|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dendritic Cell-Derived Exosomes Stimulate Stronger CD8^+ CTL Responses and Antitumor Immunity than TVimor Cell-Derived Exosomes显示文摘从树枝状的细胞(DC ) 和肿瘤细胞导出的 Exosomes (EXO ) 被用来在动物模型并且在临床的试用刺激 antitumor 免疫者回答。然而,有不,一起, antitumor 免疫者回答的 stimulatory 效率的比较由这二支通常使用的 EXO 疫苗导致了。在这研究,我们选择了房间表示学习 EXO 的特征从一个 transfected EG7 肿瘤导出的显型 ovalbumin (卵) 和由流动 cytometry 的搏动卵的 DC。我们在在 EXO 的这二种类型之间的卵特定的有免疫力的回答的正式就职比较了 stimulatory 效果。我们发现卵搏动蛋白质的导出 DCovA 的 EXO (EXODC ) 能更高效地在 vivo 刺激天真的卵特定的 CD8+ T 房间增长和区别进细胞毒素的 T 淋巴细胞,并且比 EG7 肿瘤导致更有效的 antitumor 免疫导出房间的 EXO (EXOEG7 ) 。另外,我们阐明了在 EXO 的 stimulatory 效果被主人 DC 送到 T 房间回答的 EXO 疫苗的主人 DC 的重要角色。因此,导出 DC 的 EXO 可以在 antitumor 免疫的正式就职代表一支更有效的基于 EXO 的疫苗。 | Siguo Hao Ou Bai Jinying Yuan Mabood Qureshi Jim Xiang | 2006 | Cellular & Molecular Immunology2006，3，3： | 30 |
| 2 | Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China显示文摘 | Hu Peilei Bai Liqiong Liu Fengping Ou Xichao Zhang Zhiying Yi Songlin Chen Zhongnan Gong Daofang Liu Binbin Guo Jingwei Tan Yunhong | 2014 | Chinese Medical Journal2014，，21： | 24 |
| 3 | Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of β-cells in Goto-Kakizaki rats显示文摘AIM:To study the effects of Roux-en-Y gastric bypass(RYGB) on the expression of pancreatic duodenal homeobox-1(PDX-1) and pancreatic β-cell regeneration/neogenesis,and their possible mechanisms in diabetics.METHODS:Three groups of randomly selected nonobese diabetic Goto-Kakizaki(GK) rats were subjected to RYGB,sham-RYGB and sham-operation(sham-op) surgery,respectively.The rats were euthanized at postoperative 1,2,4 and 12 wk.Their pancreases were resected and analyzed using reverse transcription polymerase chain reaction to detect the mRNA of PDX-1.Anti-PDX-1 immunohistochemical(IHC) staining and Western blotting were used to detect the protein of PDX-1.Double IHC staining of anti-Brdu and-insulin was performed to detect regenerated β-cells.The index of double Brdu and insulin positive cells was calculated.RESULTS:In comparison with sham-RYGB and sham-op groups,a significant increase in the expressions of PDX-1 mRNA in RYGB group was observed at all experimental time points(1 wk:0.378 ± 0.013 vs 0.120 ± 0.010,0.100 ± 0.010,F = 727.717,P < 0.001;2 wk:0.318 ± 0.013 vs 0.110 ± 0.010,0.143 ± 0.015,F = 301.509,P < 0.001;4 wk:0.172 ± 0.011 vs 0.107 ± 0.012,0.090 ± 0.010,F = 64.297,P < 0.001;12 wk:0.140 ± 0.007 vs 0.120 ± 0.010,0.097 ± 0.015,F = 16.392,P < 0.001);PDX-1 protein in RYGB group was also increased significantly(1 wk:0.61 ± 0.01 vs 0.21 ± 0.01,0.15 ± 0.01,F = 3031.127,P < 0.001;2 wk:0.55 ± 0.00 vs 0.15 ± 0.01,0.17 ± 0.01,F = 3426.455,P < 0.001;4 wk:0.39 ± 0.01 vs 0.18 ± 0.01,0.22 ± 0.01,F = 882.909,P < 0.001;12 wk:0.41 ± 0.01 vs 0.20 ± 0.01,0.18 ± 0.01,F = 515.833,P < 0.001).PDX-1 mRNA and PDX-1 protein production showed no statistical significance between the two sham groups.Many PDX-1 positive cells could be found in the pancreatic islets of the rats in RYGB group at all time points.In addition,the percentage of Brdu-insulin double staining positive cells was higher in RYGB group than in the other two groups(1 wk:0.22 ± 0.13 vs 0.03 ± 0.06,0.03 ± 0.06,P < 0.05;2 wk:0.28 ± 0.08 vs 0.00 ± 0.00,0.03 ± 0.06,P < 0.05;4 wk:0.24 ± 0.11 vs 0.07 ± 0.06,0.00 ± 0.00,P < 0.001;12 wk:0.20 ± 0.07 vs 0.03 ± 0.06,0.00 ± 0.00,P < 0.05).CONCLUSION:RYGB can increase the expression of pancreatic PDX-1 and induce the regeneration of β-cells in GK rats.The associated regeneration of islet cells may be a possible mechanism that how RYGB could improve type 2 diabetes mellitus. | Zhen Li,Dong-Fei Li,Jing-Xing Dai,Yu Bai,Lin Yuan,Southern Medical University,Institute