant center. We retrospectively reviewed 54(18.4%) patients with HCC recurrence after LDLT. We evaluated patterns and outcomes of HCC recurrence after LDLT, with particular attention to the Milan criteria at transplantation, treatments for HCC-recurrent patients, and factors related to survival after HCC recurrence. Furthermore, we evaluated the efficacy of combination treatment of sorafenib and an mT OR inhibitor.RESULTS: The 1-, 2-, and 3-year overall survival rates after HCC recurrence were 41.1%, 20.5%, and 15.4%, respectively. The median time interval between LDLT and HCC recurrence was 6.5 mo. Although recurrence rates according to the Milan criteria at LDLT were significantly different, HCC recurrence patterns and survival rates after HCC recurrence were not significantly different between the two groups. Time to recurrence < 12 mo(P = 0.048), multiple recurrences at HCC recurrence(P = 0.038), and palliative treatment for recurrent tumors(P = 0.003) were significant independent prognostic factors for poor survival after HCC recurrence in a multivariate analysis. The combination treatment of sorafenib and sirolimus showedsurvival benefits in the palliative treatment group(P = 0.005).CONCLUSION: Curative treatment for recurrent HCC after LDLT is the most important factor in survival rates after HCC recurrence and combination treatments of sorafenib and an m TOR inhibitor could have survival benefits in patients with HCC recurrence after LT in the palliative treatment group. | Gun Hyung Na Tae Ho Hong Young Kyoung You Dong Goo Kim | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 8 | Optimal subreflector position determination of shaped dual-reflector antennas based on the parameters iteration approach显示文摘A new method based on the parameters iteration technique has been developed to determine the optimal subreflector position for shaped Cassegrain antennas, that are distorted by gravity, to improve their electromagnetic(EM) performance. Both the features of shaped surface and the relationship between optical path difference(OPD) and far field beam pattern are employed. By describing the shaped dualreflector surface as a standard discrete parabola set, we can utilize the optical features of the standard Cassegrain system in the classical OPD relationship. Then, the actual far field beam pattern is expressed as the synthesis of ideal beam and error beam by decomposing subreflector adjustment parameters using a mechanical-electromagnetic-field-coupling-model(MEFCM). Furthermore, a numerical method for determining optimal subreflector position is presented. The proposed method is based on the iteration technique of subreflector adjustment parameters, and the optimal far field pattern is used for the iteration. The numerical solution of optimal adjustment parameters can be obtained rapidly. Results for a 25 m shaped Cassegrain antenna demonstrate that the adjustment of the subreflector to the optimal position as determined by the proposed method can improve the EM performance effectively. | Bin-Bin Xiang Cong-Si Wang Pei-Yuan Lian Na Wang You Ban | 2019 | Research in Astronomy and Astrophysics2019，19，4： | 4 |
| 9 | Lupus Myocarditis: A Case-Control Study from China显示文摘 | Li Zhang Yan-Lin Zhu Meng-Tao Li Na Gao Xin You Qing-Jun Wu Jin-Mei Su Min Shen Li-Dan Zhao Jin-Jing Liu Feng-Chun Zhang Yan Zhao Xiao-Feng Zeng | 2015 | Chinese Medical Journal2015，，19： | 4 |
| 10 | The FAST Galactic Plane Pulsar Snapshot survey:I.Project design and pulsar discoveries显示文摘Discovery of pulsars is one of the main goals for large radio telescopes.The Five-hundredmeter Aperture Spherical radio Telescope(FAST),that incorporates an L-band 19-beam receiver with a system temperature of about 20 K,is the most sensitive radio telescope utilized for discovering pulsars.We designed the snapshot observation mode for a FAST key science project,the Galactic Plane Pulsar Snapshot(GPPS)survey,in which every four nearby pointings can observe a cover of a sky patch of 0.1575 square degrees through beam-switching of the L-band 19-beam receiver.The integration time for each pointing is 300 seconds so that the GPPS observations for a cover can be made in 21 minutes.The goal of the GPPS survey is to discover pulsars within the Galactic latitude of±10∘from the Galactic plane,and the highest priority is given to the inner Galaxy within±5∘.Up to now,the GPPS survey