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| 1 | Bench-to-bedside strategies for osteoporotic fracture: from osteoimmunology to mechanosensation显示文摘Osteoporosis is characterized by a decrease in bone mass and strength, rendering people prone to osteoporotic fractures caused by low-energy forces. The primary treatment strategy for osteoporotic fractures is surgery;however, the compromised and comminuted bones in osteoporotic fracture sites are not conducive to optimum reduction and rigid fixation. In addition, these patients always exhibit accompanying aging-related disorders, including high inflammatory status, decreased mechanical loading and abnormal skeletal metabolism, which are disadvantages for fracture healing around sites that have undergone orthopedic procedures. Since the incidence of osteoporosis is expected to increase worldwide, orthopedic surgeons should pay more attention to comprehensive strategies for improving the poor prognosis of osteoporotic fractures. Herein, we highlight the molecular basis of osteoimmunology and bone mechanosensation in different healing phases of elderly osteoporotic fractures, guiding perioperative management to alleviate the unfavorable effects of insufficient mechanical loading, high inflammatory levels and pathogen infection. The well-informed pharmacologic and surgical intervention, including treatment with anti-inflammatory drugs and sufficient application of antibiotics, as well as bench-to-bedside strategies for bone augmentation and hardware selection, should be made according to a comprehensive understanding of bone biomechanical properties in addition to the remodeling status of osteoporotic bones, which is necessary for creating proper biological and mechanical environments for bone union and remodeling. Multidisciplinary collaboration will facilitate the improvement of overall osteoporotic care and reduction of secondary fracture incidence. | Yong Xie Licheng Zhang Qi Xiong Yanpan Gao Wei Ge Peifu Tang | 2019 | Bone Research2019，7，3： | 10 |
| 2 | A novel method of defective vascular reconstruction using 2-octyl-cyanoacrylate and homemade prosthetic component显示文摘 | Liang Xiangdang Cai Hongfei Sun Geng Liu Zihao Chen Wen Tang Peifu | 2014 | Chinese Medical Journal2014，，5： | 7 |
| 3 | Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis显示文摘Angiogenesis and osteogenesis are coupled.However,the cellular and molecular regulation of these processes remains to be further investigated.Both tissues have recently been recognized as endocrine organs,which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues.This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature.In addition,research progress related to the bone vasculature,vessel-related skeletal diseases,pathological conditions,and angiogenesis-targeted therapeutic strategies are also summarized.With respect to future perspectives,new techniques such as single-cell sequencing,which can be used to show the cellular diversity and plasticity of both tissues,are facilitating progress in this field.Moreover,extracellular vesicle-mediated nuclear acid communication deserves further investigation.In conclusion,a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets. | Ming Chen Yi Li Xiang Huang Ya Gu Shang Li Pengbin Yin Licheng Zhang Peifu Tang | 2021 | Bone Research2021，9，3： | 6 |
| 4 | The modern change and evolution tendency of sand coast in the eastern area of Liaodong Gulf显示文摘The modern change and evolution tendency of sand coast in the eastern area of Liaodong GulfMiaoFengmin;BiZhaoqi;LiShuyuan;Xia... | Miao Fengmin Bi Zhaoqi Li Shuyuan Xiao Yuzhong Cong Peifu Zhuang Zhenye and Xu Weidong | 1995 | Acta Oceanologica Sinica1995，14，4： | 5 |
