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| 1 | Mechanochemical preparation of sulfur-doped nanosized TiO_2 and its photocatalytic activity under visible light显示文摘In order to make nanosized TiO2 photocatalyst responsive to visible light and effectively utilize solar energy, we have, for the first time, prepared S-doped nanosized TiO2 by a mechanochemical method with hydrolysis of TiCl4. The as-prepared S-doped nanosized TiO2 possesses strong ab-sorption for visible light of 400―650 nm and shows high photocatalytic activity for decomposition of methylene blue under irradiation of visible light. The oxidation states of the S atoms incorporated into TiO2 were determined to be S6+ and S4+. The comparative study of fluorescence emission spectra shows that S-doping has also improved the separa-tion of electron-hole pairs. | ZHOU Zhiqiang ZHANG Xianyou WU Ze DONG Limin | 2005 | Chinese Science Bulletin2005，50，23： | 12 |
| 2 | The combination of PD-1 blockade with interferon-αhas a synergistic effect on hepatocellular carcinoma显示文摘Background The efficacy of immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1(PD-1)or its ligand 1(PD-L1)antibody,in hepatocellular carcinoma(HCC)is limited,and it is recommended that they be combined with other therapies.We evaluated the combination of pegylated interferon-α(Peg-IFNα)with PD-1 blockade in HCC mouse models.Methods We analyzed the effects of Peg-IFNαon tumor-infiltrating immune cells and PD-1 expression in the HCC immune microenvironment and examined the underlying mechanism of its unique effect on the PD-1 pathway.The in vivo efficacy of anti-PD-1 and Peg-IFNαwas evaluated in both subcutaneous and orthotopic mouse models of HCC.Results The combination of Peg-IFNαwith PD-1 blockade dramatically enhanced T-cell infiltration,improved the efficacy of PD-1 antibody and prolonged mouse survival compared with PD-1 antibody monotherapy.Mechanistically,Peg-IFNαcould recruit cytotoxic CD8+T cells to infiltrate the HCC microenvironment by inducing tumor cells to secrete the chemokine CCL4.Nevertheless,the HCC microenvironment quickly overcame the immune responses by upregulating PD-1 expression in CD8+T cells via the IFNα-IFNAR1-JAK1-STAT3 signaling pathway.The combination of PD-1 blockade with Peg-IFNαcould restore the cytotoxic capacity of CD8+T cells and exerted a significant synergistic effect on HCC.Conclusion These results indicate that in addition to initiating the antitumor immune response itself,Peg-IFNαcan also generate a microenvironment favoring PD-1 blockade.Thus,the combination of Peg-IFNαand PD-1 blockade can be a promising strategy for HCC. | Ying Zhu Mo Chen Da Xu Tian-En Li Ze Zhang Jian-Hua Li Xiang-Yu Wang Xin Yang Lu Lu Hu-Liang Jia Qiong-Zhu Dong Lun-Xiu Qin | 2022 | Cellular & Molecular Immunology2022，19，6： | 6 |
| 3 | Laser Doppler flowmeter study on regional cerebral blood flow in early stage after standard superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease显示文摘背景标准表面的时间的动脉中间服的动脉(STA-MCA ) 绕过外科是为 moyamoya 疾病的有效治疗,但是最近的证据建议手术后的服的 hyperperfusion 能发生。在这研究,在在外科以后的地区性的服的血流动( rCBF )的变化的 trendline 不断地在吻合的地点附近被监视以便两个都为改进 rCBF 和可能的 riskof hyperperfusion.Methods 标准 STA-MCA 调查过程的功效绕过外科在 13 个病人上被执行, rCBF 在操作以后用激光 Doppler flowmetry ( LDF )不断地被测量直到 第5 天,邻近吻合的区域的 LDF 探查植入。rCBF 变化的 trendline 手术后地为用外皮的 rCBF 的基线 LDF 价值是的社会科学统计套装软体 13.0 .Results 执行的分析被记录(84.68 吗?? | GESANG Dun-zhu ZHANG Dong ZHAO Ji-zong WANG Shuo ZHAO Yuan-li WANG Rong SUN Jian-jun MENG Ze | 2009 | Chinese Medical Journal2009，，20： | 5 |
