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| 1 | Tomato SlAN11 regulates flavonoid biosynthesis and seed dormancy by interaction with bHLH proteins but not with MYB proteins显示文摘The flavonoid compounds are important secondary metabolites with versatile human nutritive benefits and fulfill a multitude of functions during plant growth and development.The abundance of different flavonoid compounds are finely tuned with species-specific pattern by a ternary MBW complex,which consists of a MYB,a bHLH,and a WD40 protein,but the essential role of SlAN11,which is a WD40 protein,is not fully understood in tomato until now.In this study,a tomato WD40 protein named as SlAN11 was characterized as an effective transcription regulator to promote plant anthocyanin and seed proanthocyanidin(PA)contents,with late flavonoid biosynthetic genes activated in 35S::SlAN11 transgenic lines,while the dihydroflavonol flow to the accumulation of flavonols or their glycosylated derivatives was reduced by repressing the expression of SlFLS in this SlAN11-overexpressed lines.The above changes were reversed in 35S::SlAN11-RNAi transgenic lines except remained levels of flavonol compounds and SlFLS expression.Interestingly,our data revealed that SlAN11 gene could affect seed dormancy by regulating the expressions of abscisic acid(ABA)signaling-related genes SlABI3 and SlABI5,and the sensitivity to ABA treatment in seed germination is conversely changed by SlAN11-overexpressed or-downregulated lines.Yeast two-hybrid assays demonstrated that SlAN11 interacted with bHLH but not with MYB proteins in the ternary MBW complex,whereas bHLH interacted with MYB in tomato.Our results indicated that low level of anthocyanins in tomato fruits,with low expression of bHLH(SlTT8)and MYB(SlANT1 and SlAN2)genes,remain unchanged upon modification of SlAN11 gene alone in the transgenic lines.These results suggest that the tomato WD40 protein SlAN11,coordinating with bHLH and MYB proteins,plays a crucial role in the fine adjustment of the flavonoid biosynthesis and seed dormancy in tomato. | Yongfeng Gao Jikai Liu Yongfu Chen Hai Tang Yang Wang Yongmei He Yongbin Ou Xiaochun Sun Songhu Wang Yinan Yao | 2018 | Horticulture Research2018，5，1： | 13 |
| 2 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 3 | Role of AMPK in atherosclerosis via autophagy regulation显示文摘Atherosclerosis is characterized by the accumulation of lipids and deposition of fibrous elements in the vascular wall, which is the primary cause of cardiovascular diseases. Adenosine monophosphate-activated protein kinase(AMPK) is a metabolic sensor of energy metabolism that regulates multiple physiological processes, including lipid and glucose metabolism and the normalization of energy imbalances. Overwhelming evidence indicates that AMPK activation markedly attenuates atherosclerosis development. Autophagy inhibits cell apoptosis and inflammation and promotes cholesterol efflux and efferocytosis. Physiological autophagy is essential for maintaining normal cardiovascular function. Increasing evidence demonstrates that autophagy occurs in developing atherosclerotic plaques. Emerging evidence indicates that AMPK regulates autophagy via a downstream signaling pathway. The complex relationship between AMPK and autophagy has attracted the attention of many researchers because of this close relationship to atherosclerosis development. This review demonstrates the role of AMPK and autophagy in atherosclerosis. An improved understanding of this interrelationship will create novel preventive and therapeutic strategies for atherosclerosis. | Hanxiao Ou Chuhao Liu Wenjie Feng Xinwen Xiao Shengsong Tang Zhongcheng Mo | 2018 | Science China(Life Sciences)2018，61，10： | 8 |