has discovered 201 pulsars,including currently the faintest pulsars which cannot be detected by other telescopes,pulsars with extremely high dispersion measures(DMs)which challenge the currently widely used models for the Galactic electron density distribution,pulsars coincident with supernova remnants,40 millisecond pulsars,16 binary pulsars,some nulling and mode-changing pulsars and rotating radio transients(RRATs).The follow-up observations for confirmation of new pulsars have polarization-signals recorded for polarization profiles of the pulsars.Re-detection of previously known pulsars in the survey data also leads to significant improvements in parameters for 64 pulsars.The GPPS survey discoveries are published and will be updated at http://zmtt.bao.ac.cn/GPPS/. | J.L.Han Chen Wang P.F.Wang Tao Wang D.J.Zhou Jing-Hai Sun Yi Yan Wei-Qi Su Wei-Cong Jing Xue Chen X.Y.Gao Li-Gang Hou Jun Xu K.J.Lee Na Wang Peng Jiang Ren-Xin Xu Jun Yan Heng-Qian Gan Xin Guan Wen-Jun Huang Jin-Chen Jiang Hui Li Yun-Peng Men Chun Sun Bo-Jun Wang H.G.Wang Shuang-Qiang Wang Jin-Tao Xie Heng Xu Rui Yao Xiao-Peng You D.J.Yu Jian-Ping Yuan Rai Yuen Chun-Feng Zhang Yan Zhu | 2021 | Research in Astronomy and Astrophysics2021，21，5： | 4 |
| 11 | Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters显示文摘联合精力的因素(ECF ) transporters 是调停的多子单元蛋白质建筑群在大约 50% 初核质的转变金属离子和维生素的举起,包括细菌和 archaea。生物、结构的研究为维生素,而是 ECF 系统从未知的环境遗体由搬运金属离子的分子的机制集中于 ECF transporters。这里,我们报导 NikM 的第一水晶结构, TtNikM2,从 Thermoanaerobacter tengcongensis 的 ECF 类型镍 transporter 的底层绑定部件(S 部件) 。与有六个 transmembrane 片断(TS ) 的维生素特定的 S 蛋白质的结构相对照, TtNikM2 在它的 N 终端区域拥有另外的 TS,导致细胞外的 N 终点。高度保存的 N 终端环插入到 TtNikM2 的中心并且堵塞相应于维生素特定的 S 部件的底层绑定地点的一个区域。镍经由它的协作绑在 NikM 到四个氮原子,它从 Met1, His2 和 His67 残余被导出。这些氮原子形成近似平方平面的几何学,类似于在 2+ 有约束力的氨基终端的 Cu 和 Ni 2+-binding (ATCUN ) 的金属离子绑定地点的主题。在贡献镍协作的 NikM 的残余的代替损害了 Ni 运输活动。而且,系统的量化学药品调查显示这几何学启用 NikM 到有选择地也认出公司 2+ 。确实,包含一个界限公司 2+ 离子的 TtNikM2 的结构没几乎与包含五分钱离子的结构相比有 conformational 变化。一起,我们的数据揭示位于 EcfS 蛋白质的金属选择下面的 evolutionarily 保存的机制,并且提供卓见进 ion-translocation 过程由 ECF transporters 调停了。 | You Yu Mingze Zhou Franziska Kirsch Congqiao Xu Li Zhang Yu Wang Zheng Jiang Na Wang Jun Li Thomas Eitinger Maojun Yang | 2014 | Cell Research2014，24，3： | 3 |
| 12 | Collective flow and hydrodynamics in large and small systems at the LHC显示文摘In this article,we briefly review the recent progress on collective flow and hydrodynamics in large and small systems at the Large Hadron Collider(LHC),which includes the following topics:extracting the QGP viscosity from the flow data,initial-state fluctuations and final-state correlations at 2.76 A TeV Pb-Pb collisions,correlations,and collective flow in high-energy p-Pb and p-p collisions. | Huichao Song You Zhou Katarína Gajdosová | 2017 | Nuclear Science and Techniques2017，28，7： | 3 |
| 13 | Comprehensive comparison on the chemical metabolites and taste evaluation of tea after roasting using untargeted and pseudotargeted metabolomics显示文摘Roasting is a common manufacture technology for processing various teas.It is not only used in decreasing the water content of finished tea,but also improving the flavor of teas.In the present study,the roasted and non-roasted teas were compared by liquid-chromatography mass spectrometry and sensory evaluation.The roasted tea tasted less bitter and astringent.The content of main galloylated and simple catechins,caffeine and theobromine in roasted were significantly lower than non-roasted teas.Targeted taste-compounds metabolomics revealed that(-)-epigallocatechin gallate,kaempferol-glucose-rhamnose-glucose and(-)-epicatechin gallate were main contributors tightly correlated to astringent intensity.Flavonol glycosides including kaempferol-glucose,quercetin-glucose,kaempferol-glucose-rhamnose-glucose,and quercetin-glucose-rhamnose-glucose in roasted teas were also significantly less than non-roasted teas.To study the chemical changes during roasting,tea with a strong astringency was roasted under 80,100,120,140,and 160°C.With the increase of roasting temperature,the bitter and astringent intensity of tea was gradually decreased,but the main astringent compounds including(-)-epigallocatechin,(-)-epigallocatechin gallate and kaempferol/quercetin glycosides were irregularly varied with temperature.The Pearson correlation coefficient analysis suggested procyanidin B2,coumaroylquinic acids and gallotannins were tightly correlated to the astringent and bitter perceptions,while N-ethyl-2-pyrrolidonesubstituted flavan-3-ols were negatively correlated. | Zongde Jiang Zisheng Han Mingchun Wen Chi-Tang Ho You Wu Yijun Wang Na Xu Zhongwen Xie Jinsong Zhang Liang Zhang Xiaochun Wan | 2022 | Food Science and Human Wellness2022，11，3： | 3 |
