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| 1 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 2 | Dynamics for multistage pool formation of Lunnan low uplift in Tarim Basin显示文摘Lunnan area in the Tarim Basin has become animportant onshore oil production base in China. Formationof the oil and gas pools in the low uplift of Lunnan has ex-perienced a comparatively complex process of dynamics.Based on the hydrocarbon generation period of source rocks,the formation period of cap rocks and traps, the analysis oforganic inclusion and the analysis of bitumen in the reservoir,this paper draws the conclusion that the low uplift area ofLunnan has experienced three pool formation periods: thePermian period, the Cretaceous-Early Tertiary period andthe Late Tertiary-Quaternary period and two oil and gasreservoir adjustment periods: the Late Permian period andthe Late Tertiary-Quaternary period. The comprehensivestudy indicates that the large-scale Ordovician buried hill,formed in Early Hercynian, became the reservoir during thePermian period, because the Cambrian-Lower Ordovicianoil was discharged laterally into the reservoir along the topof the Ordovician weathering crust from south to north. Thereservoir experienced a complicated process-reconstruc-tion in the end of Permian, adjustment in Cretaceous-EarlyTertiary and re-discharging process in Late Tertiary-Qua-ternary, leading to the early original heavy oil reservoir ofmarine facies and the late original light oil reservoir and gaspool. Carboniferous, Triassic and Jurassic oil and gas reser-voirs result from upward adjustment and re-distribution ofOrdovician oil and gas reservoirs. Of those results, the for-mation of Triassic-Jurassic oil and gas pools came under theinfluence of the northward-tilting structure. The oil and gassourcing from the different hydrocarbon source rock inter-vals vertically migrated into the base unconformity of Trias-sic system. Then the oil and gas migrated laterally fromnorth to south and accumulated into the reservoir. | HE Dengfa JIA Chengzao LIU Shaobo PAN Wenqing WANG Shejiao | 2002 | Chinese Science Bulletin2002，47，S1： | 11 |
| 3 | A systematic review of metabolomic profiling of gastric cancer and esophageal cancer显示文摘Objective:Upper gastrointestinal(UGI)cancers,predominantly gastric cancer(GC)and esophageal cancer(EC),are malignant tumor types with high morbidity and mortality rates.Accumulating studies have focused on metabolomic profiling of UGI cancers in recent years.In this systematic review,we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with GC and EC.Methods:A systematic search of three databases(Embase,PubMed,and Web of Science)for molecular epidemiologic studies on the metabolomic profiles of GC and EC was conducted.The Newcastle–Ottawa Scale(NOS)was used to assess the quality of the included articles.Results:A total of 52 original studies were included for review.A number of metabolites were differentially distributed between GC and EC cases and non-cases,including those involved in glycolysis,anaerobic respiration,tricarboxylic acid cycle,and protein and lipid metabolism.Lactic acid,glucose,citrate,and fumaric acid were among the most frequently reported metabolites of cellular respiration while glutamine,glutamate,and valine were among the most commonly reported amino acids.The lipid metabolites identified previously included saturated and unsaturated free fatty acids,aldehydes,and ketones.However,the key findings across studies to date have been inconsistent,potentially due to limited sample sizes and the majority being hospital-based case-control analyses lacking an independent replication group.Conclusions:Studies on metabolomics have thus far provided insights into etiological factors and biomarkers for UGI cancers,supporting the potential of applying metabolomic profiling in cancer prevention and management efforts. | Sha Huang Yang Guo Zhexuan Li Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2020 | Cancer Biology & Medicine2020，17，1： | 11 |
| 4 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 5 | Accumulation process and model for the Ordovician buried hill reservoir in the western Lunnan area,the Tarim Basin显示文摘The Ordovician buried hill reservoir in the western Lunnan area, a type of dissolved fracture and cavernous reservoir, is mainly composed of heavy oil. The oil is the mixture sourcing from the Middle-Lower Cambrian and Middle-Lower Ordovician, with three stages of pool forming process: (1) the destruction and parallel migration/accumulation during the late Caledonian to early Hercynian; (2) the oil and gas accumulation during the late Hercynian characterized by adjustment upward along faults and parallel migration/accumulation; (3) the formation of heavy oil during the latest Hercynian. The Ordovician buried hill reservoir is affected by the diffusion of light oil and gas but had no hydrocarbon charging during the late Yanshan period to Himalayan period, but in this period, formed the association of heavy oil and dissolved gas cracked from crude oil with dry coefficient of 0.91-0.96. The study on accumulation process of the Ordovician buried hill reservoir has important implications for the exploration potential of early oil and gas accumulation in the cratonic area of the Tarim Basin. | ZHAO MengJun PAN WenQing HAN JianFa LIU ShaoBo QIN ShengFei ZHANG BaoMin | 2007 | Chinese Science Bulletin2007，52，A01： | 6 |