| 4 | Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin显示文摘肝 X 受体(LXR ) 有反煽动性的性质。LXR 是否在煽动性的 cytokine 表示的 post-transcriptional 控制起一个作用,不是清楚的。这里,我们第一鉴别合成 LXR 收缩筋 T0901317 支持了 IL-1, IL-6 和 TNF mRNA 降级。而且, T0901317 使动摇通过它的 3-untranslated 区域的 TNF mRNA。另外, T0901317 增加了 tristetraprolin (TTP ) 的表示,当与 siRNA 反对 TTP 废除了调停 T0901317 的煽动性的 cytokine mRNA 腐烂时。有趣地, T0901317 镇压了 ERK1/2 和 p38 的导致 LPS 的 phosphorylation 在 THP-1 巨噬细胞的激活 mitogen 的蛋白质 kinase (MAPK ) 。这里介绍的证据证实有 T0901317 的 LXR 激活禁止 ERK1/2 和 p38 MAPK 的 phosphorylation,在 TTP 的增加的表示和 LPS 导致煽动性的 cytokine mRNAs 的腐烂的可能的结果。 | Ji Xiao Quan Chen Dan Tang Weiwei OU Jiazheng Wang1 Zhongcheng Mo Chaoke Tang Liangyu Peng Deming Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 7 |
| 5 | GLOBAL STABILITY FOR A CLASS OF DIFFERENCE EQUATION显示文摘In this paper the global stability of difference equation x n+1 =a+bx nA+x n-1 is studied and a sufficient condition is obtained,which improves some previous results. | Ou Chunhua 1,2 \ Tang Hengsheng\+2\ Luo Wei 21 Institute ofMathem actica,Fudan Univ.,Shanghai200433.2Basic Sciences Departm ent,Centre-South Institute ofTechnology,Hengyang 421001. | 2000 | Applied Mathematics(A Journal of Chinese Universities)2000，15，1： | 6 |
| 6 | Relationship between 6-minute walk test and pulmonary function test in stable chronic obstructive pulmonary disease with different severities显示文摘 | CHEN Hong LIANG Bin-miao TANG Yong-jiang XU Zhi-bo WANG Ke YI Qun OU Xue-mei FENG Yu-lin | 2012 | Chinese Medical Journal2012，，17： | 5 |
| 7 | Effects of climate change on potential habitats of the cold temperate coniferous forest in Yunnan province, southwestern China显示文摘We built a classification tree(CT) model to estimate climatic factors controlling the cold temperate coniferous forest(CTCF) distributions in Yunnan province and to predict its potential habitats under the current and future climates, using seven climate change scenarios, projected over the years of 2070-2099. The accurate CT model on CTCFs showed that minimum temperature of coldest month(TMW) was the overwhelmingly potent factor among the six climate variables. The areas of TMW<-4.05 were suitable habitats of CTCF, and the areas of -1.35 < TMW were non-habitats, where temperate conifer and broad-leaved mixed forests(TCBLFs) were distribute in lower elevation, bordering on the CTCF. Dominant species of Abies, Picea, and Larix in the CTCFs, are more tolerant to winter coldness than Tsuga and broad-leaved trees including deciduous broad-leaved Acer and Betula, evergreen broadleaved Cyclobalanopsis and Lithocarpus in TCBLFs. Winter coldness may actually limit the cool-side distributions of TCBLFs in the areas between -1.35°C and -4.05°C, and the warm-side distributions of CTCFs may be controlled by competition to the species of TCBLFs. Under future climate scenarios, the vulnerable area, where current potential(suitable + marginal) habitats(80,749 km^2) shift to nonhabitats, was predicted to decrease to 55.91%(45,053 km^2) of the current area. Inferring from the current vegetation distribution pattern, TCBLFs will replace declining CTCFs. Vulnerable areas predicted by models are important in determining priority of ecosystem conservation. | LIWang-jun PENG Ming-chun Motoki HIGA Nobuyuki TANAKA Tetsuya MATSUI Cindy Q. TANG OU Xiao-kun ZHOU Rui-wu WANG Chong-yun YAN Hai-zhong | 2016 | Journal of Mountain Science2016，13，8： | 5 |
