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| 1 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 2 | Generation of multi-channel chaotic signals with time delay signature concealment and ultrafast photonic decision making based on a globally-coupled semiconductor laser network显示文摘We propose and demonstrate experimentally and numerically a network of three globally coupled semiconductor lasers(SLs)that generate triple-channel chaotic signals with time delayed signature(TDS)concealment.The effects of the coupling strength and bias current on the concealment of the TDS are investigated.The generated chaotic signals are further applied to reinforcement learning,and a parallel scheme is proposed to solve the multiarmed bandit(MAB)problem.The influences of mutual correlation between signals from different channels,the sampling interval of signals,and the TDS concealment on the performance of decision making are analyzed.Comparisons between the proposed scheme and two existing schemes show that,with a simplified algorithm,the proposed scheme can perform as well as the previous schemes or even better.Moreover,we also consider the robustness of decision making performance against a dynamically changing environment and verify the scalability for MAB problems with different sizes.This proposed globally coupled SL network for a multi-channel chaotic source is simple in structure and easy to implement.The attempt to solve the MAB problem in parallel can provide potential values in the realm of the application of ultrafast photonics intelligence. | Yanan Han Shuiying Xiang Yang Wang Yuanting Ma Bo Wang Aijun Wen Yue Hao | 2020 | Photonics Research2020，8，11： | 6 |
| 3 | Black phosphorus inverter devices enabled by in-situ aluminum surface modification显示文摘Two-dimensional black phosphorus (BP) generally exhibits a hole-dominated transport characteristic when configured as field-effect transistor devices. The effective control of charge carrier type and concentration is very crucial for the application of BP in complementary electronics. Herein, we report a facile and effective electron doping methodology on BP, through in situ surface modification with aluminum (Al). The electron mobility of few-layer BP is found to be largely enhanced to ~ 10.6 cm^2·V^–1·s^–1 by over 6 times after aluminum modification. In situ photoelectron spectroscopy characterization reveals the formation of Al–P covalent bond at the interface, which can also serve as local gate to tune the transport properties in BP layers. Finally, a spatially-controlled aluminum doping technique is employed to establish a p–n homojunction on a single BP flake, and hence to realize the complementary inverter devices, where the highest gain value of ~ 33 is obtained. | Yue Zheng Zehua Hu Cheng Han Rui Guo Du Xiang Bo Lei Yanan Wang Jun He Min Lai Wei Chen | 2019 | Nano Research2019，12，3： | 5 |
| 4 | Concise and efficient direct-view generation of arbitrary cylindrical vector beams by a vortex half-wave plate显示文摘A concise, efficient, and practical direct-view scheme is presented to generate arbitrary cylindrical vector(CV)beams, including CV beams, vortex beams, and cylindrical vector vortex(CVV) beams, by a vortex half-wave plate(VHP). Six kinds of first-order and other high-order CV beams, such as azimuthally polarized(AP) beams, antivortex radial polarization mode beams, and three-order AP beams, are formed by simply rotating a half-wave plate. The Stokes parameters and double-slit interference of multitype CV beams are investigated in detail.The polarization parameters, including degree of polarization, polarization azimuth, and ellipticity, are obtained,which demonstrates the efficient generation of CV beams. In addition, the double-slit interference experiment is introduced in the setup, and fringe misplacement and tilt appear for CVV beams, in which the misplacement number M is 2P+1 for P ≤ 2 and 2P-1 for P ≥ 3, where P is the polarization order number, and the fringe tilt offset is positively related to the topological charge number l of CVV beams. In addition, new types of VHPs can be formed by cascading two or more VHPs when the types of available VHPs are limited, assisting in more flexible generation of multitype CV beams. It is experimentally demonstrated that arbitrary CV beams with high quality are effectively achieved by the proposed setup, and the double-slit interference method can be utilized to determine and analyze CV beams rapidly and concisely by practical performance, which shows the potential to be implemented as a commercial device. | JUNLI QI WEIHUA WANG BO SHI HUI ZHANG YANAN SHEN HAIFEI DENG WENJING PU XIN LIU HUIHUI SHAN XIAOMIN MA LIANQIANG ZHANG WEI LU MEICHENG FU XIUJIAN LI | 2021 | Photonics Research2021，9，5： | 4 |