of Basic Medical Anatomy National Key Disciplines,Guangzhou 510515,Guangdong Province,China Hong-Ya Zhang,Lu-Xian Lv,Wen-Qiang Li,Second Affiliated Hospital,Xinxiang Medical College,Henan Province Key Laboratory of Biological Psychiatry,Xinxiang 453002,Henan Province,China Ou Sha,Department of Anatomy,Faculty of Medicine,Shenzhen University,Shenzhen 518060,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 4 | Seismic failure mode improvement of RC frame structure based on multiple lateral load patterns of pushover analyses显示文摘The structural failure under severe ground motions is primarily caused by their unreasonable seismic failure mode (SFM). This paper provides a methodology aiming at the SFM improvement of reinforced concrete frame structure. An RC frame is modeled and three types of failure criterion are defined as the premise of SFM. Static pushover analysis is adopted to identify the SFM. The dominant failure modes and failure paths of the structure are obtained in three lateral load patterns (inverted trian- gular distribution, uniform distribution and adaptive distribution). Based on the pushover analysis, the sequential failure of components and the probability of the occurrence of plastic hinges are determined. By this, weak components of the structure are detected and herein are strengthened. The project cost of the proposed strengthening strategy increases by 2.4%. Capacity spectrum method is used to study the performance of the strengthening structure. Pushover analysis is conducted again to present the improvement of strength and ductility. Lateral drift and local response through IDA are also studied to indicate that the strengthening of some columns and beams can improve the SFM to enhance the seismic capacity of structure. | BAI JiuLin OU JinPing | 2011 | Science China(Technological Sciences)2011，54，11： | 14 |
| 5 | Recent Development in X-Ray Imaging Technology:Future and Challenges显示文摘X-ray imaging is a low-cost,powerful technology that has been extensively used in medical diagnosis and industrial nondestructive inspection.The ability of X-rays to penetrate through the body presents great advances for noninvasive imaging of its internal structure.In particular,the technological importance of X-ray imaging has led to the rapid development of highperformance X-ray detectors and the associated imaging applications.Here,we present an overview of the recent development of X-ray imaging-related technologies since the discovery of X-rays in the 1890s and discuss the fundamental mechanism of diverse X-ray imaging instruments,as well as their advantages and disadvantages on X-ray imaging performance.We also highlight various applications of advanced X-ray imaging in a diversity of fields.We further discuss future research directions and challenges in developing advanced next-generation materials that are crucial to the fabrication of flexible,low-dose,highresolution X-ray imaging detectors. | Xiangyu Ou Xue Chen Xianning Xu Lili Xie Xiaofeng Chen Zhongzhu Hong Hua Bai Xiaowang Liu Qiushui Chen Lin Li Huanghao Yang | 2021 | Research2021，，1： | 5 |
| 6 | Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs显示文摘A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development,homeostasis,and disease of human intervertebral disks(IVDs)remains challenging.Here,the transcriptomic landscape of 108108 IVD cells was mapped using single-cell RNA sequencing of three main compartments from young and adult healthy IVDs,including the nucleus pulposus(NP),annulus fibrosus,and cartilage endplate(CEP).The chondrocyte subclusters were classified based on their potential regulatory,homeostatic,and effector