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| 1 | On the volatility of daily stock returns of Total Nigeria Plc: evidence from GARCH models, value-at-risk and backtesting显示文摘This study investigates the volatility in daily stock returns for Total Nigeria Plc using nine variants of GARCH models:sGARCH,girGARCH,eGARCH,iGARCH,aGARCH,TGARCH,NGARCH,NAGARCH,and AVGARCH along with value at risk estimation and backtesting.We use daily data for Total Nigeria Plc returns for the period January 2,2001 to May 8,2017,and conclude that eGARCH and sGARCH perform better for normal innovations while NGARCH performs better for student t innovations.This investigation of the volatility,VaR,and backtesting of the daily stock price of Total Nigeria Plc is important as most previous studies covering the Nigerian stock market have not paid much attention to the application of backtesting as a primary approach.We found from the results of the estimations that the persistence of the GARCH models are stable except for few cases for which iGARCH and eGARCH were unstable.Additionally,for student t innovation,the sGARCH and girGARCH models failed to converge;the mean reverting number of days for returns differed from model to model.From the analysis of VaR and its backtesting,this study recommends shareholders and investors continue their business with Total Nigeria Plc because possible losses may be overcome in the future by improvements in stock prices.Furthermore,risk was reflected by significant up and down movement in the stock price at a 99%confidence level,suggesting that high risk brings a high return. | Ngozi G.Emenogu Monday Osagie Adenomon Nwaze Obini Nweze | 2020 | Financial Innovation2020，6，1： | 2 |
| 2 | Development of a 96-wel! catheter-based microdilution method to test antifungal susceptibility of Candida biofilms显示文摘 | Nweze El Ghannoum A Chandra J | 2012 | J Antimicrob Chemother2012，67，1： | 1 |
| 3 | Comparative virulence ofScedosporium species in animal models显示文摘 | Nweze El Okafor JI | 2010 | Journal ofInfectious Diseases2010，14，3： | 1 |
| 4 | Oral Candida isolates among HIV- infected subjects in Nigeria 显示文摘 | Nweze El Ogbonnaya UL | 2011 | J Microbiol Immunol Infect2011，44，3： | 1 |
| 5 | Justification for the use of Ocimum gratis-simum L in herbal medicine and its interaction with disc antibiot-ics显示文摘 | NWEZE El EZE EE | 2009 | BMC Complement Altern Med2009，9，： | 1 |
| 6 | Bacteria etiological agents causing respiratory tract infections in children and their resistance patterns to a panel of ten antibiotics显示文摘 | EI Nweze S Ezute Nweze CC Emeka CC Ogbonna C Eze | 2012 | Asian Pacific Journal of Tropical Disease2012，，1： | 1 |
| 7 | Dermatophytosis in Western Africa:a review显示文摘 | Nweze EI | 2010 | Pak J Biol Sci2010，13，13： | 1 |
| 8 | Aetiology of diarrhoea and virulence properties of di- arrhoeagenie Escherichia coli among patients and healthy sub- jeers in southeast Nigeria显示文摘 | Nweze El | 2010 | J Health Popul Nutr2010，28，3： | 1 |
| 9 | FREQUENCY, URINALYSIS AND SUSCEPTIBILITY PROFILE OF PATHOGENS CAUSING URINARY TRACT INFECTIONS IN ENUGU STATE, SOUTHEAST NIGERIA显示文摘 | Dibua Uju ME Onyemerela Ifeoma S Nweze Emeka I | 2014 | Revista do Instituto de Medicina Tropical de S?o Paulo2014，，： | 1 |
| 10 | Dermatophytoses in domesticated animals显示文摘 | Nweze E I | 2011 | Rev Inst Med Trop Sao Paulo2011，53，2： | 1 |
| 11 | Activation of acyclic amp- guanine exchange factor in hepatocytes decreases nitric oxide syn- thase expressio显示文摘 | Zhang B Nweze l Lakshmanan J | 2013 | Shock2013，39，1： | 1 |
| 12 | Antimicrobial resistance containment in Africa:Moving beyond surveillance显示文摘Worldwide,infections caused by drug‐resistant pathogens constitute a significant challenge threatening therapeutic efforts.According to the World Health Organization(WHO),antimicrobial resistance(AMR)ranks among the top 10 global public health threats.Organisms with a high rate of multiple host adaptivity,significant genetic diversity(multiple lineages),high virulence factors,and genetic exchange have been isolated from various sources(humans,animals,and the environment)even without exposure to prior antibiotics.Till now,the source of AMR and how resistant clones are selected in the environment remain largely elusive,and potential anthropogenic transmission has been reported in different studies.Various drug‐resistant pathogens,lineages,resistant clones,outbreak clusters,plasmid replicates,and genes that play a critical role in resistance dissemination have been identified.Maintenance of certain multidrug‐resistant(MDR)determinants has also been shown to enhance or support the propagation of MDR.So far,significant advances have been made in understanding the burden of AMR.However,overcoming AMR requires a holistic approach,as there is no single approach with sufficient precision to curb the threat.While strengthening AMR surveillance efforts is essential,as we have shown,there is also a need to intensify efforts to strengthen therapeutic interventions,especially in priority regions such as Africa.Herein,we discussed the burden of AMR and the dissemination of AMR in humans,animals,and the environment(non‐medical drivers).We further delved into the big questions on Africa and discussed how therapeutic interventions involving vaccines and other viable biomaterials could be pivotal in reducing the burden of AMR to the barest minimum. | Zikora Kizito Glory Anyaegbunam Ifeanyi Elibe Mba Yandev Doowuese Ngozi J.Anyaegbunam Toluwalase Mba Fetuata Aminat Aina Vincent NnamdigadiChigor Emeka Innocent Nweze Emmanuel A.Ezea | 2024 | Biosafety and Health2024，6，1： | 0 |
