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| 1 | Zircon U-Pb geochronology of basement metamorphic rocks in the Songliao Basin显示文摘Zircon LA-ICP MS U-Pb dating of six metamorphic rocks and a metagranite (breccia) from southern basement of the Songliao Basin are reported in order to constrain the formation ages of basement. The basement metamorphic rocks in the Songliao Basin mainly consist of metagabbro (L45-1), amphibolite (SN117), metarhyolitical tuff (G190), sericite (Ser) schist (N103), chlorite (Chl) schist (T5-1), biotite (Bi)-actinolite (Act)-quartz (Q) schist (Y205), and metagranite (L44-1). The cathodoluminesence (CL) images of the zircons from metagabbro (L45-1) and metagranite (L44-1) indicate that they have cores of magmatic origin and rims of metamorphic overgrowths. Their U-Pb isotopic ages are 1808±21 Ma and 1873±13 Ma, respectively. The zircons with oscillatory zoning from amphibolite (SN117) and Chl schist (T5-1), being similar to those of mafic igneous rocks, yield ages of 274 ± 3.4 Ma and 264 ± 3.2 Ma, re-spectively. The zircons from metarhyolitical tuff (G190) and Ser schist (N103) display typical magmatic growth zoning and yield ages of 424 ± 4.5 Ma and 287 ± 5.1Ma, respectively. Most of zircons from Bi-Act-Q schist (Y205) are round in shape and different in absorption degree in the CL images, implying their sedimentary detritals. U-Pb dating yield concordant ages of 427 ± 3.1Ma, 455 ± 12 Ma, 696 ± 13 Ma, 1384±62 Ma, 1649±36 Ma, 1778±18 Ma, 2450±9 Ma, 2579±10 Ma, 2793±4 Ma and 2953±14 Ma. The above-mentioned results indicate that the Precambrian crystalline basement (1808―1873 Ma) exists in the southern Songliao Basin and could be related to tectonic thrust, and that the Early Paleozoic (424―490 Ma) and Late Paleozoic magmatisms (264―292 Ma) also occur in the basin basement, which are consistent with the ages of the detrital zircons from Bi-Act-Q schist in the basement. | PEI FuPing XU WenLiang YANG DeBin ZHAO QuanGuo LIU XiaoMing HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，7： | 57 |
| 2 | Permian volcanisms in eastern and southeastern margins of the Jiamusi Massif, northeastern China: zircon U-Pb chronology, geochemistry and its tectonic implications显示文摘LA-ICP-MS zircon U-Pb dating and geochemical data for the Late Paleozoic volcanic rocks from eastern and southeastern margins of the Jiamusi Massif are presented to understand the regional tectonic evolution. Zircons from eight representative volcanic rocks are euhedral-subhedral in shape and dis- play striped absorption and fine-scale oscillatory growth zoning as well as high Th/U ratios (0.33―2.37), implying a magmatic origin. The dating results show that the Late Paleozoic volcanic rocks in the study area can be divided into two stages, i.e., the Early Permian (a weighted mean 206Pb/238U age of 288 Ma) and the Middle Permian volcanisms (a weighted mean 206Pb/238U age of 268 Ma). The former is com- posed mainly of basalt, basaltic-andesite, andesite and minor dacite. They are characterized by low SiO2 contents, high Mg# (0.40―0.59), enrichment in Na (Na2O/K2O = 1.26―4.25) and light rare earth elements (LREEs), relative depletion in heavy rare earth elements (HREEs) and high field strength ele- ments (HFSEs), indicating that an active continental margin setting could exist in the eastern margin of the Jiamusi Massif in the Early Permian. The latter consists mainly of rhyolite and minor dacite with high SiO2 (77.23%―77.52%), low MgO (0.11%―0.14%), enrichment in K2O (Na2O/K2O ratios < 0.80) and Rb, Th, U and depletion in Eu, Sr, P and Ti, implying a crust-derived origin. Therefore, it is proposed that the Middle Permian volcanic rocks could have formed under the collision of the Jiamusi and the Khanka Massifs. | MENG En XU WenLiang YANG DeBin PEI FuPing Yu Yang Zhang XingZhou | 2008 | Chinese Science Bulletin2008，53，8： | 42 |
