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| 1 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 2 | CRISPR/Cas9-mediated base-editing system efficiently generates gain-of-function mutations in Arabidopsis显示文摘Dear Editor,The CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9)system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and versatility.However,introduction of a point mutation at a desired position remains a great challenge in plant genome engineering.Currently,point mutation in plants was achieved by incorporating | Yiyu Chen Zhiping Wang Hanwen Ni Yong Xu Qijun Chen Linjian Jiang | 2017 | Science China(Life Sciences)2017，60，5： | 40 |
| 3 | A shallow aftershock sequence in the north-eastern end of the Wenchuan earthquake aftershock zone显示文摘Previous studies show that mature faults are filled with fault gouge in the shallow part and thus cannot accumulate enough strain energy for earthquakes. Therefore most earthquakes are deeper than 5 km, except those events occurring on new faults or in intact rocks. From field observation, Wenchuan earthquake is found to rupture the free surface about 200 km, but the rupture may extend underground much further from teleseismic body waves inversion and aftershocks distribution. In the northeastern end of the rupture zone, deep rupture may induce stress increase near the free surface, and trigger shallow earthquakes. An Ms 5.7 aftershock occurred at Qingchuan, northeast end of Wenchuan earthquake fault on July 24, 2008, featuring thrust mechanism with a 3 km source centroid depth. The shallow focal depth is confirmed with the sPL phase recorded at station L0205. As Rayleigh wave is well only developed for source depth less than 1/5 of epicentral distance, the observed large amplitude of Rg at a distance of 15 km implied depth of 3 km or less. Dozens of aftershocks' sPL waveforms are also analyzed to confirm the source depths less than 3 km. On the other hand, no surface ruptures are found by geological survey or InSAR studies. It is strongly suggested that these aftershock sequences initiate fresh rupture in intact rocks triggered by stress increase from the deep co-seismic rupture of the Wenchuan mainshock. | Luo Yan Ni SiDao Zeng XiangFang Zheng Yong Chen QiFu Chen Yong | 2010 | Science China Earth Sciences2010，53，11： | 26 |
| 4 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 5 | Heat and power load dispatching considering energy storage of district heating system and electric boilers显示文摘As one of promising clean and low-emission energy, wind power is being rapidly developed in China.However, it faces serious problem of wind curtailment,particularly in northeast China, where combined heat and power(CHP) units cover a large proportion of the district heat supply. Due to the inherent strong coupling between the power and the heat load, the operational flexibility of CHP units is severely restricted in winter to meet the heat supply demand, which imparts considerable stress on the wind power connection to the grid. To promote the integration of wind power and enhance the flexibility of CHP units, this paper presented a method of heat and power load dispatching by exploring the energy storage ability of electric heating boilers and district heating systems. The optimization results indicate that the proposed method can integrate additional wind power into the grid and reduce the coal consumption of CHP units over the optimized period. Furthermore, the thermal inertia of a district heating system is found to contribute more to the reduction of coal consumption, whereas the electric heating boilers contribute to lower wind curtailment. | Xianzheng HUANG Zhaofeng XU Yong SUN Yali XUE Zhe WANG Zhijun LIU Zhenyuan LI Weidou NI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 20 |