| 5 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 6 | Surface functionalization on the thermal conductivity of graphene-polymer nanocomposites显示文摘Exploring thermal transport in graphene-polymer nanocomposite is significant to its applications with better thermal properties.Interfacial thermal conductance between graphene and polymer matrix plays a critical role in the improvement of thermal conductivity of graphene-polymer nanocomposite.Unfortunately,it is still challenging to understand the interfacial thermal transport between graphene nanofiller and polymer matrix at small material length scale.To this end,using nonequilibrium molecular dynamics(NEMD)simulations,we investigate the interfacial thermal conductance of graphene-polyethylene(PE)nanocomposite.The influence of functionalization with hydrocarbon chains on the interfacial thermal conductance of graphene-polymer nanocomposites was studied,taking into account the effects of model size and thermal conductivity of graphene.An analytical model is also used to calculate the thermal conductivity of nanocomposite.The results are considered to contribute to the development of new graphene-polymer nanocomposites with tailored thermal properties. | Mingchao Wang Dilini Galpaya Zheng Bo Lai Yanan Xu Cheng Yan | 2014 | International Journal of Smart and Nano Materials2014，5，2： | 2 |
| 7 | Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway显示文摘Lipid metabolism reprogramming is now accepted as a new hallmark of cancer.Hence,targeting the lipogenesis pathway may be a potential avenue for cancer treatment.Valproic acid(VPA)emerges as a promising drug for cancer therapy;however,the underlying mechanisms are not yet fully understood.In this study,we aimed to investigate the effects and mechanisms of VPA on cell viability,lipogenesis,and apoptosis in human prostate cancer PC-3 and LNCaP cells.The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 and LNCaP cells.Moreover,the expression of CCAAT/enhancer-binding proteinα(C/EBPα),as well as sterol regulatory element-binding protein 1(SREBP-1)and its downstream effectors,including fatty acid synthase(FASN),acetyl CoA carboxylase 1(ACC1),and anti-apoptotic B-cell lymphoma 2(Bcl-2),was markedly decreased in PC-3 and LNCaP cells after VPA administration.Mechanistically,the overexpression of C/EBPαrescued the levels of SREBP-1,FASN,ACC1,and Bcl-2,enhanced lipid accumulation,and attenuated apoptosis of VPA-treated PC-3 cells.Conversely,knockdown of C/EBPαby siRNA further decreased lipid accumulation,enhanced apoptosis,and reduced the levels of SREBP-1,FASN,ACC1,and Bcl-2.In addition,SREBP-1a and 1c enhanced the expressions of FASN and ACC1,but only SREBP-1a had a significant effect on Bcl-2 expression in VPA-treated PC-3 cells.Based on the results,we concluded that VPA significantly inhibits cell viability via decreasing lipogenesis and inducing apoptosis via the C/EBPα/SREBP-1 pathway in prostate cancer cells.Therefore,VPA that targets lipid metabolism and apoptosis is a promising candidate for PCa chemotherapy. | Bo Pang Juanjuan Zhang Xi Zhang Jihong Yuan Yanan Shi Ling Qiao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 8 | Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management显示文摘Coronavirus disease-2019(COVID‐19)has become a global pandemic.COVID-19 runs its course in two phases,the initial incubation phase and later clinical symptomatic phase.Patients in the initial incubation phase often have insidious clinical symptoms,but they are still highly contagious.At the later clinical symptomatic phase,the immune system is fully activated and the disease may enter the severe infection stage in this phase.Although many patients are known for their respiratory symptoms,they had neurological symptoms in their first 1-2 days of clinical symptomatic phase,and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase.The key is to prevent a patient from progressing to this severe infection from mild infection.We are sharing our experience on prevention and management of COVID-19. | Yifan Zhou Wei Li David Wang Ling Mao Huijuan Jin Yanan Li Candong Hong Shengcai Chen Jiang Chang Quanwei He Mengdie Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 9 | Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials显示文摘Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical application.Here,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for NRR.Based on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 activation.The synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR performance.This work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design. | Wenqing Zhang Keke Mao Jingxiang Low Hengjie Liu Yanan Bo Jun Ma Qiaoxi Liu Yawen Jiang Jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie Xiong | 2021 | Nano Research2021，14，9： | 2 |