| 4 | Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population显示文摘In European populations,7 single nucleotide polymorphisms(SNPs) on chromosome 17q,3 SNPs on 17q12,and 4 SNPs on 17q24.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association study.In Japanese populations,the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale experiment.However,whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still unknown.Therefore,we conducted a case-control study in a northern Chinese population and tested 2 SNPs,rs4430796 and rs1859962,on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve(PCR-HRM) combined with sequencing.We analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients' lifestyles,onset ages,Gleason scores,PSA levels,and pathologic stages.We found a significant difference in the G allele of SNP rs1859962(P = 0.035,OR = 1.51,95% CI = 1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls(P > 0.05).Neither of the SNPs was significantly associated with the onset age,Gleason score,PSA level,pathologic stage,or other clinical indicators of patients with prostate cancer(P > 0.05).Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population. | Chang-Hu Zhou Jian-Ye Wang Su-Yan Cao Xiao-Hong Shi Yao-Guang Zhang Ming Liu Xin wang Jin Huang Yi-Ge Yang Dong Wei Ze Yang | 2011 | Chinese Journal of Cancer2011，30，10： | 4 |
| 5 | Enhanced photocatalytic properties of molybdenum-doped BiVO4 prepared by sol–gel method显示文摘Bismuth vanadate(BiVO_4) has been investigated intensively and extensively due to its potential applications in the photocatalytic treatment of organiccontaining wastewater.In this study,Mo-BiVO_4 samples were synthesized by a facile sol-gel process.These samples were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),and ultravioletvisible(UV-Vis) diffuse reflectance spectroscopy.It is found that the phase structure of Mo-BiVO_4 photocatalyst is monoclinic scheelite.The photocatalytic activities of the obtained BiVO_4 samples were investigated by means of the decolorization efficiency of methyl orange(MO).The BiVO_4 and Mo-BiVO_4 photocatalysts show the response on the visible light.The doped BiVO_4 photocatalysts show higher decolorization efficiency than that of bare BiVO_4. | Gui-Lin Wang Lian-Wei Shan Ze Wu Li-Min Dong | 2017 | Rare Metals2017，36，2： | 3 |
| 6 | Comparison of in vitro digestion methods for determining bioaccessibility of Hg in rice of China显示文摘Rice consumption can be a major pathway for mercury(Hg) exposure, which can cause health hazards to Chinese residents. To accurately assess the potential health risks, the bioaccessibility of Hg in rice samples collected at background and Hg-contamination sites was examined using four in vitro methods. The results showed that < 50% of the total mercury(THg) was bioaccessible in the studied rice samples. The THg bioaccessibility in the rice samples collected at the Hg-contaminated site was higher than that observed at the background area. The bioaccessibility of arsenic(As) and cadmium(Cd) was also evaluated for comparison of the four in vitro methods used in this study. The Physiologically Based Extraction Test was found to be the most accurate method based on the consistency of the results compared to those reported in previous studies. The estimated daily intakes of THg via rice consumption using the bioaccessibility data were found to meet the recommendation value set by the JECFA and the WHO in both sites. However, the potential health risk was not negligible at the Hg-contaminated sites, due to the high THg concentration and bioaccessibility in the rice samples. | Ze Wu Xinbin Feng Ping Li Che-Jen Lin Guangle Qiu Xun Wang Huifang Zhao Hui Dong | 2018 | Journal of Environmental Sciences2018，30，6： | 3 |
| 7 | Dynamic Airy imaging through high_efficiency broadband phase microelements by femtosecond laser direct writing显示文摘Manipulating Airy beams to symmetric Airy beams(SABs)with abruptly autofocusing and self accelerating properties has attracted much attention.With such a particular propagation dynamic,SABs may provide great potential in dynamic signal imaging.On the other hand,the generation of SABs by spatial light modulators suffers from the limitations of phase gradient accuracy,low optical efficiency(<40%),and a bulky footprint.Therefore,exploring imaging applications and optimal generation methods of these Airy-type beams deserves further research.Here,based on the coordinate transformation of SAB,an asymmetric Airy beam(AAB)is realized.Symmetric/asymmetric