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| 1 | Contemporary crustal deformation of the Chinese continent and tectonic block model显示文摘We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the regional networks of CMONOC observed in 1999 and 2001. We de-lineate 9 tectonically active blocks and 2 broadly distributed deformation zones out of a denseGPS velocity field, and derive block motion Euler poles for the blocks and their relative motionrates. Our result reveals that there are 3 categories of deformation patterns in the Chinese conti-nent. The first category, associated with the interior of the Tibetan Plateau and the Tianshan oro-genic belt, shows broadly distributed deformation within the regions. The third category, associatedwith the Tarim Basin and the region east of the north-south seismic belt of China, shows block-likemotion, with deformation accommodated along the block boundaries only. The second category, mainly associated with the borderland of the Tibetan Plateau, such as the Qaidam, Qilian, Xining(in eastern Qinghai), and the Diamond-shaped (in western Sichuan and Yunnan) blocks, has thedeformation pattern between the first and the third, i.e. these regions appear to deform block-like,but with smaller sizes and less strength for the blocks. Based on the analysis of the lithosphericstructures and the deformation patterns of the regions above, we come to the inference that thedeformation modes of the Chinese continental crust are mainly controlled by the crustal structure.The crust of the eastern China and the Tarim Basin is mechanically strong, and its deformationtakes the form of relative motion between rigid blocks. On the other hand, the northward indentation of the Indian plate into the Asia continent has created the uplift of the Tibetan Plateau and the Tianshan Mountains, thickened their crust, and raised the temperature in the crust. The lower crust thus has become ductile, evidenced in low seismic velocity and high electric conductivity observed. The brittle part of the crust, driven by the visco-plastic flow of the lower crust, deforms extensively at all scales. The regions of the second category located at the borderland of the Tibetan Plateau are at the transition zone between the regions of the first and the third categories in terms of the crustal structure. Driven by the lateral boundary forces, their deformation style is also between the two, in the form of block motion and deformation with smaller blocks and less internal strength. | WANG Min (王 敏) SHEN Zhengkang (沈正康) NIU Zhijun (牛之俊) ZHANG Zusheng (张祖胜) SUN Hanrong (孙汉荣) GAN Weijun (甘卫军) WANG Qi (王 琪) REN Qun (任 群) | 2003 | Science China Earth Sciences2003，46，z2： | 33 |
| 2 | Relationship between structure and function of JWA in the modulation of cell differentiation显示文摘To elucidate the structure characteristic, regulation of expression and the potential function of JWA——anovel rctinoic acid responsible and cytoskeleton associate gene, a rat JWA homologue gene and a 621-bp JWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR), JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter of JWA at -437 to -443 bp; rat JWA homologue gene showed that there are four nucleotides different from human JWA within coding region. After treatment with TPA, an uneven pattern of JWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in | XIA Wei ZHOU Jianwei CAO Haixia ZOU Changping WANG Chengya SHEN Qun LU Hua | 2001 | Chinese Science Bulletin2001，46，24： | 11 |
| 3 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 4 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 5 | Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells显示文摘N-acetylglucosaminyltransferase V (GnT-V ) 是重要 tumorigenesis 和联系转移的酶。为了学习它的简历,工作, GnT-V 稳定地压制了房间线(GnT-V-AS/7,721 ) 在以前的学习从 7,721 个 hepatocarcinoma 房间被构造。在这研究, cDNA 数组基因表示侧面在 GnT-V-AS/7,721 之间被比较并且父母 7,721 个房间。数据显示 GnT-V-AS/7,721 显示出与 ER 压力一致的一个典型表达式模式。ER 压力的分子的机制被分析在二展开的蛋白质回答(UPR ) 在关键分子上在 GnT-V-AS/7,721 探索小径。为 ATF6 和 Ire1/XBP-1 小径,它被 BIP 的起来规定在 mRNA 和蛋白质证实 XBP-1 的拼接的形式的水平,和外观。至于 PERK/eIF2alpha 小径,激活嗯 eIF2alpha kinase 津贴被观察。从 GnT-V-AS/7,721 房间证实结果,在 UPR 的关键分子在 7,721 个房间再被检验由特定的 RNAi 处理防碍 GnT-V。结果与从 GnT-V-AS/7721 的那些是类似的,显示那块 GnT-V 能明确地激活嗯在 7,721 个房间的应力。率(3 )H 人加入与率改正了(3 ) 在 GnT-V-AS/7,721 的 H 列伊加入与控制相比极大地是下面调整的,它表明了综合的酶的缺乏的功能在堵住的 GnT-V 以后的 N-glycans。而且,与 underglycosylation 联系的女伴 GRP94 的更快的移居形式,和细胞内部的 glycoproteins 的广泛地改变的 N-glycans 结构是也在 GnT-V-AS/7,721 检测了。这些结果支持了机制损害的那块 GnT-V 表达式女伴和 N-glycan-synthesizing 酶工作,它在 vivo 引起了 UPR。 | Huan Fang Wei Huang Ying Ying Xu Zong Hou Shen Chao Qun Wu Shou Yi Qiao Yan Xu Long Yu Hui Li Chen | 2006 | Cell Research2006，16，1： | 7 |