| 6 | The M5.0 Suining-Tongnan (China) earthquake of 31 January 2010:A destructive earthquake occurring in sedimentary cover显示文摘Usually, only crystalline basement is strong enough to store the massive strain energy that can be released in a damaging earthquake. By contrast, sedimentary cover is weak, because of its relatively high porosity and fluids. Therefore, it generally cannot accumulate enough energy for strong earthquakes. On January 31, 2010, a M5.0 earthquake occurred near the border of Suining and Tongnan in China. It excited strong short-period Rayleigh waves Rg, indicative of its shallow focal depth. The focal depth is constrained to less than 4 km, most probably in the range of 1-3 km, by modeling amplitude dependence on the frequency and waveforms of teleseismic depth phases (pP, sP). Because the local Mesozoic sedimentary cover is about 6 km thick, this earthquake should have occurred in the sedimentary cover. Though some shallow earthquakes with magnitudes up to M4 occur in Paleozoic sediments, this earthquake is the first M5 event studied in Mesozoic sedimentary cover. This event provides a rare opportunity to study seismogenic processes of damaging earthquakes in sedimentary basins. | LUO Yan NI SiDao ZENG XiangFang XIE Jun CHEN Yong LONG Feng | 2011 | Chinese Science Bulletin2011，56，6： | 17 |
| 7 | Catalytic oxidation of benzene over Ce-Mn oxides synthesized by flame spray pyrolysis显示文摘Flame spray pyrolysis(FSP) was utilized to synthesize Ce-Mn oxides in one step for catalytic oxidation of benzene.Cerium acetate and manganese acetate were used as precursors.The materials synthesized were characterized using X-ray diffraction(XRD),N_2 adsorption,X-ray photoelectron spectroscopy(XPS).transmission electron microscopy(TEM),Raman spectroscopy,and Fh-temperature programmed reduction(H_2-TPR) and their benzene catalytic oxidation behavior was evaluated.Mn ions were evidenced in multiple chemical states.Crystalline Ce-Mn oxides consist of particles with size <40 nm and specific surface areas(SSA) of 20-50m^2/g.Raman spectrums and H_2-TPR results indicated the interaction between cerium and manganese oxides.Flame-made 12.5%-Ce-Mn oxide exhibited excellent catalytic activity at relatively low temperatures(T95 about 260 C) compared to other Ce-Mn oxides with different ceriumto-manganese ratios.Redox mechanism and strong interaction conform to structure analysis that Ce-Mn strong interaction formed during the high temperature flame process and the results were used to explain catalytic oxidation of benzene. | Gang Liu Renliang Yue Yi Jia Yong Ni Jie Yang Haidi Liu Zhen Wang Xiaofeng Wu Yunfa Chen | 2013 | Particuology2013，11，4： | 17 |
| 8 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 9 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 10 | Inflammatory biomarkers and cerebral small vessel disease:a community-based cohort study显示文摘Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease(CSVD),previous findings remain largely inconclusive and vary according to disease status and study designs.The present study aimed to investigate possible associations between inflammatory biomarkers and MRI markers of CSVD.Methods A group of 15 serum inflammatory biomarkers representing a variety of those putatively involved in the inflammatory cascade was grouped and assessed in a cross-sectional study involving 960 stroke-free subjects.The biomarker panel was grouped as follows:systemic inflammation(high-sensitivity C reactive protein(hsCRP),interleukin 6 and tumour necrosis factorα),endothelial-related inflammation(E-selectin,P-selectin,intercellular adhesion molecule 1,vascular cell adhesion molecule 1(VCAM-1),CD40 ligand,lipoprotein-associated phospholipase A2,chitinase-3-like 1 protein and total homocysteine(tHCY))and media-related inflammation(matrix metalloproteinases 2,3 and 9,and osteopontin).The association(s)between different inflammatory groups and white matter hyperintensity(WMH),lacunes,cerebral microbleeds(CMBs),enlarged perivascular space(PVS)and the number of deep medullary veins(DMVs)were investigated.Results High levels of serum endothelial-related inflammatory biomarkers were associated with both increased WMH volume(R^(2)=0.435,p=0.015)and the presence of lacunes(R^(2)=0.254,p=0.027).Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers revealed that VCAM-1 was significant for WMH(β=0.063,p=0.005)and tHCY was significant for lacunes(β=0.069,p<0.001).There was no association between any group of inflammatory biomarkers and CMBs or PVS.Systemic inflammatory biomarkers were associated with fewer DMVs(R^(2)=0.032,p=0.006),and backward stepwise elimination of individual systemic-related inflammatory biomarkers revealed that hsCRP(β=−0.162,p=0.007)was significant.Conclusion WMH and lacunes were associated with endothelial-related inflammatory biomarkers,and fewer DMVs were associated with systemic inflammation,thus suggesting different underlying inflammatory processes and mechanisms. | Ding-Ding Zhang Yuan Cao Jing-Yu Mu Yi-Ming Liu Feng Gao Fei Han Fei-Fei Zhai Li-Xin Zhou Jun Ni Ming Yao Ming-Li Li Zheng-Yu Jin Shu-Yang Zhang Li-Ying Cui Yong Shen Yi-Cheng Zhu | 2022 | Stroke & Vascular Neurology2022，7，4： | 11 |