cubic phase microplates(SCPPs/ACPPs)are designed and fabricated for generating SAB/AAB.The SCPP/ACPP demonstrates superior performance:compact construction(60μm × 60μm × 1.1μm),continuous variation of phase,high efficiency(~81%at 532 nm),and broadband operation from 405 to 780 nm.Dynamic imaging under monochromatic and polychromatic lights is realized by the SAB/AAB,indicating various results at different propagation distances with a certain initial signal.Further investigation reveals that the SCPP on a soft substrate maintains its physical dimensions and optical properties unchanged during stretching.Our work enables wide potential applications in integrated optics,beam manipulation,and imaging. | ZE CAI XINBO QI DENG PAN SHENGYUN JI JINCHENG NI ZHAOXIN LAO CHEN XIN JIAWEN LI YANLEI HU DONG Wu JIARU CHI | 2020 | Photonics Research2020，8，6： | 3 |
| 8 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 9 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 10 | Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation显示文摘The mortality of cancer patients has considerably improved due to progress in surgery,chemotherapy and radiotherapy.However,some types of cancers,such as melanoma,remain refractory to conventional strategies.Although melanoma accounts for only 4%of all dermatological malignancies,it is responsible for 80%of mortalities from skin tumors[1].The reported survival rate of melanoma over 5 years is not yet encouraging due | GAO Hui XU Xiao Shuang CHEN Ze Dong ZHANG Quan XU Xiang Ming | 2013 | Biomedical and Environmental Sciences2013，26，12： | 3 |
| 11 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 12 | Analysis of Phenolic Compounds in Coke Plant Wastewater by Capillary Zone Electrophoresis with Inhibited Chemiluminescence Detection显示文摘A capillary electrophoresis(CE) with on-line inhibited chemiluminescence (CL) detection was firstly used for the simultaneous analysis of benzenediol isomers and phenol. It is based on the quenching effect of benzenediol isomers and phenol on the chemiluminescence reaction of luminol with potassium ferricyanide in sodium hydroxide medium. Under the optimum conditions,the four phenols were baseline separated and detected in less than 10 min. The detection limits (S/N=3) for hydroquinone,resorcinol,catechol and phenol were 2.9×10-8 mol/L,3.7×10-7 mol/L,8.4×10-8 mol/L and 4.4×10-6 mol/L,respectively. Finally,the presented method has been successfully applied to real sample. | Xiang Dong XU Yong Gang HU Ze Yu YANG | 2006 | Chinese Chemical Letters2006，17，7： | 2 |
| 13 | Field Transmission of 100G and Beyond:Multiple Baud Rates and Mixed Line Rates Using Nyquist-WDM Technology显示文摘In this paper,we describe successful joint experiments with Deutsche Telecom on long-haul transmission of 100G and beyond over standard single mode fiber (SSMF) and with in-line EDFA-only amplification.The transmission link consists of 8 nodes and 950 km installed SSMF in DT's optical infrastructure.Laboratory SSMF was added for extended optical reach.The first field experiment involved transmission of 8 × 216.8 Gbit/s Nyquist-WDM signals over 1750 km with 21.6 dB average loss per span.Each channel,modulated by a 54.2 Gbaud PDM-CSRZ-QPSK signal,is on a 50 GHz grid,which produces a net spectral efficiency (SE) of 4 bit/s/Hz.We also describe mixed-data-rate transmission coexisting with 1T,400G,and 100G channels.The 400G channel uses four independent subcarriers modulated by 28 Gbaud PDM-QPSK signals.This yields a net SE of 4 bit/s/Hz,and 13 optically generated subcarriers from a single optical source are used in the 1T channel with 25 Gbaud PDM-QPSK modulation.The 100G signal uses real-time coherent PDM-QPSK transponder with 15% overhead of soft-decision forward-error correction (SD-FEC).The digital post filter and 1-bit maximum-likelihood sequence estimation (MLSE) are introduced at the receiver DSP to suppress noise,linear crosstalk,and filtering effects.Our results show that future 400G and 1T channels that use Nyquist WDM can transmit over long-haul distances with higher SE and using the same QPSK format. | Zhensheng Jia Jianjun Yu Hung-Chang Chien Ze Dong Di Huo | 2012 | ZTE Communications2012，10，3： | 2 |
