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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | SwordDTA: A Dynamic Taint Analysis Tool for Software Vulnerability Detection显示文摘Software vulnerabilities are the root cause of various information security incidents while dynamic taint analysis is an emerging program analysis technique. In this paper, to maximize the use of the technique to detect software vulnerabilities, we present Sword DTA, a tool that can perform dynamic taint analysis for binaries. This tool is flexible and extensible that it can work with commodity software and hardware. It can be used to detect software vulnerabilities with vulnerability modeling and taint check. We evaluate it with a number of commonly used real-world applications. The experimental results show that Sword DTA is capable of detecting at least four kinds of software vulnerabilities including buffer overflow, integer overflow, division by zero and use-after-free, and is applicable for a wide range of software. | CAI Jun ZOU Peng MA Jinxin HE Jun | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 3 |
| 3 | Self-powered electronic paper with energy supplies and information inputs solely from mechanical motions显示文摘The electronic paper(E-paper)displays features such as flexibility,sunlight visibility,and low power consumption,which makes it ideal for Internet of Things(IoT)applications where the goal is to eliminate bulky power modules.Here,we report a unique self-powered E-paper(SPEP),where information inputs and energy supplies are all converted from mechanical motion by a triboelectric nanogenerator(TENG).The operation of an electrophoretic E-paper is first investigated,identifying the current density as a determinative parameter for driving pigment particle motion and color change.Electrical and optical responses of the E-paper driven by a slidingmode TENG are then found to be consistent with that under a current source mode.All-in-one monochromic and chromatic SPEPs integrated with a flexible transparent TENG are finally demonstrated,and a pixelated SPEP is discussed for future research.The sliding-driven mechanism of SPEP allows for a potential handwriting function,is free of an extra power supply,and promises undoubtedly a wide range of future applications. | YIFAN GU TINGTING HOU PENG CHEN JINXIN CAO CHONGXIANG PAN WEIGUO HU BO-RU YANG XIONG PU AND ZHONG LIN WANG | 2020 | Photonics Research2020，8，9： | 2 |
| 4 | Anisotropic in-plane thermal conductivity for multi-layer WTe_(2)显示文摘Improving thermal transport between substrate and transistors has become a vital solution to the thermal challenge in nanoelectronics.Recently 2D WTe_(2) has sparked extensive interest because of heavy atomic mass and low Debye temperature.Here,the thermal transport of supported WTe_(2) was studied via Raman thermometry with electrical heating.The supported 30 nm WTe2 encased with 70 nm Al_(2)O_(3) delivered 4.8 W·m^(-1)·K^(-1)in-plane thermal conductivity along zigzag direction at room temperature,which was almost 1.6 times larger than that along armchair direction(3.0 W·m^(-1)·K^(-1)).Interestingly,the superior and inferior directions for thermal transport are just opposite of those for electrical transport.Hence,a heat manipulation model in WTe_(2) FET device was proposed.Within the designed configuration,waste heat in WTe_(2) would be mostly dissipated to metal contacts located along zigzag,relieving the local temperature discrepancy in the channel effectively and preventing degradation or breakdown.Our study provides new insight into thermal transport of anisotropic 2D materials,which might inspire energy-efficient nanodevices in the future. | Yuehua Wei Chuyun Deng Xiaoming Zheng Yangbo Chen Xiangzhe Zhang Wei Luo Yi Zhang Gang Peng Jinxin Liu Han Huang Weiwei Cai Qi Ge Renyan Zhang Xueao Zhang Shiqiao Qin | 2022 | Nano Research2022，15，1： | 1 |