| 14 | Screening ofα-glucosidase inhibitors in large-leaf yellow tea by offline bioassay coupled with liquid chromatography tandem mass spectrometry显示文摘Larger-leaf yellow tea(LYT)is a characteristic type of Chinese tea produced in Huoshan County,Anhui Province,which is made by mature leaves with stems.According to recent report,LYT showed competitive effects in anti-hyperglycemia in comparison to other teas such as green or black tea.However,the bioactive compounds of LYT are still undiscovered so far.For this purpose,5 fractions of LYT were prepared by sequential extraction.The in vitro bioassay results indicated that the ethyl acetate fraction of LYT had the strongest inhibitory effects onα-glucosidase andα-amylase.Fluorescence-quenching analysis and proteinbinding test revealed that the compounds of ethyl acetate fraction could inhibitα-glucosidase andα-amylase activities through binding to enzymes or other mechanisms.All chromatographic peaks of high-performance liquid chromatography(HPLC)of ethyl acetate fraction were separated and collected.The purified compounds were identified by liquid chromatography-mass spectrometry(LC-MS),and subsequently screened by calculating their inhibition ratio onα-glucosidase at the real concentration in LYT infusion.The results showed that(-)-epigallocatechin gallate,(-)-gallocatechin gallate,caffeine,N-ethyl-2-pyrrolidone-substituted flavan-3-ols were effective inhibitors forα-glucosidase. | You Wu Zisheng Han Mingchun Wen Chi-Tang Ho Zongde Jiang Yijun Wang Na Xu Zhongwen Xie Jinsong Zhang Liang Zhang Xiaochun Wan | 2022 | Food Science and Human Wellness2022，11，3： | 3 |
| 15 | Optical Coherence Tomography Features of Tuberculous Serpiginous-like Choroiditis and Serpiginous Choroiditis显示文摘Objective To investigate optical coherence tomography(OCT) characteristics of tuberculous serpiginous-like choroiditis(Tb-SLC) and serpiginous choroiditis(SC) and to perform OCT to differentiate between these conditions.Methods This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or SC.Patients underwent comprehensive ocular examinations and imaging(OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography).Findings were examined and compared between eyes with SC and Tb-SLC.Results Nine patients with active Tb-SLC(14 eyes) and 8 with active SC(12 eyes) were included.The following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group: vitreal hyper-reflective spots [5 Tb-SLC eyes(36%),no SC eyes:P = 0.02],intraretinal edema [11 Tb-SLC eyes(79%),3 SC eyes(25%):P = 0.01],sub-retinal pigment epithelium(RPE) drusenoid deposits [11 Tb-SLC eyes(79%),2 SC eyes(17%):P < 0.01],and choroidal granulomas [8 Tb-SLC eyes(57%),2 SC eyes(17%):P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes(36%),9 SC eyes(75%):P = 0.045] than in the Tb-SLC group.The incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like hyper-reflection.Conclusion Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate Tb-SLC.Additionally,a hyporeflective,wedge-shaped band may indicate SC.Therefore,OCT is likely helpful in differentiating between Tb-SLC and SC. | wang xiao na you qi sheng zhao hui ying peng xiao yan | 2018 | Biomedical and Environmental Sciences2018，31，5： | 2 |
| 16 | Extending the limitations of liver surgery: outcomes of initial human experience in a high-volume center performing single-port laparoscopic liver resection for hepatocellular carcinoma显示文摘 | Guruprasad Shetty Young You Ho Choi Gun Na Tae Hong Dong-Goo Kim | 2012 | Surgical Endoscopy2012，，6： | 2 |