| 5 | 3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering显示文摘Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged menisci.However,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some extent.Some researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been constrained.In this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account together.Subsequently,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and components.Furthermore,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering. | Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun Hao Libo Tang Peifu Yao Qi Guo Quanyi | 2021 | Bioactive Materials2021，6，6： | 3 |
| 6 | Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection显示文摘The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons.It should consider that not only to inhibit tumor growth and recurrence,but also to repair the defect and preserve the limb function.Hence,it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor.Magnetic nanoparticles(MNPs)have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation.Based on the previous stage,we successfully prepared hydroxyapatite(HAP)composite poly(lactic-co-glycolic acid)(PLGA)scaffolds and verified its good osteogenic properties,in this study,we produced an HAP composite PLGA scaffolds modified with MNPs.The composite scaffold showed appropriate porosity and mechanical characteristics,while MNPs possessed excellent magnetic and thermal properties.The cytological assay indicated that the MNPs have antitumor ability and the composite scaffold possessed good biocompatibility.In vivo bone defect repair experiment revealed that the composite scaffold had good osteogenic capacity.Hence,we could demonstrate that the composite scaffolds have a good effect in bone repair,which could provide a potential approach for repairing bone defect after bone tumor excision. | Ming Li Jianheng Liu Xiang Cui Guofei Sun Jianwei Hu Sijia Xu Fei Yang Licheng Zhang XiumeiWang Peifu Tang | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 7 | Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress显示文摘Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations(50–200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress. | Jianbo Zhao Shiqiang Fang Yajiang Yuan Zhanpeng Guo Jinhao Zeng Yue Guo Peifu Tang Xifan Mei | 2014 | Neural Regeneration Research2014，9，14： | 2 |
| 8 | Systematic reviews on reports of hip fractures in Web of Science:a bibliometric analysis of publication activity显示文摘 | Mao Zhi Wang Guoqi Mei Xifan Chen Shuo Liu Xiaoxie Zeng Xiantao Long Anhua Zhang Licheng Zhang Lihai Tang Peifu | 2014 | Chinese Medical Journal2014，，13： | 2 |
| 9 | Proximal femoral nail antirotation versus hemiarthroplasty: A study for the treatment of intertrochanteric fractures显示文摘 | Peifu Tang Fangke Hu Jing Shen Licheng Zhang Lihai Zhang | 2011 | Injury2011，，6： | 2 |
| 10 | Advanced surface engineering of titanium materials for biomedical applications:From static modification to dynamic responsive regulation显示文摘Titanium(Ti)and its alloys have been widely used as orthopedic implants,because of their favorable mechanical properties,corrosion resistance and biocompatibility.Despite their significant success in various clinical applications,the probability of failure,degradation and revision is undesirably high,especially for the patients with low bone density,insufficient quantity of bone or osteoporosis,which renders the studies on surface modification of Ti still active to further improve clinical results.It is discerned that surface physicochemical properties directly influence and even control the dynamic interaction that subsequently determines the success or rejection of orthopedic implants.Therefore,it is crucial to endow bulk materials with specific surface properties of high bioactivity that can be performed by surface modification to realize the osseointegration.This article first reviews surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical,physical and chemical treatments based on the formation mechanism of the modified coatings.Such conventional methods are able to improve bioactivity of Ti implants,but the surfaces with static state cannot respond to the dynamic biological cascades from the living cells and tissues.Hence,beyond