| 8 | Synthesis,insecticidal and acaricidal activities of novel 2-arylpyrroles显示文摘To search for novel 2-arylpyrroles with unique biological activities,a series of novel 2-arylpyrrole derivatives were designed and synthesized,and their structures were characterized by 1 H and 13 C NMR spectroscopy,MS spectrometry,and elemental analysis.Their insecticidal activities against Lepidopteran pests (e.g.Mythimna separata) and acaricidal activities against mites (e.g.Tetranychus urticae) were evaluated.The results of bioassays indicate that some of these title compounds exhibited excellent insecticidal and acaricidal activities.For example,4-bromo-1-((chloromethoxy)methyl)-2-(4-chloro phenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (6a),4-bromo-2-(4-chlorophenyl)-1-((2-fluoroethoxy)-methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (6d) showed insecticidal activity against Mythimna separata and 4-bromo-2-(4-chlorophenyl)1-((isopropoxymethoxy)methyl)-5-(trifluoro methyl)pyrrole-3-carbonitrile (7d) showed acaricidal activity against Tetranychus urticae.They were more effective than Chlorfenapyr,which has been the only commercialized member of a new class of chemicals of 2-arylpyrroles. | LIU AiPing TANG Ming YU ShuYing LIU XingPing WANG XiaoGuang PEI Hui WU DaoXin HU Li OU XiaoMing HUANG MingZhi | 2013 | Science China Chemistry2013，56，1： | 5 |
| 9 | Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE^(-/-) mice by up-regulating NPC1 expression显示文摘In this study, we studied the effect of liver X receptor (LXR) agonist T0901317 on Niemann-Pick C1 protein (NPC1) expression in apoE-/- mice. Male apoE-/- mice were randomized into 4 groups, baseline group (n=10), control group (n=14), treatment group (n=14) and prevention group (n=14). All of the mice were fed with a high-fat/high-cholesterol (HFHC) diet containing 15% fat and 0.25% cholesterol. The baseline group treated with vehicle was sacrificed after 8 weeks of the diet. The control group and the prevention group were treated with either vehicle or T0901317 daily by oral gavage for 14 weeks. The treatment group was treated with vehicle for 8 weeks, and then was treated with the agonist T0901317 for additional 6 weeks. Gene and protein expression was analyzed by real-time quantitative PCR, immunohistochemistry and Western blotting, respectively. Plasma lipid concentrations were measured by commercially enzymatic methods. We used RNA interference technology to silence NPC1 gene expression in THP-1 macrophage-derived foam cells and then detected the effect of LXR agonist T0901317 on cholesterol efflux. Plasma triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and apoA-I concentrations were markedly increased in T0901317-treated groups. T0901317 treatment reduced the aortic atherosclerotic lesion area by 64.2% in the prevention group and 58.3% in the treatment group. LXR agonist treatment increased NPC1 mRNA expression and protein levels in the small intestine, liver and aorta of apoE-/- mice. Compared with the normal cells, cholesterol efflux of siRNA THP-1 macrophage-derived foam cells was significantly decreased, whereas cholesterol efflux of LXR agonist T0901317-treated THP-1 macrophage-derived foam cells was significantly increased. Our results suggest that LXR agonist T0901317 inhibits atherosclerosis development in apoE-/- mice, which is related to up-regulating NPC1 expression. | OU Xiang1,2, DAI XiaoYan1, LONG ZhiFeng3, TANG YaLing1, CAO DongLi1, HAO XinRui1, HU YanWei1, LI XiaoXu1 & TANG ChaoKe1 1 Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Heng- yang 421001, China 2 Department of Physiology, Medical College of Shaoguan University, Shaoguan 512026, China 3 Department of Histology and Embryology, University of South China, Hengyang 421001, China | 2008 | Science China(Life Sciences)2008，51，5： | 5 |
| 10 | Advanced Chronic Obstructive Pulmonary Disease: Innovative and Integrated Management Approaches显示文摘Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing.By the year 2020,COPD will be the third leading cause of mortality and the fifth leading cause of disability worldwide.[1] | Hai-Xia Zhou Xue-Mei Ou Yong-Jiang Tang Lan Wang Yu-Lin Feng | 2015 | Chinese Medical Journal2015，，21： | 5 |
