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| 1 | Time range of Mesozoic tectonic regime inversion in eastern North China Block显示文摘An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma. | ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG Hongfu ZHANG Huafeng | 2004 | Science China Earth Sciences2004，47，2： | 89 |
| 2 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 3 | Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province显示文摘Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of viral pneumonia on chest imaging.Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis. | Kui Liu Yuan-Yuan Fang Yan Deng Wei Liu Mei-Fang Wang Jing-Ping Ma Wei Xiao Ying-Nan Wang Min-Hua Zhong Cheng-Hong Li Guang-Cai Li Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，9： | 100 |
| 4 | Theoretical research on construction quality real-time monitoring and system integration of core rockfill dam显示文摘With the enlargement of core rockfill dam construction scale and the improvement of construction mechanization level, the traditional manual construction quality control method is now difficult to meet the quality and safety demands of modern dam construction, so automatic and real-time dam construction quality monitoring with high-techs is urgently needed. The paper makes theoretical research on construction quality real-time monitoring and system integration of core rockfill dam, proposes implementation method and integrated solution of construction quality real-time monitoring of core rockfill dam construction process, realizes refining, all-whether, entire-process and real-time control and analysis on key links of dam construction, and introduces the application of the construction quality real-time monitoring and system integration technology to a practical core rockfill dam project. | ZHONG DengHua CUI Bo LIU DongHai TONG DaWei | 2009 | Science China(Technological Sciences)2009，52，11： | 59 |
| 5 | Mathematic principles of interrupted-sampling repeater jamming (ISRJ)显示文摘Coherent jamming is one of the important trends in modern radar electronic war- fare. High-speed sampling of wideband radio frequency (RF) signals and high iso- lation of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to engineering application. In this paper, a novel repeater jamming based on inter- rupted sampling technique is presented. For a jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the jamming signal feed the matched filter of a pulse compression radar. For the case of the linear frequency modulated (LFM) pulse compression radars, mathematic principles of the interrupted-sam- pling repeater jamming is developed, and then the efficiency of the jamming is de- scribed and stated as expressions of key parameters which are also beneficial to the jamming design for other coherent radars. | WANG XueSong LIU JianCheng ZHANG WenMing FU QiXiang LIU Zhong XIE XiaoXia | 2007 | Science in China(Series F)2007，50，1： | 53 |
| 6 | U–Pb ages and Hf isotopes for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southwestern margin of the North China Craton显示文摘In situ U-Pb dating and Lu-Hf isotopic analysis were carried out for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southern margin of the North China Craton (NCC). The re- sults provide further constraints on the crustal formation and evolution history of NCC. Four 207Pb/206Pb age populations were obtained from 99 analyses, with clusters at ~3.40 Ga, 2.77―2.80 Ga, ~2.50 Ga and 2.34 Ga, respectively. The 3.40 Ga old zircons have similar Hf isotopic compositions to those from Ar- chean rocks in the Jidong and Anshan areas of NCC. However, crustal remnants older than 3.6 Ga have been identified in the southern margin of NCC, the South China Craton, the northwestern part of the Qinling Orogen and its adjacent area. Thus, it is not easy to trace the source rock from which the 3.40 Ga detrital zircons were derived. It can be inferred that the crustal remnants older than 3.40 Ga might have been widely distributed in the North China Craton. The 2.77―2.80 Ga zircons make up a relatively small proportion and have the highest εHf (t) values (up to 6.1±1.6), consistent with the Hf isotopic composition of the depleted mantle at 2.83 Ga. Their single-stage Hf model age of 2.83 Ga is close to their crystallized age, suggesting that their source rocks were extracted from the contemporaneous depleted mantle. The ~2.50 Ga zircon grains constitute about 85% of the total grain population and their Hf isotopic compositions indicate major growth of juvenile crust at ~2.50 Ga but minor reworking of ancient crust. The youngest zircon dated in this study gave an U-Pb age of 2337±23 Ma, which can be considered the maximum depositional age of the formation of the Songshan Group. | DIWU ChunRong SUN Yong YUAN HongLin WANG HongLiang ZHONG XingPing LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，18： | 54 |
