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| 1 | Restoring the plant productivity of heavy metal-contaminated soil using phosphate sludge,marble waste,and beneficial microorganisms显示文摘Assisted natural remediation(ANR)has been highlighted as a promising,less expensive,and environmentally friendly solution to remediate soil contaminated with heavy metals.We tested the effects of three amendments(10%compost,C;5 or 15%phosphate sludge,PS5 and PS15;and 5 or 15%marble waste,MW5 and MW15)in combination with microorganism inoculation(rhizobacteria consortium alone,mycorrhizae alone,and the two incombination)on alfalfa in contaminated soil.Plant concentrations of Zn,Cu,and Pb were measured,along with proline and malondialdehyde production.The microbiological and physicochemical properties of the mining soil were evaluated.Application of the amendments allowed germination and promoted growth.Inoculation with the rhizobacteria consortium and/or mycorrhizae stimulated plant growth.PS and MW stimulated the production of proline.Inoculation of alfalfa with the rhizobacteria-mycorrhizae mixture and the application of MW allowed the safe cultivation of the legume,as shown by the low concentrations of metals in plant shoots.Zn and Pb concentrations were below the limits recommended for animal grazing and accumulated essentially in roots.Soil analyses showed the positive effect of the amendments on the soil physicochemical properties.All treatments increased soil p H(around 7),total organic carbon,and assimilable phosphorus content.Notably,an important decrease in soluble heavy metals concentrations was observed.Overall,our findings revealed that the applied treatments reduced the risk of metal-polluted soils limiting plant growth.The ANR has great potential for success in the restoration of polymetallic and acidic mining soils using the interaction between alfalfa,microorganisms,and organomineral amendments. | Anas Raklami Abdel-ilah Tahiri Noura Bechtaoui ElGharmali Abdelhay Eloisa Pajuelo Marouane Baslam Abdelilah Meddich Khalid Oufdou | 2021 | Journal of Environmental Sciences2021，33，1： | 8 |
| 2 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 3 | Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations显示文摘AIM To characterize AXL receptor tyrosine kinase(AXL)expression in relationship to tumor protein P53(TP53gene,p53 protein)and its role in tumor invasion and response to therapy.METHODS We used 14 cell lines,including 3 isogenic pairs carrying mutant/knockout p53,to gain insight into the relationship between AXL and TP53.These included HCT116,HCT116.p53 mutant,RKO,and RKO.p53-/-lines(all from colon cancers)as well as breast cancer cell lines MCF7 and 1001(MCF7-p53 mutant clone).He La cell line was used as a positive control for epithelial to mesenchymal transition(EMT).AXL expression was determined by Western blotting using rabbit monoclonal antibody clone C89E7.AXL si RNA silencing was performed and followed by collagen invasion assay.Cell viability analysis using the sulforhodamine B assay and the invasion assay were performed after exposure to chemotherapeutic agents(doxorubicin for breast cancer cells;5FU or irinotecan for colon cancer cells).RESULTS We showed that the introduction of p53 mutations or knockout increased expression levels of AXL in isogenic cells compared to the matching p53 wild-type parental cells.Overall,we found a trend for correlation between the potential EMT candidate AXL,p53 alterations,and EMT markers in colorectal and breast cancers.The expression of AXL in RKO cells,a rare colon cancer cell line with inactive Wnt signaling,suggests that the AXL oncogene might provide an alternative genetic pathway for colorectal carcinogenesis in the absence of Wnt signaling activation and TP53 mutation.AXL silencing in the TP53 mutant isogenic cell lines 1001,HCT116.p53 mutant and RKO.P53-/-was>95%efficient and the silenced cells were less invasive compared to the parental TP53 wild-type cells.AXL silencing showed a subtle trend to restore colon cancer cell sensitivity to5FU or irinotecan.Importantly,AXL expressing cells developed more invasive potential after exposure to chemotherapy compared to the AXL-silenced cells.CONCLUSION AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy.These findings could have applications in cancer management. | Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair S R Aravind Maha Saber-Ayad | 2017 | World Journal of Gastroenterology2017，23，19： | 7 |
| 4 | Antiarrhythmic Effect of Statin Therapy and Atrial Fibrillation显示文摘 | Laurent Fauchier Bertrand Pierre Axel de Labriolle Caroline Grimard Noura Zannad Dominique Babuty | 2008 | Journal of the American College of Cardiology2008，，8： | 2 |