| 11 | Copper transportion of WD protein in hepatocytes from Wilson disease patients in vitro显示文摘AIM: To study the effect of copper transporting P-type ATPase in copper metabolism of hepatocyte and pathogenesis of Wilson disease (WD).METHODS: WD copper transporting properties in some organelles of the cultured hepatocytes were studied from WD patients and normal controls. These cultured hepatocytes were incubated in the media of copper 15mg.L-1 only, copper 15 mg. L-1 with vincristine (agonist of P-type ArPase) 0.5mg. L-1, or copper 15 mg. L-1 withvanadate (antagonist of P-type ATPase) 18.39 mg. L-1separately. Microsome (endoplasmic reticulum and Golgi apparatus), lysosome, mitochondria, and cytosol were isolated by differential centrifugation. Copper contents in these organelles were measured with atomic absorption spectrophotometer, and the influence in copper transportion of these organelles by vanadate and vincristine were comparatively analyzed between WD patients and controls.WD copper transporting P-type ATPase was detected by SDS-PAGE in conjunction with Western blot in liver samples of WD patients and controls.RESULTS: The specific WD proteins (Mr155 000 lanes) were expressed in human hepatocytes, including the control and WD patients. After incubation with medium containing copper for 2 h or 24 h, the microsome copper concentration in WD patients was obviously lower than that of controls,and the addtion of vanadate or vincristine would change the copper transporting of microsomes obviously. When incubated with vincristine, levels of copper in microsome were significantly increased, while incubated with vanadate,the copper concentrations in microsome were obviously decreased. The results indicated that there were Wdproteins, the copper transportion P-type ATPase in the microsome of hepatocytes. WD patients possessed abnormal copper transporting function of WD protein in the microsome, and the agonist might correct the defect of copper transportion by promoting the activity of copper transportion P-type ATPase.CONCLUSION: Copper transportion P-type ATPase plays an important role in hepatocytic copper metabolism.Dysfunction of hepatocytic WD protein copper transportion might be one of the most important factors for WD. | Guo-Qing Hou~1 Xiu-Ling Liang~2 Rong Chen~2 Li-Wen Tang~3 Ying Wang~2 Ping-Yi Xu~2 Ying-Ru Zhang~2 Cui-Hua Ou~2 1 Department of Neurology.Guangzhou First Municipal People’s Hospital,Guangzhou Medical College,Guangzhou 510180,Guangdong Province.China2 Department of Neurology.First Affiliated Hospital.Sun Yat-Sen University of Medical Sciences.Guangzhou 510080.Guangdong Province.China3 Department of Pharmacology,University of Kentucky.Lexington,KY 40506.USA | 2001 | World Journal of Gastroenterology2001，7，6： | 4 |
| 12 | MTO再制造系统最优生产计划提前期研究——基于最小相对熵的方法显示文摘研究了MTO再制造系统关于单一核心部件在分拆和采购提前期均不确定下的生产运作;由于回收部件并非100%可用,使得以最小化再制造成本为目标得到的生产计划提前期呈现双峰分布的形式;本文将最小相对熵(MRE)方法应用于生产计划提前期分布的拟合,仿真算例表明:与传统的正态分布和Pearson近似方法相比,MRE近似的结果更为接近目标服务水平和真实的成本曲线,所得结论对再制造企业安排生产计划、设备投资以及旧产品回收策略等有现实的指导意义。 | 包兴 季建华 Ou Tang | 2007 | 工业工程与管理2007，12，2： | 4 |
