|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 3 | Prolonged Unconjugated Hyperbiliriubinemia in Breast-fed Male Infants with a Mutation of Uridine Diphosphate-Glucuronosyl Transferase显示文摘 | Pi-Feng Chang Yu-Cheng Lin Kevin Liu Shu-Jen Yeh Yen-Hsuan Ni | 2009 | The Journal of Pediatrics2009，，6： | 1 |
| 4 | Sensor network data fault typos 显示文摘 | Ni Kevin Ramanathan Nithya | 2009 | ACM Transactions on Sensor Networks2009，5，3： | 1 |
| 5 | Social responsibilityallocation in two-echelon supply chains: Insights fromwholesale price contracts 显示文摘 | Ni D Kevin W L Tang X W | 2010 | European J of OperationalResearch2010，207，3： | 1 |
| 6 | Sensor network data fault types 显示文摘 | Ni Kevin Ramanathan Nithya | 2009 | ACM Transactions on Sensor Networks2009，5，3： | 1 |
| 7 | Social responsibility allocation in two-echelon supply chains: Insights from wholesale price contracts显示文摘 | Debing Ni Kevin W. Li Xiaowo Tang | 2010 | European Journal of Operational Research2010，，3： | 1 |
| 8 | Cash transfer during the COVID-19 pandemic:a multicentre,randomised controlled trial显示文摘Objective To evaluate the effect of a one-time cash transfer of$C1000 in people who are unable to physically distance due to insufficient income.Design Open-label,multi-centre,randomised superiority trial.Setting Seven primary care sites in Ontario,Canada;six urban sites associated with St.Michael’s Hospital in Toronto and one in Manitoulin Island.Participants 392 individuals who reported trouble affording basic necessities due to disruptions related to COVID-19.Intervention After random allocation,participants either received the cash transfer of$C1000(n=196)or physical distancing guidelines alone(n=196).Main outcome measures The primary outcome was the maximum number of symptoms consistent with COVID-19 over 14 days.Secondary outcomes were meeting clinical criteria for COVID-19,SARS-CoV-2 presence,number of close contacts,general health and ability to afford basic necessities.Results The primary outcome of number of symptoms reported by participants did not differ between groups after 2 weeks(cash transfer,mean 1.6 vs 1.9,ratio of means 0.83;95%CI 0.56 to 1.24).There were no statistically significant effects on secondary outcomes of the meeting COVID-19 clinical criteria(7.9%vs 12.8%;risk difference−0.05;95%CI−0.11 to 0.01),SARS-CoV-2 presence(0.5%vs 0.6%;risk difference 0.0095%CI−0.02 to 0.02),mean number of close contacts(3.5 vs 3.7;rate ratio 1.10;95%CI 0.83 to 1.46),general health very good or excellent(60%vs 63%;risk difference−0.0395%CI−0.14 to 0.08)and ability to make ends meet(52%vs 51%;risk difference 0.0195%CI−0.10 to 0.12).Conclusions A single cash transfer did not reduce the COVID-19 symptoms or improve the ability to afford necessities.Further studies are needed to determine whether some groups may benefit from financial supports and to determine if a higher level of support is beneficial.Trial registration number NCT04359264. | Navindra Persaud Kevin E Thorpe Michael Bedard Stephen W Hwang Andrew Pinto Peter Jüni Bruno R da Costa 无 | 2021 | Family Medicine and Community Health2021，9，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员