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1Issues and solutions toward zinc anode in aqueous zinc-ion batteries: A mini review显示文摘Aqueous zinc-ion batteries(ZIBs)have been intensively investigated as potential energy storage devices on account of their low cost,environmental benignity,and intrinsically safe merits.With the exploitation of highperformance cathode materials,electrolyte systems,and in-depth mechanism investigation,the electrochemical performances of ZIBs have been greatly enhanced.However,there are still some challenges that need to be overcome before its commercialization.Among them,the obstinate dendrites,corrosion,and hydrogen evolution reaction(HER)on Zn anodes are critical issues that severely limit the practical applications of ZIBs.To address these issues,various strategies have been proposed,and tremendous progress has been achieved in the past few years.In this article,we analyze the origins and effects of the dendrites,corrosion,and HER on Zn anodes in neutral and mildly acid aqueous solutions at first.And then,a scientific understanding of the fundamental design principles and strategies to suppress these problems are emphasized.Apart from these,this article also puts forward some requirements for the practical applications of Zn anodes as well as several cost-effectivemodifying strategies.Finally,perspectives on the future development of Zn anodes in aqueous solutions are also briefly anticipated.This article provides pertinent insights into the challenges on anodes for the development of highperformance ZIBs,which will greatly contribute to their practical applications.Chunlin Xie Yihu Li Qi Wang Dan Sun Yougen Tang Haiyan Wang 2020Carbon Energy2020,2,4:15
2Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang 2014Cell Research2014,24,8:12
3A Review on Rill Erosion Process and Its Influencing Factors显示文摘Rills are frequently observed on slope farmlands and rill erosion significantly contributes to sediment yields. This paper focuses on reviewing the various factors affecting rill erosion processes and the threshold conditions of rill initiation. Six factors, including rainfall, runoff, soil, topography, vegetation and tillage system, are discussed. Rill initiation and network are explored. Runoff erosivity and soil erodibility are recognized as two direct factors affecting rill erosion and other types of factors may have indirect influences on rill erosion through increasing or decreasing the effects of the direct factors. Certain conditions are necessary for rill initiation and the critical conditions are different with different factors. Future studies should be focused on 1) the dynamic changes of rill networks; 2) the combined effect of multiple factors; and 3) the relationships of threshold values with other related factors.SUN Liying FANG Haiyan QI Deli LI Junlan CAI Qiangguo 2013Chinese Geographical Science2013,23,4:11
4Assessing phenological change in China from 1982 to 2006 using AVHRR imagery显示文摘在植被物候学的长期的趋势由于人的活动和气候的联合影响显示生态系统变化。在我们使用了的这研究, 1982 ~ 2006 先进很高的分辨率辐射计使差别植被索引(AVHRR NDVI ) 正常化越过中国和 TIMESAT 程序的形象确定年度植被生产和它的变化趋势。结果在 25 年的学习时期期间在国内在植被生长和它的时间的趋势显示出大空间可变性。在植被生产的重要减少在内部蒙古的草地,并且在使工业化被检测在南部的中国的区域包括珍珠河三角洲,沿着长江的长江三角洲,和区域。植被生产的重要增加在 Xinjiang,华中,和东北方中国被发现。NDVI 趋势和生长区域变化的确认用 Landsat 形象被进行,结果与从 AVHRR 数据的分析一致。我们也发现尽管植被变化的原因局部地变化,植被变化的空间模式和从国家政策的最大的影响的区域在1970年代发射了,例如经济地区和“三北方的躲蔽处福雷斯特计划”的开始,是类似的,它显示在生态系统变化和那上的国家政策的影响如此的影响能用在这份报纸描述的方法被检测[出版摘要]Haiyan WEI Philip HEILMAN Jiaguo QI Mark A.NEARING Zhihui GU Yongguang ZHANG 2012Frontiers of Earth Science2012,6,3:10