| 11 | Characteristics and sedimentary processes of lamina-controlled sand-particle imbricate structure in deposits on Lingshan Island, Qingdao, China显示文摘Imbricate structure is a common sedimentary structure and is well developed in sandy sediments.Here,we report a laminacontrolled fine-sand-particle imbricate structure in a set of very fine grained sedimentary rocks(fine sandstone,siltstone,and mudstone)at the Dockyard and Qianceng Cliff areas of Lingshan Island,Qingdao,Shandong,China.Sets of up to 300 laminae are found in stratigraphic profiles in these areas.The laminae are generally less than 1 mm thick,with most being 0.3–0.4 mm thick and the thinnest being<0.1 mm.The dip angle of the imbricate structure varies widely,between 0°and 90°,with an average dip angle of about 40°–50°,which is higher than that of imbricate riverbed gravels(about 34°).The dip angle is a function of the shape and sorting of the particles,as well as the hydrodynamic conditions under which these fine-grained sediments were deposited.Several profiles show well-developed multiscale,soft-sediment deformation structures.Flute casts,load casts,and groove casts are also common.Fragments of carbon remains occur widely and commonly constitute stringers several millimeters thick and up to 10 cm long,together with fine clasts.Vitrain lenticles are also common.Based on the imbricate structure of the Lingshan Island deposits,it is shown that in addition to paleocurrent analysis,the imbricate structure can be used to infer information about fluid properties,transport characteristics,and sedimentary processes of the depositional environment.A near-bottom underflow,either of authigenic origin or derived from cold river water in winter in a delta interdistributary bay or delta-front environment,is inferred to have provided the hydrodynamic setting in which this imbricate structure formed.The imbricate structure,together with other sedimentary structures and features,shows that the sedimentary rocks on Lingshan Island were deposited in an inland,shallow-water environment,such as a delta,and not in a deep-water or submarine continental-slope environment. | SHAO ZhuFu ZHONG JianHua LI Yong MAO Cui LIU ShengXin NI LiangTian TIAN Yuan CUI XinYing LIU YunTian WANG XiaoNan LI WeiHua LIN GangShan | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 12 | MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway显示文摘Background: Accumulating evidence demonstrates that microRNAs(miRNAs) play essential roles in tumorigenesis and cancer progression of hepatocellular carcinoma(HCC). Average targets of a miRNA were more than 100. And one miRNA may act in tumor via regulating several targets. The present study aimed to explore more potential targets of miR-449a by proteomics technology and further uncover the role of miR-449a in HCC tumorigenesis.Methods: Technologies such as i TRAQ-based quantitative proteomic were used to investigate the effect of miR-449a on HCC. The expression of c-Met and miR-449a was detected by q RT-PCR in HCC samples.Gain-and loss-of-function experiments were performed to identify the function and potential target of miR-449a in HCC cells.Results: In HCC, miR-449a was significantly downregulated, while c-Met was upregulated concurrently.Quantitative proteomics and luciferase reporter assay identified c-Met as a direct target of miR-449a.Moreover, miR-449a inhibited HCC growth not only by targeting CDK6 but also by suppressing cMet/Ras/Raf/ERK signaling pathway. Furthermore, the inhibition of c-Met expression with a specific siRNA significantly inhibited cells growth and deregulated the ERK pathway in HCC.Conclusion: The tumor suppressor miR-449a suppresses HCC tumorigenesis by repressing the c-Met/ERK pathway. | Jun Cheng Li-Ming Wu Xue-Song Deng Jian Wu Zhen Lv Hang-Fen Zhao Zhang Yang Yong Ni | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 10 |