| 10 | An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques显示文摘Dear Editor,Since early 2020,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally infecting over 500 million people and causing over 6 million deaths.The massive worldwide immunisation programmes and the arising clinical trial data present a unique opportunity to compare the vaccines and various delivery platforms(i.e.viral vector platform,mRNA platform and virus-like particle platform). | Yuanyuan Li Yanan Zhang Yu Zhou Yan Li Jiao Xu Yuanbao Ai Lei Xu Xiuli Xiao Bo Zhang Jing Jin | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 11 | 帕博利珠单抗单药或联合化疗对PD-L1≥50%晚期NSCLC疗效的回顾性分析显示文摘目的该研究旨在评估及比较帕博利珠单抗联合含铂化疗(pembrolizumab plus platinum-based chemotherapy,PC)或帕博利珠单抗单药治疗(pembrolizumab monotherapy, PM)对程序性死亡配体1(programmed death ligand 1, PD-L1)肿瘤比例评分(tumor proportion score, TPS)≥50%的晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的疗效。方法回顾性分析比较PM和PC作为一线治疗时,对PD-L1-TPS≥50%且无表皮生长因子受体(epidermal growth factor receptor,EGFR)和间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)突变NSCLC患者的疗效。结果研究纳入115例PC和91例PM治疗患者。至2020年12月30日,中位随访时间为17.13个月。PC和PM组中位无进展生存期(progression-free survival, PFS)分别为12.37个月和9.60个月(HR:0.44, P<0.001)。中位总生存期(overall survival, OS)分别为未能评估(not evaluable, NE)和28.91个月(HR:0.40, P=0.005)。亚组分析发现,除脑转移患者外,PC对大多数患者的PFS均有显著改善。PC和PM组的1年OS率分别为89.3%和76.1%;客观缓解率分别为61.7和46.9%(P=0.004)。结论标准含铂化疗基础上联合帕博利珠单抗似乎是初治、PD-L1≥50%、无EGFR或ALK突变的晚期NSCLC患者治疗的更优方案,需前瞻性研究验证该结论。 | Ya CHEN Yanan WANG Zhengyu YANG Minjuan HU Yanwei ZHANG Fangfei QIAN Wei ZHANG Bo ZHANG Baohui HAN 王李强(翻译校对) | 2022 | 中国肺癌杂志2022，25，2： | 1 |
| 12 | Review of Research on Early Cambrian Phosphatized Quadrapyrgites显示文摘The metazoan Quadrapyrgites consists, from proximal to distal ends, of an oral area, a cone, a collar, and an apex from the Early Cambrian Fortunian Stage in Xixiang Zhangjiagou section, southern Shaanxi Province, South China. Three morphological types of the apex, the most characteristic feature of the taxon, are identified from hundreds of Quadrapyrgites specimens. The Quadrapyrgites growth zone is situated at the oral end, where 12 terminal lobes are generated, uplifted, enlarged, and evaginated to form a crest; A one-by-one of crest number from 2 to 13 has been recognized. The unique growth pattern and ontogenetic sequence refute a cubozoan or cycloneuralian affinity for Olivooides and Quadrapyrgites, and instead defend a coronate scyphozoan hypothesis. An embryonic development and ontogenetic sequence with embryo and crest is constructed. | SHAO Tiequan WANG Qi LIU Yunhuan ZHANG Yanan LI Hewei HU Bo LI Chuang DONG Zhiguo ZHANG Hongtao | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 13 | Eopriapulites Sphinx—The Oldest Priapulid-Like Scalidophoran Animal显示文摘Objective Priapulid belong to scalidophoran and is located in the Cycloneuralia branch of the Ecdysozoa.It has survived for more than 50 million years,is a real'living fossil'.Priapulid was extremely prosperous in the Cambrian period.It is a small phylum in the modern ocean;only 18current types have been described.In the Cambrian life,priapulid is one of the most important living organisms | SHAO Tiequan LIU Yunhuan WANG Qi DAI Jun ZHANG Yanan TANG Hanhua LIANG Yongchun CHEN Cheng HU Bo WEI Meng YANG Tingting | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 1 |
| 14 | Evaluation of grain breakage sensitivity of maize varieties mechanically-harvested by combine harvester显示文摘A high grain breakage rate is the main problem that occurs during mechanical maize harvest in China.The breakage sensitivity of different varieties was significantly different,and the breakage resistance is heritable.Therefore,breakage resistant variety screening can help improve the field production efficiency and provide references for breeding work.In this study,42 varieties of maize were harvested with the same mechanical parameters and the same manipulator on a range of harvest dates at experimental stations in Xinxiang,Henan Province,in 2017 and Changji,Xinjiang Province,in 2018 to determine the sensitivity of grain moisture content on grain breakage rate during machine harvest for different varieties.The integral value of the grain breakage rate curve corresponding to the range of 15%to 30%grain moisture content was used as an index that expressed the sensitivity of maize grains to breakage depending on grain moisture content(BSW).Forty-two varieties were categorized as having weak,intermediate,or strong BSW.Among the same four varieties in the two stations,Lianchuang 825 and Lianchuang 808 were classified as sensitive and fragile varieties,Shandan 650 was classified as an intermediate variety,Zeyu 8911 was divided into weak sensitive and breakage-resistance varieties in Xinxiang and intermediate varieties in Changji.The BSW classification results at the two experimental sites were generally consistent,indicating that breakage sensitivity due to moisture content may be a relatively stable genetic characteristic.This study suggested that the integral method for determining BSW can be used to assess the resistance of different