| 5 | Highly in-plane anisotropy of thermal transport in suspended ternary chalcogenide Ta_(2)NiS_(5)显示文摘Energy dissipation has always been an attention-getting issue in modern electronics and the emerging low-symmetry two-dimensional(2D)materials are considered to have broad prospects in solving the energy dissipation problem.Herein the thermal transport of a typical 2D ternary chalcogenide Ta_(2)NiS_(5) is investigated.For the first time we have observed strongly anisotropic in-plane thermal conductivity towards armchair and zigzag axes of suspended few-layer Ta_(2)NiS_(5) flakes through Raman thermometry.For 7-nm-thick Ta_(2)NiS_(5) flakes,theκz i g z a g is 4.76 W·m^(−1)·K^(−1) andκa r m c h a i r is 7.79 W·m^(−1)·K^(−1),with a large anisotropic ratio(κa r m c h a i r/κz i g z a g)of 1.64 mainly ascribed to different phonon mean-free-paths along armchair and zigzag axes.Moreover,the thickness dependence of thermal anisotropy is also discussed.As the flake thickness increases,theκa r m c h a i r/κz i g z a g reduces sharply from 1.64 to 1.07.This could be attributed to the diversity in phonon boundary scattering,which decreases faster in zigzag direction than in armchair direction.Such anisotropic property enables heat flow manipulation in Ta_(2)NiS_(5) based devices to improve thermal management and device performance.Our work helps reveal the anisotropy physics of ternary transition metal chalcogenides,along with significant guidance to develop energy-efficient next generation nanodevices. | Yue Su Chuyun Deng Jinxin Liu Xiaoming Zheng Yuehua Wei Yangbo Chen Wei Yu Xiao Guo Weiwei Cai Gang Peng Han Huang Xueao Zhang | 2022 | Nano Research2022，15，7： | 1 |
| 6 | Highly anisotropic thermal conductivity of few-layer CrOCl for efficient heat dissipation in graphene device显示文摘With the packing density growing continuously in integrated electronic devices,sufficient heat dissipation becomes a serious challenge.Recently,dielectric materials with high thermal conductivity have brought insight into effective dissipation of waste heat in electronic devices to prevent them from overheating and guarantee the performance stability.Layered CrOCl,an antiferromagnetic insulator with low-symmetry crystal structure and atomic level flatness,might be a promising solution to the thermal challenge.Herein,we have systematically studied the thermal transport of suspended few-layer CrOCl flakes by microRaman thermometry.The CrOCl flakes exhibit high thermal conductivities along zigzag direction,from~392±33 to~1,017±46 W·m^(−1)·K^(−1) with flake thickness from 2 to 50 nm.Besides,pronounced thickness-dependent thermal conductivity ratio(/from~2.8±0.24 to~4.3±0.25)has been observed in the CrOCl flakes,attributed to the discrepancy of phonon dispersion and phonon surface scattering.As a demonstration to the heat sink application of layered CrOCl,we then investigate the energy dissipation in graphene devices on CrOCl,SiO_(2) and hexagonal boron nitride(h-BN)substrates,respectively.The graphene device temperature rise on CrOCl is only 15.4%of that on SiO_(2) and 30%on h-BN upon the same electric power density,indicating the efficient heat dissipation of graphene device on CrOCl.Our study provides new insights into two-dimentional(2D)dielectric material with high thermal conductivity and strong anisotropy for the application of thermal management in electronic devices. | Xiaoming Zheng Yuehua Wei Zhenhua Wei Wei Luo Xiao Guo Xiangzhe Zhang Jinxin Liu Yangbo Chen Gang Peng Weiwei Cai Shiqiao Qin Han Huang Chuyun Deng Xueao Zhang | 2022 | Nano Research2022，15，10： | 1 |
