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| 1 | 让肾脏健康人人可享,处处可及——从预防到诊治显示文摘Around 850 million people currently are affected by different types of kidney disorders.Up to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly progressive.The global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney transplantation.Hence,CKD is a major cause of catastrophic health expenditure. | Philip Kam Tao Guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal Saadi Luisa Strani Ifeoma Ulasi Kamyar Kalantar Zadeh 无 | 2020 | 肾脏病与透析肾移植杂志2020，29，1： | 6 |
| 2 | 尼日利亚翼状胬肉治疗状况的回顾性分析(英文)显示文摘目的:总结尼日利亚翼状胬肉的治疗现状。方法:选择1999-01/2002-12的4a期间的翼状胬肉手术患者,所有病例都来自于尼日利亚Enugu市的尼日利亚大学教学医院和Ebrans临床中心。收集这些患者的生理数据、临床表现、手术方法和术后并发症等资料,应用6.1版EPI-INFO方法进行数据处理。共选择3种不同的手术方法:60眼单纯施行巩膜暴露术,42眼施行联合5-氟尿嘧啶(5-FU)的巩膜暴露术,22眼施行联合丝裂霉素C的巩膜暴露术。结果:72例(124眼)施行翼状胬肉切除术的患者,术后至少随访1a,包括男41例(56.9%),女31例(43.1%),男女比例为1∶0.8。术后复发率最高的在病变第III期(55.6%),最低在病变第I期(22.2%)。3种手术方法比较,复发率分别为65.0%、52%和13.6%。结论:在像尼日利亚这样的发展中国家,联合丝裂霉素的早期手术切除术,是一种安全性强、治疗费用低、方法简单且创伤小的治疗翼状胬肉的有效手段,值得推广。 | Ernest N.Onwasigwe Ifeoma R.Ezegwui | 2006 | 国际眼科杂志2006，6，3： | 5 |
| 3 | All-epiphyseal versus trans-epiphyseal screw fixation for tillaux fractures:Does it matter?显示文摘BACKGROUND Tillaux fractures occur primarily in adolescents due to the pattern of physeal closure and are classified as Salter-Harris type III physeal fractures.Operative management with screw fixation is recommended for more than 2 mm of displacement or more than 1 mm of translation.However,the efficacy and complications of trans-physeal vs all-physeal screw fixation have not been investigated extensively.AIM To compare the clinical and functional outcomes of trans-physeal(oblique)and all-epiphyseal(parallel)screw fixation in management of Tillaux fractures among pediatric patients.METHODS This was an ethics board approved retrospective review of pediatric patients who presented to our tertiary children’s care facility with Tillaux fractures.We included patients who had surgical fixation of a Tillaux fracture over a 10 year period.Data analysis included demographics,mode of injury,management protocols,and functional outcomes.The patients were divided into group 1(oblique fixation)and group 2(parallel fixation).Baseline patient characteristics and functional outcomes were compared between groups.Statistical tests to evaluate differences included Fisher’s Exact or Chi-squared and independent samples t or Mann Whitney tests for categorical and continuous variables,respectively.RESULTS A total of 42 patients(28 females and 14 males)were included.There were no significant differences in body mass index,sex,age,or time to surgery between the groups[IK2].Sports injuries accounted for 61.9%of the cases,particularly non-contact(57.1%)and skating(28.6%)injuries.Computed Tomography(CT)scan was ordered for 28 patients(66.7%),leading to diagnosis confirmation in 17 patients and change in management plan in 11 patients.[GRC3]Groups 1 and 2 consisted of 17 and 25 patients,respectively.For mid to long-term functional outcomes,there were 14 and 10 patients in groups 1 and 2,respectively.Statistical analysis revealed no significant differences in the functional outcomes,pain scores,or satisfaction between groups.No infections,non-unions,physeal arrest,or post-operative ankle deformities were reported.Two(4.8%)patients had difficulty returning to sports post-surgery due to pain.One was a dancer,and the other patient had pain while running,which led to hardware removal.Both patients had parallel fixation.Hardware removal for groups 1 and 2 were 4(23.5%)and 5(20.0%)patients,respectively.The reasons for removal was pain in 2 patients,and parental preference in the remaining.CONCLUSION This is the largest reported series of pediatric patients with Tillaux fractures comparing functional outcomes of different methods of screw fixation orientation to the physis,which showed no difference regarding functional outcomes. | Brett Heldt Isaiah Roepe Raymond Guo Elsayed Attia Ifeoma Inneh Vinitha Shenava Indranil Kushare | 2022 | World Journal of Orthopedics2022，13，2： | 2 |
