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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Improvement of a 3D radar backscattering model using matrix-doubling method显示文摘Radiative transfer models have been widely used to simulate the radar backscattering from forested areas. A three-dimensional radar backscatter model of forest canopy developed in previous studies takes full account of spatial position of trees in a forest stand, and the interactions among crown, trunk and ground surface. The model predicted well for the co-polarized backscatter measurements, but underestimated the backscattering for cross-polarization, primarily because only the first-order scattering within tree crowns was considered in the model. The backscattering at cross-polarization depends strongly on multiple scatter- ing within tree crowns. To produce good estimations for cross-polarized component, the matrix-doubling method is employed here to compute multiple-scattering within the crown. The modified model is compared with the original model, and the field forest measurements and AIRSAR data are used for validation of the modified model. The cross-polarization backscattering is improved in different degrees for different crown structures and at different bands. | NI WenJian1,2, GUO ZhiFeng1 & SUN GuoQing3 1 State Key Laboratory of Remote Sensing Science, jointly sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Geography, University of Maryland, College Park, MD 27042, USA | 2010 | Science China Earth Sciences2010，53，7： | 4 |
| 3 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks显示文摘 | Sung Park Kyo Ni Zheng Cete Adrien P Choi Jae Yong Huang Rudan Uribe-Romo Femando J Chae Hee K O'Keeffe Michael Yaghi Omar M | 2006 | Proceedings of the National Academy of Sciences2006，103，10： | 1 |
| 4 | Pharmacologic differentiation of inflammation and fibrosis in the rat Belomycin model显示文摘 | Chaudhary NI Schnapp A Park JE | 2006 | Am J Respir Crit Care Med2006，173，1： | 1 |
| 5 | Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity显示文摘 | Gokina NI Park KM Mc Elroy-Yaggy K | 2005 | J Appl Physiol(1985)2005，98，5： | 1 |
| 6 | In vitro and in vivo antitumoral phenanthrenes from the aerial of Dendrobium nobile Lindl显示文摘 | Lee YH Park JD Baek NI | 1995 | Planta Med1995，61，2： | 1 |
| 7 | In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobole 显示文摘 | Lee YH Park JD Baek NI | 1995 | Planta Med1995，61，2： | 1 |
| 8 | Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China显示文摘 | Zongtang Sun Taoyang Chen Snorri S. Thorgeirsson Qimin Zhan Jianguo Chen Ju-Hyun Park Peixin Lu Chu Chieh Hsia Nengjin Wang Libin Xu Lingling Lu Fei Huang Yuanrong Zhu Jianhua Lu Zhengping Ni Qinan Zhang Yuying Wu Guoting Liu Zhiyuan Wu Chunfeng Qu Mitche | 2013 | Carcinogenesis2013，，8： | 1 |
| 9 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks显示文摘 | Park K S Ni Z Cote A P Choi J Y Huang Rudan Uribe-Romo F J Chae H K O'Keeffe M Yaghi 0 M | 2006 | Proceedings of the National Academy of Sciences2006，103，10： | 1 |
| 10 | Identification and characterization of Human Endometase(Matrix metalloproteinase26) from Endometrial Tumor显示文摘 | Park HI Ni J Gerkema FE | 2000 | J Biol Chem2000，275，20： | 1 |
| 11 | Pharmacologic differentiation of inflammation and fibrosis in the rat Belomycin model显示文摘 | Chaudhary NI Schnapp A Park JE | 2006 | Am J Respir Crit Care Med2006，173，9： | 1 |
| 12 | Active components from artemisia iwayomogi displaying ONOO-scavenging activity显示文摘 | Ae Ra Kim Ya Ni Zou Tae Hyun Park | 2004 | Phytotherapy Research2004，18，： | 1 |
| 13 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks 显示文摘 | Park K S Ni Z Cote A P | 2006 | Proceedings of the National Academy of Sciences of the United States of Ameri- ca2006，103，10： | 1 |
| 14 | High urea and NaCI carbonylate pmleins in renal cells in culture and in vi- vo and high urea causes 8-oxoguanine lesions in their DNA 显示文摘 | Zhang Z Dmitrieva NI Park JH | 2004 | PNAS2004，101，： | 1 |
| 15 | Pharmacologic differenti- ation of inflammation and fibrosis in the rat Belomycin model 显示文摘 | Chaudhary NI Schnapp A Park JE | 2006 | Am J Respir Crit Care Med2006，173，9： | 1 |
| 16 | Identification and characterization of human endometase (matrix metalloproteinase-26) from endometrial tumor显示文摘 | Park HI Ni J Gerkema FE | 2000 | J Biol Chem2000，275，20： | 1 |
| 17 | Intrinsic regulation of hemangioma involution by platelet-derived growth factor 显示文摘 | Roach EE Chakrabaai R Park NI | 2012 | Cell Death Dis2012，21，3： | 1 |
| 18 | Effects ofrho kinase inhibition on cerebral artery myogenic tone and reactivity 显示文摘 | Gokina NI Park KM McElroy-Yaggy K | 2005 | J Appl Physiol2005，98，5： | 1 |
| 19 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks 显示文摘 | Park K S Ni Zheng Cote A P | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，10： | 1 |
| 20 | Transdifferentiation of ciliated cells during repair of the respiratory epithelium 显示文摘 | Kwon Sik Park James NI Wells Aaron M Zorn | 2006 | Am J Respir Cell Mol Biol2006，34，： | 1 |
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