| 17 | Functional carbon materials addressing dendrite problems in metal batteries:surface chemistry,multi-dimensional structure engineering,and defects显示文摘Metal batteries that directly use active metals as anodes are considered as one of the most promising solutions to achieve the energy upgrade of battery technologies,while their practical application still suffers from dendrite problems.Functional carbon materials(FCMs)have demonstrated their great potential in suppressing metal dendrites benefitting from the multiple merits such as chemical tunability and capability of multi-dimensional structure assembly.Here,we initiate a review to present the recent progress in employing FCMs to deal with dendrite problems.It focuses on the surface chemistry and multi-dimensional carbon material engineering,which systematically overcomes the problems through diverse methods,such as reinforcing desolvation,improving interface compatibility,homogenizing electric field,buffering volume expansion and lattice mismatch.In addition,we also refine the long-standing debate about whether surface defects in FCMs are beneficial to suppress the metal dendrites or not,especially in the non-aqueous electrolyte regime.Finally,the remaining challenges for utilizing FCMs to suppress metal dendrites and the possible solutions are proposed to guide the future development. | Qi Yang Na Jiang Yuan Shao Yong Zhang Xin Zhao You Zeng Jieshan Qiu | 2022 | Science China Chemistry2022，65，12： | 2 |
| 18 | Meta-analysis on randomized controlled trials for scalp acupuncture treatment of stroke:A systematic review显示文摘OBJECTIVE:To conduct a systematic review to assess the clinical effectiveness of scalp acupuncture(SA) for stroke.METHODS:Literature searches were performed in7 databases up to 16 August 2014,and all the randomized controlled trials(RCTs) in which SA therapy was administered to stroke patients were selected.Methodological quality was assessed using the Jadad score,the Cochrane risk of bias assessment,and the Standards for Reporting Interventions in Clinical Trials of Acupuncture.RESULTS:Of a total of 2086 papers,21 RCTs were selected.Meta-analysis revealed significant differences in the total efficacy rates of the SA group and the body acupuncture(BA) group vs the medication group(P < 0.002,P < 0.000 001,respectively),the SA plus BA group vs the BA group(P < 0.001);in the motor function of the SA plus BA group vs the BA group(P = 0.077);and in the nerve function of the SA group vs the SA plus BA group(P < 0.0001).CONCLUSION:The results of our systematic review showed that SA therapy may exhibit effects in treatment efficacy and in the recovery of motor and nervous functions in patients with acute to chronic stroke.However,because of the lack of methodological quality,the thoroughly planned clinical studies are still required. | Young-Nim You Min-Yeong Song Gwang-Cheon Park Chang-Su Na Jae-Young Han Myung-Rae Cho Jae-Hong Kim | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 2 |
| 19 | Prevention and risk factors of hepatitis B recurrence after living donor liver transplantation显示文摘 | Gun Hyung Na Dong Goo Kim Jae Hyun Han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Jong Young Choi | 2014 | J Gastroenterol Hepatol2014，，1： | 2 |
| 20 | Bioactive hyaluronic acid fragments inhibit lipopolysaccharideinduced inflammatory responses via the Toll-like receptor 4 signaling pathway显示文摘The high-and the low-molecular weight hyaluronic acids(HMW-HA and LMW-HA,respectively)showed different biological activities in inflammation.However,the role of LMW-HA in inflammatory response is controversial.In this study,we aimed to investigate the effect of bioactive hyaluronan(B-HA)on lipopolysaccharide(LPS)-induced inflammatory responses in human macrophages and mice.B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase PH20.Human THP-1 cells were induced to differentiate into macrophages.THP-1-derived macrophages were treated with B-HA,LPS,or B-HA+LPS.The mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent assay.The phosphorylation levels of proteins in the nuclear factor-kB(NF-kB),mitogen-activated protein kinase(MAPK),and IRF-3 signaling pathways were measured using Western blot.The in vivo efficacy of B-HA was assessed in a mouse model of LPS-induced inflammation.Results showed that B-HA inhibited the expression of TNF-α,IL-6,IL-1,and IFN-β,and enhanced the expression of the antiinflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and in vivo.B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65,IKKα/β,IkBα,JNK1/2,ERK1/2,p38,and IRF-3.In conclusion,our results demonstrated that the B-HA attenuated the LPSstimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway.B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease. | Na You Sasa Chu Binggang Cai Youfang Gao Mizhou Hui Jin Zhu Maorong Wang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
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