5Method of Modulation Recognition Based on Combination Algorithm of K-Means Clustering and Grading Training SVM显示文摘For the existing support vector machine, when recognizing more questions, the shortcomings of high computational complexity and low recognition rate under the low SNR are emerged. The characteristic parameter of the signal is extracted and optimized by using a clustering algorithm, support vector machine is trained by grading algorithm so as to enhance the rate of convergence, improve the performance of recognition under the low SNR and realize modulation recognition of the signal based on the modulation system of the constellation diagram in this paper. Simulation results show that the average recognition rate based on this algorithm is enhanced over 30% compared with methods that adopting clustering algorithm or support vector machine respectively under the low SNR. The average recognition rate can reach 90% when the SNR is 5 dB, and the method is easy to be achieved so that it has broad application prospect in the modulating recognition.Faquan Yang Ling Yang Dong Wang Peihan Qi Haiyan Wang 2018China Communications2018,15,12:7
6The fluidity and molding ability of glass-forming Zr-based alloy melt显示文摘The fluidity and filling ability of glass-forming Zr-based alloy melt in copper mould were investigated both theoretically and experimentally. The major factors which affected the flowing behavior of the metallic melt in the mold were determined,which provides the foundation for overcoming the contradiction between the filling and formation of amorphous alloy during the rapid cooling process of the metallic melts. The casting factors to prepare a metallic ring were discussed and selected. As a result,a Zr-based bulk metallic glass ring was prepared successfully.MA MingZhen ZONG HaiTao WANG HaiYan QI YanPeng LIANG SunXing SONG AiJun ZHANG WeiGuo WANG Qiang ZHANG XinYu JING Qin LI Gong LIU RiPing 2008Science China(Physics,Mechanics & Astronomy)2008,51,4:6
7Design of Fiber Magnetic Field Sensor Based on Fiber Bragg Grating Fabry-Perot Cavity Ring-Down Spectroscopy显示文摘新奇纤维磁性的传感器理论上基于有脉搏激光注射的纤维布拉格栅栏 Fabry-Perot FBG-FP 洞铃流技术被建议并且示威。输出电场的紧张的一个一般表达式被导出,并且在铃流时间的外部磁场的效果被讨论。结果证明产量光紧张和 FBG-FP 洞的铃流时间在到外部磁场的大小的反的比例。我们的结果表明纤维的新概念有 FBG-FP 洞铃流光谱学和技术可行性的磁性的传感器。Qi LI Haiyan CHEN 2015Photonic Sensors2015,5,2:5
8Hydrothermal alteration of plagioclase microphenocrysts and glass in basalts from the East Pacific Rise near 13°N: An SEM-EDS study显示文摘The interactions of seafloor hydrothermal fluid with igneous rocks can result in leaching elements from the rocks,creating potential ore-forming fluids and influencing the chemical compositions of near-bottom seawater.The hydrothermal alteration of plagioclase microphenocrysts and basaltic glass in the pillow basalts from one dredge station(103°57.62′′W,12°50.55′N,water depth 2480 m)on the East Pacific Rise(EPR)near 13°N were analyzed using a scanning electron microscope(SEM)and energy dispersive X-ray spectrometry(EDS).The results show that the edges of the plagioclase microphenocrysts and the basaltic glass fragments are altered but the pyroxene and olivine microphenocrysts in the interior of the pillow basalts appear to be unaffected by the hydrothermal fluids.In addition,our results show that the chemical alteration at the rims of the plagioclase microphenocrysts and the edges of basaltic glass fragments can be divided into separate types of alteration.The chemical difference in hydrothermal alteration of the plagioclase microphenocrysts and the basaltic glass indicate that different degrees of hydrothermal fluid-solid phase interaction have taken place at the surface of the pillow basalts.If the degree of hydrothermal fluid-solid phase interaction is relatively minor,Si,Al,Ca and Na diffuse from the inside of the solid phase out and as a result these elements have a tendency to accumulate in the edge of the plagioclase microphenocrysts or basaltic glass.If the degree of hydrothermal fluid-solid phase interaction is relatively strong,Si,Al,Ca and Na also diffuse from the inside of solid phase out but these elements will have a relatively low concentration in the edge