| 7 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 8 | Real-time compaction quality monitoring of high core rockfill dam显示文摘The conventional quality control method of core rockfill dam construction exhibit difficulty controlling compaction parameters accurately or ensuring construction quality. This is because it is easily influenced by human behavior or lack of adequate management. We therefore establish the timely monitoring indexes and control criteria of compaction processes by considering the characteristics and quality requirements of high core rockfill dam construction. Based on the established indexes and criteria, integrating GPS, GPRS and PDA technologies, a real-time compaction quality monitoring method is proposed. The relevant key techniques are proposed as well, including automatic collection of information and a graphic algorithm for rolling-process visualization. By the proposed method and techniques, a real-time monitoring system is provided to realize the precise automatic online entire-process monitoring of compaction parameters, including compaction pass, rolling trajectory, running speed of roller, vibration status and rolled pavement thickness. The application of the Nuozhadu project shows that the proposed system can control compaction parameters effectively and ensure better construction quality. Therefore, it might become a new way towards construction quality control of high core rockfill dam. | ZHONG DengHua LIU DongHai CUI Bo | 2011 | Science China(Technological Sciences)2011，54，7： | 45 |
| 9 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 10 | The impact of meteorological changes from 2013 to 2017 on PM2.5 mass reduction in key regions in China显示文摘In 2013,China issued the'Action Plan for the Prevention and Control of Air Pollution'('Ten Statements of Atmosphere')and implemented a series of pollution reduction measures from 2013 to 2017.In key regions of China,the mass concentrations of particulate matter with aerodynamic equivalent diameters less than 2.5μm(PM2.5)have dropped significantly.However,the contributions of meteorological changes to PM2.5 reduction are largely uncertain,which has attracted particular concern from the government and the public.Here,we investigated the impact of large-scale and boundary layer(BL)meteorological conditions on aerosol pollution and estimated the contributions of meteorological changes to PM2.5 reduction based on in-depth analysis and diagnosis of various observed meteorological elements and an integrated pollution-linked meteorological index(PLAM,which is approximately and linearly related to PM mass concentration).In this study,we found that the meteorological conditions worsened in 2014 and 2015 and improved in 2016 and 2017 relative to those in 2013 in key regions in China.In 2017 relative to 2013,only^5%(approximately 13%of the total PM2.5 decline)of the 39.6%reduction in PM2.5 mass concentrations can be attributed to meteorological changes in the Beijing-Tianjin-Hebei(BTH)region,and only^7%(approximately 20%of the total PM2.5 decline)of the 34.3%reduction can be attributable to meteorological changes in the Yangtze River Delta(YRD)region.Overall,the PM2.5 reduction due to meteorological improvement is much lower than the observed PM2.5 reduction in these areas,which indicates that emission reduction during the five-year implementation of the'Ten Statements of Atmosphere'is the dominant factor in the improvement in air quality.The changes in meteorology and climate are conducive to PM2.5 reduction but do not dominate the substantial improvement in air quality.Similar to the above regions,in the Pearl River Delta(PRD)region,the impact of meteorological changes on the annual averaged PM2.5 concentration from 2013 to2017 was relatively weak,and the PM2.5 reduction was mainly due to emission reductions.During winter 2017(January,February,and December of this year),the meteorological conditions improved-20%in the BTH region(observed total PM2.5reduction:40.2%)and-30%in the YRD region(observed total PM2.5 reduction:38.2%)relative to those in 2013,showing the meteorological