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| 1 | 为用离合器切割器的食道的小粒的房间肿瘤的内视镜的 submucosal 解剖显示文摘 Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate.The shortcomings of this method are the deficiencies of fixing the knife to the target lesion,and of compressing it.These shortcomings can lead to major complications such as perforation and bleeding.To reduce the risk of complications related to ESD,we developed a new grasping type scissors forceps (Clutch Cutter,Fujifilm,Japan) which can grasp and incise the targeted tissue using an electrosurgical current.Esophagogastroduodenoscopy on a 59-year-old Japanese man revealed a 16mm esophageal submucosal nodule with central depression.Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement.The histologic diagnosis of the specimen obtained by biopsy was granular cell tumor.It was safely and accurately resected without unexpected incision by ESD using the CC.No delayed hemorrhage or perforation occurred.Histological examination confirmed that the granular cell tumor was completely excised with negative resection margin.We report herein a case of esophageal granular cell tumor successfully treated by an ESD technique using the CC. | Keishi Komori Kazuya Akahoshi Yoshimasa Tanaka Yasuaki Motomura Masaru Kubokawa Soichi Itaba Terumasa Hisano Takashi Osoegawa Naotaka Nakama Risa Iwao Masafumi Oya Kazuhiko Nakamura | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 8 |
| 2 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 3 | Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography显示文摘AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy. | Takashi Osoegawa Yasuaki Motomura Kazuya Akahoshi Naomi Higuchi Yoshimasa Tanaka Terumasa Hisano Souichi Itaba Junya Gibo Mariko Yamada Masaru Kubokawa Yorinobu Sumida Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 4 | Lysophosphatidic acid induced nuclear translocation of nuclear factor-κB in Panc-1 cells by mobilizing cytosolic free calcium显示文摘AIM: To clarify whether Lysophosphatidic acid (LPA) activates the nuclear translocation of nuclear factor-κB (NF-κB) in pancreatic cancer. METHODS: Panc-1, a human pancreatic cancer cell line, was used throughout the study. The expression of LPA receptors was confirmed by reverse-transcript polymerase chain reaction (RT-PCR). Cytosolic free calcium was measured by fluorescent calcium indicator fura-2, and the localization of NF-κB was visualized by immunofluorescent method with or without various agents, which effect cell signaling. RESULTS: Panc-1 expressed LPA receptors, LPA1, LPA2 and LPA3. LPA caused the elevation of cytosolic free calcium dose-dependently. LPA also caused the nuclear translocation of NF-κB. Cytosolic free calcium was attenuated by pertussis toxin (PTX) and U73122, an inhibitor of phospholipase C. The translocation of NF-κB was similarly attenuated by PTX and U73122, but phorbol ester, an activator of protein kinase C, alone did not translocate NF-κB. Furthermore, the translocation of NF-κB was completely blocked by Ca2+ chelator BAPTA-AM. Thapsigargin, an endoplasmic- reticulum Ca2+-ATPase pump inhibitor, also promoted the translocation of NF-κB. Staurosporine, a proteinkinase C inhibitor, attenuated translocation of NF-κB induced by LPA. CONCLUSION: These findings suggest that protein kinase C is activated endogenously in Panc-1, and protein kinase C is essential for activating NF-κB with cytosolic calcium and that LPA induces the nuclear translocation of NF-κB in Panc-1 by mobilizing cytosolic free calcium. | Yoshiyuki Arita Tetsuhide Ito Takamasa Oono Ken Kawabe Terumasa Hisano Ryoichi Takayanagi | 2008 | World Journal of Gastroenterology2008，14，28： | 5 |
| 5 | Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer显示文摘 | Hidenori Takahashi Hiroaki Ohigashi Kunihito Gotoh Shigeru Marubashi Terumasa Yamada Masayuki Murata Tatsuya Ioka Hiroyuki Uehara Masahiko Yano Osamu Ishikawa | 2013 | Annals of Surgery2013，，6： | 3 |
| 6 | Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer显示文摘AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, respectively.CONCLUSION: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases. | Hisato Igarashi Tetsuhide Ito Ken Kawabe Terumasa Hisano Yoshiyuki Arita Toyoma Kaku Ryoichi Takayanagi | 2008 | World Journal of Gastroenterology2008，14，34： | 3 |
| 7 | Successful embolization assisted by covered stents for a pseudoaneurysm following pancreatic surgery显示文摘Delayed intra-abdominal hemorrhage after pancreatic surgery is a potentially lethal complication.Transarterial coil embolization and/or the placing of an endovascular stent are minimally invasive and effective procedures.An artery that is extensively eroded and rendered friable due to operative skeletonization or postoperative inflammation sometimes contributes to delayed intra-abdominal hemorrhage or rebleeding after coil embolization.This report presents a case of successful management of postoperative hemorrhage in a-74-year-old Japanese male.He experienced bleeding from a pseudoaneurysm of the brittle hepatic artery following total pancreatectomy.Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts,but rebleeding occurred 1 mo later due to the brittleness of the artery.Rebleeding was definitively managed by the complete packing of the stent by coil embolization.He remains stable at 18 mo following the f inal embolization.A stent graft can be used for protecting a brittle artery to avoid injury by coil embolization. | Koji Tanaka Hiroaki Ohigashi Hidenori Takahashi Kunihito Gotoh Terumasa Yamada Isao Miyashiro Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 8 | Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis显示文摘 | Natsuko Kawada Kazuho Imanaka Tsukasa Kawaguchi Chie Tamai Ryu Ishihara Takashi Matsunaga Kunihito Gotoh Terumasa Yamada Yasuhiko Tomita | 2009 | Journal of Gastroenterology2009，，12： | 2 |