| 7 | Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells显示文摘癌症干细胞,像茎的癌症房间(SLCC ) ,或开始肿瘤的房间的存在被看作肿瘤形成和复发的原因,显示学习指向 SLCC 的新奇治疗的重要性。因为二竞争假设, SLCC 的起源是争论的:SLCC 也从转变祖先房间从织物成年人干细胞或 dedifferentiated 被转变。我们的以前的研究证明 SLCC 由在癌症房间增加 genomic 不稳定性是可诱导的。在这研究,堵住 SLCC 的出现, aminoethyl isothiourea ( AET ),清除自由激进分子的混合物并且被用来保护病人免受放射性的暴露的伤害,被用作与 mitomycin C ( MMC )在联合维持 genomic 稳定性的一个代理人,损坏 DNA 的通常使用的化学疗法的药。用有 VX2 肝的癌的一个兔子肿瘤模型,我们发现 MMC 独自增加了肺转移和处于不利地位的幸存结果,但是 MMC 和 AET 的联合颠倒了这效果平延长全面幸存。而且在由 immunocompromised 老鼠的一个 VX2 异种皮移植模型, MMC 独自与 AET 在联合充实 MMC 的开始肿瘤的房间,而是管理有效地消除了肿瘤房间。而且, MMC 独自提高了 genomic 不稳定性,但是与 AET 相结合的 MMC 在主要 VX2 肿瘤织物稀释了 genomic 不稳定性的程度。一起拿,我们的数据建议 genomic 保护者 AET 能由 AET 禁止 SLCC,和这联合治疗的正式就职,细胞毒素的代理人应该为未来被看作有希望的策略临床的评估。 | Yi Liang | 2015 | Frontiers of Medicine2015，9，1： | 1 |
| 8 | Identifi cation of Three FBN1 Mutations in Chinese Patients with Typical or Incomplete Marfan Syndrome by Whole-Exome Sequencing显示文摘Objective:The purpose of this work was to obtain the phenotypes and detect potential mutations in three Chinese patients with Marfan syndrome(MFS)or incomplete MFS phenotypes.Methods:Three unrelated patients with a defi nite or suspected clinical diagnosis of MFS and their family members were recruited for research.Genomic DNA was extracted from peripheral blood of these patients and their family members.All the exons were sequenced by next-generation sequencing and the variants were further validated by Sanger sequencing.The functional consequences of the mutations were analyzed with various genomic resources and bioinformatics tools.Results:Three FBN1 mutations were identifi ed in the three patients,including one novel mutation(2125G>A)and two previously reported mutations(4786C>T and 6325C>T).It was interesting to note that the parents of these patients were normal as assessed by clinical features or genetic testing,but all these mutations were detected in their offspring,except for the variant 6325C>T.We also found that a few young members of the family of probands(proband 1 and proband 2)have exhibited no manifestations of MFS so far,although they carry the same disease-causing mutation.Conclusions:We found three FBN1 mutations in three unrelated Chinese families with MFS by genome sequencing,and the relationship between genotypes and phenotypes in MFS patients needs further exploration. | Guangming Fang Jinxin Miao Ying Peng Yafei Zhai Chuchu Wang Xiaoyan Zhao Yaohe Wang Jianzeng Dong | 2020 | Cardiovascular Innovations and Applications2020，，3： | 0 |
| 9 | Identifi cation of Novel TTN Mutations in Three Chinese Familial Dilated Cardiomyopathy Pedigrees by Whole Exome Sequencing显示文摘Familial dilated cardiomyopathy(DCM)is associated with numerous genes,especially those of the sarcomere family.The titin gene(TTN)consists of 365 exons and encodes the largest sarcomere protein(titin)in our bodies.Titin is associated with many diseases,such as hypertrophic cardiomyopathy and DCM.Here we screened three Chinese families affected by DCM,and found that each harbors a stop-gain or splice site mutation in TTN(c.G20137T,c.G52522T,c.44610-2A>C).Assessment of the probands by electrocardiogram,B-mode echocardiography,and cardiac magnetic resonance imaging revealed impaired cardiac function,arrhythmia,or abnormal cardiac structure.In conclusion,using whole exome sequencing,we found three unreported TTN mutations associated with DCM.This has expanded the TTN mutation spectrum of Chinese DCM patients,especially in Henan,the most populous province.These data provide new genetic targets for the diagnosis and treatment of DCM,and will increase our understanding of the relationship between TTN mutation and DCM clinical symptoms. | Ying Peng Jinxin Miao Yafei Zhai Guangming Fang Chuchu Wang Yaohe Wang Xiaoyan Zhao Jianzeng Dong | 2020 | Cardiovascular Innovations and Applications2020，，2： | 0 |