of the plagioclase microphenocrysts or basaltic glass.Based on the chemical variation observed in the edges of plagioclase microphenocrysts and basaltic glass,we estimate that the content of Si,Al and Fe in the edges of plagioclase microphenocrysts can have a variation of 10.69%,17.59%and 109%,respectively.Similarly,the Si,Al and Fe concentrations in the edges of basaltic glass can have a variation of 9.79%,16.30%and 37.83%,respectively,during the interaction of hydrothermal fluids and seafloor pillow basalt.ZENG ZhiGang QI HaiYan CHEN Shuai YIN XueBo LI ZhaoXue 2014Science China Earth Sciences2014,57,7:5
9FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy.Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai 2022Bone Research2022,10,4:5
10Seasonal Variations of Several Main Water Masses in the Southern Yellow Sea and East China Sea in 2011显示文摘The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the observations for the Yellow Sea Warm Current (YSWC) ,the Yellow Sea Cold Water Mass (YSCWM) and the Changjiang Diluted Water (CDW) during that year.The YSWC was confirmed to be a seasonal current and its source was closely associated with the Kuroshio onshore intrusion and the northerly wind.It was also found that the YSCWM in the summer of 2011 occupied a more extensive area in comparison with the climatologically-mean case due to the abnormally powerful wind prevailing in the winter of 2010 and decaying gradually thereafter.Resulting from the reduced Changjiang River discharge,the CDW spreading toward the Cheju Island in the summer of 2011 was weaker than the long-term mean and was confined to flow southward in the other seasons.The other water masses seemed normal without noticeable anomalies in 2011.The Yellow Sea Coastal Current (YSCC) water,driven by the northerly wind,flowed southeastward as a whole except for its northeastward surface layer in summer.The Taiwan Warm Current (TWC) was the strongest in summer and the weakest in winter in its northward movement.The Kuroshio water with an enhanced onshore intrusion in autumn was stable in hydrographic features apart from the seasonal variation of its surface layer.QUAN Qi MAO Xinyan YANG Xiaodan HU Yingying ZHANG Haiyan JIANG Wensheng 2013Journal of Ocean University of China2013,12,4:5
11A Day-ahead Economic Dispatch Method Considering Extreme Scenarios Based on Wind Power Uncertainty显示文摘As the intermittency of wind power is a growing concern in the day-ahead economic dispatch,this paper proposes a day-ahead economic dispatch method considering extreme scenarios of wind power by using an uncertainty set.The uncertainty set inspired by robust optimization is used to describe wind power intermittency in this paper.Four extreme scenarios based on the uncertainty set are formulated to represent the worst cases of wind power fluctuation.An economic dispatch method considering the costs of both load shedding and wind curtailment is proposed.The economic dispatch model can be easily solved by a quadratic programming method owing to the introduction of four extreme scenarios and the uncertainty set of wind power.Simulation is done using the IEEE 30-bus system and the results verify the effectiveness of the proposed method.Jian Xu Bao Wang Yuanzhang Sun Qi Xu Ji Liu Huiqiu Cao Haiyan Jiang Ruobing Lei Mengjun Shen 2019CSEE Journal of Power and Energy Systems2019,5,2:5