functions in extracellular matrix(ECM)homeostasis.Notably,in the NP,a PROCR+resident progenitor population showed enriched colony-forming unit-fibroblast(CFU-F)activity and trilineage differentiation capacity.Finally,intercellular crosstalk based on signaling network analysis uncovered that the PDGF and TGF-βcascades are important cues in the NP microenvironment.In conclusion,a single-cell transcriptomic atlas that resolves spatially regulated cellular heterogeneity together with the critical signaling that underlies homeostasis will help to establish new therapeutic strategies for IVD degeneration in the clinic. | Yibo Gan Jian He Jun Zhu Zhengyang Xu Zhong Wang Jing Yan Ou Hu Zhijie Bai Lin Chen Yangli Xie Min Jin Shuo Huang Bing Liu Peng Liu | 2021 | Bone Research2021，9，3： | 3 |
| 7 | Radiant Image Simulation of Pulverized Coal Combustion in Blast Furnace Raceway显示文摘The relationship between two-dimensional radiant image and three-dimensional radiant energy in blast furnace raceway was studied by numerical simulation of combustion process. Taking radiant image as radiant boundary for numerical simulation of combustion process, the uneven radiation parameter can be calculated. A method to examine three-dimensional temperature distribution in blast furnace raceway was put forward by radiant image processing. The numeral temperature field matching the real combustion can be obtained by proposed numeric image processing technique. | WEN Liang-ying BAI Chen-guang OU Yang-qi CHEN Deng-fu QIU Gui-bao | 2006 | Journal of Iron and Steel Research(International)2006，13，2： | 3 |
| 8 | Realization of the global yield mechanism of RC frame structures by redesigning the columns using column tree method显示文摘Global failure mechanism, i.e., the strong-column weak-beam mechanism, can provide higher total energy dissipation capacity with less ductility demand on components than other failure modes, and results in a more uniform story drift distribution and higher resistance to earthquake loads at the system level. However, the current code-based elastic design method cannot guarantee the global failure mechanism of frame structures under severe earthquakes. In this paper, a simple, but practical design procedure is proposed to ensure the global failure mechanism of reinforced concrete(RC) frame structures by redesigning the columns using the column tree method(CTM). CTM considers the yield limit state of all beams and column bases. The code-based design is firstly carried out to determine the section information of all beams and base columns. Then, the internal force demands applied on the column tree can be derived. Lastly, the column moments, shear forces and axial forces are determined according to the free-body diagram of CTM to finish the column redesign. Two RC frame structures with 6 and 12 stories are illustrated to verify the design procedure. The analytical results demonstrate the proposed approach can realize the global failure mechanism. | BAI JiuLin OU JinPing | 2015 | Science China(Technological Sciences)2015，58，10： | 2 |
| 9 | Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity显示文摘Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still challenging.Here,we employ a capsid and antigen structure engineering(CASE)strategy to manufacture an adenoassociated viral serotype 6-based vaccine(S663V-RBD),which expresses trimeric receptor binding domain(RBD)of spike protein fused with a biological adjuvant RS09.Impressively,the engineered S663V-RBD could rapidly induce a satisfactory RBD-specific IgG titer within 2 weeks and maintain the titer for more than 4 months.Compared to the licensed