| 3 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 4 | LA-ICP-MS zircon U-Pb dating from granitoids in southern basement of Songliao basin:Constraints on ages of the basin basement显示文摘Seven LA-ICP-MS zircon U-Pb datings from granitoids in the southern basement of the Songliao basin were done in order to constrain the ages of the basin basement. The cathodoluminescence (CL) images of the zircons from seven granitoids indicate that they are euhedral-subhedral ones with striped ab-sorption and obvious oscillatory zoning rims. The dating results show that a weighted mean 206Pb/238U age is 236±3 Ma for quartz diorite (sample No.T6-1) located in the western slope of the basin,that weighted mean 206Pb/238U ages are 319±1 Ma (2126 m) and 361±2 Ma (1994 m) for diorite (sample No.YC1-1) and granite (sample No.YC1-2) located in northern part of southeastern uplift of the basin,respectively,and that weighted mean 206Pb/238U ages are 161±5 Ma,165±2 Ma,165±1 Ma and 161±4 Ma for samples Q2-1,SN121,SN122,and SN72 granitoids located in southern part of southeastern uplift of the basin,respectively. The statistical results of ages suggest that the middle Jurassic granitoids con-stitute the main part of basement granitoids,and that the Hercynian and Indo-Sino magmatisms also occur in the basin basement. It is implied that the Songliao basin should be a rift one formed in the intracontinent or active continental margin settings in the late Mesozoic after the Middle Jurassic orogeny took place. | GAO FuHong XU WenLiang YANG DeBin PEI FuPing LIU XiaoMing HU ZhaoChu | 2007 | Science China Earth Sciences2007，50，7： | 31 |
| 5 | Generation of neural progenitor cells by chemical cocktails and hypoxia显示文摘神经祖先房间(NPC ) 能被定义因素从体的房间导致。这里,我们报导 NPC 能从老鼠被产生由化学鸡尾酒的胚胎的成纤维细胞,也就是 VCR (V, VPA, HDAC 的一个禁止者;C, CHIR99021, GSK-3 kinases 和 R 的一个禁止者, Repsox, TGF-β 的一个禁止者;小径) ,在一个生理的 hypoxic 条件下面。这些导致化学药品的 NPC (ciNPCs ) 类似于鼠标关于他们为在 vitro 并且在 vivo 的不同 neuroectodermal 系的 proliferative 和自我更新的能力,基因表达式侧面,和 multipotency 的导出大脑的 NPC。进一步的实验揭示那种选择有 histone deacetylation,肝糖 synthase kinase,和 TGF-β 的禁止者的鸡尾酒;小径为 ciNPC 正式就职显示出类似的功效。而且, ciNPCs 能也与一样的化学鸡尾酒 VCR 从老鼠尾巴尖端成纤维细胞和人的尿房间被导致。因此,我们的学习证明没有介绍外长的因素,到 NPC 的体的房间的那系特定的变换能被化学鸡尾酒完成。 | Lin Cheng Wenxlang Hu Binlong Qiu Jian Zhao Yongchun Yu Wuqiang Guan Min Wang Wuzhou Yang Gang Pei | 2014 | Cell Research2014，24，6： | 32 |
| 6 | Chronology and Geochemistry of Mesozoic Volcanic Rocks in the Linjiang Area,Jilin Province and their Tectonic Implications显示文摘锆石 U-Pb 年龄和 geochemical 分析结果在 Linjiang 区域为 Naozhigou, Ergulazi,和 Sidaogou 形成的暴烈的岩石被介绍,抑制岩浆来源和他们的构造背景的性质的东南的吉林省。Naozhigou 形成主要由安山岩和流纹岩和它的加权的吝啬的 206Pb/238 为 13 锆石谷物的 U 年龄是 222 ± 1 妈。Ergulazi 形成由玄武岩的安山岩,玄武岩的 trachyandesite,和安山岩组成,并且六谷物给加权的吝啬的 206Pb/ Z38 131 ± 4 妈的 U 年龄。Sidaogou 形成主要由 trachyandesite 组成并且流纹岩,和六锆石谷物产出一个加权的平均数 206Pb/238 113 ± 4 妈的 U 年龄。暴烈的岩石有 SiO 2=60.24%77.46%, MgO =0.36%1.29%( Mg #= 0.32 0.40 )为 Naozhigou 形成, SiO 2=51.60%59.32%, MgO =3.70%5.54%( Mg #= 0.50 0.60 )为 Ergulazi 形成,和 SiO 2=58.28%76.32%, MgO =0.07%1.20%( Mg #= 0.14 0.46 )为 Sidaogou 形成。踪迹元素分析结果显示这些暴烈的岩石被丰富在轻稀土元素元素( LREE )和大离子亲石元素元素( LILE )描绘,在重稀土元素元素( HREE )的相对弄空和高度回答力量元素( HFSE , Nb , Ta ,并且 Ti ),并且否定 Eu 异例。与原始披风相比,在 Linjiang 区域的中生代暴烈的岩石有相对高的起始的 87Sr/86 Sr 比率(0.7053 0.7083 ) 并且低 ɛ
Nd (t) 价值(到 2.43 的 −8.38 ) ,和显示一个食火鸟趋势。为 Naozhigou 形成的晚三叠纪的岩浆能从部分融化被导出一最新有北方中国 Craton 地下室的次要的参与的 accretional 外壳并且在 Yangtze Craton 和北方中国 Craton 的碰撞以后在前下面形成了紧张的环境。为 Ergulazi 和 Sidaogou 形成的早白垩纪暴烈的岩石能在活跃大陆人边缘与有关的构造背景下面被形成向西 Izanagi 板的 subduction。 | YU Yang XU Wenliang PEI Fuping YANG Debin ZHAO Quanguo | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 27 |