| 6 | Crustal Motion Characteristics in the Eastern Margin of the Tibetan Plateau and Adjacent Regions after the Wenchuan Earthquake显示文摘The Wenchuan earthquake has altered the crustal motion characteristics in the eastern margin of the Tibetan Plateau and adjacent regions.Using discontinuous GPS survey data for 2008–2012, the velocity field for the Eurasia reference framework has been obtained, and the general trend of contemporary crustal motion after the occurrence of the Wenchuan earthquake has been studied.In addition, using the velocity field, the block movement velocity has been estimated by least-squares fitting.Furthermore, the properties and displacement rates of main faults have been obtained from the differences in velocity vectors of the blocks on both sides of the faults.The results reveal that there are no obvious changes in the general characteristics of crustal motion in this area after the Wenchuan earthquake.The earthquake mainly changed the rate of the movement of the Chuan-Qing block and caused variation in the movement direction of the South China block.The effect of the earthquake on faults is mainly reflected in variations in fault displacement velocity; there is no fundamental change in the properties of fault activity.The displacement rates of the Xianshuihe fault decreased by 3–4 mm/a, the Longmenshan fault increased by 9–10 mm/a, and the northern segment of the Anninghe fault increased by approximately 9 mm/a.Furthermore, the displacement rates of the Minjiang, Xueshan, Huya, Longquanshan, and Xinjin faults increased by 2–3 mm/a.This implies that the effects of the Wenchuan earthquake on crustal movement can mainly be observed in the Chuan-Qing, South China, and N-Chuan-Dian blocks and their internal faults, as well as the Xianshuihe and Longmenshan faults and the northern section of the Anninghe fault.The reason for this is that the Wenchuan earthquake disturbed the kinematic and dynamic balance in the region. | TANG Wenqing ZHANG Qingzhi PAN Zhongxi LI Jun YANG Cheng | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 5 |
| 7 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 8 | Effect of algal flocculation on dissolved organic matters using cationic starch modified soils显示文摘Modified soils(MSs) are being increasingly used as geo-engineering materials for the sedimentation removal of cyanobacterial blooms. Cationic starch(CS) has been tested as an effective soil modifier, but little is known about its potential impacts on the treated water.This study investigated dissolved organic matters in the bloom water after algal removal using cationic starch modified soils(CS-MSs). Results showed that the dissolved organic carbon(DOC) could be decreased by CS-MS flocculation and the use of higher charge density CS yielded a greater DOC reduction. When CS with the charge density of 0.052, 0.102 and0.293 meq/g were used, DOC was decreased from 3.4 to 3.0, 2.3 and 1.7 mg/L, respectively.The excitation–emission matrix fluorescence spectroscopy and UV254 analysis indicated that CS-MS exhibits an ability to remove some soluble organics, which contributed to the DOC reduction. However, the use of low charge density CS posed a potential risk of DOC increase due to the high CS loading for effective algal removal. When CS with the charge density of 0.044 meq/g was used, DOC was increased from 3.4 to 3.9 mg/L. This study suggested, when CS-MS is used for cyanobacterial bloom removal, the content of dissolved organic matters in the treated water can be controlled by optimizing the charge density of CS. For the settled organic matters, other measures(e.g., capping treatments using oxygen loaded materials) should be jointly applied after algal flocculation. | Wenqing Shi Lei Bi Gang Pan | 2016 | Journal of Environmental Sciences2016，28，7： | 3 |
| 9 | Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila显示文摘 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 3 |
| 10 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 11 | Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci)显示文摘表明小径的刺猬(Hh ) 在胚胎的开发和成年织物动态平衡起重要作用。如此的生物功能被抄写因素肘脉 interruptus (Ci ) 调停。然而,受动器 Ci 本身的 transcriptional 规定糟糕被调查。通过一幅基于 RNAi 的基因屏幕,我们识别了那女性无菌(1 ) homeotic (Fsh ) ,抄写激活剂,直接激活 Ci 抄写。生物化学试金在 Fsh 之中表明了物理相互作用,性梳子额外(Sce ) ,并且 Polycomb (Pc ) 。功能的试金进一步证明 Pc 和 Sce 为 Ci 被要求表示,没被 Engrailed 的 derepression 多半调停,) , Ci 的一个抑压者,在 Pc 或 Sce 异种房间。最后,我们提供证明 Pc/Sce 在 Ci 地点便于 Fsh 的绑定并且在 Fsh 和 Pc 之间的物理相互作用为调停 Fsh 的 Ci 抄写是必要的证据。一起拿,我们不仅揭开那 Ci 被复杂的 Fsh-Pc-Sce transcriptionally 调整而且在 transcriptional 为在 Fsh 和 PcG 蛋白质之间的协作提供证据规定。 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 2 |