| 13 | Effect of isothermal heat treatment on semi-solid microstructure of AZ91D magnesium alloy containing rare earth Gd显示文摘The AZ91 D magnesium alloy containing rare earth Gd was prepared in this study, and the effect of semi-solid isothermal heat treatment on the microstructure of the alloy was investigated to obtain an optimum semi-solid structure. Results show that Gd can refine the microstructure of AZ91 D magnesium alloy, and the optimum semi-solid AZ91 D microstructure can be achieved by adding 1.5wt.% Gd. After treated at 585 °C for 30 min, the well distributed rose-shaped and near-spherical semi-solid microstructures of AZ91D+1.5wt.%Gd alloy can be obtained. The liquid phase of the semi-solid alloy consists of three components, namely, the molten pool, the 'entrapped liquid' pool and the liner liquid film which separates two neighbor particles. The solid phase is composed of two phases, the primary α-Mg particles and the α-Mg phase formed in the second stage of solidification. With the increase of holding time, melting which causes the decrease of the primary α-Mg particle size is the dominant mechanism in the initial stage while coalescence and Ostwald ripening tend to be the principles later. | Yong Hu Li Rao Xu-wu Ni | 2015 | China Foundry2015，12，1： | 9 |
| 14 | Slip model for the 2011 M_w 9.0 Sendai (Japan) earthquake and its M_w 7.9 aftershock derived from GPS data显示文摘用为 8 h 的测量 GPS 的 coseismic 和 seismic 以后排水量跟随 M w 2011 年 3 月 11 日, coseismic 和 seismic 以后差错的 9.0 仙台地震滑动模型基于一个分层的外壳的模型被开发。主要吃惊的测地学的时刻大小是被测量近似 M w 8.98。slip 展出清楚的反向的特征,与大约 23.3 m 的 hypocenter,和大小附近的最大值。某罢工滑倒行为可以发生在山峰破裂地区的二个方面上。主要吃惊释放的几乎 90% 地震时刻发生在深度不到 40 km。精力由差错释放了在跟随主要吃惊的 8 h 滑倒近似等于 M w 的地震 8.13。与 1.5 m 的最大值, seismic 以后滑倒在 coseismic 破裂差错的西南的部分被集中,它与 M w 的地点和行为同意很好 7.9 余震。这暗示在在主要吃惊以后的 8 h 的 seismic 以后变丑被 M w 主要导致 7.9 余震。另外, seismic 以后 0.20.4 m 滑倒在 coseismic 破裂的下面剧降延期被观察,它可能被在滑倒以后的效果在这个时期期间引起了。 | DIAO FaQi XIONG Xiong NI SiDao ZHENG Yong GE Can | 2011 | Chinese Science Bulletin2011，56，27： | 8 |
| 15 | Experimental study on MSW gasification and melting technology显示文摘以便开发市政的稳固的浪费(MSW ) 气化和融化的技术,二预备试验和一个原则综合实验分别地被完成。当时, MSW 的气化特征在 500 750 ° C 被学习等价比率(嗯) 是 0.2 0.5 使用使流体化床的 gasifier。当温度是 550 700 ° C 时并且嗯是 0.2 0.4, syngas 的低热价值(LHV ) 到达 4000 12000 kJ/Nm3。苍蝇灰的融化的特征用一个改正床炉子在 1100 1460 ° C 被调查。超过 99.9% 戴奥辛能被分解,这被证明并且很重金属当温度是 1100 1300 ° C 时,能被团结。原则综合实验在使流体化床的气化和打漩融化系统被执行。MSW 在 550 650 ° C 高效地被气化,打漩融化炉子稳定地并且过去在 1200 1300 ° C 坚持说 95% 苍蝇灰能被打漩融化炉子抓住。结果提供了实际经验和基本数据开发 MSW 气化和融化的技术。 | XIAO Gang JIN Bao-sheng ZHONG Zhao-ping CHI Yong NI Ming-jiang CEN Ke-fa XIAO Rui HUANG Ya-ji HUANG He | 2007 | Journal of Environmental Sciences2007，19，11： | 7 |
| 16 | Model design and structure research for integration system of energy, information and transportation networks based on ANP-fuzzy comprehensive evaluation显示文摘For lack of deep research on model, system structure and top-level design, the integrated system concept of energy, information and transportation networks fails to provide effective guidance for transferring the theory to practice. In this paper, with dispatching of energy flow and information flow as a focus, clean energy of wind power and solar power as carrier, battery charging & swapping station as medium and all kinds of transportation flows as entity, a five-in-one threenetwork integrated system model is built by full use of technologies of Internet of Vehicles(IOV) and Internet of things(IOT) to promote the innovative concept of three-network integration into practice, and provide a reference for future researches. | Tianjing Wu Shaohua Liu Ming Ni Yong Zhao Pei Shen Syed Furqan Rafique | 2018 | Global Energy Interconnection2018，1，2： | 7 |
| 17 | Melatonin enhances salt tolerance by promoting MYB108A-mediated ethylene biosynthesis in grapevines显示文摘The signal molecules melatonin and ethylene play key roles in abiotic stress tolerance.The interplay between melatonin and ethylene in regulating salt tolerance and the underlying molecular mechanism of this interplay remain unclear.Here,we found that both melatonin and 1-aminocyclopropane-1-carboxylic acid(ACC,a precursor of ethylene)enhanced the tolerance of grapevine to NaCl;additionally,ethylene participated in melatonin-induced salt tolerance.Further experiments indicated that exogenous treatment and endogenous induction of melatonin increased the ACC content and ethylene production in grapevine and tobacco plants,respectively.The expression of MYB108A and ACS1,which function as a transcription factor and a key gene involved in ethylene production,respectively,was strongly induced by melatonin treatment.Additionally,MYB108A directly bound to the promoter of ACS1 and activated its transcription.MYB108A expression promoted ACC synthesis and ethylene production by activating ACS1 expression in response to melatonin treatment.The suppression of MYB108A expression partially limited the effect of melatonin on the induction of ethylene production and reduced melatonin-induced salt tolerance.Collectively,melatonin promotes ethylene biosynthesis and salt tolerance through the regulation of ACS1 by MYB108A. | Lili Xu Guangqing Xiang Qinghua Sun Yong Ni Zhongxin Jin Shiwei Gao Yuxin Yao | 2019 | Horticulture Research2019，6，1： | 7 |