traditional static design,dynamic responsive avenues are then emerging.The dynamic stimuli sources for surface functionalization can originate from environmental triggers or physiological triggers.In short,this review surveys recent developments in the surface engineering of Ti materials,with a specific emphasis on advances in static to dynamic functionality,which provides perspectives for improving bioactivity and biocompatibility of Ti implants. | Pinliang Jiang Yanmei Zhang Ren Hu Bin Shi Lihai Zhang Qiaoling Huang Yun Yang Peifu Tang Changjian Lin | 2023 | Bioactive Materials2023，，9： | 2 |
| 11 | Design of non-polarizing color splitteing filters used for projection display system显示文摘 | Weibin Chen Peifu Gu | 2005 | Display2005，26，： | 1 |
| 12 | rhBMP-2 not alendronate com-bined with HA-TCP biomaterial and distraction osteogenesis enhancebone formation显示文摘 | LiMing Li Gang Tang Peifu | 2011 | Arch Orthop Trauma Surg2011，131，6： | 1 |
| 13 | Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury显示文摘 | Wei Zhang Yuan Gao Yan Zhou Jianheng Liu Licheng Zhang Anhua Long Lihai Zhang Peifu Tang Ali I. Abdalla | 2015 | BioMed Research International2015，，： | 1 |
| 14 | Solution to the bulging problem in the open-die extrusion of a spline shaft and relevant photoplastic theoretical study显示文摘 | Zhaohui Huang Peifu Fu | | 0，，： | 1 |
| 15 | Properties of dielectric coatings produced by ion assisted deposition显示文摘 | Gu Peifu Chen Yenming Hu Xuequn | 1989 | Applied Optics1989，28，15： | 1 |
| 16 | LCD Projection Display System with High Brightness显示文摘A new compact XGA projection is designed with three 0.99' liquid crystal panels. By using 275W UHP lamp, above 3000 ANSI lumens could be achieved with the uniformity of 85%. The color temperature is 6742K. | Zhou Ping, Lu Wei, Zheng Zhenrong, Li Haifeng, Gu Peifu, Liu Xu State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, China | 2003 | 光学学报2003，23，S1： | 1 |
| 17 | Low Power Processor Design for Wireless Sensor Network Applications显示文摘 | Xu Yongjun Liu Lingyi Shen Peifu | 2005 | IEEE Journal of Solid-state Circuits2005，8，5： | 1 |
| 18 | Composite Metallogenic Systems in the Weihai Area of Shandong and Evolution of Continental Dynamic Regimes显示文摘摘要:把地区性的地质的调查基于9张l:50,000规模并且由 metallogenic 系统的理论和综合分析指导了结构并且 metallogenic 特征,这份报纸在此提出 Weihai 区域的合成 metallogenic 系统,山东省,瞄准在区域在起源和众多的存款的控制矿石的结构上解决这些问题。它的科学意义在下列三个方面被反映:(1 ) 合成 metallogenic 系统的基本特征能被认出,它由二种类型组成:原生地变形热水的 metallogenic 系统和中生代 magmatic 热水的 metallogenic 系统(即 Indosinian 早 Yanshanian 接触交代矿床 metallogenic 系列和中间迟了的 Yanshanian magmatic 热水的 metallogenic 系列) 。二个系列分别地显示弓形、 NW 正确的侧面的安排和 N-S 平行带的分布,与相应矿物质集合是 Au+Ag+Pb+Zn,等等;并且 Cu+Mo+Fe, Au+Ag+Cu+Pb-Zn+Mo+Co-Ni+suIfides+silicides+K-feldspar,等等(2 ) 合成 metallogenic 系统可以被用来解释沉积物的复杂基因关系。通过在三主要 metallogenic 之间的关系的分析,间隔和他们的相应来源摇系列(Jingshan 和 Rongcheng 组;超级单位的 Wendong 和早中间的 Yanshanian Weideshan 超级单位;并且中间迟了的 Yanshanian Weideshan 和 Laoshan 超级单位) 象 Fanjiabu 金沉积物的案例研究一样,我们区分了在接触交代矿床(skarn类型)之间的同宗象 noncognate 重叠在之间一样的 metallogenic 系列和magmatic热水的 metallogenic 系列二并且变形热水的 metallogenic 系统。(3 ) 合成 metallogenic 系统是容易与大陆人的进化有关动态政体。变形热水的 metallogenic 系统的形成从扩展经历了 tectono 动态的政体的三种不同类型的转变 ? 压缩 ? 砍接触交代矿床(skarn 类型) 的从压缩的 metallogenic 系统 ? 扩展 ? 压缩;并且从扩展的 magmatic 热水的 metallogenic 系统的 ? 和平的板的 subductive 压缩。三种类型的进化都被归因于洞关上或 paleocontinent 的分叉集中,和所有他们的矿化作用从集中的结束对应于转变的间隔到 Weihai paleocontinent 的早集成。都,这些将有益于我们大陆人 metallogenic 过程的动力学的更深的学习。 | SUN Zhongshi WANG Peifu DENG Jun WANG Qingfei WANG Jianping MU Taisheng SUN Li FAN Siqi YE Songqing LIU Zhenghong CUI Shuxue | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 1 |
| 19 | Freeform LED lens for uniform illumination 显示文摘 | Ding Yi Zheng Zhenrong Gu Peifu | 2008 | Opt Express2008，16，12： | 1 |
| 20 | Solution to the Bulging Problem in the Opendie Cold Extrusion of a Spline Shaft and Relevant Photoplastic Theoretical Study显示文摘 | Huang Zhaohui Fu Peifu | 2001 | Journal of Materials Processing Technology2001，114，： | 1 |
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