| 7 | Additive manufacturing of metals:Microstructure evolution and multistage control显示文摘As a revolutionary industrial technology,additive manufacturing creates objects by adding materials layer by layer and hence can fabricate customized components with an unprecedented degree of freedom.For metallic materials,unique hierarchical microstructures are constructed during additive manufacturing,which endow them with numerous excellent properties.To take full advantage of additive manufacturing,an in-depth understanding of the microstructure evolution mechanism is required.To this end,this review explores the fundamental procedures of additive manufacturing,that is,the formation and binding of melt pools.A comprehensive processing map is proposed that integrates melt pool energy-and geometry-related process parameters together.Based on it,additively manufactured microstructures are developed during and after the solidification of constituent melt pool.The solidification structures are composed of primary columnar grains and fine secondary phases that form along the grain boundaries.The post-solidification structures include submicron scale dislocation cells stemming from internal residual stress and nanoscale precipitates induced by intrinsic heat treatment during cyclic heating of adjacent melt pool.Based on solidification and dislocation theories,the formation mechanisms of the multistage microstructures are thoroughly analyzed,and accordingly,multistage control methods are proposed.In addition,the underlying atomic scale structural features are briefly discussed.Furthermore,microstructure design for additive manufacturing through adjustment of process parameters and alloy composition is addressed to fulfill the great potential of the technique.This review not only builds a solid microstructural framework for metallic materials produced by additive manufacturing but also provides a promising guideline to adjust their mechanical properties. | Zhiyuan Liu Dandan Zhao Pei Wang Ming Yan Can Yang Zhangwei Chen Jian Lu Zhaoping Lu | 2022 | Journal of Materials Science & Technology2022，，5： | 27 |
| 8 | BMPs functionally replace KLf4, and support efficient reprogramming of mouse fibroblasts by Oct4 alone显示文摘由定义因素的导致的 pluripotent 干细胞的产生成为了一个有用模型调查 reprogramming 和房间命运决心的机制。然而,基于因素的 reprogramming 的精确机制仍然保持不清楚。这里,我们证明 Klf4 主要在 reprogramming 的起始的阶段行动开始 mesenchymal-to-epithelial 转变并且能是机能上地由骨头代替了形态基因的蛋白质(BMP ) 。BMP 增加了老鼠的 Oct4/Sox2-mediated reprogramming 的效率胚胎的成纤维细胞(MEF ) 到 ~1% 。BMP 也支持了 MEF 和尾巴的单个因素的基于 Oct4 的 reprogramming 胫骨的成纤维细胞。我们的研究在 reprogramming 澄清 Klf4 的贡献并且在区分的房间作为 pluripotency 的单个 setter 建立 Oct4。 | Jiekai Chen Jing Liu Jiaqi Yang You Chen Jing Chen Su Ni Hong Song Lingwen Zeng Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，1： | 26 |
| 9 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 10 | Input-occupancy-output models of the non-competitive type and their application - an examination of the China-US trade surplus显示文摘本文构建了一种能够反映中国加工贸易特点的非竞争(进口)型投入占用产出模型,提出了一个国家全部出口与分部门、分大类商品的单位出口对国内增加值和就业的拉动效应的计算方法,从数学上证明了出口总值等于出口商品所包含的完全国内增加值与完全进口额之和,并据此编制了2002年中美两国的非竞争(进口)型投入占用产出表,测算和分析了中美两国出口对各自国内增加值和就业的影响。 | Lawrence J. Lau Xikang Chen Cuihong Yang Leonard K. Cheng K. C. Fung Yun-Wing Sung Kunfu Zhu Jiansuo Pei Zhipeng Tang | 2010 | Social Sciences in China2010，31，1： | 24 |
| 11 | Improvement of snow depth retrieval for FY3B-MWRI in China显示文摘The primary objective of this work is to develop an operational snow depth retrieval algorithm for the FengYun3B Microwave Radiation Imager(FY3B-MWRI)in China.Based on 7-year(2002–2009)observations of brightness temperature by the Advanced Microwave Scanning Radiometer-EOS(AMSR-E)and snow depth from Chinese meteorological stations,we develop a semi-empirical snow depth retrieval algorithm.When its land cover fraction is larger than 85%,we regard a pixel as pure at the satellite passive microwave remote-sensing scale.A 1-km resolution