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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Structural organization of an intact phycobilisome and its association with photosystem II显示文摘Phycobilisomes (PBS ) 是在 cyanobacteria 和红水藻把精力转移到光合的反应中心的轻收获的天线。PBS 是建筑群 phycobiliproteins (PBP ) 填写了的 supermolecular 为精力吸收和连接器蛋白质的熊色基。尽管一些单个部件的结构用晶体学被决定了,全部 PBS 建筑群的三维的结构,为理解精力转移机制批评,仍然保持未知。这里,我们从淡水藻类的一种 sp 与 photosystem II (PSII ) 在建筑群报导未经触动的 PBS 和 PBS 的结构。与生物化学、分子的分析在联合用单个粒子的电子显微镜学拉紧 PCC 7120。在 PBS 结构,所有 PBP trimers 和保存连接器蛋白质领域明白地被定位,并且所有色基的全球分发是坚定的。我们提供 ApcE 和 ApcF 为在 PBS 的底部的伸出的形成是批评的证据,它在调停起一个重要作用和 PSII 的 PBS 相互作用。我们的结果在不同汇编层次提供卓见进未经触动的 PBS 的分子的体系结构并且为理解 PBS 吸收的光能怎么被转移到 PSII 提供基础。 | Leifu Chang Xianwei Liu Yanbing Li Cui-Cui Liu Fan Yang Jindong Zhao Sen-Fang Sui | 2015 | Cell Research2015，25，6： | 12 |
| 4 | Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 MAPK pathway显示文摘Isatis indigotica Fort.(Ban-Lan-Gen)is an herbal medicine prescribed for influenza treatment.However,its active components and mode of action remain mostly unknown.In the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in vivo.Our results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription activity.Erucic acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 MAPK signaling.Furthermore,the NF-kB and p38 MAPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized cells.Additionally,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic acid.In vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens expression.Meanwhile,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-MA(H1N1)strain infection.Our findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza. | Xiaoli Liang Yuan Huang Xiping Pan Yanbing Hao Xiaowei Chen Haiming Jiang Jing Li Beixian Zhou Zifeng Yang | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 10 |
| 5 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 6 | Nanostructured perovskite oxides as promising substitutes of noble metals catalysts for catalytic combustion of methane显示文摘Heterogeneous catalytic combustion provides a feasible technique for high efficient methane utilization.Perovskites ABO_3-type materials have received renewed attention as a potential alternative for noble metals supported catalysts in catalytic methane combustion due to excellent hydrothermal stability and sulfur resistance. Recently, the emergence of nanostructured perovskite oxides(such as threedimensional ordered nanostructure, nano-array structure) with outstanding catalytic activity has further driven methane catalytic combustion research into spotlight. In this review, we summarize the recent development of nanostructured perovskite oxide catalysts for methane combustion, and shed some light on the rational design of high efficient nanostructured perovskite catalysts via lattice oxygen activation,lattice oxygen mobility and materials morphology engineering. The emergent issues needed to be addressed on perovskite catalysts were also proposed. | Ji Yang Yanbing Guo | 2018 | Chinese Chemical Letters2018，29，2： | 8 |
| 7 | Recent progress in flexible and wearable bio-electronics based on nanomaterials显示文摘能监视并且确定的灵活、可拉长的生物传感器特定的微型环境产生的电或化学的信号吸引了很多注意。能亲密地被纳入皮或组织的便携生物传感器为医药诊断和治疗提供一个新机会。在最近的年里,为灵活、可拉长的系统在设备集成和材料和生产过程的设计有庞大的进步。这里,我们在在灵活、可拉长的生物传感器采用的 nanomaterials 描述最近的开发。我们考察为象免除有机体的气体那样的重要生理、生物的标记的察觉使用的如此的生物传感器的成功的例子。而且,我们关于包括多功能的 nanomaterials 的综合平台提供最近的成就的详细概述。与在生物电子的多功能的 nanomaterials 的有效集成有关的问题和挑战也被讨论。 | Yanbing Yang Xiangdong Yang Yaning Tan Quan Yuan | 2017 | Nano Research2017，10，5： | 8 |