| 5 | Recent Advances on Graphene Quantum Dots for Electrochemical Energy Storage Devices显示文摘Graphene quantum dots(GQDs)which are nanofragments of graphene with an average size between 2 and 50 nm have attracted much attention due to their outstanding properties such as high conductivity,high surface area,and good solubility in various solvents.GQDs combine the quantum confinement and edges effects and the properties of graphene.Therefore,GQDs offers a broad range of applications in various fields(medicine,energy conversion,and energy storage devices).This review will present the recent research based on the introduction of GQDs in batteries,supercapacitors,and microsupercapacitors as electrodes materials or mixed with an active material as an auxiliary agent.Tables,discussed on selected examples,summarize the electrochemical performances and finally,challenges and perspectives are recalled for the subsequent optimization strategy of electrode materials.This review is expected to appeal a broad interest on functional GQDs materials and promote the further development of high-performance energy storage device. | Noura Zahir Pierre Magri Wen Luo Jean Jacques Gaumet Philippe Pierrat | 2022 | Energy & Environmental Materials2022，5，1： | 2 |
| 6 | Soil Phosphorus Fractions Change in Winter in a Corn-Soybean Rotation with Tillage and Phosphorus Fertilization显示文摘Determining how agricultural management practices affect soil phosphorus(P) over the winter may further our understanding of the soil P cycle under specific environmental conditions in eastern Canada. This study assessed changes over winter for soil P fractions and other selected chemical properties as affected by tillage and P fertilization. In 1992, a long-term corn(Zea mays L.) and soybean(Glycine max L.) rotational experiment was established in the province of Quebec, Canada. Soil samples(0–15 cm) were collected in fall 2001 and 2007 after a soybean harvest, and in the following spring 2002 and 2008 before corn seeding, in main plots under moldboard plow and no-till managements and selected subplots fertilized with 0, 17.5, or 35 kg P ha-1and 160 kg N ha-1. Soil samples were analyzed for P fractions and other chemical properties to assess changes over winter for 2001–2002 and 2007–2008. Changes over winter of all soil P fractions were significant for the two periods, indicating the occurrence of soil P transformation and movement over winter. The Mehlich-3-extractable Fe, Al, Ca, and Mg decreased during the two studied periods. Tillage had no significant effect on all soil P fractions. The resin-extractable P in 2001–2002 and Na HCO3-extractable inorganic P and Na OH-extractable organic P during the two winters were significantly increased under P fertilization. This study demonstrated that P in cultivated soils changed during winter as a result of changes in labile P fractions possibly due to the solubilization of residual fertilizer P combined with environmental factors. | Yi-Chao SHI Noura ZIADI Aimé J.MESSIGA Roger LALANDE HU Zheng-Yi | 2015 | Pedosphere2015，25，1： | 2 |
| 7 | Calponin 3 promotes invasion and drug resistance of colon cancer cells显示文摘BACKGROUND Calponin 3(CNN3)is an actin-binding protein expressed in smooth muscle and non-smooth muscle cells.It is required for cytoskeletal rearrangement and wound healing.AIM To dissect the role of CNN3 in carcinogenesis with a focus on colon cancer.METHODS A total of 20 cancer cell lines(8 breast,11 colon,and HeLa cervical cancer cell as a positive control for mesenchymal phenotype)and 57 formalin-fixed,paraffinembedded sections from archived sporadic colorectal carcinomas were included in this study.CNN3 expression analysis by western blot or immunohistochemistry was followed by functional analyses.The CNN3 gene was silenced by specific small interfering RNA(commonly known as siRNA),followed by confirmation of the silencing efficiency by western blotting.Then,the silenced cells and control siRNA-transfected cells were analyzed for changes in epithelial and mesenchymal markers,invasion,and response to 5-fluoruracil treatment.We also performed proteomics analysis using a phospho-kinase array-based panel of 45 proteins.RESULTS CNN3 showed positive expression in 6/8 breast and 9/11 colon cancer lines and in HeLa cells.Interestingly,the colorectal adenocarcinoma line SW480 was negative,while the cell line developed from its matching lymph node metastasis(SW620)was positive for CNN3.CNN3 expression was fairly consistent with the metastatic phenotype in colon cancer because it was absent in one other colon cell line from a primary site and expressed in all others.We selected SW620 for subsequent functional analyses.CNN3-silenced SW620 cells showed a reduction