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| 1 | Risk of Ulcerative Colitis-Associated Colorectal Cancer in China: A Multi-Center Retrospective Study显示文摘 | Wei Gong Nonghua Lv Bangmao Wang Ye Chen Yinglong Huang Wenshen Pan Bo Jiang | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 2 | Early Management Experience of Perforation after ERCP显示文摘 | Guohua Li Youxiang Chen Xiaojiang Zhou Nonghua Lv Stuart Sherman | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 3 | Suppression of growth and migration by blocking the hedgehog signaling pathway in gastric cancer cells显示文摘 | Runwei Yan Xiang Peng Xiaogang Yuan Dengliang Huang Jiang Chen Quqin Lu Nonghua Lv Shiwen Luo | 2013 | Cellular Oncology2013，，5： | 1 |
| 4 | Risk of Ulcerative Colitis-Associated Colorectal Cancer in China: A Multi-Center Retrospective Study显示文摘 | Wei Gong Nonghua Lv Bangmao Wang Ye Chen Yinglong Huang Wenshen Pan Bo Jiang | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
| 5 | Suppression of growth and migration by blocking the hedgehog signaling pathway in gastric cancer cells显示文摘 | Runwei Yan Xiang Peng Xiaogang Yuan Dengliang Huang Jiang Chen Quqin Lu Nonghua Lv Shiwen Luo | 2013 | Cellular Oncology2013，，5： | 1 |
| 6 | Efficacy and safety of probiotics as adjuvant agents for Helicobacterpylori infection: A meta?analysis显示文摘 | Zhifa Lv Ben Wang Xiaojiang Zhou Fucai Wang Yong Xie Huilie Zheng Nonghua Lv | 2015 | Experimental and Therapeutic Medicine2015，，3： | 1 |
| 7 | Effect and safety of anaprazole in the treatment of duodenal ulcers:a randomized,rabeprazole-controlled,phase Ⅲ non-inferiority study显示文摘Background:The pharmacokinetic and clinical behaviors of many proton pump inhibitors(PPIs)in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms.This non-inferiority study evaluated the efficacy and safety of the novel PPI anaprazole compared with rabeprazole.We also explored the influence of Helicobacter pylori(H.pylori)infection status and CYP2C19 polymorphism on anaprazole.Methods:In this multicenter,randomized,double-blind,double-dummy,positive-drug parallel-controlled,phase Ⅲ study,Chinese patients with duodenal ulcers were randomized 1:1 to receive rabeprazole 10 mg+anaprazole placebo or rabeprazole placebo+anaprazole 20 mg once daily for 4 weeks.The primary efficacy endpoint was the 4-week ulcer healing rate assessed by blinded independent review.Secondary endpoints were the proportion of patients with improved overall and individual duodenal ulcer symptoms at 4 weeks.Furthermore,exploratory subgroup analysis of the primary endpoint by H.pylori status and CYP2C19 polymorphism was conducted.Adverse events were monitored for safety.Non-inferiority analysis was conducted for the primary endpoint.Results:The study enrolled 448 patients(anaprazole,n=225;rabeprazole,n=223).The 4-week healing rates were 90.9%and 93.7%for anaprazole and rabeprazole,respectively(difference,-2.8%[95%confidence interval,-7.7%,2.2%]),demonstrating non-inferiority of anaprazole to rabeprazole.Overall duodenal ulcer symptoms improved in 90.9%and 92.5%of patients,respectively.Improvement rates of individual symptoms were similar between the groups.Healing rates did not significantly differ by H.pylori status or CYP2C19 genotype for either treatment group.The incidence of treatment-emergent adverse events was similar for anaprazole(72/220,32.7%)and rabeprazole(84/219,38.4%).Conclusions:The efficacy of anaprazole is non-inferior to that of rabeprazole in Chinese patients with duodenal ulcers.Registration:ClinicalTrials.gov,NCT04215653. | Huiyun Zhu Xue Pan Li Zhang Hongxin Sun Huizhen Fan Zhongwei Pan Caibin Huang Zhenwang Shi Jin Ding Qi Wang Yiqi Du Nonghua Lyu Zhaoshen Li | 2022 | Chinese Medical Journal2022，135，24： | 1 |
| 8 | Early Management Experience of Perforation after ERCP显示文摘 | Guohua Li Youxiang Chen Xiaojiang Zhou Nonghua Lv Stuart Sherman | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 9 | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update显示文摘 | Yuan Guo Nonghua Lu Aiping Bai Gerly A. C. Brito | 2013 | BioMed Research International2013，，： | 1 |
| 10 | Suppression of growth and migration by blocking the hedgehog signaling pathway in gastric cancer cells显示文摘 | Runwei Yan Xiang Peng Xiaogang Yuan Dengliang Huang Jiang Chen Quqin Lu Nonghua Lv Shiwen Luo | 2013 | Cellular Oncology2013，，5： | 1 |
| 11 | Risk of Ulcerative Colitis-Associated Colorectal Cancer in China: A Multi-Center Retrospective Study显示文摘 | Wei Gong Nonghua Lv Bangmao Wang Ye Chen Yinglong Huang Wenshen Pan Bo Jiang | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
| 12 | Clinicopathologic Analysis of 2,889 Nanchang-Area Patients with Colorectal Polyps显示文摘OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with colorectal polyps who were diagnosed by colonoscopy and pathology in our hospital from 1990 to 2004. The analysis involved the incidence, average patient age, polyp location and pathological types. We recorded the changes of the polyp clinicopathologic features by comparing the clinicopathologic types of colorectal polyps over fi ve-year periods. RESULTS Of the 21,853 patients who received a colonoscopy, 2,889(13.2%) were diagnosed with colorectal polyps. Their average age was 46.6±16.5 years, with a male to female ratio of 1.8:1. The males were older than females (47.1±17.5 vs. 45.5±14.5, P<0.05). Location of the polyps: 41% in the rectum, 27.7% in the sigmoid colon, 35.8% in the left side verus 23.1% in the right side (P<0.05). Patients with polyps located in the transverse and ascending colon were older than those with polyps in the rectum and sigmoid colon (P<0.05). Adenomatous polyps comprised the most common type (67%) and the rectum was the most common site for each type, especially juvenile and retention polyps. Juvenile polyps were found in the youngest patients(12±4.8, P<0.05) and the adenomatous in the oldest (52±14, P<0.05). The ratio of patients with polyposis comprised 1.2%, and patients with polyps accompanied with colorectal cancer comprised 6.1%. Examination of the changes in the incidence, the average patient age, and adenomatous type showed that they had all increased, but the frequency of infl ammatory and retention polyps decreased. CONCLUSION Colorectal polyps are a common problem. The frequency is greater in males compared to females and the rectum and sigmoid colon had the highest incidence. Most juvenile and retention polyps were found in young patients, but most adenomatous occurred in adults. In recent years, the incidence of colorectal polyps, the average patient age, and the adenomatous type have increased in the Nanchang area, but inflammatory and retention types decreased. | Guohua Li Wangdi Liao Ping Xu Nonghua Lv Chongwen Wang | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 0 |
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