land use/land cover(LULC)map from the Data Center for Resources and Environmental Sciences,Chinese Academy of Sciences,is used to determine fractions of four main land cover types(grass,farmland,bare soil,and forest).Land cover sensitivity snow depth retrieval algorithms are initially developed using AMSR-E brightness temperature data.Each grid-cell snow depth was estimated as the sum of snow depths from each land cover algorithm weighted by percentages of land cover types within each grid cell.Through evaluation of this algorithm using station measurements from 2006,the root mean square error(RMSE)of snow depth retrieval is about 5.6 cm.In forest regions,snow depth is underestimated relative to ground observation,because stem volume and canopy closure are ignored in current algorithms.In addition,comparison between snow cover derived from AMSR-E and FY3B-MWRI with Moderate-resolution Imaging Spectroradiometer(MODIS)snow cover products(MYD10C1)in January 2010 showed that algorithm accuracy in snow cover monitoring can reach 84%.Finally,we compared snow water equivalence(SWE)derived using FY3B-MWRI with AMSR-E SWE products in the Northern Hemisphere.The results show that AMSR-E overestimated SWE in China,which agrees with other validations. | JIANG LingMei WANG Pei ZHANG LiXin YANG Hu YANG JunTao | 2014 | Science China Earth Sciences2014，57，6： | 22 |
| 12 | Unmanned aerial systems coordinate target allocation based on wolf behaviors显示文摘Unmanned aerial systems (UASs), especially the cluster of UAS, are highly focused and widely used in various domains. The application of small and inexpensive UAS with a large-scale group to perform complex tasks has become a mainstream trend. Thus, collaborative task assignment of UAS has become a problem that must be solved. | Haibin DUAN Qing YANG Yimin DENG Pei LI Huaxin QIU Tianjie ZHANG Daifeng ZHANG Mengzhen HUO Yankai SHEN | 2019 | Science China(Information Sciences)2019，62，1： | 22 |
| 13 | Size distribution of the secondary organic aerosol particles from the photooxidation of toluene显示文摘In a smog chamber, the photooxidation of toluene was initiated by hydroxyl radical(OH·) under different experimental conditions. The size distribution of secondary organic aerosol(SOA) particles from the above reaction was measured using aerodynamic particle sizer spectrometer. It was found from our experimental results that the number of SOA particles increased with increasing the concentration of toluene. As the reaction time prolonged, the sum of SOA particles was also increased. After a reaction time of 130 min, the concentration of secondary organic aerosol particles would be kept constant at 2300 particles/cm3. Increasing illumination power of blacklamps could significantly induce a higher concentration of secondary organic aerosol particle. The density of SOA particles would also be increased with increasing concentration of CH3ONO, however, it would be decreased as soon as the concentration of CH-3ONO was larger than 225.2 ppm. Nitrogen oxide with initial concentration higher than 30.1 ppm was also found to have little effect on the formation of secondary organic aerosol. | HAO Li-qing WANG Zhen-ya HUANG Ming-qiang PEI Shi-xin YANG Yong ZHANG Wei-jun | 2005 | Journal of Environmental Sciences2005，17，6： | 21 |