| 6 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 7 | Cytotoxic effects of mono-(2-ethylhexyl) phthalate on human embryonic stem cells显示文摘 | SHI Cheng CHEN Xi CAI Xiao-hui YU Wei-dong LIANG Rong LU Qun SHEN Huan | 2013 | Chinese Medical Journal2013，，9： | 6 |
| 8 | Salicyloyl-aspartate synthesized by the acetyl-amido synthetase GH3.5 is a potential activator of plant immunity in Arabidopsis显示文摘水杨酸酸(SA ) 对病原体感染在植物免疫回答起一个关键作用,特别在全身的获得的抵抗的建立。水杨酸盐的另外的形式是否也在植物免疫工作,没被探索。我们的以前的学习揭示了那 salicyloyl-aspartate (SA 毒蛇) ,唯一的报导的内长的 SA 氨基的酸在植物结合,高度在病原体感染以后在 Arabidopsis 标注激活的变异的 gh3.5-1D 被积累。在这研究,我们把了在 Arabidopsis 的 SA 毒蛇生产。在 vitro,生物化学的实验证明 GH3.5 蛋白质能与丁氨二酸酸催化 SA 的变化形式形成 SA 毒蛇。SA 毒蛇没在植物作为一个活动分子被变换成免费 SA 和可能的幕。SA 毒蛇能导致致病相关(PR ) 基因表示和增加疾病抵抗到病原的 Pseudomonas syringae。我们的当前的学习也支持 GH3.5 是在植物荷尔蒙新陈代谢的多功能酶的观点。 | Ying Chen Hui Shen Muyang Wang Qun Li Zuhua He | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 6 |
| 9 | Effect of microenvironmental quantitative regulation on growth of Korean pine trees planted under secondary forest显示文摘Korean pine(Pinus koraiensis) and broadleaved mixed forest in Northeast China has been changed regressively into secondary forest with almost no conifers.Planting Korean pine trees under the canopy of secondary forest is a feasible approach for recovering Korean pine and broadleaved mixed forest.For establishing an effective growth promotion method for under-canopy planted young Korean pine trees,two stands were selected as the experiment plots,Stand A(planted in 1989) and Stand B(planted in 1982),and an experiment of microenvironment regulation was conducted relying mainly on Opening degree(K=1,K=1.5,K=2,CK) in 2004.The results were shown that the adjustment had promoted growth of diameter and height of Korean pine planted in Stand A and Stand B,and had a significant influence on the growth rate of basal diameter,diameter at breast height and height in the two growth stands.The four years periodic increment of mean diameter and height of Korean pine planted in 1989 and in 1982 after regulation in K=1 level were 63.4%(D0) and 82.7%(H),64.8%(D1.3) and 69.7%(H) higher than that of control respectively.Quantitative regulation had significant influence on specific leaf area of Korean pine planted in 1989,and the current year specific leaf area(SLA) was lager than perennial year SLA.Quality indexes of natural pruning capacity,normal form quotient and crown size was not significantly changed but shown a positive tendency.The regulation scheme of Opening degree K=1 might be proper for adjusting the microenvironment of Korean pine trees planted under the canopy of secondary forest when the Korean pine trees were in the growth period of 15 to 26 years old in the experiment region. | CONG Jian Shen Hai-Long YANG Wen-Hua FAN Shao-Hui ZHANG Qun | 2011 | Journal of Forestry Research2011，22，2： | 5 |
| 10 | Method for predicting economic peak yield for a single well of coalbed methane显示文摘The development of coalbed methane (CBM) in China poses great difficulties because of high investments, low produc- tion and high risks. So a study of the economic effect of a single well at its preliminary stage is helpful for commercial exploitation of CBM. Affected by wellbore flow pressure, initial reservoir pressure, relative permeability, Langmuir pressure and other factors, the trend of declining production of a single CBM well agrees, by and large, with a hyperbolic pattern of decline. Based on Arps’s equation, nearly 200 wells production with different peak yields and initial rates of were simulated. Given the present cost of drill- ing, gas production and engineering on the ground, the gross investment for the development of a single coalbed methane well was estimated for the Fanzhuang block in central China. Considering the current industrial policies for CBM, we established an eco- nomic assessment model and analyzed economic peaks. The results show the economic benefits with or without government subsi- dies at different peak yields of a single CBM well. The results of the evaluation can be directly applied in the Fanzhuang block. The evaluation method, formulated in our study, can be used to other areas with similar conditions. | YANG Shen KANG Yong-shang ZHAO Qun WANG Hong-yan LI Jing-ming | 2008 | Journal of China University of Mining and Technology2008，18，4： | 5 |