| 4 | Cytomegalovirus retinitis in the highly active anti-retroviral therapy era显示文摘Cytomegalovirus(CMV)retinitis is an opportunistic infection that has traditionally affected those who have HIV/AIDS or immunosuppressed individuals.CMV retinitis previously infected one-third of AIDS patients in the pre-highly active antiretroviral therapy(HAART)era,but since HAART,Western countries have seen an 80%decrease in the incidence of the disease.More recently,CMV retinitis has been reported in patients who are immunosuppressed,often due to chemotherapy or immunomodulatory medications.The diagnosis of CMV retinitis is often suspected based on clinical findings,with polymerase chain reaction for confirmation of CMV,especially in atypical cases.Highly active antiretroviral therapy and anti-CMV medications(systemic or local)remain the mainstay of treatment.However,for those who are not responsive to HAART,CMV retinitis remains a challenge,and can still lead to significant vision loss.Moreover,a regimen of anti-CMV medications can sometimes lead to viral resistance or organ toxicity.Complications such as immune recovery retinitis and rhegmatogenous retinal detachments continue to threaten the vision of patients who develop CMV retinitis.These complications can arise following initiation of treatment or if patients show disease progression.Proper vision screening for CMV retinitis in immunosuppressed patients at-risk is necessary for early detection and treatment. | Ifeoma N.Ude Steven Yeh Jessica G.Shantha | 2022 | Annals of Eye Science2022，，1： | 1 |
| 5 | Evaluation of anti-inflammatory property of the leaves of Sansevieria liberica ger.and labr.(fam:dracaenaceae)显示文摘Objective:To evaluate the anti-inflammatory property of leaves of Sansevieria liberica Ger. and Labr.and to ascertain the toxicity and phytochemical profiles of the extract of the leaves. Methods:The juice from the fresh leaves was expressed manually and lyophilized.The crude extract(CE) was then fractionated into n-hexane fraction(HF),chloroform fraction(CF), ethylacetate fraction(EF) and methanol fraction(MF).The crude extract(CF) and the fractions were screened for anti-inflammatory activity using egg albumen-induced paw(systemic) edema in rats as a measure of acute inflammation.The toxicity test and phytochemical screening were done using standard procedures.Results:The CE and the fractions significantly(P<0.05) inhibited the development of paw edema induced by egg albumen in rats.The potency/activity of the CE and the fractions increased in the order HF>CE>MF>CF>EF,with the CE and HF at 400 mg/kg exhibiting inhibition comparable to that obtained with 5 mg/kg diclofenac sodium. Acute toxicity test on CE established an oral and intraperitoneal LD50 of > 5 000 mg/kg in mice. Phytochemical screening of the CE and the fractions showed the presence of various bioactive substances such as alkaloids,saponins,flavonoids,terpenoids,steroids,glycosides,reducing sugars,tannins,resins,carbohydrates,proteins,acidic compounds,fats and oils.Conclusions: The results of the study showed that the leaves of Sansevieria liberica Ger and Labr.possess antiinflammatory effects which may be due to its bioactive constituents.Further purification on these bioactive constituents may result in the development of potent anti-inflammatory agent with low toxicity and better therapeutic index. | Eze Charity Chinasa Inya-Agha Stella Ifeoma Ezugwu Christopher Obodoike Ezea Samson Chhukwuemeka | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 1 |
| 6 | Isolation,fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction显示文摘Objective:To investigate the antiplasmodial activity of Phyllanthus niniri(P.niruri) methanol extract(ME) and its fractions in mice.Methods:P.niruri methanol extract and its chloroform. ethanol and aqueous portions were tested against chloroquine-sensitive Plasmodium berghei berghei in early,established and repository models of infection using Knight and Peter’s 4-day suppressive model,Rvlev and Peters curative model and Peters prophylactic model respectively. Results:Chemosuppression of parasitemia(37.65%-50.53%) was elicited by 100-400 mg/kg(b.w.) of ME.Al doses of 100 mg/kg b.w..the chloroform fraction(F1) significantly(P<0.01) suppressed parasitaemia by 85.29%,while ethanol and aqueous fractions(F2 and F3.respectively) elicited 67.06%and 51.18%chemosuppression.the most active fraction.F1 was selected for further antiplasmodial screening.In established infection.ME reduced parasitaemia(15.81%- 62.96%) while F1 significantly(P<0.01) reduced parasitaemia(44.369—90.48%).with effects comparable to that of chloroquine(96.48%).The prophylactic antiplasmodial activity of ME(92.50%suppression) was also significant(P<0.01) and was more effective than pyrimethamine(85.00%).additionally, cell membrane integrity of non-parasitized erythrocytes intubated with 125-500 mg/mL F1 was maintained.Conclusions:These findings indicate the antiplasmodial efficacy of P.niruri methanol extract,and the localization of this effect in its chloroform fraction. | Obidike Ifeoma Okhale Samuel Aboh Mercy Itohan Salawu Oluwakanyinsola Adeola | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，3： | 1 |