| 8 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 9 | An option for green and sustainable future: Electrochemical conversion of ammonia into nitrogen显示文摘Green and sustainable options are needed to ease the current energy and environmental crisis, and alleviate the greenhouse effect and energy shortage. As an alternative carbon–neutral synthetic fuel, ammonia shows great potential due to its high energy density, non-toxic by-products, and mature related infrastructures. However, related practical applications have been severely hampered on ammoniaoxidation due to the high cost of catalysts and immature energy utilization systems. Here, we comprehensively summarized the efforts which have been made in recent years with the aim of providing a deep sight into the development and deficiencies in this territory and trying to establish a simple framework of basic knowledge for researchers. The exploration of mechanism is discussed first and then the relevant catalysts studied in recent years are summarized. Besides, the progress of direct ammonia fuel cells(DAFCs) is also presented and the challenges as well as perspectives on future developments of electrocatalysts for ammonia electro-oxidation and its practical application are provided at the end. | Bo Zhou Nana Zhang Yujie Wu Weijun Yang Yanbing Lu Yanyong Wang Shuangyin Wang | 2021 | Journal of Energy Chemistry2021，30，9： | 5 |
| 10 | Construction of MoS2 field effect transistor sensor array for the detection of bladder cancer biomarkers显示文摘Bladder cancer is one of the commonest malignant tumors of urinary system with high recurrence. However, currently developed bladder cancer urine diagnosis methods are hindered by the low detection sensitivity and accuracy. Herein, a molybdenum disulfide(MoS2) nanosheets-based field effect transistor(FET) sensor array was constructed for simultaneous detection of multiple bladder cancer biomarkers in human urine. With the excellent electronic property of MoS2 and the high specific identification capability of recognition molecules, the proposed biosensor array could simultaneously detect nuclear matrix protein 22(NMP22) and cytokeratin 8(CK8) with a wide linear range of 10-6–10-1 pg mL-1 and an ultra-low detection limit of 0.027 and 0.019 aM, respectively. Furthermore, this highly sensitive and specific MoS2 FET sensor array could be used to identify bladder cancer biomarkers from human urine samples. This designed high-performance biosensor array shows great potential in the future diagnosis of bladder cancer. | Yujie Yang Bo Zeng Yingxue Li Huageng Liang Yanbing Yang Quan Yuan | 2020 | Science China Chemistry2020，63，7： | 5 |
| 11 | Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy显示文摘Activating transcription factors, ATFs, are a group of bZIP transcription factors that act as homodimers or heterodimers with a range of other bZIP factors. In general, ATFs respond to extracellular signals, indicating their important roles in maintaining homeostasis. The ATF family includes ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs, the functions of ATFs are also diverse. ATFs play an important role in cell proliferation, apoptosis, differentiation and inflammation-related pathological processes. The expression and phosphorylation status of ATFs are also related to neurodegenerative diseases and polycystic kidney disease. Various miRNAs target ATFs to regulate cancer proliferation, apoptosis, autophagy, sensitivity and resistance to radiotherapy and chemotherapy. Moreover, ATFs are necessary to maintain cell redox homeostasis. Therefore, deepening our understanding of the regulation and function of ATFs will provide insights into the basic regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into genomic responses through transcription factors. Under pathological conditions, especially in cancer biology and response to treatment, the characterization of ATF dysfunction is important for understanding how to therapeutically utilize ATF2 or other pathways controlled by transcription factors. In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. | Meilin Chen Yijun Liu Yuqin Yang Yanbing Qiu Zhicheng Wang Xiaoxu Li Wenling Zhang | 2022 | Genes & Diseases2022，9，4： | 3 |