| 9 | Results of Surgical Resection for Patients With Hilar Bile Duct Cancer: Application of Extended Hepatectomy After Biliary Drainage and Hemihepatic Portal Vein Embolization显示文摘 | Seiji Kawasaki Hiroshi Imamura Akira Kobayashi Terumasa Noike Shiro Miwa Shin-ichi Miyagawa | 2003 | Annals of Surgery2003，，1： | 2 |
| 10 | A Primary Heptic Plsma Cell Tumor in a Dog显示文摘 | Mica AOKI Tetsujum KIM Terumasa SHLMADA etal | 2004 | Vet Med Sci2004，66，4： | 1 |
| 11 | Effects of Surface Roughness of Roll Metal Pins on Their Friction and Wear Characteristics 显示文摘 | Terumasa Hisakado Kentarou Miyazaki | 2000 | Wear2000，239，： | 1 |
| 12 | Comparison of the Indocyanine Green Fluorescence and Blue Dye Methods in Detection of Sentinel Lymph Nodes in Early-stage Breast Cancer显示文摘 | Tomoharu Sugie Terumasa Sawada Nobumi Tagaya Takayuki Kinoshita Kazuhiko Yamagami Hirofumi Suwa Takafumi Ikeda Kenichi Yoshimura Miyuki Niimi Akira Shimizu Masakazu Toi | 2013 | Annals of Surgical Oncology2013，，7： | 1 |
| 13 | Conductive and Transparent Multilayer Films for Low-temperature-sintered Mesoporous TiO2 Electrodes of Dye-sensitized Solar Cells显示文摘 | SEIGO I TETSUYA T TERUMASA K | 2003 | Chem Mater2003，15，： | 1 |
| 14 | Regenerative medicine of cornea by cell sheet engineering using temperature-responsive culture surfaces显示文摘Recently,regenerative medicine has been focused on as next-generation definitive therapies for several diseases or injuries for which there are currently no effective treatments.These therapies have been rapidly developed through the effective fusion between different fields such as stem cell biology and biomaterials.So far,we have proposed'cell sheet engineering'through our core technology that simply applies alterations of the temperature which allows regulation of the attachment or detachment of living cells on the culture surfaces grafted with the temperature-responsive polymer'poly(N-isoproplyacrylamide)'.This technology enables us to construct bioengineered sheet-like tissues,termed'cell sheets',without the need of using biodegradable scaffolds and protease treatments that are traditionally used.Therefore,our carrier-free cell sheets not only are independent of the issues observed in conventional methods,but also showed further advantages in the reconstruction of the corneal epithelium or endothelium(e.g.improvement of optical transparency and cell-cell interactions to host stroma in reconstructed tissues).Moreover,our approach does not have issues such as immune rejection or limited number of donors,due to the use of cell sheets derived from autologous limbal(in patients with unilateral disease)or oral mucosal epithelial cells(in patients with bilateral disorders).Indeed,we have successfully performed the clinical application for the reconstruction of ocular surfaces through the transplantation of our carrier-free corneal epithelial cell sheets,as evidenced by improved visual acuity as well as long-term maintenance of postoperative health conditions on ocular surfaces in all patients.We have also proposed a novel approach for the reconstruction of the corneal endothelium using corneal endothelial cell sheets by demonstrating its successful application.Thus,our cell sheet engineering technique provides a breakthrough in the field of regenerative medicine applied to the cornea. | UMEMOTO Terumasa YAMATO Masayuki NISHIDA Kohji OKANO Teruo | 2013 | Chinese Science Bulletin2013，58，35： | 1 |
| 15 | Real-Time Intraoperative Assessment of Residual Liver Functional Reserve Using Pulse Dye Densitometry显示文摘 | Hirofumi Akita Yo Sasaki Terumasa Yamada Kunihito Gotoh Hiroaki Ohigashi Hidetoshi Eguchi Masahiko Yano Osamu Ishikawa Shingi Imaoka | 2008 | World Journal of Surgery2008，，12： | 1 |
| 16 | Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases 显示文摘 | ATSUSHI K TERUMASA I | 2013 | Frontiers in Microbiology2013，，4： | 1 |
| 17 | Intrinsic restriction activity by AID/ APOBEC family of enzymes against the mobility of retroelements 显示文摘 | ATSUSHI K TERUMASA I | 2011 | Mob Geoet Elements2011，1，3： | 1 |
| 18 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 19 | Comparative morphology of interstitial cells of cajal :Ultrastructural characterization显示文摘 | Terumasa K | 1999 | Microscopy Res Technique1999，47，： | 1 |
| 20 | High power and high-brightness laser butt welding with using hot wire for thick high strength steel plate显示文摘 | Ohnishi Terumasa Kawahito Yousuke Katayama Seiji | 2011 | Quarterly Journal of the Japan Welding Society2011，29，1： | 1 |
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