| 7 | Integrating an Evidence-Based Medicine Rotation into an internal Medicine Residency Program 显示文摘 | Elie A A Ifeoma S I Samer E D | 2004 | Aca- demic Medicine2004，，79： | 1 |
| 8 | Analgesic, anti-inflammatory, and heme biomineralization inhibitory properties of Entada africana ethanol leaf extract with antiplasmodial activity against Plasmodium falciparum显示文摘 | Ifeoma C. Ezenyi Lalasoanirina Ranarivelo Salawu A. Oluwakanyinsola Martins Emeje | 2014 | Journal of Basic and Clinical Physiology and Pharmacology2014，，2： | 1 |
| 9 | FREQUENCY, URINALYSIS AND SUSCEPTIBILITY PROFILE OF PATHOGENS CAUSING URINARY TRACT INFECTIONS IN ENUGU STATE, SOUTHEAST NIGERIA显示文摘 | Dibua Uju ME Onyemerela Ifeoma S Nweze Emeka I | 2014 | Revista do Instituto de Medicina Tropical de S?o Paulo2014，，： | 1 |
| 10 | The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System显示文摘 | Ifeoma Chinwude Obidike Oluwakanyinsola Adeola Salawu Mary Ndukuba Charles Ogbonnaya Okoli Uche Alex Osunkwo | 2010 | Journal of Dietary Supplements2010，，4： | 1 |
| 11 | Prediabetes and cardiovascular complications study:Highlights on gestational diabetes, self-management and primary health care显示文摘International collaboration on the prediabetes and cardiovascular complications study started in 2013.In 2017,a reflection was reported.Incompleteness of documentation and screening of antenatal cases for gestational diabetes mellitus(GDM)was concerning.Hence,further observations have been made that warrant an update.The objective of this review is to highlight gaps between clinical knowledge and practice in GDM,diabetes self-management and primary health care(PHC)for rural dwellers.We followed a descriptive field notes method.Antenatal records of patients screened for GDM with incomplete documentation were examined to determine incompleteness of data in those that also met the criteria for GDM risk assessment.Experiences on development of a diabetes register and education and notes on behavioural change wheel were also reviewed.Other data included cross-sectional evaluation of activities of daily living at two private hospitals.Up to 29%had high GDM risk factors,which fulfilled selection criteria for laboratory screening.Demographic data was complete in all women;however,incomplete documentation was observed with as much as 98%of basic data.High levels of physical activity were found in the population,and health lectures proved effective in food choices.The workforce need for diabetes care seems underestimated,but this may be better understood with reactivation of PHC services.The observations highlight behavioural change wheel issues on GDM and PHC services that need concerted focus.Two proposals are to advance the use of a‘risk assessment and screening sheet’for GDM screening and enlightenment of stakeholders on the central hub role of PHC in diabetes management. | Ezekiel Uba Nwose Phillip Taderera Bwititi Otovwe Agofure Echinei Jacob Oshionwu Ekenechukwu Esther Young Eferhire Aganbi Solomon Ekwuweokwuenu Egwenu Helen Egoyibo Chime Fortunatus Darius Gbeinbo Alex Odufu John Nwakaego Okuzor Azuka Okuleye Kennedy Aninze Innocent Chuks Onyia Euzebus Chinonye Ezugwu Eunice Obiajuru Igumbor Ifeoma Isabel Ulasi | 2021 | World Journal of Meta-Analysis2021，9，6： | 1 |