| 11 | STRESS-INDUCED CRYSTALLIZATION OF POLYURETHANE/MONTMORILLONITE NANOCOMPOSITE显示文摘Exfoliated polyurethane/montmorillonite nanocomposites with both high elongation at break and high tensile strength were studied by dynamic-infrared spectroscopy (dynamic-IR). The results show that crystallization induced by additional stress is impeded by the nano-layered organo montmorillonite. | Xin-hua Dai Xiang-dong Luo Qun Gu Xiao-li Zhang De-yan Shen Liang-he Shi Jian Xu State Key Laboratory of Polymer Physics and Chemiscy Center for Molecular Science, Institute of Chemistry,Chinese Academy of Sciences, Beijing 100080, China | 2002 | Chinese Journal of Polymer Science2002，20，5： | 4 |
| 12 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 13 | Potent anti-angiogenesis and anti-tumor activity of a nove human anti-VEGF antibody, MIL60显示文摘 | Jing Yang Qun Wang Chunxia Qiao Zhou Lin Xinying Li Yifei Huang Tingting Zhou Yan Li Beifen Shen Ming Lv Jiannan Feng | 2014 | Cellular & Molecular Immunology2014，11，3： | 4 |
| 14 | Cloning,expression and function of phosphate transporter encoded gene in Oryza sativa L.显示文摘OsPT6:1,a phosphate transporter encoding gene from the leaf samples of Oryza sativa, was identified through PCR with specifically designed primers.The phylogenetic analysis and the conserved amino acid residue site detection suggested OsPT6:1 a possible high-affinity phosphate transporter encoding gene.In situ hybridization and RT-PCR demonstrated the expression of OsPT6:1 in both roots and leaves.The peak expression signal was observed in mesophyll cells under low phosphorus(P)induction.A homologous recombination study indicated that OsPT6:1 can enhance the Pi uptake efficiency of Pichia pastoris.At the meantime,the introduction of OsPT6:1 was able to complement the Pi uptake function of yeast cells with high-affinity phosphate transporters de- ficient.Those results substantiated our contention that OsPT6:1 encoded a high-affinity phosphate transporter of Oryza sativa. | MING Feng 1,2* ,LU Qun 1,2* ,WANG Wei 1,2* ,ZHANG Shanshan 1,2 ,GUO Bin 1,2 &SHEN Daleng 1,2 1.Institute of Genetics,State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University,Shanghai 200433,China 2.Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science, School of Life Science,Fudan University,Shanghai 200433,China | 2006 | Science China(Life Sciences)2006，49，5： | 4 |
| 15 | Distribution control and formation mechanism of gas inclusions in directionally solidified Al2O3-Er3Al5O12-ZrO2 ternary eutectic ceramic by laser floating zone melting显示文摘Distribution control and formation mechanism of gas inclusions formed in directionally solidified Al2O3-Er3Al5O12-ZrO2 eutectic ceramic rods are explored during laser floating zone melting. In atmospheric environment, highly-dense bubble-free eutectic rods are well fabricated at low solidification rate(<25μm/s). Gas inclusions form intermittently when the solidification rate is in the range of 25-50 μm/s,but produce continuously at higher solidification rates(100-200 μm/s). The gas inclusions exhibit an elongated finger-like pattern along the growth direction, which of the maximum value of diameter first increases and then decreases with increasing the solidification rate. Meanwhile, the volume fraction of gas inclusions increased gradually with the solidification rate. Based on the effect of surface tension gradient, heterogeneous nucleation of gas bubbles is evaluated to be the primary formation mechanism of gas inclusions. | Haijun Su Yuan Liu Qun Ren Zhonglin Shen Haifang Liu Di Zhao Guangrao Fan Min Guo Jun Zhang Lin Liu Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，7： | 4 |
| 16 | Theory, technology and prospects of conventional and unconventional natural gas显示文摘The development of natural gas in China has entered a golden and leap-forward stage, which is a necessary bridge to clean energy. This in-depth study on the status quo, theory, technology and prospect of natural gas development shows:(1) The global remaining proven recoverable reserves of natural gas are 186×1012 m3, and the reserves-production ratio is 52.4, indicating a solid resource base for long-term and rapid development.