BBIBP-CorV(Sinopharm,China),a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type,C.37(Lambda)and B.1.617.2(Delta).More interestingly,the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the capsid.Given its effectiveness,the CASE-based S663VRBD may provide a new solution for the current and next pandemic. | Fuhua Wu Shuang Luo Yongshun Zhang Yangsen Ou Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 10 | Flame radiant image numerilaztion for pulverized coal combustion in BF raceway显示文摘 | WEN L Y OU YANG Q BAI C G | 2005 | Journal of Chongqing University:English Edition2005，4，4： | 1 |
| 11 | Antipsychotic drugs clozapine and olanzapine upregulate bc1-2 mRNA and protein in rat frontal cortex and hippocampus显示文摘 | Ou Bai Hong-hong Zhang Xin-min Li | 2004 | Brain Research2004，1010，： | 1 |
| 12 | Four antagonists of arsenic on apoptosis and telomerase activity changes during As2 O3 treatment in three leukemia cell lines显示文摘 | Wei YM Ou YX Bai H | 2001 | Acta Pharmacol Sin2001，22，8： | 1 |
| 13 | Polarimetric heterodyning fiber grating laser sensors 显示文摘 | Guan Bai'ou Jin Long Zhang Yang | 2012 | Journal of Lightwave Technology2012，30，8： | 1 |
| 14 | High sensitivity distributed Bragg reflector fiber laser displacement sensor 显示文摘 | Zhang Yang Guan Bai'ou | 2009 | IEEE Photonics Technology Letters2009，21，5： | 1 |
| 15 | Effect of chidamide on treating hepatosplenic T-cell lymphoma: A case report显示文摘BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare subtype of non-Hodgkin’s lymphoma,which has an aggressive clinical course and an extremely poor prognosis.Chidamide is a novel,orally active,benzamide-type histone deacetylase(HDAC)inhibitor that has been used for peripheral T-cell lymphoma(PTCL)treatment.However,to date,there has been no report of the treatment and effect of the HDAC inhibitor chidamide in HSTCL,which is a special subtype of PTCL.CASE SUMMARY A 45-year-old male patient was admitted with splenomegaly and slight bicytopenia.He was diagnosed with HSTCL via splenectomy.The patient was treated with fractionated cyclophosphamide,vincristine,doxorubicin,and dexamethasone alternating with high-dose methotrexate and cytarabine regiment as inductive therapy.Unfortunately,the disease progressed rapidly during chemotherapy before a suitable allogeneic gene transplant donor was found.The chidamide-combined chemotherapy regimen and single-drug oral maintenance regimen achieved complete remission,duration of response of 9 mo,and overall survival of 15 mo.CONCLUSION The novel agent chidamide can be used in HSTCL to achieve deep remission and improve the duration of response and overall survival. | Xing-Tong Wang Wei Guo Mo Sun Wei Han Zhong-Hua Du Xiu-Xiu Wang Bei-Bei Du Ou Bai | 2020 | World Journal of Clinical Cases2020，8，14： | 1 |
| 16 | Tobacco smocking in china : prevalence, dis- ease burden, challenges and future strategies显示文摘 | Zhang J Ou JX Bai CX | 2011 | Respirology2011，16，11： | 1 |
| 17 | Tobacco smoking in China: prevalence,disease burden,challenges and future strate- gies显示文摘 | Zhang J Ou JX Bai CX | 2011 | Respirol2011，16，8： | 1 |
| 18 | Head-related transfer function synthesis based on a three dimensional array model and singular value decomposition显示文摘 | BAI M R OU K Y | 2005 | Journal of Sound & Vibration2005，281，35： | 1 |
| 19 | Four antagonists of arsenic on apoptosis and telomerase activity changes during As2 03 treatmentin three leukemia cell lines显示文摘 | Wei YM Ou YX Bai H | 2001 | Acta Pharmacol Sin2001，22，8： | 1 |
| 20 | The building of vsFI'PD service based on linux显示文摘 | OU Jun WU Qing-xiu BAI Xiao-bo | 2011 | China Computer & Communication2011，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员