| 12 | Plastic multilayered closure versus orthopedic surgeon closure after spinal instrumentation in pediatric neuromuscular scoliosis显示文摘Objective To compare wound complication rates between orthopedic closure(OC)and plastic multilayered closure(PMC)in patients undergoing primary posterior spinal fusion for neuromuscular scoliosis(NMS).We hypothesize that multilayered closure will be associated with better postoperative outcomes.Methods We collected data on pediatric patients diagnosed with NMS who underwent first time spinal instrumentation between 1 January 2018 and 31 May 2021.Patient demographics,length of surgery,spinal levels fused and operative variables,wound complication rate,treatments,and need for wound washout were reviewed in depth and recorded.Results In total,86 patients were reviewed:46 with OC and 40 with PMC.There was a significant increase in operating room(OR)time with PMC compared with OC(6.7±1.2 vs 7.3±1.3,p=0.016).There was no difference in complication rate,mean postoperative day of complication or unplanned return to the OR for OC and PMC,respectively.There was a slightly significant increase in the number of patients going home with a drain in the PMC cohort compared with the OC cohort(2.1%vs 15%,p=0.046).Conclusions PMC demonstrated longer OR times than OC and did not demonstrate a statistically significant reduction in wound complications or unplanned returns to the OR.However,other studies have demonstrated statistical and clinical significance with these variables.Surgical programs should review internal patient volumes and outcomes for spinal fusion in NMS patients and consider if PMC after spinal fusions in pediatric patients with NMS or other scoliosis subtypes is an appropriate option in their institution to minimize postoperative wound complications. | Ekene U Ezeokoli Poornima L Tamma Neritan Borici Ifeoma Inneh Edward P Buchanan Brian G Smith | 2023 | World Journal of Pediatric Surgery2023，6，1： | 0 |
| 13 | Antimalarial activities of butanol and ethylacetate fractions of Combretum nigricans leaf显示文摘Objective: To evaluate the antimalarial activity of the ethylacetate and butanol fractions of Combretum nigricans(C. nigricans) leaf extract in mice. Methods: C. nigricans solvent(butanol and ethylacetate) fractions were screened for their phytochemical constituents using standard procedures illustrated by Harborne and Evans. The Peters' 4-day suppressive test against early malaria infection, Rane's curative test against established malaria and prophylactic test for residual activity were employed for evaluating the antimalarial potential in mice. Results: The phytochemical screening revealed the presence of alkaloids, terpenoids, saponins, and flavonoids in both fractions at different intensity. Both fractions exhibited significant antimalarial activity in all test models(P<0.05). The ethylacetate fraction of C. nigricans had better chemosuppressive and curative effects compared to the butanol fraction, which however, elicited a better chemoprophylactic effect. The chemosuppressive effect of C. nigricans ethylacetate fraction(200-800 mg/kg) was 77.6%, 69.1% and 86.1%; curative effect was 62.3%, 71.3% and 72.4%; while the chemoprophylactic activity was 32.1%, 48.6% and 61.2% respectively. C. nigricans butanol fraction(200-800 mg/kg) had 40.3%, 54.1% and 69.1% chemosuppression; 26.2%, 36.9% and 34.5% curative effect; and 48.4%, 70.0% and 87.4% chemoprophylaxis. Conclusions: Both solvent fractions of C. nigricans possess antimalarial activity, and may be useful at different stages of malaria therapy. | Enegide Chinedu Peter A.Akah Dabum L.Jacob Ifeoma A.Onah Chimere Y.Ukegbu Chukwuma K.Chukwuemeka | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，4： | 0 |
| 14 | Kidney health for all: bridging the gap in kidney health education and literacy显示文摘The high burden of kidney disease,global disparities in kidney care,and poor outcomes of kidney failure bring a concomitant growing burden to persons affected,their families,and carers,and the community at large.Health literacy is the degree to which persons and organizations have or equitably enable individuals to have the ability to find,understand,and use information and services to make informed health⁃related decisions and actions for themselves and others.Rather than viewing health literacy as a patient deficit,improving health literacy largely rests with health care providers communicating and educating effectively in codesigned partnership with those with kidney disease.For kidney policy makers,health literacy provides the imperative to shift organizations to a culture that places the person at the center of health care.The growing capability of and access to technology provides new