maize varieties to grain breakage during mechanical harvesting.The integral method was used to identify twelve breakage-resistant varieties in Xinxiang Station,and six breakage-resistant varieties in Changji Station.This study provides a method for screening maize varieties that are suited to mechanical grain harvesting and for studying the mechanisms of grain breakage resistance. | Yizhou Wang Lulu Li Shang Gao Yanan Guo Guoqiang Zhang Bo Ming Ruizhi Xie Jun Xue Peng Hou Keru Wang Shaokun Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 15 | Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner显示文摘Dear Editor,The ongoing outbreak of pneumonia(coronavirus disease 2019,COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a global health emergency.Scutellaria Baicalensis Georgi extract,a Traditional Chinese Medicine(TCM)widely used for treating infection of multiple different viruses,1 also shows beneficial effects when treating COVID-19.However,underline mechanism for broad antiviral activity of Scutellaria B.extract remains elusive,which limits its further application. | Shichao Huang Yu’e Liu Yanan Zhang Ru Zhang ChengJie Zhu Lihong Fan Gang Pei Bo Zhang Yufeng Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 16 | Scission of C–O and C–C linkages in lignin over RuRe alloy catalyst显示文摘The performance of lignin depolymerization is basically determined by the interunit C–O and C–C bonds.Numerous C–O bond cleavage strategies have been developed, while the cleavage of C–C bond between the primary aromatic units remains a challenging task due to the high dissociation energy of C–C bond.Herein, a multifunctional Ru Re alloy catalyst was designed, which exhibited exceptional catalytic activity for the cleavage of both C–O and C–C linkages in a broad range of lignin model compounds(β-1, a-5, 5–5,β-O-4, 4-O-5) and two stubborn lignins(kraft lignin and alkaline lignin), affording 97.5% overall yield of monocyclic compounds from model compounds and up to 129% of the maximum theoretical yield of monocyclic products based on C–O bonds cleavage from realistic lignin. Scanning transmission electron microscopy(STEM) characterization showed that Ru Re(1:1) alloy particles with hexagonal close-packed structure were homogeneously dispersed on the support. Quasi-in situ X-ray photoelectron spectroscopy(XPS), and X-ray absorption spectroscopy(XAS) indicate that Ru species were predominantly metallic state, whereas Re species were partially oxidized;meanwhile, there was a strong interaction between Ru and Re, where the electron transfer from Re to Ru was occurred, resulting in great improvement on the capability of C–O and C–C bonds cleavage in lignin conversion. | Xinxin Li Yangming Ding Xiaoli Pan Yanan Xing Bo Zhang Xiaoyan Liu Yuanlong Tan Hua Wang Changzhi Li | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 17 | Study on Toughening Phenolic Foams in Phosphorus-Containing Tung Oil-Based Derivatives显示文摘Phenolic foams(PFs)as thermal insulation material with outstanding flame retardancy are required to match society’s ever-expanding safety expectations;however,a trade-off exists between flame retardancy and toughness.Here,for the first time,we synthesized a novel reactive phosphorus-containing tung-oil-based derivative and used it to toughen PF,resulting in PFs with a combination of excellent mechanical properties and flame retardancy.Compared with pure PF,the modified PFs exhibit enhanced mechanical properties,with specific compressive and flexural strengths as high as 5.67 MPa and 12.46 MPa,which represent increases of 90.67%and 178.7%over those of pure PF,respectively.Meanwhile,the limiting oxygen index(LOI)values of the modified PFs are improved as much as 40.83%.Scanning electron microscopy micrographs show that the microstructure of the modified PFs is better than that of pure PF,with a more uniform cell morphology,a narrower pore size distribution range,and a smaller average pore size,all of which are beneficial to the foam’s mechanical properties.This study provides a scientific paradigm for the development of advanced PFs based on renewable biological resources. | Fei Song Puyou Jia Yanan Xiao Caiying Bo Lihong Hu Yonghong Zhou | 2019 | Journal of Renewable Materials2019，7，10： | 1 |
| 18 | AnaLysis on later- al deformation of high-formwork in different column's spacing of bridging显示文摘 | Liu Li Wang Bo Liu Yanan | 2014 | Applied Me- chanics and Materials2014，，580583： | 1 |
| 19 | Analysis on lateral deformation of high-forrnwork in differ- ent column's spacing of bridging 显示文摘 | Liu Li Wang Bo Liu Yanan | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 20 | Influence of bridging arrangement location on the mechani- cal characteristics of the high-forrnwork support system 显示文摘 | Liu Li Liu Yanan Wang Bo | 2014 | Applied Mechanics and Materials2014，，580583： | 1 |
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