|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Purification of neu-ropeptides using gradient reversed-phase high-performance liquid chromatography with novel detection methodologies显示文摘 | Wu Gong Zhang Naixia | 2000 | Acta Biochimica et Biophysica Sinica2000，32，4： | 1 |
| 2 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 3 | Purification of neuropeptides using gradient reversed-phase high-performance liquid chromatography with novel detection methodologies显示文摘 | Li Yiming Wu Gong Zhang Naixia | 2000 | Acta Biochimica et Biophysica Sinica2000，32，4： | 1 |
| 4 | Personalized tourist route recommendation model with a trajectory understanding via neural networks显示文摘Travel recommendations form a major part of tourism service. Traditional collaborative filtering and Markov model are not appropriate for expressing the trajectory features,for travel preferences of tourists are dynamic and affected by previous behaviors. Inspired by the success of deep learning in sequence learning,a personalized recurrent neural network (P-RecN) is proposed for tourist route recommendation. It is data-driven and adaptively learns the unknown mapping of historical trajectory input to recommended route output. Specifically,a trajectory encoding module is designed to mine the semantic information of trajectory data,and LSTM neural networks are used to capture the sequence travel patterns of tourists. In particular,a temporal attention mechanism is integrated to emphasize the main behavioral intention of tourists. We retrieve a geotagged photo dataset in Shanghai,and evaluate our model in terms of accuracy and ranking ability. Experimental results illustrated that P-RecN outperforms other baseline approaches and can effectively understand the travel patterns of tourists. | Naixia Mou Qi Jiang Lingxian Zhang Jiqiang Niu Yunhao Zheng Yanci Wang Tengfei Yang | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 5 | 急性髓系白血病致癌性RNA去甲基酶FTO的小分子靶向干预研究显示文摘文章简介RNA甲基化是高等生物mRNA上最普遍的修饰,参与RNA稳定性、定位、运输、剪切等调控,在基因表达调控中发挥重要作用。2011年FTO被鉴定为m^6A修饰去甲基化酶,开辟了'表观转录'研究新方向。2017年报导急性髓系白血病(AML)高表达FTO导致下游某些mRNA上甲基化丰度降低,引起蛋白水平变化,促进AML形成。然而由于缺乏高质量的小分子工具,FTO是否可以成为抗肿瘤药物的作用靶标有待于深入确证。 | 黄悦 Rui Su Yue Sheng Lei Dong Ze Dong Hongjiao Xu Tengfeng Ni Zijie Scott Zhang Tao Zhang Chenying Li Li Han Zhenyun Zhu Fulin Lian Jiangbo Wei Qiangqiang Deng Yungui Wang Mark Wunderlich Zhiwei Gao Guoyu Pan Dafang Zhong Hu Zhou Naixia Zhang Jianhua Gan Hualiang Jiang James C.Mulloy Zhijian Qian Jianjun Chen 杨财广 | 2020 | 科学新闻2020，，2： | 0 |
| 6 | Root morphological traits and their relations with yield components of dry-raised mid-season indica rice显示文摘Research on root morphological traitsof dry-raised seedlings(D-RS)atdifferent growth stages of rice have sofar attracted less attention.In thisstudy,using mid-season indica | ZHANG Yajie, Su Zufang, YANG Lianxin, SHA Aihong, and Xu Naixia, Dept of Agronomy, Yangzhou Univ, Yangzhou 225009, China | 2002 | Chinese Rice Research Newsletter2002，10，3： | 0 |
| 7 | A hydrogen–deuterium exchange mass spectrometry-based protocol for protein–small molecule interaction analysis显示文摘Protein–small molecule interaction is vital in regulating protein functions and controlling various cellular processes.Hydrogen deuterium exchange mass spectrometry(HDX-MS)is a powerful methodology to study protein–small molecule interactions,however,to accurately probe the conformational dynamics of the protein upon small molecule binding,the HDX-MS experimental conditions should be carefully controlled and optimized.Here,we present the detailed continuous-labeling,bottom-up HDX-MS protocol for studying protein–small molecule interactions.We took a side-by-side HDX kinetics comparison of the Hsp90N protein with or without the treatment of small molecules(i.e.,Radicicol,Geldanamycin)for displaying conformational changes induced by molecular interactions between Hsp90N and small molecules.Our sensitive and robust experimental protocol can facilitate the novice to quickly carry out the structural characterization of protein–small molecule interactions. | Qian Meng Yuan-Li Song Chen Zhou Han He Naixia Zhang Hu Zhou | 2023 | Biophysics Reports2023，9，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员