| 13 | Effects of octreotide on glucose transporter type 2expression in obese rat small intestine显示文摘AIM:To investigate the effects of the somatostatin analogue,octreotide,on maltose and sucrase activities and expression of glucose transporter type 2(GLUT2) in obese rat intestinal mucosa.METHODS:We divided 49 Sprague-Dawley rats into a group of 31 high fat diet-induced obese rats and a group of 18 normal controls.The obese rats were separated into an octreotide treated group of 16 rats and an obese group of 15.The intervention group was injected with octreotide at 40μg/kg body weight every 12 h for 8 d.Rat body weight was measured weekly to calculate Lee's index.After euthanization,maltase and sucrase activities in the small intestine were measuredby activity assays,and the fasting plasma glucose level was measured.The expression of GLUT2 in small intestinal mucosa was analyzed by immunohistochem-istry,reverse transcriptase polymerase chain reaction and Western blotting assays.RESULTS:Body weight,Lee's index,fasting plasma glucose level,maltase activity in small intestinal mucosa,mucosa and apical GLUT2,GLUT2 mRNA and protein expression levels were all significantly higher in the obese group than in the normal control group(605.61±141.00 vs 378.54±111.75,337.61 ±10.82 vs 318.73±20.10,8.60±1.38 vs 7.33± 0.70,156.01±58.81 vs 50.43±30.49,390 744.2 ±62 469.21 vs 170 546.50±50 646.14,26 740.18 ±3809.60 vs 354.98±57.19,0.26±0.11 vs 0.07 ±0.02,and 2.08±0.59 vs 1.27±0.38,respectively,all P<0.01).Sucrase activity did not differ between the two groups.Octreotide intervention significantly decreased the body weight and fasting plasma glucose level of obese rats(508.27±94.39 vs 605.61±141.00,7.58±1.51 vs 8.60±1.38,respectively,all P<0.05).The intestinal mucosa and apical GLUT2,expression of GLUT2 mRNA and protein were also significantly lower in the octreotide intervention group than in the obese group(269 975.2 ±53 730.94 vs 390 744.2±62 469.21,3758.06± 364.51 vs 26 740.18±3809.60,0.08±0.02 vs 0.26± 0.11,and 1.31±0.27 vs 2.08±0.59,respectively,all P<0.01).CONCLUSION:High fat dietinduced obesity is associated with elevated intestinal maltase activity,GLUT2 expression,and permanent apical GLUT2 in the small intestinal mucosa of rats.Octreotide can inhibit these effects. | Na Wei Rui Liu Yan Ou Xian Li Ou Qiang Wei Guo Cheng-Wei Tang | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 14 | Intensifying Gaseous Reduction of High Phosphorus Iron Ore Fines by Microwave Pretreatment显示文摘Gaseous reduction kinetics of the high phosphorus iron ore fines from Hubei in China and effect of microwave pretreatment on the gaseous reduction behavior were studied. Gaseous reduction kinetics were investigated by TG (Thermogravimetric) methods using LINSEIS STA PT 1600 thermal analysis equipment. Microwave pretreatments to the ore fines with four power levels were performed using a high temperature microwave reactor. Its effect was examined by TG methods and its mechanism was analyzed by SEM (scanning electron microscope) and EDS (energy dispersive spectrometer). Gaseous reduction tests were carried out using a tubular furnace. Results of kinetic study indicate that controlling step of the gaseous reduction of the ore fines is a mixing control of gas internal diffusion and interface chemical reaction when reduction fraction is less than 0.8 and is solid state diffusion when reduction fraction is more than 0.8. Microwave pretreatment of the ore fines could change the pore structure of the oolitic unit to generate cracks, fissures and loose zones, which promotes reduction in the early stage and delays the occurrence of sintering. Gaseous reduction tests show in the condition that the ore fines are pretreated with a microwave power of 450 W for 4 min and reduced under temperature of 1 273 K, the gaseous reduction of the ore fines could be apparently intensified. Using CO or H2 as a reductant and ore fines being reduced for 1.5 to 2 h , increase of metallization rate of the ore fines is 10% to 13%. | TANG Hui-qing WANG Jun-wei GUO Zhan-cheng OU Tie | 2013 | Journal of Iron and Steel Research(International)2013，20，5： | 4 |