factors played more important role in the decrease of PM2.5 in winter of these years in the two regions,respectively.The meteorological conditions in winter 2016 were 14%better than those in winter 2017,but the PM2.5 reduction in winter 2016 was still less than that in winter 2017,reinforcing the significant contributions of the increasing efforts to reduce PM2.5 emissions in 2017.The substantial progress of strict emission measures was also confirmed by a comparison of several persistent heavy aerosol pollution episodes(HPEs)with similar meteorological conditions.It is found that the decrease of PM2.5mass caused by emission reduction increases year by year,especially the decrease of PM2.5 concentration in 2016 and 2017.In China,HPEs mainly occur in winter,when meteorological conditions are approximately 40-100%worse than in other seasons.This worsening is partly due to the harbor effect of high topography,including downdrafts and the weak wind zone,and partly due to the increasingly stable regional BL structure caused by climate warming.For the formation of HPEs,it occurred under regional stagnant and stable conditions associated with upper-level circulation patterns,including the zonal westerly winds type and high-pressure ridges.After pollution formation,PM2.5 with mass accumulated to a certain degree can further worsen the BL meteorological conditions.The feedback effect associated with worsening conditions dominates PM2.5 mass explosive growth.In the context of high air pollutant emissions in China,unfavorable meteorological conditions are the necessary external conditions for the formation and accumulation of HPEs.Therefore,reducing aerosol pollution significantly during the earlier transport stage is critical in reducing persistent HPEs.Currently,even under favorable meteorological conditions,allowing emissions without restriction is also not advisable because aerosol pollution allowed to accumulate to a certain extent will significantly worsen the BL meteorological conditions and close the'meteorological channels'available for pollution dispersion. | Xiaoye ZHANG Xiangde XU Yihui DING Yanju LIU Hengde ZHANG Yaqiang WANG Junting ZHONG | 2019 | Science China Earth Sciences2019，62，12： | 42 |
| 11 | Colorectal cancer in Guangdong Province of China:A demographic and anatomic survey显示文摘AIM:To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province,China.METHODS:A review of patient records from 1986 to 2006 from five hospitals was conducted. Patient data was obtained,including age,gender,location of le-sions,staging and histological type of CRC. The Chi-square test was used to assess differences in rates and a significance level of 0.05 was used. Univariate com-parisons were made via Fisher's exact tests.RESULTS:Analysis was carried out on 8172 CRC patents,6.1% (499/8172) of the patients were aged ≤ 30 years. The peak incidence was between the ages 61-70 years (27.8%). The mean age at CRC diagnosis increased from 52 years (1986-1988) to 60 years(2004-2006) and the proportion of young CRC patients decreased from 8.0% to 5.9% over the same period. Of 8172 lesions,4434 (54.3%) were located in rectum and 3738 (45.7%) in colon. The incidence of rectal cancer decreased significantly from 59.4% (1989-1991) to 51.8% (2004-2006) and right sided colon cancer increased from 40.6% to 48.2%. The mean age,ana-tomic distribution,histological type and differentiation degree were significantly different among the four geographical areas (P < 0.05).CONCLUSION:The hospitalization rate for CRC has increased in Guangdong in recent years. The characteristics of CRC from the five hospitals located in the four different areas of Guangdong Province are also different. Further studies are needed to assess more recent trend in the incidence and prevalence of CRC as well as the respective roles of genetic and environ-mental factors in CRC. | Xu, An-Gao Yu, Zhi-Jin Jiang, Bo Wang, Xin-Ying Zhong, Xu-Hui Liu, Ji-Hong Lou, Qiu-Yun Gan, Ai-Hua | 2010 | World Journal of Gastroenterology2010，16，8： | 40 |