opportunities to enhance education and awareness of kidney disease for all stakeholders.Advances in telecommunication,including social media platforms,can be leveraged to enhance persons’and providers’education;The World Kidney Day declares 2022 as the year of“Kidney Health for All”to promote global teamwork in advancing strategies in bridging the gap in kidney health education and literacy.Kidney organizations should work toward shifting the patient⁃deficit health literacy narrative to that of being the responsibility of health care providers and health policy makers.By engaging in and supporting kidney health-centered policy making,community health planning,and health literacy approaches for all,the kidney communities strive to prevent kidney diseases and enable living well with kidney disease. | Robyn G.Langham Kamyar Kalantar-Zadeh Ann Bonner Alessandro Balducci Li-Li Hsiao Latha A.Kumaraswami Paul Laffin Vassilios Liakopoulos Gamal Saadi Ekamol Tantisattamo Ifeoma Ulasi Siu-Fai Lui for the World Kidney Day Joint Steering Committee | 2022 | 肾脏病与透析肾移植杂志2022，31，1： | 0 |
| 15 | Production and Evaluaton of Yoghurt Flavoured with Beetroot (Beta vulgaris L,)显示文摘 | Mbaeyi-Nwaoha Ifeoma Elizabeth Nwachukwu Godstar Onyinyechi | 2012 | Journal of Food Science and Engineering2012，2，10： | 0 |
| 16 | Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties显示文摘Objective:To evaluate the antiplasmodial properties of fractions of chloroform portion of Phyllanthus niruri(P.niruri) methanol extract and identify a suitable chemical marker present therein.Methods:Chloroform portion of P.niruri methanol extract was separated from silica gel using gradient systems of hexane,ethylacetate and methanol.The fractions were screened for antiplasmodial activity against Plasmodium falciparum HB3 and FcM29.Fractions with IC_(50)<10μg/ml.against parasites were further screened for peripheral analgesic activity,while cytotoxicity was evaluated using THP-1 cells.Results:Fractions 12-14 were very active(IC_(50)<10 μg/mL) against Plasmodium falciparum and showed no significant cytotoxicity.Fractions 12 and 13 exhibited significant(P<0.01) reduction in acetic acid-induced writhing in mice,decreasing the number of writhes by 66.67% and 65.22% respectively and comparable with 100 mg/kg aspirin(65.22%).From fraction 12,a compound was isolated and identified as sitosteryl-6-β-D-glucoside-6'-palmitate by ~1H,^(13)C nuclear magnetic resonance and mass spectroscopies.Conclusions:Our findings illustrate antiplasmodial column fractions of P.niruri with analgesic activity and identify sitosteryl glucoside pahmitate as a chemical marker of activity. | Ezenyi Ifeoma Chinwude Kulkarni Roshan Joshi Swati Salawu Oluwakanyinsola Adeola Emeje Martins | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，9： | 0 |
| 17 | An Assessment of the Role of Art as a Resource for Learning and Development of the Child With Computer Applications显示文摘 | Francis Okechukwu Amadi Priscilla Ifeoma Okechukwu | 2016 | Journal of Literature and Art Studies2016，6，7： | 0 |
| 18 | Business Education in the E-World:Challenges and theWay Forward显示文摘With the rapid development and utilization of information and communication technology(ICT)facilities in the teaching and learning processes especially in the teaching and learning of business education,it becomes important to ascertain the state of business education in the electronic world(e-world),benefits of ICT integration in business education and challenges facing business education in the e-world and the way out. | Jacinta Ifeoma Obidile Josephat N.Onyeagba | 2019 | US-China Education Review(A)2019，9，6： | 0 |
| 19 | 尼日利亚埃努古春季结膜炎的临床特征(英文)显示文摘目的:调查在埃努古春季结膜炎的临床特征。方法:对连续的100例在埃努古州科技大学(ESUT)教学医院就诊春季角结膜炎的患者,进行关于生物数据,发病年龄,家族史和相关过敏史的前瞻性问卷调查。其后,患者在×2放大镜或裂隙灯下进行检查。结果:在100例患者中,男68例,女32例。72%<15岁。发病的主要(65.0%)在4岁之前。大部分(59.6%)的人在干燥炎热的季节和季节变化时瘙痒更为剧烈。只有29%有过敏体质有关,其中包括过敏性鼻炎(75.9%),哮喘(10.3%)和特应性皮炎(13.8%)。角膜的过敏反应不是一个突出的特点。结论:在埃努古春季结膜炎主要患者是儿童,男性比女性更加受到影响。发病常见于10岁左右。大多数患者全年发痒,但在一些在炎热的旱季发痒严重。过敏性鼻炎是最常见的过敏性并发症。 | Ifeoma Regina Ezegwui | 2009 | 国际眼科杂志2009，9，10： | 0 |
| 20 | Influence of Parenting Styles on In-School Adolescents Achievement Goal Orientation and Academic Achievement显示文摘 | Obi Ifeoma E. Okeke Therese U. | 2014 | Psychology Research2014，4，5： | 0 |
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