| 15 | Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice显示文摘Semicarbazide 敏感的胺 oxidase (SSAO ) 催化主要的芳香、脂肪族的胺的氧化 deamination。增加的 SSAO 活动在动脉粥样硬化和糖尿病 mellitus 被发现了。我们假设肝 X 受体(LXR ) 的 anti-atherogenic 效果可能与 SSAO 基因表示和它的活动的抑制有关。在这研究,我们在 apolipoprotein E 大美人在 SSAO 基因表示和它的活动上调查了 LXRagonist T0901317 的效果(apoE /) 老鼠。男 apoE / 老鼠(8 个星期旧) 随机被划分成四个组:基础控制组;车辆组;预防组;并且处理组。SSAO 基因表示被即时量的聚合酶链反应分析,它的活动是坚定的。superoxide dismutase 的活动和在主动脉和肝的 malondialdehyde 的内容也是坚定的。在对待 T0901317 的鼠标, SSAO 基因表示显著地在主动脉,肝,小肠,和大脑被减少。在浆液并且在这些纸巾的 SSAO 活动也被禁止。在预防组和处理组的主动脉和肝的 superoxide dismutase 的数量与车辆组相比是显著地更高的(P < 0.05 ) 。在这二个组的纸巾的 Malondialdehyde 与车辆组相比是显著地更低的(P < 0.05 ) 。我们的结果证明 T0901317 在 atherogenic apoE / 老鼠禁止 SSAO 基因表示和它的活动。LXR 收缩筋 T0901317 的 atheroprotective 效果与 SSAO 基因表示和它的活动的抑制有关。 | Xiaoyan Dai Xiang Ou Xinrui Hao Dongli Cao Yaling Tang Yanwei Hu Xiaoxu Li Chaoke Tang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 16 | A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis显示文摘Excessive accumulation of cholesterol inβcells initiates endoplasmic reticulum(ER)stress and associated apoptosis.We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin(SCGN)and then attenuates insulin secretion.Here,we aimed to determine whether cholesterol-induced SCGN decrease is involved in the modulation of ER stress and apoptosis in pancreaticβcells.In this study,MIN6 cells were treated with oxidized low-density lipoprotein(ox-LDL)for 24 h,and then intracellular lipid droplets and cell apoptosis were quantified,and SCGN and ER stress markers were identified by western blot analysis.Furthermore,small interfer RNA(siRNA)-mediated SCGN knockdown and recombinant plasmid-mediated SCGN restoration experiments were performed to confirm the role of SCGN in ER stress and associated cell apoptosis.Finally,the interaction of SCGN with ATF4 was computationally predicted and then validated by a co-immunoprecipitation assay.We found that ox-LDL treatment increased the levels of ER stress markers,such as phosphorylated protein kinase-like endoplasmic reticulum kinase,phosphorylated eukaryotic initiation factor 2 alpha,activating transcription factor 4(ATF4),and transcription factor CCAAT-enhancer-binding protein homologous protein,and promoted MIN6 cell apoptosis;in addition,the expression of SCGN was downregulated.siRNA-mediated SCGN knockdown exacerbatedβ-cell ER stress by increasing ATF4 expression.Pretreatment of MIN6 cells with the recombinant SCGN partly antagonized ox-LDL-induced ER stress and apoptosis.Furthermore,a co-immunoprecipitation assay revealed an interaction between SCGN and ATF4 in MIN6 cells.Taken together,these results demonstrated that pancreaticβ-cell apoptosis induced by ox-LDL treatment can be attributed,in part,to an SCGN/ATF4-dependent ER stress response. | Li Wu Yuncheng Lv Ying Lv Sunmin Xiang Zhibo Zhao Ziqing Tang Linling Ou Bin Yan Xinhua Xiao Gebo Wen Renxian Cao Jing Yang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 17 | Environmental cost and pollution risk caused by the industrial transfer in Qinghai Province显示文摘由于精力与升起迫使环境保护和恢复的消费和费用,工业转移从对中央、西方的区域东方在中国澎湃。然而,极其易碎的生态的条件和严重的水缺乏是为在西方的中国的工业开发的重要障碍。污染从东方中国由转移工业引起了的脆弱的环境罐头熊是否成为一个重要问题。这研究第一在中国的不同区域估计精力和环境费用,并且估计必要性升级 Qinghai 省的工业结构。然后,转移工业引起的浪费水,浪费气体,和烟的排出物被输入产量模型计算。根据环境上的浪费排放的效果分析, Qinghai 省的污染风险被估计。结果说明当环境费用在西方的中国是更高的时,在中国的环境保护和恢复的费用有坡度分布,精力效率是更低的。工业结构调整在不同部门的污染上有不同影响。尽管机械和设备,宾馆和迎合的服务的发展,和房地产,租借,并且企业服务增加了污染物质的排放,它是由象建设和金属产品那样的另外的工业引起的减少的排出物的偏移量。因此,尽管经济开发将增加环境污染,工业调整有效地装减少浪费水和浪费气体排出物减少污染风险。仍然为在 Qinghai 省的工业转移有巨大的挑战协调环境和工业开发,这应该被注意。 | Qun'ou JIANG Chengcai TANG Jinyan ZHAN Wei ZHANG Feng WU | 2014 | Frontiers of Earth Science2014，8，3： | 2 |