| 12 | Significance of dredging on sediment denitrification in Meiliang Bay,China:A year long simulation study显示文摘An experiment for studying the effects of sediment dredging on denitrification in sediments was carried out through a one-year incubation of undredged (control) and dredged cores in laboratory. Dredging the upper 30 cm of sediment can significantly affect physico-chemical characteristics of sediments. Less degradation of organic matter in the dredged sediments was found during the experiment. Denitrification rates in the sediments were estimated by the acetylene blockage technique, and ranged from 21.6 to 102.7 nmol N2/(g dry weight (dw)·hr) for the undredged sediment and from 6.9 to 26.9 nmol N2/(g dw·hr) for dredged sediments. The denitrification rates in the undredged sediments were markedly higher (p<0.05) than those in the dredged sediments throughout the incubation, with the exception of February 2006. The importance of various environmental factors on denitrification was assessed, which indicated that denitrification was regulated by temperature. Nitrate was probably the key factor limiting denitrification in both undredged and dredged sediments. Organic carbon played some role in determining the denitrification rates in the dredged sediments, but not in the undredged sediments. Sediment dredging influenced the mineralization of organic matter and denitrification in the sediment; and therefore changed the pattern of inherent cycling of nitrogen. | Jicheng Zhong Chengxin Fan Lu Zhang Edward Hall Shiming Ding Bao Li Guofeng Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 40 |
| 13 | Jamming de-chirping radar using interrupted-sampling repeater显示文摘Interrupted-sampling repeater jamming (ISRJ) is a novel jamming mode for pulse compression radar in principle.In this paper,a jamming approach of applying ISRJ to de-chirping radar is presented.The principles of ISRJ are expounded,and the ways to achieve a train false target for de-chirping radar are analyzed.The characteristics of false target,including time-domain characteristic,frequency-domain characteristic and amplitude characteristic,are described.Based on this,the power requirement for jammer is put forward and the key elements that determine the space distribution location between true and false targets are discussed in detail.At last,simulation results are presented and addressed.This work is beneficial to the jamming design and use of ISRJ. | FENG DeJun TAO HuaMin YANG Yong LIU Zhong | 2011 | Science China(Information Sciences)2011，54，10： | 35 |
| 14 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 15 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 16 | Clay minerals in surface sediments of the Pearl River drainage basin and their contribution to the South China Sea显示文摘Clay minerals have played a significant role in the study of the East Asian monsoon evolution in the South China Sea by being able to track oceanic current variations and to reveal contemporaneous pa- leoclimatic changes prevailing in continental source areas.As one of the most important rivers input- ting terrigenous matters to the northern South China Sea,the Pearl River was not previously paid at- tention to from the viewpoint of clay mineralogy.This paper presents a detailed study on clay minerals in surface sediments collected from the Pearl River drainage basin(including all three main channels, various branches,and the Lingdingyang in the estuary)by using the X-ray diffraction(XRD)method. The results indicate that the clay mineral assemblage consists dominantly of kaolinite(35%-65%), lesser abundance of chlorite(20%-35%)and illite(12%-42%),and very scare smectite occurrences (generally<5%).Their respective distribution does not present any obvious difference throughout the Pearl River drainage basin.However,downstream the Pearl River to the northern South China Sea,the clay mineral assemblage varies significantly:kaolinite decreases gradually,smectite and illite increase gradually.Additionally,illite chemistry index steps down and illite crystallinity steps up.These varia- tions indicate the contribution of major kaolinite,lesser illite and chlorite,and very scarce smectite to the northern South China Sea from the Pearl River drainage basin.The maximum contribution of clay minerals from the Pearl River is 72%to the northern margin and only 15%to the northern slope of the South China Sea.In both glacials and interglacials,kaolinite indicates that the ability of mechanical erosion occurred in the Pearl River drainage basin. | LIU ZhiFei Christophe COLIN HUANG Wei CHEN Zhong Alain TRENTESAUX CHEN JianFang | 2007 | Chinese Science Bulletin2007，52，8： | 33 |