| 12 | Recent progress in synthesis of lanthanide-based persistent luminescence nanoparticles显示文摘Persistent luminescence nanoparticles(PLNPs)are a kind of phosphors that can remain luminescent for seconds to several days after the stoppage of excitation.Lanthanides show the special capability to largely broaden the emission range and enhance the luminescence intensity of PLNPs due to their dense energy structure and unique electronic configurations.In the past decades,various methods have been developed for the synthesis of lanthanide-based PLNPs with excellent pe rsistent luminescence propertie s,and the lanthanide-based PLNPs are widely studied in areas including biome dicine,energy,and information storage.In this review,we summarized the research progress in the synthe sis of lanthanidebased PLNPs and outline d several typical synthesis methods.We discussed the fundamental concepts of preparation methods as well as the advantages and drawbacks of the typical synthetic approache s.Moreove r,the current challenges and the potential solutions for the development of lanthanide-based PLNP s are also discussed in an attempt to provide strate gies to further improve the optical properties of lanthanide-based PLNPs.We hope this review can contribute to the design of lanthanide-based PLNPs with desired properties and further promote their applications in biomedicine,energy,and information science. | Yurong Wei Chengxu Gong Min Zhao Lei Zhang Shaodan Yang Peixu Li Zhao Ding Quan Yuan Yanbing Yang | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 13 | Effect of tumor necrosis factor inhibitors on rheumatoid arthritis-induced peripheral neuropathy A cohort study显示文摘In this historical cohort study,236 patients with primary rheumatoid arthritis were treated with the tumor necrosis factor inhibitors,etanercept or infliximab(n = 80),or by conventional methods(n = 156).Results revealed that 11 patients developed varying types of peripheral neuropathy at 1-2 years post-treatment(mean 16 months).The incidence of peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 8.8%(7/80),which was significantly higher than the conventional treatment group(2.6%;4/156).The relative risk of developing peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 3.41(95% confidence interval:1.03-11.31).Comparison of the tumor necrosis factor inhibitors revealed that etanercept and infliximab had no significant difference in terms of inducing peripheral neuropathy.Experimental findings indicate that tumor necrosis factor inhibitors may increase the risk of peripheral neuropathy. | Naizhi Wang Yingying Guo Lili Yang Wenyi Fu Yanbing Xu Linxin Hou Shuai Zhao Ning Zhang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 14 | Direct fabrication of carbon nanotube-graphene hybrid films by a blown bubble method显示文摘有 graphene 的碳 nanotubes (CNT ) 的杂交提供集成两材料的属性的一个有希望的工具,从而创新的普遍申请。这里,我们在场直接由一个吹的水泡方法装配混合 CNT-graphene 电影的一个方法与选择底层退火结合了。我们把 polymethylmethacrylate (PMMA ) 用作聚合矩阵吹包含自我装配的多围的 CNT 数组的水泡,然后由在 Cu 底层上的热退火把水泡电影转变成一部 CNT-graphene 混合电影;PMMA 为在 CNT 网络之中对很少层 graphene 变得单个直到担任碳来源一连续地, hybridized 结构被形成。比作赤裸(non-hybridized ) CNT 联网,混合电影展览改进了电的电导率和结构的完整。我们的方法也启用一节多围的 CNT-Si 太阳能电池的制造,它有高力量变换效率,通过混合 CNT-graphene 结构的集会。 | Shiting Wu Enzheng Shi Yanbing Yang Wenjing Xu Xinyang Li Anyuan Cao | 2015 | Nano Research2015，8，5： | 2 |
| 15 | Disruption of the white matter structural network and its correlation with baseline progression rate in patients with sporadic amyotrophic lateral sclerosis显示文摘Objective:There is increasing evidence that amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease impacting large-scale brain networks.However,it is still unclear which structural networks are associated with the disease and whether the network connectomics are associated with disease progression.This study was aimed to characterize the network abnormalities in ALS and to identify the network-based biomarkers that predict the ALS baseline progression rate.Methods:Magnetic resonance imaging was performed on 73 patients with sporadic ALS and 100 healthy participants to acquire difusion-weighted magnetic resonance images and construct white matter(WM)networks using tractography methods.The global and regional network properties were compared between ALS and healthy subjects.The single-subject WM network matrices of patients were used to predict the ALS baseline progression rate using machine learning algorithms.Results:Compared with the healthy participants,the patients with ALS showed signifcantly decreased clustering coefcient