| 12 | Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials显示文摘Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical application.Here,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for NRR.Based on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 activation.The synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR performance.This work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design. | Wenqing Zhang Keke Mao Jingxiang Low Hengjie Liu Yanan Bo Jun Ma Qiaoxi Liu Yawen Jiang Jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie Xiong | 2021 | Nano Research2021，14，9： | 2 |
| 13 | Present-day Block Movement and Fault Activity on the Eastern Margin of the Tibetan Plateau显示文摘The geology and tectonics in the eastern margin of Tibetan Plateau are complex. The main tectonic framework is composed of blocks and faults. Using discontinuous global positioning system survey data for 2008–2014, the velocity field for the Eurasia reference framework was obtained. Based on the velocity field, the present-day velocities of the blocks and boundary faults were estimated. The results reveal that the movement rates of the Chuan-Qing, South China, Chuan-Dian and Indo-China blocks are(17.02±0.60) mm/a,(8.77±1.51) mm/a,(13.85±1.31) mm/a and(6.84 ± 0.74) mm/a, respectively, and their movement directions are 99.5°, 120.3°, 142.9° and 153.3°, respectively. All blocks exhibit clockwise rotation. The displacement rates of the Xianshuihe, Longmenshan, Anninghe, Zemuhe, Xiaojiang and Red River faults are(7.30±1.25–8.30±1.26) mm/a,(10.07±0.97–11.79±0.89) mm/a,(0.96±0.74–2.98±1.73) mm/a,(2.03±0.49–3.20±0.73) mm/a,(3.45±0.40–6.02±0.50) mm/a and(6.23±0.56) mm/a, respectively. The Xianshuihe, Anninghe, Zemuhe and Xiaojiang faults show leftlateral strike-slip movement, while the Longmenshan and Red River faults show right-lateral strikeslip. These characteristics of the blocks and faults are related to the particular tectonic location and dynamic mechanism. | TANG Wenqing ZHANG Yongshuang ZHANG Qingzhi ZHOU Hongfu PAN Zhongxi LI Jun YANG Cheng | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 2 |
| 14 | The Tarim picrite–basalt–rhyolite suite, a Permian flood basalt from northwest China with contrasting rhyolites produced by fractional crystallization and anatexis显示文摘 | Wei Tian Ian H. Campbell Charlotte M. Allen Ping Guan Wenqing Pan Mimi Chen Hongjiao Yu Wenping Zhu | 2010 | Contributions to Mineralogy and Petrology2010，，3： | 1 |
| 15 | Visible-Light-Induced Degradation of Rhodamine B by Nanosized Bi2WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | J Phys Chem B2005，109，22： | 1 |
| 16 | Efficiency enhancement in DIBSQ:PC71BM organic photovoltaic cells by using Liq-doped Bphen as a cathode buffer layer显示文摘 | Guo CHEN Changfeng SI Pengpeng ZHANG Kunping GUO Saihu PAN Wenqing ZHU Bin WEI | 2017 | Frontiers of Materials Science2017，11，3： | 1 |
| 17 | Visiblelightinduced degradation of rhodamine B by nanosized Bi2 WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | The Journal of Physical Chemistry B2005，109，22： | 1 |
| 18 | Spatial spillover and regional economic growth in China显示文摘 | Chong-En Bai Hong Ma Wenqing Pan | 2012 | China Economic Review2012，，4： | 1 |
| 19 | Inter-industry Technology Spillover Effects in China:Evidence from 35 Industrial Sectors显示文摘The present paper calculates 35 industrial sectors' similarity matrices for the period of 1997-2008 using China's input-output tables for 1997,2002 and 2007,and uses these to measure inter-industry technology spillover to analyze the spillover effects on industrial sectors' labor productivity.The empirical analysis shows that inter-industry technology spillover has a significant positive effect on the labor productivity of each industry.The elasticity of productivity effects of inter-industry technology spillover is not only larger than that of direct R&D input,but also increases over time.We group the industries into four major categories and find that the inter-industry technology spillover effect within the categories is,on average,greater than that between the four categories,indicating that technology spillover occurs more easily between similar industries.This research shows that the interindustry technology spillover effect in China has begun to increase,and the government should take advantage of this effect. | Wenqing Pan Delin Yang Min Lin | 2012 | China & World Economy2012，20，2： | 1 |
| 20 | Visible-Light-Induced Degradation of Rhodamine B by Nanosized Bi2WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | The Journal of Physical Chemistry B2005，109，22： | 1 |
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