(2) Ten formation and distribution laws of conventional and unconventional natural gas reservoirs have been proposed. In terms of exploration geology, the theory of conventional 'monolithic' giant gas fields with different gas sources, and an unconventional gas accumulation theory with continuous distribution of 'sweet areas' in different lithologic reservoirs have been established; in terms of development geology, a development theory of conventional structural gas reservoirs is oriented to 'controlling water intrusion', while a development theory of unconventional gas is concentrated on man-made gas reservoirs.(3) With the geological resources(excluding hydrates) of 210×1012 m3 and the total proven rate of the resources less than 2% at present, the natural gas in China will see a constant increase in reserve and production; by 2030, the proven geological reserves of natural gas are expected to reach about(6 000-7 000)×108 m3, the production of conventional and unconventional natural gas each will reach about 1 000×108 m3, and the gas consumption will reach 5 500×108 m3. The dependence on imported natural gas may be 64% by 2030, and 70% by 2050.(4) Ten measures for future development of natural gas have been proposed, including strengthening exploration in large-scale resource areas, increasing the development benefits of unconventional gas, and enhancing the peak adjusting capacity of gas storage and scale construction of liquified natural gas. | ZOU Caineng YANG Zhi HE Dongbo WEI Yunsheng LI Jian JIA Ailin CHEN Jianjun ZHAO Qun LI Yilong LI Jun YANG Shen | 2018 | Petroleum Exploration and Development2018，45，4： | 4 |
| 17 | A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection显示文摘在 intracytoplasmic 精子注射( ICSI )以后的全部或近总数的授精失败是一个稀罕事件,但是因为精子缺点,它在激活 oocyte.The 大小写反复发生在 one-day-old 上在钙 ionophore A23187 ( A23187 )激活以后介绍成功的怀孕和实时出生在其丈夫承受了 oligoasthenoteratozoospermia 的一个病人的未受精的卵母细胞,并且经历了的人,在 ICSI.In 以后重复了近总数的授精失败第二个 ICSI 周期,仅仅一个卵母细胞是 | Lu Qun Chen Xi Li Yang Zhang Xiao-hong Liang Rong Zhao Yong-ping Wei Li-hui Shen Huan | 2012 | Chinese Medical Journal2012，，3： | 4 |
| 18 | A distributed approach for lidar-based relative state estimation of multi-UAV in GPS-denied environments显示文摘In this paper,we present a distributed framework for the lidar-based relative state estimator which achieves highly accurate,real-time trajectory estimation of multiple Unmanned Aerial Vehicles(UAVs)in GPS-denied environments.The system builds atop a factor graph,and only on-board sensors and computing power are utilized.Benefiting from the keyframe strategy,each UAV performs relative state estimation individually and broadcasts very partial information without exchanging raw data.The complete system runs in real-time and is evaluated with three experiments in different environments.Experimental results show that the proposed distributed approach offers comparable performance with a centralized method in terms of accuracy and real-time performance.The flight test demonstrates that the proposed relative state estimation framework is able to be used for aggressive flights over 5 m/s. | Hongming SHEN Qun ZONG Hanchen LU Xuewei ZHANG Bailing TIAN Lei HE | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 19 | Control Efficacy of 45% Propamocarb·Denamidone SC against Potato Late Blight显示文摘The effects of different doses of 45% propamocarb·fenamidone SC on potato late blight were studied in the paper. The results showed that the overall control effect of 45% propamocarb·fenamidone SC against potato late blight on the 14 th day after the third spraying were 67. 64%- 83. 78%. The yield of potato reached 19 972. 5- 23 302. 5 kg / hm2,with higher marketable tuber rate and lower rotten tuber rate. With the increase in fungicide dose,the difference in control effect against late blight was significant,but the yield-increasing effect on potatoes was not significant. The appropriate application dosage of 45% propamocarb·fenamidone SC were 450- 675 g / hm2. | Xiao Chunfang Shen Yanfen Tian Henglin Gao Jianhua Zhang Yuanxue Chen Jiaji Cheng Qun Xu Yi | 2014 | Plant Diseases and Pests2014，5，5： | 3 |
| 20 | Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis显示文摘A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel.The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis.This treatment also inhibited the expression of the cell cycle regulatory proteins,survivin,cyclinD1,c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel. | Yunliang Xie Yanbo Liu Weigao Shen Bo Zhang Qun Liu | 2012 | Neural Regeneration Research2012，7，13： | 3 |
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