12Fe-Si-Mn-Oxyhydroxide Encrustations on Basalts at East Pacific Rise near 13°N:An SEM-EDS Study显示文摘Fe-Si-Mn-oxyhydroxide encrustations at the East Pacific Rise(EPR) near 13°N were analyzed using the scanning electron microscope(SEM) with an energy dispersive spectrometer(EDS). These encrustations are mainly composed of amorphous FeSi-Mn-oxyhydroxides forming laminated, spherical, porous aggregates with some biodetritus, anhydrite, nontronite, and feldspar particles. Anhydrite particles and nontronite crystals in the Fe-Si-Mn-oxyhydroxide encrustations imply that the Fe-Si-Mn- oxyhydroxide may have formed under relatively low- to high-temperature hydrothermal conditions. The Fe-Si-Mn-oxyhydroxide encrustations on pillow basalts are 1–2 mm thick. The growth rate of ferromanganese crusts in the survey area suggests that these encrustations are an unlikely result of hydrogenic deposition alone having a hydrothermal and(Fe/Mn ratio up to 7.7 and Fe/(Fe+Mn+Al) ratio exceeding 0.78) hydrogenic origin(0.22 Fe/Mn ratio close to the mean value of 0.7 for open-ocean seamount crusts). The varying Fe/Mn ratios indicate that the Fe-Si-Mn-oxyhydroxide encrustations have formed through several stages of seafloor hydrothermalism. It is suggested that, at the initial formation stage, dense Fe-Si-oxyhydroxides with low Mn content deposit from a relatively reducing hydrothermal fluid, and then the loose Fe-Si-Mn-oxyhydroxides deposit on the Fe-Si-oxyhydroxides. As the oxidation degree of hydrothermal fluid increases and Si-oxide is inhibited, Mn-oxide will precipitate with Fe-oxyhydroxides.WANG Xiaoyuan ZENG Zhigang QI Haiyan CHEN Shuai YIN Xuebo YANG Baoju 2014Journal of Ocean University of China2014,13,6:5
13Grade classification of neuroepithelial tumors using high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and pattern recognition显示文摘Clinical data have shown that survival rates vary considerably among brain tumor patients,according to the type and grade of the tumor.Metabolite profiles of intact tumor tissues measured with high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy (HRMAS 1H NMRS) can provide important information on tumor biology and metabolism.These metabolic fingerprints can then be used for tumor classification and grading,with great potential value for tumor diagnosis.We studied the metabolic characteristics of 30 neuroepithelial tumor biopsies,including two astrocytomas (grade I),12 astrocytomas (grade II),eight anaplastic astrocytomas (grade III),three glioblastomas (grade IV) and five medulloblastomas (grade IV) from 30 patients using HRMAS 1H NMRS.The results were correlated with pathological features using multivariate data analysis,including principal component analysis (PCA).There were significant differences in the levels of N-acetyl-aspartate (NAA),creatine,myo-inositol,glycine and lactate between tumors of different grades (P<0.05).There were also significant differences in the ratios of NAA/creatine,lactate/creatine,myo-inositol/creatine,glycine/creatine,scyllo-inositol/creatine and alanine/creatine (P<0.05).A soft independent modeling of class analogy model produced a predictive accuracy of 87% for high-grade (grade III-IV) brain tumors with a sensitivity of 87% and a specificity of 93%.HRMAS 1H NMR spectroscopy in conjunction with pattern recognition thus provides a potentially useful tool for the rapid and accurate classification of human brain tumor grades.CHEN WenXue LOU HaiYan ZHANG HongPing NIE Xiu LAN WenXian YANG YongXia XIANG Yun QI JianPin LEI Hao TANG HuiRu CHEN FenEr DENG Feng 2011Science China(Life Sciences)2011,54,7:5
14Cisplatin-induced vestibular hair cell lesion-less damage at high doses显示文摘Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-response function for vestibular hair cells follows a similar pattern, we treated vestibular organotypic cultures with doses of cisplatin ranging from 10 to 1000 μM. Vestibular hair cell lesions progressively increased as the dose of cisplatin increased with maximum damage occurring around 50-100 μM, but the lesions progressively decreased at higher doses resulting in little hair cell loss at 1000 μM. The U-shaped doseresponse function for cisplatin-treated vestibular hair cells in culture appears to be regulated by copper transporters, Ctrl, ATP7A and ATP7B, that dose-dependently regulate the uptake, sequestration and extrusion of cisplatin.Dalian Ding Haiyan Jiang Jianhui Zhang Xianrong Xu Weidong Qi Haibo Shi Shankai Yin Richard Salvi 2018Journal of Otology2018,13,4:4
15KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer显示文摘Background:Although immune checkpoint inhibitors(ICIs)against programmed cell death protein 1(PD-1)and its ligand PD-L1 have demonstrated potency towards treating patients with non-small cell lung carcinoma(NSCLC),the potential association between Kirsten rat sarcoma viral oncogene homolog(KRAS)oncogene substitutions and the efficacy of ICIs remains unclear.In this study,we aimed to find point mutations in the KRAS gene resistant to ICIs and elucidate resistance mechanism.Methods:The association between KRAS variant status and the efficacy of ICIs was explored with a clinical cohort(n=74),and confirmed with a mouse model.In addition,the tumor immune microenvironment(TIME)of KRASmutant NSCLC,such as CD8+tumor-infiltrating lymphocytes(TILs)and PD-L1 level,was investigated.Cell lines expressing classic KRAS substitutions were used to explore signaling pathway activation involved in the formation of TIME.Furthermore,interventions that improved TIME were developed to increase responsiveness to ICIs.Results:We observed the inferior efficacy of ICIs in KRAS-G12D-mutant NSCLC.Based upon transcriptome data and immunostaining results from KRAS-mutant NSCLC,KRAS-G12D point mutation negatively correlated with PD-L1 level and secretion of chemokines CXCL10/CXCL11 that led to a decrease in CD8+TILs,which in turn yielded an immunosuppressive TIME.The analysis of cell lines overexpressing classic KRAS substitutions further revealed that KRAS-G12D mutation suppressed PD-L1 level via the P70S6K/PI3K/AKT axis and reduced CXCL10/CXCL11 levels by down-regulating high mobility group protein A2(HMGA2)level.Notably,paclitaxel,a chemotherapeutic agent,upregulated HMGA2 level,and in turn,stimulated the secretion of CXCL10/CXCL11.Moreover,PD-L1 blockade combined with paclitaxel significantly suppressed tumor growth compared with PD-L1 inhibitor monotherapy in a mouse model with KRAS-G12D-mutant lung adenocarcinoma.Further analyses revealed that the combined treatment significantly enhanced the recruitment of CD8+TILs via the up-regulation of CXCL10/CXCL11 levels.Results of clinical study also revealed the superior efficacy of chemo-immunotherapy in patients with KRAS-G12D-mutant NSCLC compared with ICI monotherapy.Conclusions:Our study elucidated the molecular mechanism by which KRASG12D mutation drives immunosuppression and enhances resistance of ICIs in NSCLC.Importantly,our findings demonstrate that ICIs in combination with chemotherapy may be more effective in patients with KRAS-G12D-mutant NSCLC.Chengming Liu Sufei Zheng Zhanyu Wang Sihui Wang Xinfeng Wang Lu Yang Haiyan Xu Zheng Cao Xiaoli Feng Qi Xue Yan Wang Nan Sun Jie He 2022Cancer Communications2022,42,9:4
16Smectite formation in metalliferous sediments near the East Pacific Rise at 13°N显示文摘A 43 cm long E271 sediment core collected near the East Pacific Rise(EPR) at 13°N were studied to investigate the origin of smectite for understanding better the geochemical behavior of hydrothermal material after deposition.E271 sediments are typical metalliferous sediments. After removal of organic matter, carbonate, biogenic opal,and Fe-Mn oxide by a series of chemical procedures, clay minerals(<2 μm) were investigated by X-ray diffraction,chemical analysis and Si isotope analysis. Due to the influence of seafloor hydrothermal activity and close to continent, the sources of clay minerals are complex. Illite, chlorite and kaolinite are suggested to be transported from either North or Central America by rivers or winds, but smectite is authigenic. It is enriched in iron, and its contents are highest in clay minerals. Data show that smectite is most