C_(p)(P=0.0034,t=2.98),normalized clustering coefcientγ(P=0.039,t=2.08),and small‐worldnessσ(P=0.038,t=2.10)at the global network level.The patients also showed decreased regional centralities in motor and non-motor systems including the frontal,temporal and subcortical regions.Using the single-subject structural connection matrix,our classifcation model could distinguish patients with fast versus slow progression rate with an average accuracy of 85%.Conclusion:Disruption of the WM structural networks in ALS is indicated by weaker small-worldness and disturbances in regions outside of the motor systems,extending the classical pathophysiological understanding of ALS as a motor disorder.The individual WM structural network matrices of ALS patients are potential neuroimaging biomarkers for the baseline disease progression in clinical practice. | Wenbin Li Qianqian Wei Yanbing Hou Du Lei Yuan Ai Kun Qin Jing Yang Graham J.Kemp Huifang Shang Qiyong Gong | 2021 | Translational Neurodegeneration2021，10，3： | 2 |
| 16 | Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer显示文摘Bladder cancer is the most common malignant tumor in the urinary system,with high morbidity,mortality and recurrence after surgery.However,current bladder cancer urine diagnosis methods are limited by the low accuracy and specificity due to the low abundance of bladder cancer biomarkers in the urine with complex biological environments.Herein,we present a high stability indium gallium zinc oxide field effect transistor(IGZO-FET)biosensor for efficient identification of bladder cancer biomarkers from human urine samples.The recognition molecular functionalized IGZO-FET biosensor exhibits stable electronic and sensing performance due to the large-area fabrication of IGZO thin-film FET.Owing to the excellent electrical performance of IGZO-FET,the IGZO-FET biosensor exhibits high sensitivity and extremely low detection limit(2.7 amol/L)towards bladder cancer biomarkers.The IGZO-FET biosensor is also able to directly detect bladder tumor biomarker in human urine with high sensitivity and specificity,and could differentiate bladder cancer patients’urine samples from healthy donors effectively.These results indicate that our designed high-performance biosensor shows great potential in the application of portable digital bladder cancer diagnosis devices. | Yingxue Li Bo Zeng Yujie Yang Huageng Liang Yanbing Yang Quan Yuan | 2020 | Chinese Chemical Letters2020，31，6： | 2 |
| 17 | Electroluminescence in organic single-layer light-emitting diodes at high fields显示文摘 | Shengyi Yang Zheng Xu Zhenjia Wang Yanbing Hou Xurong Xu Xiqing Zhang | 2001 | Science in China Series : Information Sciences2001，，3： | 1 |
| 18 | Identification of a new heavy neutron-rich isotope238Th显示文摘 | Xiong Bing Yang Weifan Yuan Shuanggui Ma Taotao He Jianjun Xu Yanbing Li Zongwei | 1999 | Journal of Radioanalytical and Nuclear Chemistry1999，，1： | 1 |
| 19 | Influence of the electric field on carriers recombination zone in bilayer organic electroluminescent device显示文摘The electroluminescence (EL) of bilayer devices (ITO/Polymer/Alqa/AI) made from two PPV derivatives (MN-PPV and MEH-PPV), respectively, and the influence of the organic layers’ thickness on the characteristics of the device are investigated. Different spectra and variations are observed for different thicknesses of Alq3 layer in this bilayer organic light-emitting diodes (LEDs) as increasing applied bias. Based on the energy level and field-assisted tunneling at the interface, we attributed these phenomena to electric field redistribution in the device and field-assisted charges being transported and tunneling through energy barrier at high electric field. | Shengyi Yang Zhenjia Wang Zheng Xu Xiaohong Chen Yanbing Hou Xurong Xu | 2000 | Chinese Science Bulletin2000，45，17： | 1 |
| 20 | The preparation of reagentless electrochemical immunosensor based on a nano-gold and chitosan hybrid film for human chorionic gonadotrophin显示文摘 | Guangming Yang Yanbing Chang Hua Yang | 2009 | Analytica Chimica Acta2009，644，12： | 1 |
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