| 17 | New chaotic system and its hyperchaos generation显示文摘To seek for lower-dimensional chaotic systems that have complex topological attractor structure with simple algebraic system structure, a new chaotic system of three-dimensional autonomous ordinary differential equations is presented. The new system has simple algebraic structure, and can display a 2-scroll attractor with complex topological structure, which is different from the Lorenz's, Chen's and Lu¨'s attractors. By introducing a linear state feedback controller, the system can be controlled to generate a hyperchaotic attractor. The novel chaotic attractor, hyperchaotic attractor and dynamical behaviors of corresponding systems are further investigated by employing Lyapunov exponent spectrum, bifurcation diagram, Poincar′e mapping and phase portrait, etc., and then verified by simulating an experimental circuit. | Bao Bocheng Liu Zhong Xu Jianping | 2009 | Journal of Systems Engineering and Electronics2009，20，6： | 34 |
| 18 | Prevention of postoperative intracranial infection in patients with cerebrospinal fluid rhinorrhea显示文摘背景 Intracranial 感染是学习试图与脑髓的液体 rhinorrhea 在病人识别手术后的 intracranial 感染的风险因素并且为 167 个病人全部的 prevention.Methods A 建议建议的 neurosurgery.This 的普通手术后的复杂并发症( 113 男性和 54 男性, 34.4 年的平均年龄)与四年级生操作的脑髓的液体 rhinorrhea ,作者是回顾地,收集的 reviewed.The 数据包括了病原学,以前的历史。 | YANG Zhi-jun ZHONG Hong-liang WANG Zhen-min ZHAO Fu LIU Pi-nan | 2011 | Chinese Medical Journal2011，，24： | 34 |
| 19 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 20 | Prevalence and features of fatty liver detected by physical examination in Guangzhou显示文摘AIM:To investigate the prevalence of fatty liver discovered upon physical examination of Chinese patients and determine the associated clinical characteristics.METHODS:A total of 3433 consecutive patients who received physical examinations at the Huangpu Division of the First Affiliated Hospital at Sun Yat-sen University in Guangzhou,China from June 2010 to December2010 were retrospectively enrolled in the study.Results of biochemical tests,abdominal ultrasound,electrocardiography,and chest X-ray were collected.The diagnosis of fatty liver was made if a patient met any two of the three following ultrasonic criteria:(1)liver and kidney echo discrepancy and presence of an increased liver echogenicity(bright);(2)unclear intrahepatic duct structure;and(3)liver far field echo decay.RESULTS:The study population consisted of 2201males and 1232 females,with a mean age of 37.4±12.8 years.When all 3433 patients were considered,the overall prevalence of hyperlipidemia was 38.1%,of fatty liver was 26.0%,of increased alanine aminotransferase(ALT)and/or aspartate aminotransferase(AST)levels was 11.9%,of gallstone was 11.4%,of hyperglycemia was 7.3%,of hypertension was 7.1%,and of hyperuricemia was 6.2%.Of the 2605 patients who completed the abdominal ultrasonography exam,677(26.0%)were diagnosed with fatty liver and the prevalence was higher in males(32.5%vs females:15.3%,P<0.001).The overall prevalence of fatty liver increased with age,with the peak prevalence(39.5%)found in the 60 to 70-year-old age group.Among patients between the ages of 18 to 50-year-old,the prevalence of fatty liver was significantly higher in males(20.2%vs females:8.7%,P<0.001);the difference in prevalence between the two sexes in patients>50-year-old did not reach statistical significance.Only 430 of the patients diagnosed with fatty liver had complete information;among those,increased ALT and/or AST levels were detected in only 30%,with all disturbances being mild or moderate.In these 430 patients,the overall prevalence of hypertriglyceridemia was 31.4%,of mixed type hyperlipidemia was 20.9%,of hypercholesterolemia was 12.3%,of hyperglycemia was 17.6%,of hypertension was 16.0%,of hyperuricemia was 15.3%,and of gallstone was 14.4%.Again,the prevalences of hypertriglyceridemia and hyperuricemia were higher in males(hypertriglyceridemia,36.0%vs females:12.0%,P<0.05;hyperuricemia,17.3%vs females:7.2%,P<0.05);in contrast,however,the prevalences of mixed type hyperlipidemia and hypercholesterolemia was higher in females(mixed type hyperlipidemia,18.7% vs females:30.1%,P<0.05,hypercholesterolemia,9.5%vs females:24.1%,P<0.05).Finally,comparison of the fatty liver group to the non-fatty liver group showed that prevalences of hyperlipidemia,hyperglycemia,hypertension,and hyperuricemia were higher in the former(all P<0.01).CONCLUSION:A high prevalence of fatty liver is detected upon physical examination in Guangzhou,and the primary associated clinical findings are hyperlipidemia,hyperglycemia,hypertension,and hyperuricemia. | Xian-Hua Liao Xu Cao Jie Liu Xiao-Hua Xie Yan-Hong Sun Bi-Hui Zhong | 2013 | World Journal of Gastroenterology2013，19，32： | 30 |
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