likely formed by the reaction of hydrothermal Fe-oxyhydroxide with silica and seawater in metalliferous sediments. The Si that participates in this reaction may be derived from siliceous microfossils(diatoms or radiolarians), hydrothermal fluids, or detrital mineral phases. And their δ30 Si values are higher than those of authigenic smectites, which implies that a Si isotope fractionation occurs during the formation because of the selective absorption of light Si isotopes onto Feoxyhydroxides. Sm/Fe mass ratios(a proxy for overall REE/Fe ratio) in E271 clay minerals are lower than those in metalliferous sediments, as well as distal hydrothermal plume particles and terrigenous clay minerals. This result suggests that some REE are lost during the smectite formation, perhaps because their large ionic radii of REE scavenged by Fe-oxyhydroxides preclude substitution in either tetrahedral or octahedral lattice sites of this mineral structure, which decreases the value of metalliferous sediments as a potential resource for REE.RONG Kunbo ZENG Zhigang YIN Xuebo CHEN Shuai WANG Xiaoyuan QI Haiyan MA Yao 2018Acta Oceanologica Sinica2018,37,9:4
17Effects of Zr,Ti and Sc additions on the microstructure and mechanical properties of Al-0.4Cu-0.14Si-0.05Mg-0.2Fe alloys显示文摘The evolution of microstructure and mechanical properties of Al-0.4 Cu-0.14 Si-0.05 Mg-0.2 Fe(wt.%)alloys, micro-alloyed with Zr, Ti and Sc, were investigated. The addition of 0.2%Zr to base alloy accelerates the precipitation of Si-rich nano-phase in α-Al matrix, which plays an important role in improving the mechanical properties of an alloy. The tensile strength increases from 102 MPa for the base alloy to 113 MPa for the Zr-modified alloy. Adding 0.2%Zr + 0.2%Ti to base alloy effectively refines a-Al grain size and accelerates the precipitation of Si and Cu elements, leading to heavy segregation at grain boundary.By further adding 0.2%Sc to Zr + Ti modified alloy, the segregation of Si and Cu elements is suppressed and more Si and Cu precipitates appeared in α-Al matrix. Accompanied with the formation of coherent Al_3Sc phase, the tensile strength increases from 108 MPa for the Zr + Ti modified alloy to 152 MPa for the Sc-modified alloy. Due to excellent thermal stability of Al_3Sc phase, the Sc-modified alloy exhibits obvious precipitation hardening behavior at 350℃, and the tensile strength increases to 203 MPa after holding at 350 ℃ for 200 h.Jian Feng Bing Ye Lijie Zuo Ruijuan Qi Qudong Wang Haiyan Jiang Rong Huang Wenjiang Ding Jie Yao Chuntao Wang 2018Journal of Materials Science & Technology2018,34,12:3
18Issues and rational design of aqueous electrolyte for Zn-ion batteries显示文摘Aqueous Zn-ion batteries(AZIBs)are regarded as a promising alternative to the widely used lithium-ion batteries in large-scale energy storage systems.The researches on the development of novel aqueous electrolyte to improve battery performance have also attracted great interest since the electrolyte is a key com-ponent for Zn2+migration between cathode and anode.Herein,we briefly sum-marized and illuminated the recent development tendency of aqueous electrolyte for AZIBs,then deeply analyzed its existing issues(water decomposition,cathode dissolution,corrosion and passivation,and dendrite growth)and discussed the corresponding optimization strategies(pH regulation,concentrated salt solution,electrolyte composition design,and functional additives).The internal mecha-nisms of these strategies were further revealed and the relationships between issues and solutions were clarified,which could guide the future development of aqueous electrolytes for AZIBs.Qi Zhang Zefang Yang Huimin Ji Xiaohui Zeng Yougen Tang Dan Sun Haiyan Wang 2021SusMat2021,1,3:3