| 14 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 15 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 16 | Effects of plant species coexistence on soil enzyme activities and soil microbial community structure under Cd and Pb combined pollution显示文摘The relationship between plant species coexistence and soil microbial communities under heavy metal pollution has attracted much attention in ecology.However,whether plant species coexistence could offset the impacts of heavy metal combined pollution on soil microbial community structure and soil enzymes activities is not well studied.The modified ecological dose model and PCR-RAPD method were used to assess the effects of two plant species coexistence on soil microbial community and enzymes activities subjected to Cd and Pb combined stress.The results indicated that monoculture and mixed culture would increased microbe populations under Cd and Pb combined stress,and the order of sensitivity of microbial community responding to heavy metal stress was:actinomycetes > bacteria > fungi.The respirations were significantly higher in planted soil than that in unplanted soil.The plant species coexistence could enhance soil enzyme activities under Cd and Pb combined.Furthermore,planted soil would be helpful to enhance soil genetic polymorphisms,but Cd and Pb pollution would cause a decrease on soil genetic polymorphisms.Mixed culture would increase the ecological dose 50%(ED50) values,and the ED50 values for soil enzyme activities decreased with increasing culture time.The dehydrogenase was most sensitive to metal addition and easily loses activity under low dose of heavy metal.However,it was difficult to fully inhibit the phoshpatase activity,and urease responded similarly with phosphatase. | Yang Gao Pei Zhou Liang Mao Yueer Zhi Chunhua Zhang Wanjun Shi | 2010 | Journal of Environmental Sciences2010，22，7： | 19 |
| 17 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 18 | Study of the Antifungal Ability of Bacillus subtilis Strain PY-1 in Vitro and Identification of its Antifungal Substance (Iturin A)显示文摘杆菌紧张,作为 PY-1 表示了,从棉花的脉管的捆被孤立。生物化学,生理并且 16S rDNA 顺序分析证明它应该属于杆菌敏锐。PY-1 紧张对许多普通植物显示出强壮的能力在 vitro 的真菌的病原体。这紧张生产的抗菌素处于中立、基本的条件是稳定的,并且对高温度不敏感。从 PY-1 紧张的文化肉汤,五抗真菌的混合物被酸的降水,甲醇抽取,胶化过滤和反向阶段的 HPLC 孤立。先进鉴定被集体 spectrometry 和原子磁性的回声光谱学执行。这五抗真菌的混合物被证明是 iturin A 的异构体:A2, A3, A4, A6 和 A7。在快原子轰炸团 spectrometry/mass spectrometry 导致碰撞的分离系列,从二个优先的线性 acylium 离子的破碎离子被观察,并且优先的离子, Tyr-Asn-Gln-Pro-Asn-Ser-betaAA-Asn-CO+ ,首先被报导。 | Meng GONG Jiang-Dong WANG Jing ZHANG Hao YANG Xiao-Feng LU Yan PEI Jing-Qiu CHENG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，4： | 17 |
| 19 | Effects of laser energy density on forming accuracy and tensile strength of selective laser sintering resin coated sands显示文摘Baozhu sand particles with size between 75 μm and 150 μm were coated by resin with the ratio of 1.5 wt.% of sands. Laser sintering experiments were carried out to investigate the effects of laser energy density(E = P/v), with different laser power(P) and scanning velocity(v), on the dimensional accuracy and tensile strength of sintered parts. The experimental results indicate that with the constant scanning velocity, the tensile strength of sintered samples increases with an increase in laser energy density; while the dimensional accuracy apparently decreases when the laser energy density is larger than 0.032 J·mm-2. When the laser energy density is 0.024 J·mm-2, the tensile strength shows no obvious change; but when the laser energy density is larger than 0.024 J·mm-2, the sample strength is featured by the initial increase and subsequent decrease with simultaneous increase of both laser power and scanning velocity. In this study, the optimal energy density range for laser sintering is 0.024-0.032 J·mm-2. Moreover, samples with the best tensile strength and dimensional accuracy can be obtained when P = 30-40 W and v = 1.5-2.0 m·s-1. Using the optimized laser energy density, laser power and scanning speed, a complex coated sand mould with clear contour and excellent forming accuracy has been successfully fabricated. | Xu Zhifeng Liang Pei Yang Wei Li Sisi Cai Changchun | 2014 | China Foundry2014，11，3： | 17 |
| 20 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
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