| 10 | Discovery of Digenic Mutation, KCNH2 c.1898A > C and JUP c.916dupA, in a Chinese Family with Long QT Syndrome via Whole-Exome Sequencing显示文摘Long QT syndrome(LQTS),which is caused by an ion channel–related gene mutation,is a malignant heart disease with a clinical course of a high incidence of ventricular fi brillation and sudden cardiac death in the young.Mutations in KCNH2(which encodes potassium voltage-gated channel subfamily H member 2)are responsible for LQTS in many patients.Here we report the novel mutation c.1898A>C in KCNH2 in a Chinese family with LQTS through whole-exome sequencing.The c.916dupA mutation in JUP(which encodes junction plakoglobin)is also discovered.Mutations in JUP were found to be associated with arrhythmogenic right ventricular cardiomyopathy.The double mutation in the proband may help explain his severe clinical manifestations,such as sudden cardiac death at an early age.Sequencing for the proband’s family members revealed that the KCNH2 mutation descends from his paternal line,while the mutation in JUP came from his maternal line.The data provided in this study may help expand the spectrum of LQTS-related KCNH2 mutations and add support to the genetic diagnosis and counseling of families affected by malignant arrhythmias. | Yafei Zhai Jinxin Miao Ying Peng Guangming Fang Chuchu Wang Yaohe Wang Xiaoyan Zhao Jianzeng Dong | 2020 | Cardiovascular Innovations and Applications2020，，2： | 0 |
| 11 | Security-Critical Components Recognition Algorithm for Complex Heterogeneous Information Systems显示文摘With the skyrocketing development of technologies,there are many issues in information security quantitative evaluation(ISQE)of complex heterogeneous information systems(CHISs).The development of CHIS calls for an ISQE model based on security-critical components to improve the efficiency of system security evaluation urgently.In this paper,we summarize the implication of critical components in different filed and propose a recognition algorithm of security-critical components based on threat attack tree to support the ISQE process.The evaluation model establishes a framework for ISQE of CHISs that are updated iteratively.Firstly,with the support of asset identification and topology data,we sort the security importance of each asset based on the threat attack tree and obtain the security-critical components(set)of the CHIS.Then,we build the evaluation indicator tree of the evaluation target and propose an ISQE algorithm based on the coefficient of variation to calculate the security quality value of the CHIS.Moreover,we present a novel indicator measurement uncertainty aiming to better supervise the performance of the proposed model.Simulation results show the advantages of the proposed algorithm in the evaluation of CHISs. | Jinxin Zuo Yueming Lu Hui Gao Tong Peng Ziyv Guo Tong An Enjie Liu | 2021 | Computers, Materials & Continua2021，，8： | 0 |
| 12 | 3-2 A Study on Nano-indentation of 4H-SiC Irradiated by He and Si Ions显示文摘Part of single crystal 4H-SiC wafers were implanted with 230 keV He+ ion at room temperature (RT) with fluences in the range 1.0 1015 2.0 1016 (0.040.8 dpa). The last single crystal 4H-SiC were implanted with 230 keV Si5+ ion at RT with fluences in the range 1.0 1015 1.0 1017 (0.044.0 dpa). Hardness versus maximum penetration depth curves for unimplanted 4H-SiC, and He/Si ion implanted 4H-SiC at different fluences. Nanoindentation was performed to investigate the hardening behavior of single crystals 4H-SiC under irradiation. | Han Yi Li Bingsheng Wang Zhiguang Peng Jinxin | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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