| 13 | Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles显示文摘Background:Malaria and neglected communicable protozoa parasitic diseases,such as leishmaniasis,and trypanosomiasis,are among the otherwise called diseases for neglected communities,which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa,Asia,and the Americas.Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period,which have encouraged resistance.These have prompted many researchers to focus on fin ding new drugs that are safe,effective,and affordable from marine environ merits.The aim of this review was to show the diversity,structural scaffolds,in-vitro or in-vivo efficacy,and recent progress made in the discovery/isolation of marine natural products(MNPs)with potent bioactivity against malaria,leishmaniasis,and trypanosomiasis.Main text:We searched PubMed and Google scholar using Boolean Operators(AND,OR,and NOT)and the combination of related terms for articles on marine natural products(MNPs)discovery published only in English language from January 2016 to June 2020.Twenty nine articles reported the isolation,identification and antiparasitic activity of the isolated compounds from marine environment.A total of 125 compounds were reported to have been isolated,out of which 45 were newly isolated compounds.These compounds were all isolated from bacteria,a fungus,sponges,algae,a bryozoan,cnidarians and soft corals.In recent years,great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds.Comparably,some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs.However,very few of these MNPs have a pharmaceutical destiny due to lack of the following:sustainable production of the bioactive compounds,stan da rd efficient screening methods,knowledge of the mechanism of action,partnerships between researchers and pharmaceutical industries.Conclusions:It is crystal clear that marine organisms are a rich source of antiparasitic compounds,such as alkaloids,terpenoids,peptides,polyketides,terpene,coumarins,steroids,fatty acid derivatives,and lactones.The current and future technological innovation in natural products drug discovery will bolster the drug armamentarium for malaria and neglected tropical diseases. | Justus Amuche Nweze Florence N.Mbaoji Yan-Ming Li Li-Yan Yang Shu-Shi Huang Vincent N.Chigor Emmanuel A.Eze Li-Xia Pan Ting Zhang Deng-Feng Yang | 2021 | Infectious Diseases of Poverty2021，10，1： | 0 |
| 14 | Comparative analysis of urinary schistosomiasis among primary school children and rural farmers in Obollo-Eke,Enugu State,Nigeria:Implications for control显示文摘Objective:To determine the prevalence,sex-age related intensity of urinary schistosomiasis and to compare such parameters among rural school children and rural fanners in selected communities in Obollo-Eke located in Southeast,Nigeria.Methods:A cross-sectional survey involving 1 337 school children and farmers was conducted in Obollo-Eke community between September 2006 and July 2007.Demographic data of subjects was collected using a questionnaire prepared for this purpose.Urine samples were collected and examined for haematuria and ova of Schistosoma haematobium(S.haematobium) using Medi-test Combi 9 and sedimentation technique respectively.Results:The prevalence of urinary schistosomiasis based on microscopic examination of the urine sediment for the ova of 5.haematobium was 17.5%while the prevalence of haematuria was 15.6%.Infection intensity varied from light to heavy.In general,the prevalence was higher among males(20.8%) than females(14.6%;P>0.05) and was slightly higher among primary school children(18.0%;n=762) than farmers(16.9%;n=575;P>0.05).The age-specific prevalence of schistosomiasis among the study subjects ranged from 8.3%to 21.2%in 0-5 years and 11-15 years age groups respectively.Conclusions:Haematuria and mean egg/10 mL urine (r = 0.95;P<0.01) showed that both procedures are reliable for the diagnosis of the disease and can be used to ascertain the prevalence of the disease in any community.The comparative analysis of urinary bilharziasis among primary school children and rural farmers demonstrated that the infection is moderately high in these two risk population groups at Obollo-Eke.A robust intervention strategy is clearly needed. | Celestine Chidi Ogbonna Geme Urge Dori Emeka Innocent Nweze Gilbert Muoneke Innocent Ejike Nwankwo Nkiru Akputa | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，10： | 0 |
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