| 14 | Current and Passive Smokers Have Poorer Quantity and Quality of Diet in Shanghai, China: A Crosssectional Survey显示文摘Smoking is a major risk factor for chronic diseases,it has been estimated that 300 million adults currently smoke in China,and the smoking prevalence in males is as high as 52.9%,with 1million smoking-related deaths yearly.Therefore,smoking is also a huge health burden in China[1].Researchers have suggested an association between diet and smoking status with respect to both food and nutrient intakes.According to such studies,smokers tended to have a poor diet. | WANG Zheng Yuan LI Li ZANG Jia Jie SHI Ze Huan JIN Wei QI De Yun TANG Chuan Xi GAO Hong Mei WANG Jin Xiang ZHU Zhen Ni JIA Xiao Dong GUO Chang Yi | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
| 15 | Bio-inspired design of hierarchical FeP nanostructure arrays for the hydrogen evolution reaction显示文摘由 FeP nanopetals 组成的层次 FeP nanoarray 电影成功地经由 phosphorization 跟随的一条启发简历的热水的线路被综合。作为一个水晶生长修饰词,甘油在控制 FeO 的形态学和结构起一个重要作用(哦) 先锋在 biomineralization 过程期间,当时 FeO 的下列转移和 pseudomorphic 转变(哦) 电影成功地产生 FeP 数组电影。同样准备的 FeP 电影电极展出优秀的氢进化反应(她的) 在一个宽 pH 范围上的性能。理论计算表明在 FeP 电影的混合 P/Fe 结束为 nanostructured 电极的高催化的活动负责。这新卓见将支持有效金属的进一步的探索为 HER 的基于 phosphoride 的催化剂。更重要地,这研究衔接在生物、无机的自我装配的 nanosystems 之间的差距并且可以在精力设备用申请为功能的 nanostructures 的准备开创一条新大街。 | Ya Yan Xue Rong Shi Mao Miao Ting He Ze Hua Dong Ke Zhan Jun He Yang Bin Zhao Bao Yu Xia | 2018 | Nano Research2018，11，7： | 2 |
| 16 | Acoustic radiation force impulse elastography, FibroScan?, Forns’ indexand their combination in the assessment of liver fibrosis in patients with chronichepatitis B, and the impact of inflammatory activity and steatosis on these diagnosticmethods显示文摘 | Dao?Ran Dong Mei?Na Hao Cheng Li Ze Peng Xia Liu Gui?Ping Wang An?Lin Ma | 2015 | Molecular Medicine Reports2015，，6： | 2 |
| 17 | Influence of EPS isolated from thermophilic sulphate-reducing bacteria on carbon steel corrosion显示文摘 | Ze Hua Dong Tao Liu HongFang Liu | 2011 | Biofouling2011，，5： | 2 |
| 18 | Heterogeneous corrosion of mild steel under SRB-biofilm characterised by electrochemical mapping technique显示文摘 | Ze Hua Dong Wei Shi Hong Mei Ruan Guo An Zhang | 2011 | Corrosion Science2011，，9： | 2 |
| 19 | Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice显示文摘General anesthesia severely affects the metabolites in the brain.Glycogen,principally stored in astrocytes and providing the short-term delivery of substrates to neurons,has been implicated as an affected molecule.However,whether glycogen plays a pivotal role in modulating anesthesia-arousal remains unclear.Here,we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain regions.Glycogen synthase(GS)and glycogen phosphorylase(GP),key enzymes of glycogen metabolism,showed increased activity after isoflurane exposure.Upon blocking glycogenolysis with 1,4-dideoxy-1,4-imino-Darabinitol(DAB),a GP antagonist,we found a prolonged time of emergence from anesthesia and an enhancedδfrequency in the EEG(electroencephalogram).In addition,augmented expression of glycogenolysis genes in glycogen phosphorylase,brain(Pygb)knock-in(PygbH11/H11)mice resulted in delayed induction of anesthesia,a shortened emergence time,and a lower ratio of EEG-δ.Our findings revealed a role of brain glycogen in regulating anesthesiaarousal,providing a potential target for modulating anesthesia. | Ze Fan Zhihao Zhang Shiyi Zhao Yuanyuan Zhu Dong Guo Bo Yang Lixia Zhuo Jiao Han Rui Wang Zongping Fang Hailong Dong Yan Li Lize Xiong | 2020 | Neuroscience Bulletin2020，36，12： | 2 |
| 20 | Structural insight into substrate recognition by histone demethylase LSD2/KDM1 b显示文摘 | Fei Chen Huirong Yang Zhenghong Dong Jian Fang Ping Wang Tingting Zhu Wei Gong Rui Fang Yujiang Geno Shi Ze Li Yanhui Xu | 2013 | Cell Research2013，23，2： | 2 |
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