| 18 | Authenticating GNSS civilian signals:a survey显示文摘Civilian services of Global Navigation Satellite System are threatened by spoofng attacks since it is hard to determine the authenticity of a navigation signal with a detailed structure open to the public.Signal authentication efectively protects the security of the signal by attaching unforgeable information to one or several elements of the signal.Receivers can verify the authenticity of the signal by extracting and validating this information.Developing good signal authentication schemes requires understanding possible spoofng modes,signal element specialty,and performance evaluation methods.This paper is an overview of navigation signal authentication,where the theories and reported approaches are described in detail.A design/performance matrix that demonstrates the advantages and defects of the signal element and its authentication design is summarized.Recommendations are proposed to improve the robustness,security,efciency,and implementation hardness for future designs of navigation signal authentication. | Muzi Yuan Xiaomei Tang Gang Ou | 2023 | Satellite Navigation2023，4，1： | 2 |
| 19 | Interaction of ions in water system containing copper-zinc alloy for boiler energy saving显示文摘Copper-zinc alloy element for boiler energy saving was put in the intake of simulated boiler system to investigate the interaction and transfer of ions in water system both theoretically and experimentally. The fouling was analyzed by scanning electron microscopy (SEM) and energy dispersive X-ray detector (EDX). The results show that the transfer of calcium and magnesium ions in heat-transfer-surface-water system is affected by zinc ions dissolved from the alloy because of primary battery reaction. Some calcium ions of calcium carbonate crystal are replaced by zinc ions, the growth of aragonite crystal nucleus is retarded, and the transition of calcium carbonate from aragonite to calcite is hampered. | MING Xing LIANG Jinsheng OU Xiuqin TANG Qingguo DING Yan | 2006 | Rare Metals2006，25，z1： | 2 |
| 20 | Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases显示文摘Sepsis is a dysregulated immune response to infection and potentially leads to life-threatening organ dysfunction,which is often seen in serious Covid-19 patients.Disulfiram(DSF),an old drug that has been used to treat alcohol addiction for decades,has recently been identified as a potent inhibitor of the gasdermin D(GSDMD)-induced pore formation that causes pyroptosis and inflammatory cytokine release.Therefore,DSF represents a promising therapeutic for the treatment of inflammatory disorders.Lactoferrin(LF)is a multifunctional glycoprotein with potent antibacterial and anti-inflammatory activities that acts by neutralizing circulating endotoxins and activating cellular responses.In addition,LF has been well exploited as a drug nanocarrier and targeting ligands.In this study,we developed a DSF-LF nanoparticulate system(DSF-LF NP)for combining the immunosuppressive activities of both DSF and LF.DSF-LF NPs could effectively block pyroptosis and inflammatory cytokine release from macrophages.Treatment with DSF-LF NPs showed remarkable therapeutic effects on lipopolysaccharide(LPS)-induced sepsis.In addition,this therapeutic strategy was also applied to treat ulcerative colitis(UC),and substantial treatment efficacy was achieved in a murine colitis model.The underlying mode of action of these DSF-LF-NPs may contribute to efficiently suppressing macrophage-mediated inflammatory responses and ameliorating the complications caused by sepsis and UC.As macrophage pyroptosis plays a pivotal role in inflammation,this safe and effective biomimetic nanomedicine may offer a versatile therapeutic strategy for treating various inflammatory diseases by repurposing DSF. | An-te Ou Jia-xin Zhang Yue-fei Fang Rong Wang Xue-ping Tang Peng-fei Zhao Yu-ge Zhao Meng Zhang Yong-zhuo Huang | 2021 | Acta Pharmacologica Sinica2021，42，11： | 2 |
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