19Characterization of a PDR type ABC transporter gene from wheat (Triticum aestivum L.)显示文摘DON, as a virulence factor, plays an important role in the infection of Fusarium graminearum in wheat. The infection ability of F. graminearum depends on its capacity of producing DON. The production of DON by F. graminearum is significantly decreased in the wheat varieties with scab resistance. In this study, GeneChip analysis indicated that an EST encoding an ATP-binding cassette (ABC) transporter was up-regulated by 45 times in a wheat landrace Wangshuibai, which is resistant to DON accumulation. A pair of EST-derived primers were designed based on the EST sequence, and a clone was then isolated from a wheat genomic DNA TAC library. The TAC clone was sequenced using chromosome walking and gene prediction was conducted using Softberry. A cDNA clone of this gene was subsequently isolated from Wangshuibai induced by DON using gene-specific primers designed according to the untranslated sequence of the gene. The genome size of the gene is 7377 bp, consisting of 19 exons with coding sequences of 4308 bp. It encodes a protein with 1435 amino acid residues and the calculated molecular weight is about 161 kD. BLAST analysis indicated that the gene may belong to pleiotropic drug resistance (PDR) sub-family, and hence designated as TaPDR1 (Triticum aestivum pleiotropic drug resistance). TaPDR1 was located on chromosome 5A of wheat using nullisomic-tetrasomic lines of Chinese Spring. TaPDR1 was up-regulated by induction of both DON and F. graminearum. Expression patterns of TaPDR1 were different in wild-type Wangshuibai and the fast-neutron induced Wangshuibai mutant lacking FHB1, a major QTL of FHB resistance and DON resistance in chromosome arm 3BS. These results suggested that TaPDR1 might be a candidate gene responsible for DON ac-cumulation resistance. The expression profile showed that TaPDR1 expression was neither induced by hormones typically involved in biotic stress, such as JA and SA, nor by abiotic stresses, such as heat, cold, wounding and NaCl. However, TaPDR1 expression was regulated by Al3+ and [Ca2+], indicating that [Ca2+]i might mediate the signal of TaPDR1 expression.SHANG Yi XIAO Jin MA LuLin WANG HaiYan QI ZengJun CHEN PeiDu LIU DaJun WANG XiuE 2009Chinese Science Bulletin2009,54,18:3
20Antioxidative stress-induced damage in cochlear explants显示文摘The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However,little is known about fighting oxidative stress. In the current study, we evaluated antioxidant-induced cochlear damage by applying several different additional antioxidants. To determine whether excessive antioxidants can cause damage to cochlear cells, we treated cochlear explants with 50 m M M40403, a superoxide dismutase mimetic, 50 m M coenzyme Q-10, a vitamin-like antioxidant, or 50 m M d-methionine, an essential amino acid and the important antioxidant glutathione for 48 h. Control cochlear explants without the antioxidant treatment maintained their normal structures after incubation in the standard serum-free medium for 48 h, indicating the maintenance of the inherent oxidative and antioxidant balance in these cochlear explants. In contrast, M40403 and coenzyme Q-10-treated cochlear explants displayed significant hair cell damage together with slight damage to the auditory nerve fibers.Moreover, d-methiodine-treated explants exhibited severe damage to the surface structure of hair cells and the complete loss of the spiral ganglion neurons and their peripheral fibers. These results indicate that excessive antioxidants are detrimental to cochlear cells, suggesting that inappropriate dosages of antioxidant treatments can interrupt the balance of the inherent oxidative and antioxidant capacity in the cell.Dalian Ding Jianghui Zhang Fang Liu Peng Li Weidong Qi Yazhi Xing Haibo Shi Haiyan Jiang Hong Sun Shankai Yin Richard Salvi 2020Journal of Otology2020,15,1:3
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