in collagen invasion and loss of mesenchymal markers.CNN3 silencing caused an increase in the SW620 colon cancer cell sensitivity to 5-fluorouracil.Phosphokinase array-based proteomics analysis showed that CNN3 silencing in SW620 reduced extracellular signal-regulated kinase,β-Catenin,mutant p53,c-Jun,and heat shock protein 60 activities but increased that of checkpoint kinase 2.CNN3 was expressed in 20/57(35%)colon cancer cases as shown by immunohistochemistry.CNN3 was associated with a decrease in overall survival in colon cancer in silico.CONCLUSION These results show the involvement of CNN3 in lymph node metastasis and resistance to chemotherapy in colon cancer and suggest that significant oncogenic pathways are involved in these CNN3-related actions. | Vidhya A Nair Noura A Al-khayyal Sivaramakrishnan Sivaperumal Wael M Abdel-Rahman | 2019 | World Journal of Gastrointestinal Oncology2019，11，11： | 2 |
| 8 | Rapid determination ot soil orgamc matter quality indicators usmg visible near infrared reflectance spectroscopy显示文摘 | AMervlan 5t Luce Noura Ziadi Bernie J Zebarth et aI | 2014 | Geoderma2014，，： | 1 |
| 9 | Immunohistochemical assessment of localization and frequency of micremetastasis in lymph nodes of colorectal cancer显示文摘 | Noura S Yamamoto H Miyake Y | 2002 | Clin Cancer Res2002，8，3： | 1 |
| 10 | Sensor Fault Detection, Identification and Fault Tolerant Control:Application to Active Suspension显示文摘 | Abbas Chamseddine Hassan Noura | 2006 | Proceeding of the 2006 American Control Conference2006，，： | 1 |
| 11 | Tumor markers for colorectal cancer显示文摘 | Yamamoto H Miyake Y Noura S | 2001 | Gan To Kagaku Ryoho2001，28，： | 1 |
| 12 | Single-incision laparoscopic cecectomy for low-grade appendiceal mucinous neoplasm after laparoscopic rectectomy显示文摘In this case report,we discuss single-incision laparoscopic cecectomy for low-grade appendiceal neoplasm after laparoscopic anterior resection for rectal cancer.The optimal surgical therapy for low-grade appendiceal neoplasm is controversial;currently,the options include appendectomy,cecectomy,right hemicolectomy,and open or laparoscopic surgery.Due to the risk of pseudomyxoma peritonei,complete resection without rupture is necessary.We have encountered 5 cases of lowgrade appendiceal neoplasm and all 5 patients had no lymph node metastasis.We chose the appendectomy or cecectomy without lymph node dissection if preoperative imaging studies did not suspect malignancy.In the present case,we performed cecectomy without lymph node dissection by single-incision laparoscopic surgery(SILS),which is reported to be a reduced port surgery associated with decreased invasiveness and patient stress compared with conventional laparoscopic surgery.We are confident that SILS is a feasible alternative to traditional surgical procedures for borderline tumors,such as low-grade appendiceal neoplasms. | Shiki Fujino Norikatsu Miyoshi Shingo Noura Tatsushi Shingai Yasuhiko Tomita Masayuki Ohue Masahiko Yano | 2014 | World Journal of Gastrointestinal Surgery2014，6，5： | 1 |
| 13 | Comparative detection of lymph node mierometastases of stage Ⅱ colorectal cancer by reverse transcriptase polymerase chain reaction and immunohistoehemistry显示文摘 | Noura S Yamamoto H Ohnishi T | 2002 | J Clin Oncol2002，20，20： | 1 |
| 14 | A case of apocrine adenocarcinoma suspected as an axillary lymph node metastasis from cecal cancer显示文摘 | Ogino T Noura S Ohue M | | 0，，： | 1 |
| 15 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 16 | A case of chemoradiation with tissue expander for local reccuience Jrectal cancer显示文摘 | Tanaka K Noura S Ohue M | 2005 | Can To Kagaku Ryoho2005，32，11： | 1 |
| 17 | Super-Efficiency in DEA by Effectiveness of Each Unitin Society显示文摘 | Noura A A Hosseinzadeh L F Jahanshahloo G R Fanati R S | 2011 | Applied Mathematics Letters2011，24，5： | 1 |
| 18 | Overexpression of MT1-MMP is insufficient to increase experimental livermetastasis of human colon cancer cells显示文摘 | Hirofumi Yamamoto Shingo Noura Jiro Okami Mamoru Uemura Ichiro Takemasa Masataka Ikeda Hideshi Ishii Mitsugu Sekimoto Nariaki Matsuura Morito Monden Masaki Mori | 2008 | International Journal of Molecular Medicine2008，，6： | 1 |
| 19 | Catt~ic acid phenethyl a ester, 5 - lipoxygenase enzyme inhibitor alleviates diabetic atherosclerotic manitestations:Effect on vascular reaetivity and stiffness显示文摘 | Noura A H Hany M E B | 2014 | Chemico-Biological Interactions2014，，213： | 1 |
| 20 | Evaluation of the lateral sentinel node by indoeyanine green for rectal cancer based on mierometastasis determined by reverse transcriptase-polymerase chain reaction 显示文摘 | Noura S Ohue M Seki Y | 2008 | Oncol Rep2008，20，4： | 1 |
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