| 18 | Circulating microRNAs as potential biomarkers for diagnosis of congenital heart defects显示文摘BACKGROUND: Micro RNAs are small non-coding RNAs of approximately 22 nucleotides in length, and play important regulatory roles in normal heart development and the pathogenesis of heart diseases. Recently, a few prospective studies have implicated the diagnostic role of micro RNAs in congenital heart defects(CHD).DATA RESOURCES: This review retrieved the research articles in Pub Med focusing on the altered microR NAs in cardiac tissue or serum of patients with CHD versus healthy normal controls, as well as the studies exploring circulating microR NAs as potential biomarkers for(fetal) CHD.RESULTS: Most of the studies of interest were conducted in recent years, implicating that the topic in this review is a newly emerging field and is drawing much attention. Moreover, a number of differentially expressed microR NAs between CHD specimens and normal controls have been reported.CONCLUSION: Circulating micro RNAs may serve as potential biomarkers for diagnosis of CHD in the future, with more efforts paving the road to the aim. | Wan-qin Xie Lin Zhou Yong Chen Bin Ni | 2016 | World Journal of Emergency Medicine2016，7，2： | 7 |
| 19 | Near-infrared spectra combined with partial least squares for pH determination of toothpaste of different brands显示文摘Near-infrared spectroscopy(NIR),which is generally used for online monitoring of the food analysis and production process, was applied to determine the internal quality of toothpaste samples.It is acknowledged that the spectra can be significantly influenced by non-linearities introduced by light scatter,therefore,four data preprocessing methods,including off-set correction, 1st-derivative,standard normal variate(SNV) and multiplicative scatter correction(MSC),were employed before the date analysis. The multivariate calibration model of partial least squares(PLS) was established and then was used to predict the pH values of the toothpaste samples of different brand.The results showed that the spectral date processed by MSC was the best one for predicting the pH value of the toothpaste samples. | Yong Nian Ni Wei Lin | 2011 | Chinese Chemical Letters2011，22，12： | 6 |
| 20 | Application of transient burning rate model of solid propellant in electrothermal-chemical launch simulation显示文摘A 30 mm electrothermal-chemical(ETC) gun experimental system is employed to research the burning rate characteristics of 4/7 high-nitrogen solid propellant. Enhanced gas generation rates(EGGR) of propellants during and after electrical discharges are verified in the experiments. A modified 0D internal ballistic model is established to simulate the ETC launch. According to the measured pressure and electrical parameters, a transient burning rate law including the influence of EGGR coefficient by electric power and pressure gradient(dp/dt) is added into the model. The EGGR coefficient of 4/7 high-nitrogen solid propellant is equal to 0.005 MW-1. Both simulated breech pressure and projectile muzzle velocity accord with the experimental results well. Compared with Woodley's modified burning rate law, the breech pressure curves acquired by the transient burning rate law are more consistent with test results. Based on the parameters calculated in the model, the relationship among propellant burning rate, pressure gradient(dp/dt) and electric power is analyzed. Depending on the transient burning rate law and experimental data, the burning of solid propellant under the condition of plasma is described more accurately. | Yan-jie NI Yong JIN Gang WAN Chun-xia YANG Hai-yuan LI Bao-ming LI | 2016 | Defence Technology(防务技术)2016，12，2： | 6 |
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